Family Search for PF01868 (RNase_P-MRP_p29)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF01868
PF01868 hits 22 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
6ahrD / O95707 Cryo-em structure of human ribonuclease p (see paper)
Aligns to 53:135 / 145 (57.2%), covers 100.0% of PF01868, 98.5 bits
NP_079666 ribonuclease P protein subunit p29 from Mus musculus
Aligns to 129:211 / 221 (37.6%), covers 100.0% of PF01868, 98.0 bits
RPP29_HUMAN / O95707 Ribonuclease P protein subunit p29; hPOP4 from Homo sapiens (Human) (see 5 papers)
O95707 ribonuclease P (subunit 9/10) (EC 3.1.26.5) from Homo sapiens (see paper)
NP_006618 ribonuclease P protein subunit p29 from Homo sapiens
Aligns to 128:210 / 220 (37.7%), covers 100.0% of PF01868, 97.3 bits
- function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:10024167, PubMed:10352175, PubMed:30454648). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:15096576). - Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.
Matsumori, Life science alliance 2022 - “...factor Transcription regulation Nucleus/nucleolus Q9NYV6 POP4 Ribonuclease P protein subunit p29 Hydrolase, tRNA processing Nucleus/nucleolus O95707 RPL5 60S ribosomal protein L5 Ribonucleoprotein, ribosomal protein Cytoplasm nucleus/nucleolus P46777 RPL6 60S ribosomal protein L6 Ribonucleoprotein, ribosomal protein Cytoplasm, nucleus Q02878 RPL7 60S ribosomal protein L7 Ribonucleoprotein, ribosomal protein...”
- Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms.
Shastrula, The Journal of biological chemistry 2018 - GeneRIF: Rpp29 regulates H3.3-mediated epigenetic mechanisms by processing a transcribed signal that recruits H3.3 to its incorporation sites
- Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis.
Jiang, Biochemical and biophysical research communications 2017 (PubMed)- GeneRIF: Collectively, the present results suggest that PhoRpp21 binds the loop between P11 and P12 helices through overall positively charged clusters on the surface of the complex and serves as a scaffold for PhoRpp29 to optimize structural conformation of its N-terminal helix (alpha2) in PhoRpp21, as well as C-terminal residues in PhoRpp29, for RNase P activity.
- A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.
Abu-Zhayia, Scientific reports 2017 - GeneRIF: Results demonstrate that Rpp29 promotes homology-directed repair of double-strand breaks. It is rapidly and transiently recruited to laser-microirradiated DNA sites.
- RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition.
Newhart, Molecular biology of the cell 2016 - GeneRIF: Rpp29 represses H3.3 nucleosome deposition, a finding with implications for epigenetic regulation.
RNP1_PYRFU / Q8U007 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 5 papers)
NP_579545 hypothetical protein from Pyrococcus furiosus DSM 3638
Aligns to 41:123 / 127 (65.4%), covers 100.0% of PF01868, 96.1 bits
- function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
subunit: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp4 which stimulates the catalytic RNA. - Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P
Chen, Journal of molecular biology 2011 - “...the dashed line; type M below. Aligned sequences are from Pyrococcus furiosus ( Pfu , NP_579545), Pyrococcus horikoshii ( Pho , NP_143607), Methanothermobacter thermautotrophicus ( Mth , 10QK_A), Methanosarcina barkeri ( Mba , YP_303669), and Methanobrevibacter smithii ( Msm , EFC93468), Archaeoglobus fulgidus ( Afu ,...”
RNP1_METJA / Q57903 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 3 papers)
6k0aF / Q57903 Cryo-em structure of an archaeal ribonuclease p (see paper)
NP_247439 conserved hypothetical protein from Methanocaldococcus jannaschii DSM 2661
Aligns to 5:87 / 95 (87.4%), covers 98.8% of PF01868, 94.8 bits
- function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
subunit: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp4 which stimulates the catalytic RNA. - Ligand: rna (6k0aF)
- Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P
Chen, Journal of molecular biology 2011 - “...( Afu , 1TSF_A), Methanococcus maripaludis ( Mma , YP_001549331), Methanocaldococcus jannaschii ( Mja , NP_247439), Methanococcus aeolicus ( Mae , YP_001325580) and Methanococcus vanielli ( Mva , YP_001323236). Figure 4 NMR-based binding assay of Pfu RPP29 N-terminal deletion derivatives to RPP21. Both RPP2917 (C) and...”
YP_001325580 ribonuclease P protein component 1 from Methanococcus aeolicus Nankai-3
Aligns to 5:88 / 96 (87.5%), covers 98.8% of PF01868, 91.6 bits
RNP1_METTH / O26119 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see 2 papers)
MTH11 conserved protein from Methanothermobacter thermautotrophicus str. Delta H
Aligns to 5:88 / 93 (90.3%), covers 98.8% of PF01868, 90.3 bits
- function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
subunit: Consists of a catalytic RNA component and at least 4-5 protein subunits. - Ribonuclease P: the evolution of an ancient RNA enzyme
Walker, Critical reviews in biochemistry and molecular biology 2006 - “...the genome of Methanothermobacter thermoautotrophicus are Mth11 (Pop4/Rpp29), Mth687 (Pop5/hPop5), Mth688 (Rpp1/Rpp30) and Mth1618 (Rpr2/Rpp21). These proteins...”
- “...system (Hall and Brown, 2004). In this study, Mth11 (Pop4/Rpp29) was shown to be a key protein involved in several protein-protein interactions, showing...”
- Interactions between RNase P protein subunits in archaea
Hall, Archaea (Vancouver, B.C.) 2004 - “...complex yeast RNase P holoenzyme. Keywords: archaebacteria, MTH11, MTH1618, MTH687, MTH688, ribonuclease P. Introduction Ribonuclease P (RNase P) is a...”
- “...and methods Construction of two-hybrid expression plasmids The MTH11, MTH687, MTH688 and MTH1618 open reading frames were amplified by polymerase chain reaction...”
- Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P
Boomershine, Proceedings of the National Academy of Sciences of the United States of America 2003 - “...2003) We have determined the solution structure of Mth11 (Mth Rpp29), an essential subunit of the RNase P enzyme from the archaebacterium Methanothermobacter...”
- “...from Methanothermobacter thermoautotrophicus (Mth) identified four proteins (Mth11, Mth1618, Mth687, and Mth688) that are homologous to those of eukaryotic...”
- Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins
Hall, RNA (New York, N.Y.) 2002 - “...protein subunit. Four hypothetical open reading frames (MTH11, MTH687, MTH688, and MTH1618) were identified in the genome of M. thermoautotrophicus that...”
- “...Pop5p, Rpp1p, and Rpr2p+ These four ORFs are MTH11, MTH687, MTH688, and MTH1618, respectively+ All four ORFs have obvious homologs in other archaeal genomes...”
- Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
Xiao, Annual review of biochemistry 2002 - “...In Methanothermobacter thermoautotrophicus, the open reading frames MTH11 (POP4 homolog), MTH687 (POP5 homolog), MTH688 (RPP1 homolog), and MTH1618 (RPR2...”
- “...RNase P Human gene -- -- -- -- -- MTH1618 MTH688 -- -- -- MTH687 MTH11 -- -- -- -- Archaeal RNase P 88 85 85 85 156 1, 18, 90 18, 83, 85 1 1, 85 1 1, 18, 89 18,...”
YP_001323236 ribonuclease P protein component 1 from Methanococcus vannielii SB
P14022 Ribonuclease P protein component 1 from Methanococcus vannielii
Aligns to 5:91 / 99 (87.9%), covers 100.0% of PF01868, 89.9 bits
O28362 ribonuclease P (EC 3.1.26.5) from Archaeoglobus fulgidus (see 2 papers)
AF1917 conserved hypothetical protein from Archaeoglobus fulgidus DSM 4304
Aligns to 8:89 / 102 (80.4%), covers 98.8% of PF01868, 89.3 bits
RNP1_PYRHO / O59425 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 4 papers)
O59425 ribonuclease P (subunit 5/5) (EC 3.1.26.5) from Pyrococcus horikoshii (see 3 papers)
PH1771 hypothetical protein from Pyrococcus horikoshii OT3
Aligns to 41:122 / 127 (64.6%), covers 98.8% of PF01868, 87.7 bits
- function: Part of ribonuclease P (RNase P), a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
subunit: Consists of a catalytic RNA component and at least 5 protein subunits. Forms a heterodimeric subcomplex with Rnp4. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity. - Expression, purification and structural analysis of the Pyrococcus abyssi RNA binding protein PAB1135
Luz, BMC research notes 2010 - “...has been shown to be formed by one catalytic RNA and the proteins Ph1481, Ph1601, Ph1771, and Ph1877, which show homology to the human RNase P subunits hPop5, Rpp21, Rpp29, and Rpp30, respectively [ 10 ]. The structures of these P. horikoshii proteins have been solved...”
- Ribonuclease P: the evolution of an ancient RNA enzyme
Walker, Critical reviews in biochemistry and molecular biology 2006 - “...Subunit P RNA PH rnpB (+) Mr (pI) 107 (+) Protein PH1771 PH1481 15.1 14.0 11.2 10.0 PH1877 PH1601 24.7 14.6 9.6 10.5 (+) (+) (+) 1 Data from (Xiao et al.,...”
- “...RNA (type A) and at least four proteins: Ph1771 (Pop4/Rpp29), Ph1481 (Pop5/hPop5), Ph1877 (Rpp1/Rpp30) and Ph1601 (Rpr2/Rpp21). It has also been suggested that...”
- Differential association of protein subunits with the human RNase MRP and RNase P complexes
Welting, RNA (New York, N.Y.) 2006 - “...archaeal hPop4 and Rpp21 orthologs of Pyrococcus horikoshii (Ph1771 and Ph1601, respectively) have been shown to be essential components of an active,...”
- Reconstitution of archaeal ribonuclease P from RNA and four protein components
Kouzuma, Biochemical and biophysical research communications 2003 (PubMed)- “...database revealed that the four genes, PH1481, PH1601, PH1771, and PH1877, have a significant homology to those encoding RNase P protein subunits, hpop5, Rpp21,...”
YP_303669 putative ribonuclease P subunit P29 from Methanosarcina barkeri str. fusaro
Aligns to 10:102 / 110 (84.5%), covers 98.8% of PF01868, 87.3 bits
- Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P
Chen, Journal of molecular biology 2011 - “...( Pho , NP_143607), Methanothermobacter thermautotrophicus ( Mth , 10QK_A), Methanosarcina barkeri ( Mba , YP_303669), and Methanobrevibacter smithii ( Msm , EFC93468), Archaeoglobus fulgidus ( Afu , 1TSF_A), Methanococcus maripaludis ( Mma , YP_001549331), Methanocaldococcus jannaschii ( Mja , NP_247439), Methanococcus aeolicus ( Mae ,...”
RNP1_METMP / P60832 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanococcus maripaludis (strain S2 / LL) (see paper)
P60832 ribonuclease P (subunit 2/5) (EC 3.1.26.5) from Methanococcus maripaludis (see paper)
MMP1407 Protein of unknown function UPF0086 from Methanococcus maripaludis S2
Aligns to 3:88 / 96 (89.6%), covers 100.0% of PF01868, 84.0 bits
- function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
subunit: Consists of a catalytic RNA component and at least 5 protein subunits. - The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis
Li, PLoS genetics 2019 - “...Flag-tagged TRAM0076, some were highly enriched. These included the messages encoding RNase P protein ( MMP1407 ) and its RNA component, two histones ( MMP0386 and MMP1347 ), translation initiation factors ( MMP1406 ), elongation factor 1 and subunits ( MMP1370 and MMP1401 ), RNA polymerase...”
7c79D / P38336 Cryo-em structure of yeast ribonuclease mrp (see paper)
Aligns to 143:235 / 251 (37.1%), covers 98.8% of PF01868, 83.9 bits
POP4_YEAST / P38336 RNases MRP/P 32.9 kDa subunit; RNA-processing protein POP4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YBR257W Pop4p from Saccharomyces cerevisiae
NP_009816 RNase P/RNase MRP complex subunit from Saccharomyces cerevisiae S288C
Aligns to 171:263 / 279 (33.3%), covers 98.8% of PF01868, 83.7 bits
- function: Required for 5.8S rRNA and tRNA processing; associated with RNase MRP and RNase P.
subunit: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. - Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae
Eisenstatt, Genetics 2021 - “...RPL6B RAD4 RAD14 YFL039C YIL106W YPL128C YNL232W YBR257W YML065W YHR118C YLR115W YLR115W YOR250C YJR141W YOL123W YBR154C YJL011C YJR006W YPR088C YNR038W YLR276C...”
- Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics
Jaime, BMC genomics 2012 - “...in regulation of membrane traffic mainly regulates pottassium influx; similar to ADP-ribosylation factor. 0.756 HOM YBR257W 3.534 POP4 subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5ends; binds to the RPR1 RNA subunit in RNase...”
- Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate visualization
Cheng, BMC bioinformatics 2008 - “...promoter 9.82E-04 3.31E-01 YBL014C, YBR154C, YDR156W, YER148W, YNL113W, YOR224C, YOR341W rRNA processing 5.33E-04 1.80E-01 YBR142W, YBR257W, YCL059C, YDR365C, YDR478W, YGR159C, YLR223C, YMR049C, YMR290C, YOL144W, YOR145C, YPL211W ribosome biogenesis and assembly 1.09E-15 3.66E-13 YAL025C, YBL024W, YBL054W, YBR034C, YBR084W, YBR142W, YBR267W, YCL059C, YDL153C, YDL167C, YDR060W, YDR165W, YDR300C, YDR312W,...”
- Discover protein sequence signatures from protein-protein interaction data
Fang, BMC bioinformatics 2005 - “...YJL001W, YPR103W, YGR135W, YML092C, YGR253C, YER094C, YGL011C 5 YBL092W cytoplasm, nucleus 2 YGR034W, YDL191W 6 YBR257W cytoplasm, nucleus 2 YHR203C, YJR014W, YJR145C 7 YCR031C cytoplasm, nucleus 2 YGR034W 8 YCR072C cytoplasm, nucleus 1 9 YDL075W cytoplasm, nucleus 3 YDR292C 10 YDR064W cytoplasm, nucleus 1,2 YGR262C, YAL035W...”
- Basic phenotypic analysis of six novel yeast genes reveals two essential genes and one which affects the growth rate
Sanjuan, Yeast (Chichester, England) 1999 (PubMed)- “...frames (ORFs), located on chromosome II: YBR254c, YBR255w, YBR257w, YBR258c, YBR259w and YBR266c. Disruption of the ORFs was carried out in the diploid strain...”
- “...of the heterozygous disruptants showed that YBR254c and YBR257w are essential genes. YBR257w was later characterized and renamed POP4, its gene product being...”
- A novel protein shared by RNase MRP and RNase P
Chu, RNA (New York, N.Y.) 1997 (secret) - Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
Perederina, Nature communications 2020 - GeneRIF: Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP.
RNP1_SCHPO / Q9P7W9 Probable ribonuclease P protein subunit 1; EC 3.1.26.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 121:207 / 217 (40.1%), covers 100.0% of PF01868, 83.6 bits
- function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
HISP_10940 ribonuclease P protein component 1 from Haloarcula hispanica N601
Aligns to 6:87 / 94 (87.2%), covers 97.6% of PF01868, 83.2 bits
- Insights into gene regulation of the halovirus His2 infecting Haloarcula hispanica
Lee, MicrobiologyOpen 2020 - “...AND PROCESSING Translation, ribosomal structure and biogenesis Ribosomal protein S4E 0.765 1.438 0.967 0.294 M HISP_10940 INFORMATION STORAGE AND PROCESSING Translation, ribosomal structure and biogenesis RNase P/RNase MRP subunit p29 0.148 1.246 0.903 0.195 M HISP_10925 INFORMATION STORAGE AND PROCESSING Translation, ribosomal structure and biogenesis Ribosomal...”
- “...1 ; COG=J), which as components of ribosomes participate in protein translation. A fifth gene (HISP_10940) specifies ribonuclease P protein component1, an enzyme that is also involved in translation (Table 1 , Table S1C, COG=J; https://doi.org/10.6084/m9.figshare.11800872 ). Interestingly, the hierarchical clustering grouped eight viral genes (His2V_gp16...”
TP01_1174, TpMuguga_01g01174 uncharacterized protein from Theileria parva strain Muguga
Aligns to 163:245 / 253 (32.8%), covers 95.2% of PF01868, 81.6 bits
- The genomes of three stocks comprising the most widely utilized live sporozoite Theileria parva vaccine exhibit very different degrees and patterns of sequence divergence
Norling, BMC genomics 2015 - “...TpMuguga_01g01165 ATP-dependent RNA helicase SUV3 homolog mitochondrial - M/ 5 0.015 0.3049 25 23 TP01_1173, TP01_1174 TpMuguga_01g01174 Ribonuclease P protein subunit p29 - _/ 3 0.0123 0.255 7 7 TP01_0275, TP01_0273, TP01_0274, TP01_0272 TpMuguga_01g02345 Phosphatidylinositol 4-phosphate 5-kinase 7 - _/ 4 0.0142 3 TP01_1063 TpMuguga_01g02455 Uncharacterized...”
- “...ATP-dependent RNA helicase SUV3 homolog mitochondrial - M/ 5 0.015 0.3049 25 23 TP01_1173, TP01_1174 TpMuguga_01g01174 Ribonuclease P protein subunit p29 - _/ 3 0.0123 0.255 7 7 TP01_0275, TP01_0273, TP01_0274, TP01_0272 TpMuguga_01g02345 Phosphatidylinositol 4-phosphate 5-kinase 7 - _/ 4 0.0142 3 TP01_1063 TpMuguga_01g02455 Uncharacterized protein...”
HVO_2556 ribonuclease P protein component 1 from Haloferax volcanii DS2
Aligns to 6:136 / 143 (91.6%), covers 97.6% of PF01868, 81.5 bits
POP4_ARATH / Q9ZW76 Ribonuclease MRP protein subunit POP4; RNase MRP POP4; RNA-processing protein POP4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
AT2G43190 ribonuclease P family protein from Arabidopsis thaliana
Aligns to 215:292 / 296 (26.4%), covers 90.5% of PF01868, 68.0 bits
- function: Component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences (PubMed:22549728). Required for rRNA maturation, including 5.8S rRNA processing (PubMed:22549728). Seems not involved in tRNA maturation (PubMed:22549728).
subunit: Component of nuclear RNase MRP complexes (By similarity). Several subunits of RNase P are also part of the RNase MRP complex (By similarity). RNase MRP consists of a catalytic RNA moiety and several protein subunits (By similarity).
disruption phenotype: Accumulation of unprocessed cytosolic rRNA precursors, especially the large 35S rRNA precursor, as well as of the internal transcribed spacer 1 (ITS1) fragment corresponding to the region between the 18S and 5.8S rRNAs that contains the A3 cleavage sites. - Upon heat stress processing of ribosomal RNA precursors into mature rRNAs is compromised after cleavage at primary P site in Arabidopsis thaliana
Darriere, RNA biology 2022 - “...NUC1 (At1g48920), FIB1 (At5g52470), FIB2 (At4g25630), XRN2 (At5g42540), RRP7 (At5g38720), LAS1-like (At5g12220), MRP1/POP1 (At2g47300), MRP1/POP4 (At2g43190), UTP24 (At2g46230), NOB1 (At5g41190), RCL1 (At5g22100), RTL2 (At3g20420), XRN3 (At1g75660), NOL12 (At1g11240), DIS3/RRP44A (At2g17510), RRP6L2 (At5g35910), RRP41 (At3g61620) and TRL (At5g53770) and MTR4 (At1g59760). Author contributions The experimental work was...”
- Bidirectional promoters in seed development and related hormone/stress responses
Kourmpetli, BMC plant biology 2013 - “...(GAUT7) mitochondrion golgi AT2G39460 AT2G39450 331 y 60S ribosomal protein L23aA manganese transporter cytosol golgi AT2G43190 AT2G43180 187 AtPOP4 (RNA processing) Phosphoenolpyruvate carboxylase family nucleolus plastid AT2G45740 AT2G45730 556 y peroxin11 (PEX11) family eukaryotic initiation factor 3 subunit peroxisome cytosol AT3G03160 AT3G03150 264 y y unknown...”
- GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essential for female gametogenesis and male competence in Arabidopsis
Wang, PloS one 2012 - “.... Besides GAF1/AtRPP30, five other homologues of the RNases P/MRP complexes were found: At2G47300 (AtPOP1), At2G43190 (AtPOP4), AT1G04635 (AtPOP5), At5G41270 (AtRPR2), and At1G50910 (AtRMP1). In Arabidopsis , none of the homologues has been studied. To investigate whether these homologues have similar interaction in Arabidopsis as in...”
Sb09g023150 No description from Sorghum bicolor
Aligns to 230:310 / 322 (25.2%), covers 91.7% of PF01868, 66.9 bits
- Mapping QTLs and association of differentially expressed gene transcripts for multiple agronomic traits under different nitrogen levels in sorghum
Gelli, BMC plant biology 2016 - “...qBY-9, qChl3-9, qPH-9 Sb09g022390 9 52044973 8.308 Ribosomal protein qAD-9a qGY-9, qChl2-9a, qBY-9, qChl3-9, qPH-9 Sb09g023150 9 52794183 2.46 ribonuclease P family protein qAD-9a qGY-9, qChl2-9a, qBY-9, qChl3-9, qPH-9 Sb09g023320 9 52948577 6.593 Major facilitator superfamily protein qAD-9a qGY-9, qChl2-9a, qBY-9, qChl3-9, qPH-9 Sb09g024840 9 54319624...”
PF3D7_0627900 ribonuclease P protein subunit p29, putative from Plasmodium falciparum 3D7
Aligns to 199:281 / 291 (28.5%), covers 91.7% of PF01868, 64.3 bits
XP_024348284 Ribonuclease P protein subunit p29 from Echinococcus granulosus
Aligns to 123:210 / 249 (35.3%), covers 97.6% of PF01868, 59.6 bits
Or search for genetic data about PF01868 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory