Other Characterized Proteins Similar to hisC
Finding the characterized proteins for hisC (histidinol-phosphate aminotransferase) in L-histidine biosynthesis
Or see clustering for step hisC
Or see all steps for L-histidine biosynthesis
Or cluster curated proteins matching a keyword
Definition of hisC
- Curated proteins or TIGRFams with EC 2.6.1.9
- UniProt sequence HIS8_BACSU: RecName: Full=Histidinol-phosphate aminotransferase; EC=2.6.1.9; AltName: Full=Imidazole acetol-phosphate transaminase;
- UniProt sequence A0A2R7PAQ8: RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; AltName: Full=Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023};
- UniProt sequence A0A975E8Y9: RecName: Full=Histidinol-phosphate aminotransferase {ECO:0000256|HAMAP-Rule:MF_01023}; EC=2.6.1.9 {ECO:0000256|HAMAP-Rule:MF_01023}; AltName: Full=Imidazole acetol-phosphate transaminase {ECO:0000256|HAMAP-Rule:MF_01023};
- Ignore hits to BPHYT_RS14905 when looking for 'other' hits (Aromatic-amino-acid transaminase (EC 2.6.1.57))
- Comment: In Bacillus subtilis, the histidinol-phosphate aminotransferase activity is provided by a gene that is in a cluster of genes for tyrosine and phenylalanine biosynthesis (PMID:4431). Homology suggests that this activity is provided by "HisH" (BSU22620), which indeed is just upstream of tyrA (PMID:6092865). This protein is now usually referred to as "HisC" (HIS8_BACSU). GAMENC_05715 from Acidovorax sp. FHTAMBA (nearly identical to A0A2R7PAQ8) can complement a hisC- strain of E. coli (Bradley Biggs) and is in a histidine synthesis gene cluster. GW822FHT02A01_217 from Rhodoferax sp. GW822-FHT02A01 (similar to A0A975E8Y9) can complement a hisC- strain of E. coli (Bradley Biggs) and is in a histidine synthesis gene cluster. Fitness data for BPHYT_RS14905 from Burkholderia phytofirmans suggests that it is an aromatic amino acid transaminase, but it is 55% identical to TK06_RS12685, which can complement a hisC- mutant of E.coli (Bradley Biggs), so any similarity to it is ignored.
Fetched 23 sequences
Running ublast to find other characterized proteins with 40% identity and 70% coverage
Found hits to 1 other characterized sequences. (Found 21 hits including self hits.)
Removing ignored items reduces this to 0 close sequences.
There are also 1 HMM-only high-coverage hits.
HMM-only sequences
(Since these sequences' annotations are outside the definition for hisC, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)
A0A0D3RBW0 tryptophan—pyruvate aminotransferase (EC 2.6.1.99) from Streptomyces griseus
PFams: Aminotran_1_2
375 amino acids: PaperBLAST, CDD
Close but ignored sequences
(Sequences that are similar to these will still be high-confidence candidates for hisC.)
BPHYT_RS14905 Aromatic-amino-acid transaminase (EC 2.6.1.57) from Burkholderia phytofirmans PsJN
PFams: Aminotran_1_2
370 amino acids: PaperBLAST, CDD, reanno::BFirm:BPHYT_RS14905
40% identical to
P17731 histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous) (EC 2.6.1.1; EC 2.6.1.9) from Bacillus subtilis (strain 168)
PFams: Aminotran_1_2, Aminotran_5
360 amino acids: PaperBLAST, CDD