Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aroA (3-phosphoshikimate 1-carboxyvinyltransferase) in chorismate biosynthesis

Or see other characterized proteins similar to aroA

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Definition of aroA

Curated proteins or TIGRFams with EC 2.5.1.19
UniProt sequence Q72EV5_DESVH: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210};
UniProt sequence I9A2E3: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210};
UniProt sequence L0FR45: RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|ARBA:ARBA00012450}; EC=2.5.1.19 {ECO:0000256|ARBA:ARBA00012450}; AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|ARBA:ARBA00030046};
Predicted: UniProt sequence G0EEF0: SubName: Full=EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) {ECO:0000313|EMBL:AEM37991.1};
Comment: Add AroA from Desulfovibrio vulgaris (DVU0463) because it is a bit diverged, is conserved essential, and clusters with aromatic amino acid biosynthesis genes. HMPREF1058_RS13970 (I9A2E3) is cofit with chorismate synthase (Surya Tripathi); also, it is 71% identical to BT2186 / BT_RS11065, which can complement an aroA- strain of E. coli (Bradley Biggs). PYRFU_RS00635 (G0EEF0) from Pyrolobus fumarii is from this family, has similar active site residues (alignment to Q83E11 shows three conserved residues, and D315 => R331), and its closest homologs are in chorisomate synthesis operons (but, these are under 30% identity); it is probably the missing aroA.

Fetched 46 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 44 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 409-516 amino acids (not heteromeric)

AROA_COXBU / Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Coxiella burnetii
PFams: EPSP_synthase
438 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0D6KU47 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Tolypothrix sp.
PFams: EPSP_synthase
449 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0P4UM05 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Leptolyngbya boryana
PFams: EPSP_synthase
447 amino acids: PaperBLAST, CDD, Compare to cluster

A0A139XBW5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Scytonema hofmannii
PFams: EPSP_synthase
452 amino acids: PaperBLAST, CDD, Compare to cluster

A2T9R8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Dunaliella salina
PFams: EPSP_synthase
514 amino acids: PaperBLAST, CDD, Compare to cluster

A3TGI7 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Janibacter sp.
PFams: EPSP_synthase
432 amino acids: PaperBLAST, CDD, Compare to cluster

A6TL04 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Alkaliphilus metalliredigens
PFams: EPSP_synthase
425 amino acids: PaperBLAST, CDD, Compare to cluster

A6WUV8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Brucella anthropi
PFams: EPSP_synthase
450 amino acids: PaperBLAST, CDD, Compare to cluster

B1XM36 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus sp.
PFams: EPSP_synthase
446 amino acids: PaperBLAST, CDD, Compare to cluster

B4VHX1 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Coleofasciculus chthonoplastes
PFams: EPSP_synthase
453 amino acids: PaperBLAST, CDD, Compare to cluster

B4WHQ7 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus sp.
PFams: EPSP_synthase
409 amino acids: PaperBLAST, CDD, Compare to cluster

B8CWX4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Halothermothrix orenii
PFams: EPSP_synthase
430 amino acids: PaperBLAST, CDD, Compare to cluster

C3MC80 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Sinorhizobium fredii
PFams: EPSP_synthase
448 amino acids: PaperBLAST, CDD, Compare to cluster

C9EGX2 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Rahnella aquatilis
PFams: EPSP_synthase
427 amino acids: PaperBLAST, CDD, Compare to cluster

F5A7Q0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Bacillus cereus
PFams: EPSP_synthase
429 amino acids: PaperBLAST, CDD, Compare to cluster

I4GHG6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Microcystis aeruginosa
PFams: EPSP_synthase
446 amino acids: PaperBLAST, CDD, Compare to cluster

K9QNN0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp.
PFams: EPSP_synthase
449 amino acids: PaperBLAST, CDD, Compare to cluster

K9RIB8 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Rivularia sp. PCC 7116
PFams: EPSP_synthase
448 amino acids: PaperBLAST, CDD, Compare to cluster

K9TRT1 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oscillatoria sp.
PFams: EPSP_synthase
450 amino acids: PaperBLAST, CDD, Compare to cluster

K9TX81 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Chroococcidiopsis thermalis
PFams: EPSP_synthase
448 amino acids: PaperBLAST, CDD, Compare to cluster

K9VBD9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oscillatoria sp.
PFams: EPSP_synthase
451 amino acids: PaperBLAST, CDD, Compare to cluster

b0908 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli K-12 substr. MG1655
P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli (strain K12)
AROA_ECOLI / P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Escherichia coli (strain K12)
P0A6D3 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Escherichia coli
PFams: EPSP_synthase
427 amino acids: PaperBLAST, CDD, Compare to cluster

Q31RQ5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus elongatus
Q5N2J9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Synechococcus elongatus
PFams: EPSP_synthase
448 amino acids: PaperBLAST, CDD, Compare to cluster

Q93VK6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Oryza sativa
PFams: EPSP_synthase
511 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_VIBCH / Q9KRB0 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Q9KRB0 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Vibrio cholerae serotype O1
PFams: EPSP_synthase
426 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_AGRSC / Q9R4E4 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Agrobacterium sp. (strain CP4)
Q9R4E4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Agrobacterium sp.
PFams: EPSP_synthase
455 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_STRPN / Q9S400 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Q9S400 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Streptococcus pneumoniae
PFams: EPSP_synthase
427 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_PETHY / P11043 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EC 2.5.1.19 from Petunia hybrida (Petunia)
PFams: EPSP_synthase
516 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_KLEPN / P24497 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Klebsiella pneumoniae
PFams: EPSP_synthase
427 amino acids: PaperBLAST, CDD, Compare to cluster

AROA1_HALH5 / Q9KCA6 3-phosphoshikimate 1-carboxyvinyltransferase 1; 5-enolpyruvylshikimate-3-phosphate synthase 1; EPSP synthase 1; EPSPS 1; EC 2.5.1.19 from Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
PFams: EPSP_synthase
431 amino acids: PaperBLAST, CDD, Compare to cluster

Q72EV5_DESVH 3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; 5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210}
439 amino acids: PaperBLAST, CDD, Compare to cluster

P20691 5-enolpyruvoylshikimate-3-phosphate synthase (EC 2.5.1.19) from Bacillus subtilis (strain 168)
PFams: EPSP_synthase
428 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 390-450 amino acids (not heteromeric)

Q482G5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Colwellia psychrerythraea
PFams: EPSP_synthase
426 amino acids: PaperBLAST, CDD, Compare to cluster

A0A2K1XRJ2 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Populus trichocarpa
PFams: EPSP_synthase
390 amino acids: PaperBLAST, CDD, Compare to cluster

A1Z0H6 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Pseudomonas fluorescens
PFams: EPSP_synthase
444 amino acids: PaperBLAST, CDD, Compare to cluster

B2IYE4 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc punctiforme
PFams: EPSP_synthase
426 amino acids: PaperBLAST, CDD, Compare to cluster

K9PSG5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Calothrix sp.
PFams: EPSP_synthase
426 amino acids: PaperBLAST, CDD, Compare to cluster

AROA_MYCTU / P9WPY5 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WPY5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Mycobacterium tuberculosis
PFams: EPSP_synthase
450 amino acids: PaperBLAST, CDD, Compare to cluster

Q3MAV9 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp.
PFams: EPSP_synthase
426 amino acids: PaperBLAST, CDD, Compare to cluster

Q8YMB5 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) from Nostoc sp.
PFams: EPSP_synthase
425 amino acids: PaperBLAST, CDD, Compare to cluster

I9A2E3 3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000256|HAMAP-Rule:MF_00210}; EC=2.5.1.19 {ECO:0000256|HAMAP-Rule:MF_00210}; 5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSP synthase {ECO:0000256|HAMAP-Rule:MF_00210}; Short=EPSPS {ECO:0000256|HAMAP-Rule:MF_00210}
408 amino acids: PaperBLAST, CDD, Compare to cluster

L0FR45 3-phosphoshikimate 1-carboxyvinyltransferase; EC=2.5.1.19; 5-enolpyruvylshikimate-3-phosphate synthase
405 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 1583-1588 amino acids (not heteromeric)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans
CH_122161 pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans
PFams: DHQ_synthase, Fe-ADH_2, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, SDH_C
1583 amino acids: PaperBLAST, CDD, Compare to cluster

P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
1588 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

G0EEF0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
459 amino acids: PaperBLAST, CDD

H9TE88 shimimate dehydratase/3,4-dihydroxycyclohexa-1,5-diene-1-carboxylate--CoA ligase (from HMM only) from Streptomyces flaveolus
PFams: EPSP_synthase, AMP-binding, AMP-binding_C
998 amino acids: PaperBLAST, CDD