Family Search for PF01868 (RNase_P-MRP_p29)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF01868 hits 22 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

RPP29_HUMAN / O95707 Ribonuclease P protein subunit p29; hPOP4 from Homo sapiens (Human) (see 5 papers)
O95707 ribonuclease P (subunit 9/10) (EC 3.1.26.5) from Homo sapiens (see paper)
Aligns to 128:210 / 220 (37.7%), covers 100.0% of PF01868, 97.3 bits

• function: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  subunit: Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:10024167, PubMed:10352175, PubMed:30454648). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:15096576).

RNP1_PYRFU / Q8U007 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 5 papers)
Aligns to 41:123 / 127 (65.4%), covers 100.0% of PF01868, 96.1 bits

• function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
  subunit: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp4 which stimulates the catalytic RNA.

RNP1_METJA / Q57903 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 3 papers)
Aligns to 5:87 / 95 (87.4%), covers 98.8% of PF01868, 94.8 bits

• function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
  subunit: Consists of a catalytic RNA component and at least 4 protein subunits. Forms a subcomplex with Rnp4 which stimulates the catalytic RNA.

RNP1_METTH / O26119 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) (see 2 papers)
Aligns to 5:88 / 93 (90.3%), covers 98.8% of PF01868, 90.3 bits

• function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
  subunit: Consists of a catalytic RNA component and at least 4-5 protein subunits.

O28362 ribonuclease P (EC 3.1.26.5) from Archaeoglobus fulgidus (see 2 papers)
Aligns to 8:89 / 102 (80.4%), covers 98.8% of PF01868, 89.3 bits

RNP1_PYRHO / O59425 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 4 papers)
O59425 ribonuclease P (subunit 5/5) (EC 3.1.26.5) from Pyrococcus horikoshii (see 3 papers)
Aligns to 41:122 / 127 (64.6%), covers 98.8% of PF01868, 87.7 bits

• function: Part of ribonuclease P (RNase P), a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Binds RNase P RNA.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
  subunit: Consists of a catalytic RNA component and at least 5 protein subunits. Forms a heterodimeric subcomplex with Rnp4. Reconstituted enzyme missing individual protein subunits is suboptimally active, showing each subunit contributes to optimization of activity.

RNP1_METMP / P60832 Ribonuclease P protein component 1; RNase P component 1; Rpp29; EC 3.1.26.5 from Methanococcus maripaludis (strain S2 / LL) (see paper)
P60832 ribonuclease P (subunit 2/5) (EC 3.1.26.5) from Methanococcus maripaludis (see paper)
Aligns to 3:88 / 96 (89.6%), covers 100.0% of PF01868, 84.0 bits

• function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
  subunit: Consists of a catalytic RNA component and at least 5 protein subunits.

POP4_YEAST / P38336 RNases MRP/P 32.9 kDa subunit; RNA-processing protein POP4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 171:263 / 279 (33.3%), covers 98.8% of PF01868, 83.7 bits

• function: Required for 5.8S rRNA and tRNA processing; associated with RNase MRP and RNase P.
  subunit: Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.

RNP1_SCHPO / Q9P7W9 Probable ribonuclease P protein subunit 1; EC 3.1.26.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 121:207 / 217 (40.1%), covers 100.0% of PF01868, 83.6 bits

• function: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
  catalytic activity: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

POP4_ARATH / Q9ZW76 Ribonuclease MRP protein subunit POP4; RNase MRP POP4; RNA-processing protein POP4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 215:292 / 296 (26.4%), covers 90.5% of PF01868, 68.0 bits

• function: Component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences (PubMed:22549728). Required for rRNA maturation, including 5.8S rRNA processing (PubMed:22549728). Seems not involved in tRNA maturation (PubMed:22549728).
  subunit: Component of nuclear RNase MRP complexes (By similarity). Several subunits of RNase P are also part of the RNase MRP complex (By similarity). RNase MRP consists of a catalytic RNA moiety and several protein subunits (By similarity).
  disruption phenotype: Accumulation of unprocessed cytosolic rRNA precursors, especially the large 35S rRNA precursor, as well as of the internal transcribed spacer 1 (ITS1) fragment corresponding to the region between the 18S and 5.8S rRNAs that contains the A3 cleavage sites.

Or search for genetic data about PF01868 in the Fitness Browser