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Align P51111 to PF12372 (Htt_N-HEAT)

P51111 has 3110 amino acids

Query:       Htt_N-HEAT  [M=851]
Accession:   PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
          0 1126.8   3.6          0 1126.8   3.6    1.6  2  P51111    


Domain annotation for each sequence (and alignments):
>> P51111  
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.2   0.1       0.1       0.1      60      99 ..     104     156 ..      75     253 .. 0.51
   2 ! 1126.8   3.6         0         0       1     850 [.     727    1602 ..     727    1603 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.2 bits;  conditional E-value: 0.1
  Htt_N-HEAT  60 gLkdessgtlrlaisavesClrn....LadSkeflqlLqllie............l 99 
                  L+++ +   r+     + Cl++    L+dS+   + L+l  e            +
      P51111 104 LLCSDDASRRRM---VADECLNKvikaLMDSNLPRLQLELYKEikkngaprslraA 156
                 466666666666...34556666666677777777777777665555555544432 PP

  == domain 2  score: 1126.8 bits;  conditional E-value: 0
  Htt_N-HEAT    1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqlli 97  
                  y +h Dpq+rg++++l++++++++ls+++l++++wl ++++ ++ ++++l +++ ll+k+Lkdess+t++la++av++C+ +L++S++++++Lqlli
      P51111  727 YIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTG-NTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLI 822 
                  679***************************************99.9*************************************************** PP

  Htt_N-HEAT   98 ellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.eed 179 
                  ++l lk+s+ywlv++elle+la+++++lv+              ++t++ +lqervl++v+i+ll+dedprvr++aa+++++++pkLfyk+++ ++d
      P51111  823 DMLPLKNSSYWLVRTELLETLAEIDFRLVSfleakaeslhrgphHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQgQAD 919 
                  ************************************************************************************************* PP

  Htt_N-HEAT  180 eitakAkelsekllscltellveleshd..slisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsleypva 274 
                   + a+A+++s+ +l+ l++ ++   sh   s+i++++++yslL +      t+ ++e++lSr+v+++s++L++s+++al++gC+eal++ls+++pv+
      P51111  920 PVEAVARDQSSVYLKLLMHETQP-PSHFsvSTITRIYRGYSLLPS-----VTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAFPVC 1010
                  ******************66644.33335799*************.....7999******************************************* PP

  Htt_N-HEAT  275 lyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrnik...lsdsepsk........Wdals 360 
                  +++ +W+c v+      + +a+des++++++g++s++l+LLss+++++dl+a +d+LilagnLla++a ++++   +s++e+s+        W+al 
      P51111 1011 TWSLGWHCGVP------PLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAIQDALILAGNLLAASAPKSLRsswASEEEGSSaatrqeeiWPALG 1101
                  **********8......99******************************************************99999***9999************ PP

  Htt_N-HEAT  361 dtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlarrqssparngi...............va 442 
                  d++lv+++eql++h+l+++ni+a+vldd+tpg+a+k+alpsl+++++lSp++r    + kekep+e++++ ++sp++ g+               ++
      P51111 1102 DRTLVPMVEQLFSHLLKVINICAHVLDDETPGPAIKAALPSLTNPPSLSPIRR----KGKEKEPGEQTST-PMSPKKGGEastasrqsdtsgpvtAS 1193
                  *****************************************************....9***********8.9******99**************99* PP

  Htt_N-HEAT  443 kkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvqqLLksL 539 
                  k++slGsF+h+p+ylrl+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++eevL+ylk+++++ep++++ cvqqLLk+L
      P51111 1194 KSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTL 1290
                  ************************************************************************************************* PP

  Htt_N-HEAT  540 FgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvansss.skvqaeeeae...wlgllkkkslkvarklaavlk 627 
                  FgtNlas+++     psk+++r++R   ++s+   ++g+yh++f++P++++++al  a++s  ++vqa++e++   w+++l+k+s++ +++l++v+k
      P51111 1291 FGTNLASQFDglssnPSKSQCRAQR-LGSSSV---RPGLYHYCFMAPYTHFTQAL--ADASLrNMVQADQEHDasgWFDVLQKVSAQLKTNLTSVTK 1381
                  *************************.889999...9*******************..8988889*****************************9999 PP

  Htt_N-HEAT  628 gvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSy 724 
                   +r+d+++i+n+IRlfE+lvik+LkqYt+t+sv+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF+FLvlLSy
      P51111 1382 -NRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSY 1477
                  .9*********************************************************************************************** PP

  Htt_N-HEAT  725 eryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrveaneek 821 
                  eryhsk+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+++ka+++kele+q+evv+++LlrL++yh+v+e++il+l++c++e ne+k
      P51111 1478 ERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKE-NEDK 1573
                  ********************************************************************************************.**** PP

  Htt_N-HEAT  822 wkrasrqvadvvLpllaklkisldsthql 850 
                  wkr+srqvad++Lp+lak+++++ds+++l
      P51111 1574 WKRLSRQVADIILPMLAKQQMHIDSHEAL 1602
                  ***************************97 PP



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