NP_001263041.1 has 3583 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.4e-258 846.6 30.8 7.1e-217 708.7 14.8 6.6 6 NP_001263041.1
Domain annotation for each sequence (and alignments):
>> NP_001263041.1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.0 0.0 0.09 0.09 2 24 .. 1021 1043 .. 1020 1045 .. 0.92
2 ! 14.6 0.0 4.6e-07 4.6e-07 96 169 .. 1243 1355 .. 1235 1365 .. 0.81
3 ! 0.7 0.2 0.0072 0.0072 232 332 .. 1495 1599 .. 1481 1615 .. 0.76
4 ! 56.5 0.1 9.8e-20 9.8e-20 432 549 .. 1633 1753 .. 1613 1780 .. 0.83
5 ! 69.6 0.4 1.1e-23 1.1e-23 637 777 .. 1843 1979 .. 1837 1994 .. 0.93
6 ! 708.7 14.8 7.1e-217 7.1e-217 1 851 [] 2011 2836 .. 2011 2836 .. 0.98
Alignments for each domain:
== domain 1 score: -3.0 bits; conditional E-value: 0.09
Htt_N-HEAT 2 anhsDpqlrgvvllllekfikav 24
++h Dp lrg v ++++f++++
NP_001263041.1 1021 HDHCDPILRGGVQQVVGNFLQSS 1043
68******************985 PP
== domain 2 score: 14.6 bits; conditional E-value: 4.6e-07
Htt_N-HEAT 96 liellalktsaywlvkvellellaklkyvlve..........................................nitassrlqervldsvlia 146
l +l + + ywlv+ + e++++l+yvl+ i++ + +++l l++
NP_001263041.1 1243 LSKLRLCHHNKYWLVQNKYAEVISNLNYVLLRsyyanfrcaidnknsgarkqdskwppmdassvchsvrdaegeDIVCTYE--AQFL-AELLH 1332
33444447899***************************************************9999998777554433333..3555.56789 PP
Htt_N-HEAT 147 llqdedprvrsaaaaaivkaipk 169
ll+d+d+rvr+ aa + + i +
NP_001263041.1 1333 LLGDDDARVREHAACCLCRFIMQ 1355
***************99998874 PP
== domain 3 score: 0.7 bits; conditional E-value: 0.0072
Htt_N-HEAT 232 alesslSrivcklselLlvsaskalllgCleallalsleypvalyekaWgckv..ksklkrdasvakdesaqqvelgllslvlsLLsssylnf 322
+ e+ l +++ +l+++L++ k++ +g + al l ++ + y++ W + + + + ++++l+ ++ +L+++++l+
NP_001263041.1 1495 QEEKVLAKVLYRLTNKLMTLNDKNVQFGIIYALRLLLRHFNFVDYQQVWLEFNfvEICISYAYYNNATAADLGCQNDLIDVMGKLMAGAMLSS 1587
44558999999**************************************75532233334444444445556788899999999999999987 PP
Htt_N-HEAT 323 d..ltaHldlLi 332
taHld+L+
NP_001263041.1 1588 GepNTAHLDFLL 1599
422688888887 PP
== domain 4 score: 56.5 bits; conditional E-value: 9.8e-20
Htt_N-HEAT 432 qssp..arngivakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqlle.lAtlq.edgkiaeevLmylkle 520
+ s+ ar+ +a + lG F + +y++ly+iL++a +Yk+t+++ ea + lL++ L+ +s le +A+ k ee+L yl
NP_001263041.1 1633 PKSElfAREQPAATLQALGYFAGDYVYMKLYNILRGANDSYKITINQ-EAGSLLICLLKTCLHAVSLCLEgMASASpPELKLIEEILHYLTRL 1724
33333445555778899*****************************9.*********************96676652467999********** PP
Htt_N-HEAT 521 iqsepkatvrcvqqLLksLFgtNlasnls 549
i+ p+ v c+ qLLk LF++N as++
NP_001263041.1 1725 INYAPAECVACLRQLLKYLFAQNYASQVR 1753
**************************976 PP
== domain 5 score: 69.6 bits; conditional E-value: 1.1e-23
Htt_N-HEAT 637 lnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhs 729
+ +I+lfE++vi L + s+ +q +l+LL+qL l v y+ lds +v vL +++iE G r++ ++p + FLv+L ++
NP_001263041.1 1843 VRLIKLFEPMVIYCLTL-FMKSNALVQAPILRLLSQLLDLNVTYSILDSKNVIFDQVLSNMDLIEGGIDRNAFIMVPPMLRFLVQLTHKS--D 1932
578*************9.7899****************************************************************9975..6 PP
Htt_N-HEAT 730 kaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkae 777
+++i+ipkii + l+a g v + Al+ + ++F + ++l+++
NP_001263041.1 1933 RQLITIPKIISITNNLLANGSVRVVALL-ALKTLSYELFFMHSQLEEA 1979
79*******************9999999.***********99998863 PP
== domain 6 score: 708.7 bits; conditional E-value: 7.1e-217
Htt_N-HEAT 1 yanhsDpqlrgvvllllekfikavlsqqv....llyerwlqslesiknrkaqdldalvklllkgLkde.....ssgtlrlaisavesClrn.. 82
+++++D+q r+vvl++lekfi+a++sqqv ll+er++q+l+++++r+aqd+da++++l++gL+++ +g+lrl +esC+rn
NP_001263041.1 2011 QRRELDTQ-REVVLGMLEKFIEARPSQQVlallLLFERSVQQLDTPPYRSAQDADAVYGTLCRGLCSRqwrlhNAGDLRL----LESCFRNng 2098
689*****.**********************999**********************************************....********* PP
Htt_N-HEAT 83 ...LadSkeflqlLqllie.........llalktsaywlvkvellellaklkyvlvenitassrlqervl.dsvliallqdedprvrsaaaaa 162
LadSk flqlLql+ie +la+++++++++k+e+++l++++k++l++n+ta++rlq+ + + + + +qde+p+++saaaaa
NP_001263041.1 2099 nhvLADSKRFLQLLQLFIEqgvgnfgdlALAMVMLSNVILKTEEIYLVNHIKLYLKNNPTAERRLQALMPsSPSAAPHWQDEAPSTSSAAAAA 2191
*****************************************************************9999744567899*************** PP
Htt_N-HEAT 163 ivkaipkLfyktrseedeitakAkelsekllscltellveleshdslisaaskayslLakr.....snvc...rtkdales......slSriv 241
+++a++ f++ rs+++ei+++Ak+l ekll+cl+ ll +le++ ++s+ay++L++r nvc r+kdal+s ++S+++
NP_001263041.1 2192 RAAAAS--FSAGRSSISEINYFAKVLCEKLLACLEVLL-GLEPS-----SSSHAYCQLTGRfmdalLNVCcrsRHKDALQSvfrlvlAESEFL 2276
******..899************************888.87765.....59**************999999********************** PP
Htt_N-HEAT 242 cklselLlvsas........kalllgCleallalsleypvalyekaWgckvksklkrd.......asvakdesaqqvelgllslvlsLLsssy 319
ck+++lLl+sa+ +a+ll+Cl+++la++le+pval+e+a + +k++l+r+ as+++d+saqqv+ +L++++y
NP_001263041.1 2277 CKYYSLLLMSAAglvgsyllDAVLLACLRLVLAMRLEEPVALLEQAAQLPLKTNLQRAllrevcrASAGCDWSAQQVR--------RLFEGRY 2361
**********************************************99999**************9************........******* PP
Htt_N-HEAT 320 lnfdltaHldlLi.......lagnLlagaalrniklsdsepskWdalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqal 405
lnf++++Hl++++ ++g+Ll++a++rn++ rl++q++r+vlrll++l+e+++++++g++++da+p+lqa+
NP_001263041.1 2362 LNFLIADHLEFICelcqerpECGSLLQVALFRNAH------------------RLSRQSVRIVLRLLGRLCEPAEREASGDVGSDADPTLQAM 2436
***********************************..................**************************************** PP
Htt_N-HEAT 406 qvlSplkrlkeeekkekepserlarr...qssp.arngivakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLev. 493
q+lS+l++l+e+e++ ++p+er+arr qs++ arn+i y+rl+e ++Lagge++d++++lLlkdLe+
NP_001263041.1 2437 QLLSRLHQLYEGERSLQLPIERMARRlsaQSGQpARNVI---------------YERLVE----------GDLAGGEDQDALRTLLLKDLECr 2504
*************************98899999999998...............*****9..........*********************** PP
Htt_N-HEAT 494 .................fsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvqqLLksLFgtNlasnlspskqearllRealagslaam 569
f+ql+++At+++d+++++++Lm+l+leiqsepk +q+LL+sL ++++ea+llR+a+agslaam
NP_001263041.1 2505 qdnetatpsriideswlFAQLIKFATQHADAPQQQKQLMLLLLEIQSEPK-----LQRLLRSL----------GTEHEAKLLRHAIAGSLAAM 2582
**************************************************.....********..........9******************* PP
Htt_N-HEAT 570 lsgfyhkifqh..........Plarvseal...rvansssskvqaeeeaewlgllkkkslkvarklaavlkgvrndektilnyI..RlfEklv 647
+s+f++k++qh Plarvs+al rva+++++k++++++ e +l+var++ a+++++rn+e+t+l+yI Rl+Ek+v
NP_001263041.1 2583 MSAFRQKCIQHaphinymqptPLARVSCALlmsRVASTEATKCRNPPTGE--------QLDVARAVGALMACIRNAEQTALIYIdaRLMEKFV 2667
**************************************************........9********************************** PP
Htt_N-HEAT 648 iksLkqYtvtssvelqkqvleLLaqL.......vqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhskaii 733
+++L++ ++++++LLa+L +q+++++++++s+q+++g++L++++ ++
NP_001263041.1 2668 VEHLLR---------REHLPQLLAYLgwlagaaKQILAMPTRQESEQDALGVLLATVN--------------------------------TLL 2719
******.........*******************************************................................9** PP
Htt_N-HEAT 734 gipkiiqlcdglmasgqra........vthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrvea. 817
++p+++++++++ +++ r+ v++ci ++++iF++R+++++++a + +a+++++lakL++ +++ i++l+s+rv+a
NP_001263041.1 2720 QQPRVWRELNASSDPSLRCelldlldsVARCI-----LQDTIFYRRHRRDRNKA-KGPAPQAIFLAKLIE-------TQIEIESLASGRVLAg 2799
********************************.....*************9999.9**************.......**************** PP
Htt_N-HEAT 818 .neekwkrasrqva..dvvLpllaklkisldsthqly 851
+e+++++a++++a +v+L+l+++++isl++thq+y
NP_001263041.1 2800 vEEARLQFAGQDLArfQVALSLVTSIGISLLRTHQFY 2836
***********************************97 PP
Or compare NP_001263041.1 to CDD or PaperBLAST