Other Characterized Proteins Similar to metB

GapMind for Amino acid biosynthesis

Other Characterized Proteins Similar to metB

Finding the characterized proteins for metB (cystathionine gamma-synthase) in L-methionine biosynthesis

Or see clustering for step metB

Or see all steps for L-methionine biosynthesis

Or cluster curated proteins matching a keyword

Definition of metB

Curated proteins or TIGRFams with EC 2.5.1.48
Curated sequence O31631: Cystathionine gamma-synthase/O-acetylhomoserine (thiol)-lyase; CGS/OAH thiolyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase; EC 2.5.1.-
Ignore hits to Q1M0P5 when looking for 'other' hits (Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48. cystathionine gamma-synthase (EC 2.5.1.48))
Comment: Many metB proteins have some activity as O-succinylhomoserine sulfhydrylase (metZ) as well, and many metZ proteins are annotated with this EC number. So this step may include both enzymes. METI_BACSU (O31631) has activity as CGS but is given a more vague EC number. Q1M0P5 is now thought to be a gamma-lyase instead (see link_RS00540-MONOMER), so it is ignored.

Fetched 14 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 47 other characterized sequences. (Found 61 hits including self hits.)

Removing ignored items reduces this to 46 close sequences.

Close sequences

(Sequences that are similar to these will not be high-confidence candidates for metB.)

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD, BRENDA::Q5H4T8
56% identical to

METB_MYCTU / P9WGB7 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_1_2
388 amino acids: PaperBLAST, CDD

P31373 Cys3 (EC 4.4.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
CYS3_YEAST / P31373 Cystathionine gamma-lyase; gamma-CTLase; Gamma-cystathionase; Sulfur transfer protein 1; EC 4.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P31373 cystathionine gamma-lyase (EC 4.4.1.1) from Saccharomyces cerevisiae
PFams: Cys_Met_Meta_PP
394 amino acids: PaperBLAST, CDD, BRENDA::P31373
52% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

A2RM21 cystathionine gamma-lyase (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lactococcus lactis
RF|YP_001033049.1 cystathionine beta-lyase; EC 4.4.1.8 from Lactococcus lactis subsp. cremoris MG1363
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD, BRENDA::A2RM21
52% identical to

CGL_DICDI / Q55DV9 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Dictyostelium discoideum (Social amoeba)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD, SwissProt::Q55DV9
52% identical to

B2LXT6 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus nidulans
CH_122519 cystathionine gamma-lyase; EC 4.4.1.1 from Emericella nidulans
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
419 amino acids: PaperBLAST, CDD, CharProtDB::CH_122519
51% identical to

CH_124009 cystathionine-gamma-lyase [Acremonium chrysogenum] from Magnaporthe grisea 70-15
PFams: Cys_Met_Meta_PP, Aminotran_1_2
426 amino acids: PaperBLAST, CDD, CharProtDB::CH_124009
49% identical to

MCCB_BACSU / O05394 Cystathionine gamma-lyase; Gamma-cystathionase; Homocysteine gamma-lyase; EC 4.4.1.1; EC 4.4.1.2 from Bacillus subtilis (strain 168)
O05394 cystathionine beta-synthase (O-acetyl-L-serine) (EC 2.5.1.134) from Bacillus subtilis
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
379 amino acids: PaperBLAST, CDD, BRENDA::O05394
50% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

GB|AAF14695.1 cystathionine beta-lyase; EC 4.4.1.8 from Austrochilidae
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
380 amino acids: PaperBLAST, CDD, CharProtDB::CH_088676
51% identical to

Q4WCI1 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus fumigatus
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
412 amino acids: PaperBLAST, CDD, BRENDA::Q4WCI1
48% identical to

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD, metacyc::HP_RS00540-MONOMER
50% identical to

METC_COXBU / Q83A83 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD, SwissProt::Q83A83
50% identical to

Q5MQ31 methionine gamma-lyase (EC 4.4.1.11) from Brevibacterium linens
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
425 amino acids: PaperBLAST, CDD, BRENDA::Q5MQ31
49% identical to

Q96VU7 cystathionine gamma-lyase (EC 4.4.1.1) from Neurospora crassa
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
417 amino acids: PaperBLAST, CDD, BRENDA::Q96VU7
49% identical to

B3TNN9 cystathionine gamma-lyase (subunit 1/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, BRENDA::B3TNN9
48% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

CH_122042 cystathionine gamma-synthase (Eurofung) from Emericella nidulans
PFams: Cys_Met_Meta_PP
594 amino acids: PaperBLAST, CDD, CharProtDB::CH_122042
48% identical to

MET7_SCHPO / O74314 Probable cystathionine gamma-synthase; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Cys_Met_Meta_PP
610 amino acids: PaperBLAST, CDD

B3TNN8 cystathionine gamma-lyase (subunit 2/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, BRENDA::B3TNN8
48% identical to

P32929 cystathionine γ-lyase monomer (EC 4.4.1.1; EC 4.4.1.2; EC 4.2.1.22) from Homo sapiens
CGL_HUMAN / P32929 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Homo sapiens (Human)
P32929 cystathionine gamma-lyase (EC 4.4.1.1) from Homo sapiens
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
405 amino acids: PaperBLAST, CDD, BRENDA::P32929
46% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

CGL_MOUSE / Q8VCN5 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Mus musculus (Mouse)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
398 amino acids: PaperBLAST, CDD, SwissProt::Q8VCN5
47% identical to

P18757 cystathionine γ-lyase subunit (EC 4.4.1.1) from Rattus norvegicus
CGL_RAT / P18757 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; Probasin-related antigen; PRB-RA; EC 4.4.1.1; EC 4.4.1.2 from Rattus norvegicus (Rat)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, SwissProt::P18757
47% identical to

METZ_MYCTU / P9WGB5 O-succinylhomoserine sulfhydrylase; OSH sulfhydrylase; OSHS sulfhydrylase; EC 2.5.1.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Cys_Met_Meta_PP
406 amino acids: PaperBLAST, CDD, SwissProt::P9WGB5
47% identical to

P55218 O-succinyl-L-homoserine sulfhydrylase (EC 2.5.1.48) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
METZ_PSEAE / P55218 O-succinylhomoserine sulfhydrylase; OSH sulfhydrylase; OSHS sulfhydrylase; EC 2.5.1.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5, DegT_DnrJ_EryC1
403 amino acids: PaperBLAST, CDD

MEGL_FUSNN / Q8RDT4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-cysteine desulfidase; EC 4.4.1.11; EC 4.4.1.2; EC 4.4.1.28 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355)
Q8RDT4 methionine gamma-lyase (EC 4.4.1.11) from Fusobacterium nucleatum subsp. nucleatum
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
395 amino acids: PaperBLAST, CDD, BRENDA::Q8RDT4
45% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

MEGL_FUSNP / Q8L0X4 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Fusobacterium nucleatum subsp. polymorphum (Fusobacterium polymorphum)
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
395 amino acids: PaperBLAST, CDD, SwissProt::Q8L0X4
45% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

Ga0059261_3194 O-acetylhomoserine sulfhydrylase (EC:2.5.1.49) from Sphingomonas koreensis DSMZ 15582
PFams: Cys_Met_Meta_PP, Aminotran_5, Aminotran_1_2
402 amino acids: PaperBLAST, CDD, reanno::Korea:Ga0059261_3194
44% identical to

Q8KNG3 methionine gamma-lyase (EC 4.4.1.11) from Micromonospora echinospora
PFams: Cys_Met_Meta_PP, Aminotran_1_2
381 amino acids: PaperBLAST, CDD, BRENDA::Q8KNG3
45% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

A0A1L7H888 methionine gamma-lyase (EC 4.4.1.11) from Clostridium tetani
PFams: Cys_Met_Meta_PP, Beta_elim_lyase, DegT_DnrJ_EryC1, Aminotran_1_2, Met_gamma_lyase, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::A0A1L7H888
43% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

A0A0J6G7P5 methionine γ-lyase (EC 4.4.1.11) from Pseudomonas deceptionensis
MEGL_PSEDM / A0A0J6G7P5 L-methionine gamma-lyase; MGL; EC 4.4.1.11 from Pseudomonas deceptionensis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase
399 amino acids: PaperBLAST, CDD, SwissProt::A0A0J6G7P5
44% identical to

Q84AR1 methionine gamma-lyase (EC 4.4.1.11); alliin lyase (EC 4.4.1.4) from Citrobacter freundii
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Beta_elim_lyase, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::Q84AR1
44% identical to

METC_BACSU / O31632 Cystathionine beta-lyase MetC; CBL; Beta-cystathionase MetC; Cysteine lyase MetC; Cysteine-S-conjugate beta-lyase MetC; EC 4.4.1.13 from Bacillus subtilis (strain 168)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
390 amino acids: PaperBLAST, CDD, SwissProt::O31632
43% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

SO1812 Methionine gamma-lyase (EC 4.4.1.11) from Shewanella oneidensis MR-1
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
397 amino acids: PaperBLAST, CDD, reanno::MR1:200974
43% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

MEGL_TREDE / Q73KL7 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)
Q73KL7 methionine gamma-lyase (EC 4.4.1.11) from Treponema denticola
PFams: Cys_Met_Meta_PP, Met_gamma_lyase
401 amino acids: PaperBLAST, CDD, BRENDA::Q73KL7
43% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

P13254 MdeA from Pseudomonas putida
MEGL_PSEPU / P13254 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methioninase; EC 4.4.1.11; EC 4.4.1.2 from Pseudomonas putida (Arthrobacter siderocapsulatus)
PFams: Cys_Met_Meta_PP, Beta_elim_lyase, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, SwissProt::P13254
42% identical to

J7TA22 methionine gamma-lyase (EC 4.4.1.11) from Clostridium sporogenes
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
400 amino acids: PaperBLAST, CDD, BRENDA::J7TA22
43% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

MEGL_PORGI / Q7MX71 L-methionine gamma-lyase; MGL; Homocysteine desulfhydrase; L-methionine-alpha-deamino-gamma-mercaptomethane-lyase; METase; EC 4.4.1.11; EC 4.4.1.2 from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Q7MX71 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
399 amino acids: PaperBLAST, CDD, BRENDA::Q7MX71
41% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

O15565 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, BRENDA::O15565
41% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

E9AFE7 cystathionine gamma-lyase (EC 4.4.1.1) from Leishmania major
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1
409 amino acids: PaperBLAST, CDD, BRENDA::E9AFE7
42% identical to

P53780 cystathionine β-lyase monomer (EC 4.4.1.13) from Arabidopsis thaliana
METC_ARATH / P53780 Cystathionine beta-lyase, chloroplastic; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Arabidopsis thaliana (Mouse-ear cress)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
464 amino acids: PaperBLAST, CDD, SwissProt::P53780
42% identical to

C3VMV9 methionine gamma-lyase (EC 4.4.1.11) from Porphyromonas gingivalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
393 amino acids: PaperBLAST, CDD, BRENDA::C3VMV9
41% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

A0A0M3VI47 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Mimosa pudica
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
457 amino acids: PaperBLAST, CDD, BRENDA::A0A0M3VI47
42% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

L7N4M1 O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) from Mycobacterium tuberculosis
PFams: Cys_Met_Meta_PP
449 amino acids: PaperBLAST, CDD, BRENDA::L7N4M1
41% identical to

CH_122245 cystathionine beta-lyase; EC 4.4.1.8 from Emericella nidulans
PFams: Cys_Met_Meta_PP, Aminotran_1_2
439 amino acids: PaperBLAST, CDD, CharProtDB::CH_122245
41% identical to

CBL_NEUCR / Q1K8G0 Cystathionine beta-lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1K8G0 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Neurospora crassa
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
457 amino acids: PaperBLAST, CDD, BRENDA::Q1K8G0
41% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

IBOG2_AMAMK / A0A0C2S258 Cystathionine gamma-synthase-like enzyme iboG2; Ibotenic acid biosynthesis cluster protein G2; EC 4.4.-.- from Amanita muscaria (strain Koide BX008)
PFams: Cys_Met_Meta_PP
628 amino acids: PaperBLAST, CDD, SwissProt::A0A0C2S258
40% identical to

O15564 methionine gamma-lyase (EC 4.4.1.11) from Trichomonas vaginalis
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, Aminotran_1_2, Aminotran_5
396 amino acids: PaperBLAST, CDD, BRENDA::O15564
41% identical to

H7C6A2 cystathionine gamma-synthase (EC 2.5.1.48) from Corynebacterium glutamicum
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
386 amino acids: PaperBLAST, CDD

Q86D27 methionine gamma-lyase (EC 4.4.1.11) from Entamoeba histolytica
PFams: Cys_Met_Meta_PP, Aminotran_1_2
392 amino acids: PaperBLAST, CDD, BRENDA::Q86D27
40% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

Q86D28 methionine gamma-lyase (EC 4.4.1.11) from Entamoeba histolytica
PFams: Cys_Met_Meta_PP, Aminotran_1_2
389 amino acids: PaperBLAST, CDD, BRENDA::Q86D28
41% identical to

A0PKT3 cystathionine gamma-synthase (EC 2.5.1.48) from Mycobacterium ulcerans
PFams: Cys_Met_Meta_PP, Met_gamma_lyase, DegT_DnrJ_EryC1, Aminotran_5
388 amino acids: PaperBLAST, CDD

METW_YEAST / Q12198 Homocysteine/cysteine synthase; Hydrogen sulfide utilizing 1; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylase; EC 2.5.1.47; EC 2.5.1.49 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Cys_Met_Meta_PP
575 amino acids: PaperBLAST, CDD, SwissProt::Q12198
41% identical to

METX_YEAST / Q04533 Putative cystathionine gamma-synthase YML082W; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Cys_Met_Meta_PP
649 amino acids: PaperBLAST, CDD

Close but ignored sequences

(Sequences that are similar to these will still be high-confidence candidates for metB.)

METB_HELPX / Q1M0P5 Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48 from Helicobacter pylori (Campylobacter pylori)
Q1M0P5 cystathionine gamma-synthase (EC 2.5.1.48) from Helicobacter pylori
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD, SwissProt::Q1M0P5
51% identical to