Family Search for PF02130 (YbeY)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF02130

PF02130 hits 65 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YbeY / b0659 endoribonuclease YbeY from Escherichia coli K-12 substr. MG1655 (see 19 papers)
YBEY_ECOLI / P0A898 Endoribonuclease YbeY; EC 3.1.-.- from Escherichia coli (strain K12) (see 6 papers)
Aligns to 15:144 / 155 (83.9%), covers 93.8% of PF02130, 133.8 bits

• function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. Involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'- and 3'- ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs.
  cofactor: Zn(2+) (Binds 1 zinc ion.)
  disruption phenotype: Mutants show defects in 16S rRNA maturation, ribosome activity, translational fidelity, and ribosome assembly. They have severe growth defect at high temperatures, essentially no thermotolerance at lethal temperatures. They also show a decrease in polysomes and a large increase in both free 50S and free 30S ribosomal subunits relative to 70S ribosomes.

YBEY_HAEIN / P71335 Endoribonuclease YbeY; EC 3.1.-.- from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
Aligns to 14:144 / 154 (85.1%), covers 91.5% of PF02130, 130.8 bits

• function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  cofactor: Zn(2+) (Binds 1 zinc ion.)

YBEY_THEMA / Q9X1J7 Endoribonuclease YbeY; EC 3.1.-.- from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Aligns to 9:133 / 150 (83.3%), covers 93.8% of PF02130, 116.0 bits

• function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  cofactor: Zn(2+) (Binds 1 zinc ion.)

YBEY_ARATH / Q8L5Z4 Endoribonuclease YBEY, chloroplastic; EC 3.1.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 144:271 / 584 (21.9%), covers 79.8% of PF02130, 108.1 bits

• function: Endoribonuclease required for chloroplast ribosomal RNA (rRNA) processing and essential for normal growth and development. May be involved in maturation of both the 5' and 3' ends of 16S, 23S, and 4.5S rRNAs. Cleaves chloroplast rRNAs, mRNAs and tRNAs in vitro.
  cofactor: Zn(2+) (Binds 1 zinc ion.)
  disruption phenotype: Seedling lethality.

YBEY_HUMAN / P58557 Endoribonuclease YbeY; EC 3.1.-.- from Homo sapiens (Human) (see paper)
Aligns to 15:148 / 167 (80.2%), covers 80.6% of PF02130, 95.7 bits

• function: Single strand-specific metallo-endoribonuclease involved in rRNA maturation.
  cofactor: Zn(2+) (Binds 1 zinc ion.)

YBEY_MYCGE / P47628 Endoribonuclease YbeY; EC 3.1.-.- from Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium) (see paper)
Aligns to 15:149 / 154 (87.7%), covers 86.8% of PF02130, 68.5 bits

• function: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
  cofactor: Zn(2+) (Binds 1 zinc ion.)
  disruption phenotype: Probably essential, it was not disrupted in a global transposon mutagenesis study.

Or search for genetic data about PF02130 in the Fitness Browser