Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for metC (cystathionine beta-lyase) in L-methionine biosynthesis

Or see other characterized proteins similar to metC

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metC

Curated proteins or TIGRFams with EC 4.4.1.13
Ignore hits to Q84UD0 when looking for 'other' hits (cysteine-S-conjugate beta-lyase (EC 4.4.1.13); L-cystine beta-lyase (EC 4.4.1.35))
Ignore hits to Q9EYM7 when looking for 'other' hits (cysteine-S-conjugate beta-lyase (EC 4.4.1.13))
Ignore hits to Q9SIV0 when looking for 'other' hits (S-alkyl-thiohydroximate lyase SUR1; Protein ABERRANT LATERAL ROOT FORMATION 1; Protein HOOKLESS 3; Protein ROOTY; Protein ROOTY 1; Protein SUPERROOT 1; EC 4.4.1.-. alkyl-thiohydroximate C-S lyase (EC 4.4.1.13))
Ignore hits to CH_088676 when looking for 'other' hits (cystathionine beta-lyase; EC 4.4.1.8)
Ignore hits to Q46061 when looking for 'other' hits (L-cysteine desulfidase (EC 4.4.1.28))
Curated sequence Q5H4T8: cystathionine gamma-lyase (EC 4.4.1.1)
Comment: BRENDA annotates Q84UD0 with this EC number but it may be a cystine lyase only (PMID:12525491). BRENDA annotates Q9EYM7 with this EC but it appears to be a cystathionine beta synthase (PMID:12101301). Q9SIV0 appears to be specific to glucosinolate biosynthesis. CH_088676 is annotated as this but with a different EC number, so it is ignored. Q4606 is annotated as cysteine desulfidase but is nearly identical to Q93QC6, which is a cystathionine beta-lyase, so it is ignored. XoMetC (Q5H4T8) is annotated as a gamma-lyase by BRENDA, but it also has beta-lyase activity (PMID:24531493).

Fetched 30 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 30 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 340-465 amino acids (2/18 heteromeric)

METC_BACSU / O31632 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase MetC; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13 from Bacillus subtilis (strain 168)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
390 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0M3VI47 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Mimosa pudica
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
457 amino acids: PaperBLAST, CDD, Compare to cluster

A2RM21 cystathionine gamma-lyase (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lactococcus lactis
RF|YP_001033049.1 cystathionine beta-lyase; EC 4.4.1.8 from Lactococcus lactis subsp. cremoris MG1363
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD, Compare to cluster

B3TNN8 cystathionine gamma-lyase (subunit 2/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, Compare to cluster

B3TNN9 cystathionine gamma-lyase (subunit 1/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, Compare to cluster

E3VL26 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Saccharomyces cerevisiae
PFams: Cys_Met_Meta_PP
465 amino acids: PaperBLAST, CDD, Compare to cluster

b3008 cystathionine β-lyase / L-cysteine desulfhydrase / alanine racemase (EC 4.4.1.13; EC 4.4.1.1; EC 4.4.1.28; EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655
P06721 cystathionine β-lyase / L-cysteine desulfhydrase / alanine racemase (EC 4.4.1.13; EC 4.4.1.1; EC 5.1.1.10) from Escherichia coli (strain K12)
METC_ECOLI / P06721 Cystathionine beta-lyase MetC; CBL; CL; Beta-cystathionase MetC; Cysteine desulfhydrase MetC; CD; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13; EC 4.4.1.28 from Escherichia coli (strain K12)
P06721 alanine racemase (EC 5.1.1.1) from Escherichia coli
PFams: Cys_Met_Meta_PP
395 amino acids: PaperBLAST, CDD, Compare to cluster

P43623 cysteine-S-conjugate β-lyase monomer (EC 4.4.1.13; EC 4.4.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
METC_YEAST / P43623 Putative cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Increased recombination centers protein 7; EC 4.4.1.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P43623 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Saccharomyces cerevisiae
PFams: Cys_Met_Meta_PP
340 amino acids: PaperBLAST, CDD, Compare to cluster

CBL_NEUCR / Q1K8G0 Cystathionine beta-lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1K8G0 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Neurospora crassa
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
457 amino acids: PaperBLAST, CDD, Compare to cluster

Q4FME3 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1) from Candidatus Pelagibacter ubique
PFams: Cys_Met_Meta_PP, Aminotran_1_2
367 amino acids: PaperBLAST, CDD, Compare to cluster

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD, Compare to cluster

ALGLR_THEMA / Q9X0Z7 L-alanine/L-glutamate racemase; EC 5.1.1.1; EC 5.1.1.3 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Q9X0Z7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1); glutamate racemase (EC 5.1.1.3) from Thermotoga maritima
PFams: Cys_Met_Meta_PP
379 amino acids: PaperBLAST, CDD, Compare to cluster

P53101 cystathionine β-lyase (EC 4.4.1.13) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
STR3_YEAST / P53101 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Sulfur transfer protein 3; EC 4.4.1.13 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Cys_Met_Meta_PP
465 amino acids: PaperBLAST, CDD, Compare to cluster

P53780 cystathionine β-lyase monomer (EC 4.4.1.13) from Arabidopsis thaliana
METC_ARATH / P53780 Cystathionine beta-lyase, chloroplastic; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
464 amino acids: PaperBLAST, CDD, Compare to cluster

METC_BORAV / Q07703 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Osteotoxin; EC 4.4.1.13 from Bordetella avium
PFams: Cys_Met_Meta_PP
396 amino acids: PaperBLAST, CDD, Compare to cluster

METC_STAHJ / Q4L332 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Staphylococcus haemolyticus (strain JCSC1435)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
391 amino acids: PaperBLAST, CDD, Compare to cluster

ALGLR_WOLPM / Q73GL9 L-alanine/L-glutamate racemase; EC 5.1.1.1; EC 5.1.1.3 from Wolbachia pipientis wMel
Q73GL9 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); alanine racemase (EC 5.1.1.1); glutamate racemase (EC 5.1.1.3) from Wolbachia pipientis
PFams: Cys_Met_Meta_PP
403 amino acids: PaperBLAST, CDD, Compare to cluster

METC_COXBU / Q83A83 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 354-401 amino acids (not heteromeric)

CBL_BACSU / Q08432 Cystathionine beta-lyase PatB; CBL; Beta-cystathionase PatB; Cysteine lyase PatB; Cysteine-S-conjugate beta-lyase PatB; EC 4.4.1.13 from Bacillus subtilis (strain 168)
PFams: Aminotran_1_2
387 amino acids: PaperBLAST, CDD, Compare to cluster

A0A223K4L6 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); amino-acid racemase (EC 5.1.1.10) from Latilactobacillus sakei
PFams: Aminotran_1_2
391 amino acids: PaperBLAST, CDD, Compare to cluster

A6YH85 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Aminotran_1_2
401 amino acids: PaperBLAST, CDD, Compare to cluster

b1622 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 4.4.1.28; EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655
P23256 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 5.1.1.10) from Escherichia coli (strain K12)
MALY_ECOLI / P23256 Protein MalY; EC 4.4.1.13 from Escherichia coli (strain K12)
CH_000574 maltose regulon modulator MalY; EC 4.4.1.8 from Escherichia coli K12
PFams: Aminotran_1_2
390 amino acids: PaperBLAST, CDD, Compare to cluster

CBL_THET8 / Q5SHW0 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: Aminotran_1_2
354 amino acids: PaperBLAST, CDD, Compare to cluster

Q64HC5 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Corynebacterium striatum
CBL_CORST / Q64HC5 Cysteine-S-conjugate beta-lyase; C-S lyase; Cystathionine beta-lyase; CBL; EC 4.4.1.13 from Corynebacterium striatum
PFams: Aminotran_1_2
377 amino acids: PaperBLAST, CDD, Compare to cluster

CBL_CORGT / Q93QC6 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Corynebacterium glutamicum (Brevibacterium saccharolyticum)
PFams: Aminotran_1_2
368 amino acids: PaperBLAST, CDD, Compare to cluster

Q8L0M8 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Streptococcus anginosus
PFams: Aminotran_1_2
388 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 422-455 amino acids (not heteromeric)

Q16773 kynurenine aminotransferase I subunit (EC 2.6.1.117; EC 2.6.1.7; EC 4.4.1.13; EC 2.6.1.64) from Homo sapiens
KAT1_HUMAN / Q16773 Kynurenine--oxoglutarate transaminase 1; Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I; EC 2.6.1.7; EC 4.4.1.13; EC 2.6.1.64 from Homo sapiens (Human)
Q16773 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Homo sapiens
PFams: Aminotran_1_2
422 amino acids: PaperBLAST, CDD, Compare to cluster

Q6YP21 Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7; EC 4.4.1.13) from Homo sapiens
Q6YP21 kynurenine-oxoglutarate transaminase (EC 2.6.1.7); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Homo sapiens
PFams: Aminotran_1_2
454 amino acids: PaperBLAST, CDD, Compare to cluster

KAT3_MOUSE / Q71RI9 Kynurenine--oxoglutarate transaminase 3; Cysteine-S-conjugate beta-lyase 2; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; KATIII; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III; EC 2.6.1.7; EC 4.4.1.13; EC 2.6.1.63 from Mus musculus (Mouse)
Q71RI9 glutamine-pyruvate transaminase (EC 2.6.1.15); kynurenine-oxoglutarate transaminase (EC 2.6.1.7); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Mus musculus
PFams: Aminotran_1_2
455 amino acids: PaperBLAST, CDD, Compare to cluster

KAT1_RAT / Q08415 Kynurenine--oxoglutarate transaminase 1; Kynurenine--oxoglutarate transaminase I; Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; EC 2.6.1.7; EC 4.4.1.13; EC 2.6.1.64 from Rattus norvegicus (Rat)
Q08415 kynurenine-oxoglutarate transaminase (EC 2.6.1.7) from Rattus norvegicus
PFams: Aminotran_1_2
423 amino acids: PaperBLAST, CDD, Compare to cluster