Family Search for PF01595 (CNNM)

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PF01595 hits 230 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YfjD / b4461 UPF0053 family inner membrane protein YfjD from Escherichia coli K-12 substr. MG1655 (see 3 papers)
Aligns to 10:189 / 428 (42.1%), covers 96.1% of PF01595, 183.7 bits

PAEA_SALT1 / A0A0F6BAS6 Polyamine export protein from Salmonella typhimurium (strain 14028s / SGSC 2262) (see paper)
Aligns to 5:197 / 447 (43.2%), covers 100.0% of PF01595, 147.4 bits

• function: Involved in cadaverine and putrescine tolerance in stationary phase. May facilitate the efflux of both cadaverine and putrescine from the cytoplasm, reducing potentially toxic levels under certain stress conditions.
  disruption phenotype: Deletion mutant loses viability in stationary phase when grown in acidic medium with nitrite. Mutant is sensitive to cadaverine and putrescine but not to spermine or spermidine at pH 9.

YtfL / b4218 UPF0053 family inner membrane protein YtfL from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PAEA_ECOLI / P0AE45 Polyamine export protein from Escherichia coli (strain K12) (see 2 papers)
Aligns to 5:197 / 447 (43.2%), covers 99.4% of PF01595, 146.9 bits

• function: Involved in cadaverine and putrescine tolerance in stationary phase. May facilitate the efflux of both cadaverine and putrescine from the cytoplasm, reducing potentially toxic levels under certain stress conditions.
  disruption phenotype: Deletion of the gene results in increased sensitivity to cadaverine and putrescine, but not to spermidine and spermine.

CNNM4_CAEEL / Q17586 Metal transporter cnnm-4; CNNM family homolog 4 from Caenorhabditis elegans (see paper)
Aligns to 116:293 / 467 (38.1%), covers 87.8% of PF01595, 115.5 bits

• function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-5 to regulate Mg(2+) homeostasis.
  disruption phenotype: No visible phenotype. Quintuple knockout with cnnm-1, cnnm-2, cnnm-3 and cnnm-5 results in a reduced lifespan and 100% sterility.

CNNM3_CAEEL / A0A131MCZ8 Metal transporter cnnm-3; CNNM family homolog 3 from Caenorhabditis elegans (see paper)
Aligns to 202:374 / 797 (21.7%), covers 95.6% of PF01595, 113.3 bits

• function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.
  disruption phenotype: No visible phenotype. Double knockout with cnnm-1 results in increased levels of intestinal Mg(2+) and reduced levels in other tissues. This Mg(2+) deficiency in tissues leads to a reduced lifespan, 100% sterility, and smaller animals that exhibit a developmental delay with defective gonad development and which therefore do not produce oocytes or form vulva. In addition, the gonad development defect in the cnnm-1 and cnnm-3 double knockout is rescued when the AMPK alpha subunit aak-2 is also knocked out. Double knockout with cnnm-2 results in 22% sterility. Quintuple knockout with cnnm-1, cnnm-2, cnnm-4 and cnnm-5 results in a reduced lifespan and 100% sterility.

UEX_DROME / A0A0B7P9G0 Unextended protein; Putative metal transporter uex from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 191:361 / 834 (20.5%), covers 100.0% of PF01595, 111.6 bits

• function: Probable metal transporter (By similarity). Acts downstream of PRL-1 and protects the nervous system against olfactory carbon dioxide stimulation (PubMed:31404830).
  subunit: Interacts with PRL-1, possibly at the plasma membrane.
  disruption phenotype: RNAi-mediated knockdown in the nervous system results in a held-up wing phenotype after eclosion and upon carbon dioxide stimulation.

MAM3_YEAST / Q12296 Protein MAM3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 66:237 / 706 (24.4%), covers 97.2% of PF01595, 103.9 bits

• function: Involved in metal homeostasis and more specially in manganese sensitivity.

CNNM4_MOUSE / Q69ZF7 Metal transporter CNNM4; Ancient conserved domain-containing protein 4; mACDP4; Cyclin-M4 from Mus musculus (Mouse) (see 4 papers)
Aligns to 184:355 / 771 (22.3%), covers 94.5% of PF01595, 102.1 bits

• function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.
  subunit: Interacts with COX11.

CNNM4_RAT / P0C588 Metal transporter CNNM4; Ancient conserved domain-containing protein 4; Cyclin-M4 from Rattus norvegicus (Rat) (see 2 papers)
Aligns to 185:356 / 772 (22.3%), covers 94.5% of PF01595, 101.8 bits

• function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions. May play a role in biomineralization and retinal function.
  subunit: Interacts with COX11.

CNNM2_HUMAN / Q9H8M5 Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2 from Homo sapiens (Human) (see 2 papers)
Aligns to 260:431 / 875 (19.7%), covers 93.4% of PF01595, 101.6 bits

• function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).

CNNM2_MOUSE / Q3TWN3 Metal transporter CNNM2; Ancient conserved domain-containing protein 2; mACDP2; Cyclin-M2 from Mus musculus (Mouse) (see 3 papers)
Q3TWN3 cystathionine beta-synthase (EC 4.2.1.22) from Mus musculus (see paper)
Aligns to 260:431 / 875 (19.7%), covers 93.4% of PF01595, 101.5 bits

• function: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).
  subunit: Isoform 1 and isoform 2 may interact with each other

CNNM4_HUMAN / Q6P4Q7 Metal transporter CNNM4; Ancient conserved domain-containing protein 4; Cyclin-M4 from Homo sapiens (Human) (see 5 papers)
Q6P4Q7 P-type Mg2+ transporter (EC 7.2.2.14) from Homo sapiens (see paper)
Aligns to 187:358 / 775 (22.2%), covers 94.5% of PF01595, 101.4 bits

• function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.
  subunit: Interacts with COX11.

CNNM1_CAEEL / A3QM97 Metal transporter cnnm-1; CNNM family homolog 1 from Caenorhabditis elegans (see paper)
Aligns to 206:375 / 811 (21.0%), covers 93.9% of PF01595, 100.9 bits

• function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-2, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.
  disruption phenotype: No visible phenotype. Double knockout with cnnm-3 results in increased levels of intestinal Mg(2+) and reduced levels in other tissues. This Mg(2+) deficiency in tissues leads to a reduced lifespan, 100% sterility, and smaller animals that exhibit a developmental delay with defective gonad development and which therefore do not produce oocytes or form vulva. In addition, the gonad development defect in the cnnm-1 and cnnm-3 double knockout is rescued when the AMPK alpha subunit aak-2 is also knocked out. Quintuple knockout with cnnm-2, cnnm-3, cnnm-4 and cnnm-5 results in a reduced lifespan and 100% sterility.

CNNM2_CAEEL / Q9GYL2 Metal transporter cnnm-2; CNNM family homolog 2 from Caenorhabditis elegans (see paper)
Aligns to 154:320 / 760 (22.0%), covers 80.1% of PF01595, 97.1 bits

• function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis.
  disruption phenotype: No visible phenotype. Double knockout with cnnm-3 results in 22% sterility. Quintuple knockout with cnnm-1, cnnm-3, cnnm- 4 and cnnm-5 results in a reduced lifespan and 100% sterility.

CNNM1_HUMAN / Q9NRU3 Metal transporter CNNM1; Ancient conserved domain-containing protein 1; Cyclin-M1 from Homo sapiens (Human) (see paper)
Aligns to 227:413 / 951 (19.7%), covers 93.4% of PF01595, 76.2 bits

• function: Probable metal transporter.

CNNM1_MOUSE / Q0GA42 Metal transporter CNNM1; Ancient conserved domain-containing protein 1; mACDP1; Cyclin-M1; Cyclin-like protein 1; CLP-1 from Mus musculus (Mouse) (see 2 papers)
Aligns to 227:413 / 951 (19.7%), covers 93.4% of PF01595, 74.2 bits

• function: Probable metal transporter.

CNNM5_CAEEL / G5ED05 Metal transporter cnnm-5; CNNM family homolog 5 from Caenorhabditis elegans (see paper)
Aligns to 141:322 / 722 (25.2%), covers 95.6% of PF01595, 54.6 bits

• function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-4 to regulate Mg(2+) homeostasis.
  disruption phenotype: No visible phenotype. Quintuple knockout with cnnm-1, cnnm-2, cnnm-3 and cnnm-4 results in a reduced lifespan and 100% sterility.

Or search for genetic data about PF01595 in the Fitness Browser