Family Search for PF02656 (DUF202)
PF02656.15 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Rv2272 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN (NCBI) from Mycobacterium tuberculosis H37Rv
Aligns to 17:84 / 122 (55.7%), covers 98.5% of PF02656, 64.4 bits
- Nonclassical T cells and their antigens in tuberculosis
De, Cold Spring Harbor perspectives in medicine 2014 - “...proteins, namely of 1-deoxy-D-xylulose 5-phosphate synthase 2 and Rv2272 protein, which activated gd T cells from pulmonary TB patients (Xi et al. 2013)....”
- Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones
De, Frontiers in Immunology 2014 - “...IPP, HMBPP ( 43 45 ) Tetanus toxoid ( 30 , 31 ) DXS2 or Rv2272 peptides ( 40 ) V1 clones HLA-A24, HLA-A2 ( 9 , 10 ) V4V1 HLA-B27 ( 32 ) V3V2 Histidyl-tRNA synthetase ( 39 ) MOUSE Hybridoma G8 T10, T22, T27...”
- “...isopentenyl pyrophosphate; MICA or MICB, MHC class I chain-related protein A or B; NP, 4-hydroxy-3-nitrophenylacetyl; Rv2272, mycobacterium transmembrane protein; T10, T22, or T27, MHC class Ib proteins; PE, algae protein phycoerythrin . CD1 molecules have been found to interact with the human TCR. The first isolated...”
- Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells
Harly, Frontiers in immunology 2014 - “...characterized which led to the identification of new protein/peptides of mycobacterial origin (e.g., OXYS, DXS2, Rv2272) ( 94 , 95 ) that can interact with V9V2 TCRs and activate a large fraction of V9V2 T cells isolated from peripheral blood of tuberculosis infected patients but not...”
- Identification of a new tuberculosis antigen recognized by γδ T cell receptor
Xi, Clinical and vaccine immunology : CVI 2013 - “...The extracellular region (extracellular peptide [EP]) of Rv2272, a TP2-matched mycobacterial transmembrane protein, was also shown to activate T cells from...”
- “...transmembrane region of the unknown transmembrane protein (Rv2272). Statistical analysis. Statistical comparisons were performed using the Student t test....”
- Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
Das, BMC genomics 2013 - “...tuberculosis [ 19 ]. In case of F99 several trans-membrane protein coding genes, such as Rv2272 and Rv2273 were missing. Although we have considered repeat regions by realigning short reads with multiple matches, a number of prophage proteins (phiRV2) were not mapped. Prophage proteins are quite...”
- Genomic signatures of the haarlem lineage of Mycobacterium tuberculosis: implications of strain genetic variation in drug and vaccine development
Cubillos-Ruiz, Journal of clinical microbiology 2010 - “...exemplified here by deletion of the transmembrane proteins Rv2272 and Rv2273 as part of HSD2. Consequently, vaccine candidates should be effective against...”
- Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments
Cubillos-Ruiz, BMC research notes 2008 - “...643 PE-PGRS33 2365930 1774 helZ (Helicase) Rv2102 (Conserved hypothetical protein) 2546849 6480 Rv2271 (Hypothetical protein) Rv2272 (Probable conserved transmembrane protein) Rv2273 (Probable conserved transmembrane protein) Rv2274c (Hypothetical protein) Rv2275 (Hypothetical protein) cyp121 (Cytochrome P450) Rv2277c (Probable glycerolphosphodiesterase) 2792261 170 PE-PGRS42 3117314 439 Repeat region (DR) Intergenic...”
AFUA_8G05950 conserved hypothetical protein from Aspergillus fumigatus Af293
Aligns to 116:192 / 222 (34.7%), covers 98.5% of PF02656, 61.5 bits
YidH / b3676 conserved inner membrane protein YidH from Escherichia coli K-12 substr. MG1655 (see 2 papers)
Aligns to 13:80 / 115 (59.1%), covers 98.5% of PF02656, 59.6 bits
FGR18 putative uncharacterized protein from Candida albicans (see paper)
Aligns to 1:80 / 120 (66.7%), covers 92.6% of PF02656, 59.2 bits
- CharProtDB CGD description: Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction)
XP_846013 vacuolar transporter chaperone, putative from Trypanosoma brucei brucei TREU927
Aligns to 62:127 / 180 (36.7%), covers 95.6% of PF02656, 58.5 bits
cg0135 putative inner membrane protein (RefSeq) from Corynebacterium glutamicum ATCC 13032
Aligns to 21:88 / 122 (55.7%), covers 98.5% of PF02656, 57.2 bits
VTC1_SCHPO / Q9UR17 Vacuolar transporter chaperone 1; Negative regulator of cdc42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
nrf1 GTPase regulator Nrf1 from Schizosaccharomyces pombe (see 3 papers)
Aligns to 24:86 / 122 (51.6%), covers 98.5% of PF02656, 53.9 bits
- function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (By similarity). Involved in the control of cell polarity.
subunit: The VTC complex is an integral membrane heterooligomer composed of at least vtc1, vtc2 and vtc4 (By similarity). Interacts with GTP-bound Ras-like cdc42, which is subsequently inactivated. - CharProtDB Source (per GeneDB): GeneDB_Spombe
VTC1_YEAST / P40046 Vacuolar transporter chaperone 1; Negative regulator of CDC42 protein 1; Phosphate metabolism protein 4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YER072W Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase (RefSeq) from Saccharomyces cerevisiae
Aligns to 24:86 / 129 (48.8%), covers 97.1% of PF02656, 53.4 bits
- function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.
subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1. - Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes
Gibney, Proceedings of the National Academy of Sciences of the United States of America 2013 - “...YDR340W RPL4A BMH1 YIR027C YML107C DAL1 PML39 YER072W YOL153C YFR010W YBL081W YOR170W YLR392C VTC1 YOL153C UBP6 YBL081W YOR170W ART10 Inositol hexakisphosphate...”
- A Whole Genome Screen for Minisatellite Stability Genes in Stationary-Phase Yeast Cells
Alver, G3 (Bethesda, Md.) 2013 - “...YMR258C YMR258c EDC3 YEL015w PRM4 YPL156c VPS61 YDR136c YMR304C-A YMR304c-a EFT2 YDR385w PSD2 YGR170w VTC1 YER072w YOL024W YOL024w ELC1 YPL046c PXL1 YKR090w YAP1801 YHR161c YOL079W YOL079w FDC1 YDR539w QCR10 YHR001w-a YAT2 YER024w YOL153C YOL153c FIN1 YDR130c RDS1 YCR106w YBL096C YBL096c YOR170W YOR170w FOB1 YDR110w REC104 YHR157w...”
- The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast
Chesi, PloS one 2012 - “...PPM1 YHR180W YHR180W YJR033C RAV1 YJL053W PEP8 YKR028W SAP190 YIL054W YIL054W YBR231C SWC5 YIL040W APQ12 YER072W VTC1 YLL044W YLL044W YJL004C SYS1 YJR074W MOG1 YJL012C VTC4 YOR199W YOR199W YKL081W TEF4 YMR031W-A YMR031W-A YHR135C YCK1 YIL145C PAN6 YOL018C TLG2 YDR089W YDR089W YDL095W PMT1 YKR001C VPS1 YDR295C HDA2 YLL030C...”
- High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome
Yu, BMC genomics 2012 - “...- - - - - - 8.45 - - - - 6.10 - - P YER072W VTC1 B - - - - - - 8.94 - - - - 8.59 - - S YOL049W GSH2 C - 5.42 - - - - - - 6.15 -...”
- The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization
Kim, The Journal of biological chemistry 2009 - “...APS3 (YJL024C) APM3 (YBR288C) RAV2 (YDR202C) VTC1 (YER072W) ARL1 (YBR164C) AVL9P (YLR114C) COG8 (YML071C) GYP1 (YOR070C) SEC28 (YIL076W) ARR4/GET3 (YDL100C)...”
- “...vesicle Golgi component component VTC1 vesicle vacuole (YER072W) component sorting CMK2 stress (YOL016C) calcium CAJ1 stress (YER048C) cochaperone intracellular...”
- Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism
Raisner, Genetics 2008 - “...YOL004W YIL084C YMR263W YNL097C YPL181W YBR095C YAL013W YER072W YLR436C YPR067W YIL055C YNL239W YCL005W YKL116C YOL045W Lipid particles Cytoplasm Cytoplasm...”
- Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
Yu, PloS one 2008 - “...YBR296C PHM6 YDR281C PPN1 YDR452W PHO8 * YDR481C PHM8 YER037W HIS1 YER055C HOR2 YER062C VTC1 YER072W VTC2 YFL004W SPL2 * YHR136C PHO12 * YHR215W VTC4 YJL012C PHO86 * YJL117W PHO84 * YML123C PHM7 YOL084W CTF19 YPL018W VTC3 YPL019C KRE29 YER038C SWC3 YAL011W YAR069C YAR069C YAR070C YAR070C...”
- Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae
Namy, Genetics 2002 (secret) - More
AO090012000979 No description from Aspergillus oryzae RIB40
Aligns to 646:711 / 756 (8.7%), covers 98.5% of PF02656, 51.6 bits
- Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822
He, BMC genomics 2019 - “...(AO090011000649, AO090005000455), ribosome assembly protein (AO090701000541), ATP-dependent RNA helicase (AO090023000510), DNA replication licensing factors MCM4 (AO090012000979, AO090011000793), choline dehydrogenases (AO090026000028, AO090003001420, AO090023000847), RNA-dependent RNA polymerase (AO090020000563), and DNA-directed RNA polymerase (AO090012000486) were approved to have much lower transcriptional level in response to nicotine exposure through qRT-PCR....”
XP_001690865 vacuolar transport chaperone-like protein from Chlamydomonas reinhardtii
Aligns to 45:119 / 158 (47.5%), covers 97.1% of PF02656, 49.8 bits
AFUA_2G09040, Afu2g09040 vacuolar transporter chaperone (Vtc4), putative from Aspergillus fumigatus Af293
Aligns to 677:740 / 801 (8.0%), covers 97.1% of PF02656, 48.2 bits
- Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach
Kaltdorf, Frontiers in molecular biosciences 2016 - “...protein AFUA_2G17650 0.523 2.921 2.795 DUF907 domain protein AFUA_2G17300 n.s. 4.050 1.057 GSH Glutathione S-transferase AFUA_2G09040 n.s. 1.360 1.053 Vacuolar transporter chaperone (Vtc4) AFUA_2G04010 n.s. 1.125 1.182 SUC Alpha,alpha-trehalose-phosphate synthase subunit ESSENTIAL GENES AFUA_3G14440 0.916 1.174 n.s. Cytochrome c oxidase family protein AFUA_4G10480 n.s. 2.375 1.812...”
- “...protein AFUA_2G17300 261 220 481 14 Glutathione S-transferase AFUA_1G17010 261 220 481 14 Glutathione S-transferase AFUA_2G09040 307 195 502 15 Vacuolar transporter chaperone (Vtc4) AFUA_2G04010 220 302 522 16 Alpha, alpha-trehalose-phosphate synthase subunit AFUA_6G12950 220 302 522 16 Trehalose-phosphate synthase/phosphatase complex subunit Tps1, putative B I...”
- Functional characterization of the Aspergillus fumigatusPHO80 homologue
de, Fungal genetics and biology : FG & B 2008 (PubMed)- “...(phoDPHO84), Afu7g06350 (phoEPHO89), Afu4g06020 (phoCPHO81), and Afu2g09040 (vacuolar transporter Vtc4) as more expressed both in the phoBPHO80 mutant...”
- “...Afu4g03610 Phosphate:H + symporter ( phoD PHO84 ) Afu2g09040 Vacuolar transporter chaperone Vtc4 Afu4g06020 Cyclin dependent kinase inhibitor, Nuc2 ( phoC PHO81...”
cg0136 hypothetical protein (RefSeq) from Corynebacterium glutamicum ATCC 13032
Aligns to 6:71 / 105 (62.9%), covers 95.6% of PF02656, 47.8 bits
Rv2273 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN (NCBI) from Mycobacterium tuberculosis H37Rv
MT2334 hypothetical protein (NCBI) from Mycobacterium tuberculosis CDC1551
Aligns to 10:73 / 109 (58.7%), covers 98.5% of PF02656, 47.5 bits
- Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
Das, BMC genomics 2013 - “...19 ]. In case of F99 several trans-membrane protein coding genes, such as Rv2272 and Rv2273 were missing. Although we have considered repeat regions by realigning short reads with multiple matches, a number of prophage proteins (phiRV2) were not mapped. Prophage proteins are quite often present...”
- Genomic signatures of the haarlem lineage of Mycobacterium tuberculosis: implications of strain genetic variation in drug and vaccine development
Cubillos-Ruiz, Journal of clinical microbiology 2010 - “...by deletion of the transmembrane proteins Rv2272 and Rv2273 as part of HSD2. Consequently, vaccine candidates should be effective against challenge not only...”
- Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments
Cubillos-Ruiz, BMC research notes 2008 - “...(Helicase) Rv2102 (Conserved hypothetical protein) 2546849 6480 Rv2271 (Hypothetical protein) Rv2272 (Probable conserved transmembrane protein) Rv2273 (Probable conserved transmembrane protein) Rv2274c (Hypothetical protein) Rv2275 (Hypothetical protein) cyp121 (Cytochrome P450) Rv2277c (Probable glycerolphosphodiesterase) 2792261 170 PE-PGRS42 3117314 439 Repeat region (DR) Intergenic between Rv2813 and Rv2814 3192481...”
- Mycobacterium tuberculosis genes induced during infection of human macrophages
Dubnau, Infection and immunity 2002 - “...infC nirA dut Unknown Rv0036c, Rv0406c, Rv0811c, Rv1778c, Rv2273, Rv2468c, Rv2632c, Rv2717c, Rv3427c, Rv3493c, Rv3717 a The Rv number is the number assigned to...”
- Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress
Lin, Infection and immunity 2016 - “...MT1973 MT1997 MT2016 MT2031 MT2040 MT2097 MT2100 MT2101 MT2334 MT2339 MT2469 MT2471 MT2598 MT2901 Rv1607 Rv1877 Rv1922 Rv1946c Rv1964 Rv1979c Rv1986 Rv2037c...”
An12g04710 vacuolar transporter chaperone 4 from Aspergillus niger CBS 513.88
Aligns to 688:751 / 808 (7.9%), covers 97.1% of PF02656, 45.9 bits
VTC2_YEAST / P43585 Vacuolar transporter chaperone 2; Phosphate metabolism protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YFL004W Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 686:752 / 828 (8.1%), covers 97.1% of PF02656, 44.3 bits
- function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1. - Mutation rates across budding yeast chromosome VI are correlated with replication timing
Lang, Genome biology and evolution 2011 - “...WWM1 115102 GL47 YFR054C Hypothetical 258842 GL23 YFL007W BLM3 123474 GL48 YFR055W Hypothetical 264191 GL24 YFL004W VTC2 131805 GL49 YFR057W Hypothetical 269048 a Position is the location at which the gene is first encountered moving across Chromosome VI starting at the left telomere. b Strains omitted...”
- Non-coding RNA prediction and verification in Saccharomyces cerevisiae
Kavanaugh, PLoS genetics 2009 - “...file. Figure S7 Regions producing Z-scores 3.5 for intergenic sequence between SEC4 (YFL005W) and VTC1 (YFL004W). Positions along the 828 bp sequence are shown on the scale at the top of the figure. All windows producing a Z-score 3.5 are plotted below the scale as a...”
- “...The first column provides the sequence name. This region lies between SEC4 (YFL005W) and VTC2 (YFL004W) and is 828 bp long. The sequence name ends with the boundary values for the window being evaluated. The second column (Pos) specifies the beginning position of the window. The...”
- Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
Yu, PloS one 2008 - “...YDR281C PPN1 YDR452W PHO8 * YDR481C PHM8 YER037W HIS1 YER055C HOR2 YER062C VTC1 YER072W VTC2 YFL004W SPL2 * YHR136C PHO12 * YHR215W VTC4 YJL012C PHO86 * YJL117W PHO84 * YML123C PHM7 YOL084W CTF19 YPL018W VTC3 YPL019C KRE29 YER038C SWC3 YAL011W YAR069C YAR069C YAR070C YAR070C KRE2 YDR483W...”
- Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis
Rojas, BMC genomics 2008 - “...COS7 LSC2 SUN4 YLR414C YDR214W KRI1 SES1 YFL002W-A COX20 MCR1 TAT2 YLR454W YDR476C KRR1 SIT1 YFL004W CPA1 MDH1 TDH1 YML128C YER134C LOS1 SKP1 YGR038C-B CTS1 MDH2 TDH2 YMR090W YER182W LYS7 SMD3 YGR081C CYC3 MEP1 TDH3 YMR173W-A YGL047W MGM101 SNF8 YGR161W-B CYT1 MEP3 THO1 YMR181C YGR201C NAT3...”
- Expression evolution in yeast genes of single-input modules is mainly due to changes in trans-acting factors
Wang, Genome research 2007 - “...the promoter regions of YCR075C, YDL137W, YEL052W, YEL053C, YFL004W, YGR157W, YLR438W, YML075C, YOR306C, and YPL157W between BY and RM. After the replacement of...”
- “...Ratio Swap/BY (95% CI) Effect YCR075C YDL137W YEL052W YEL053C YFL004W YGR157W YLR438W YML075C YOR306C YPL157W 0.74 1.27 0.83 0.84 0.68 0.66 1.31 1.97 0.58 0.93...”
- New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
Ogawa, Molecular biology of the cell 2000 - “...phosphate metabolism. The amino acid sequences of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4...”
- “...proteins encoded by these three genes share homology with YFL004w as described later (Figure 3A). The expression of YFL004w was also regulated by the PHO...”
VTC3_YEAST / Q02725 Vacuolar transporter chaperone 3; Phosphate metabolism protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YPL019C Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 698:765 / 835 (8.1%), covers 97.1% of PF02656, 42.9 bits
- function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for LMA1 release prior to membrane fusion (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1. - Effects of the yeast RNA-binding protein Whi3 on the half-life and abundance of CLN3 mRNA and other targets
Cai, PloS one 2013 - “...PDR15 YDR406W 1.4 0.0 0.0 0.7 0.0 ICT1 YLR099C 1.1 0.0 0.0 0.2 0.0 VTC3 YPL019C 1.2 0.1 0.2 0.2 0.5 CMK2 YOL016C 1.1 0.1 0.0 0.2 0.1 YIL100W YIL100W 1.0 0.7 0.8 0.7 Down-regulated SAM3 YPL274W 1.4 0.5 0.1 0.8 0.4 GDH1 YOR375C 1.4 0.2...”
- Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast
Poschke, PLoS genetics 2012 - “...+++ C Unknown YJR119C +++ MRPL9 YGR220C + BUD31 YCR063W +++ NPC2 YDL046W +++ VTC3 YPL019C + CTK1 YKL139W +++ C RTG3 YBL103C +++ MSR1 YHR091C + SIN3 YOL004W +++ B,C TPM2 YIL138C +++ EDE1 YBL047C + E EAF3 YPR023C +++ SUR4 YLR372W +++ C KRE28...”
- The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast
Chesi, PloS one 2012 - “...YDR089W YDL095W PMT1 YKR001C VPS1 YDR295C HDA2 YLL030C RRT7 YJL029C VPS53 YPR179C HDA3 YIL047C SYG1 YPL019C VTC3 YEL057C YEL057C YLR087C CSF1 YNL148C ALF1 YBR014C GRX7 YDR174W HMO1 YDR297W SUR2 YOR123C LEO1 YLR372W SUR4 YHL023C NPR3 YDL122W UBP1 YBR103W SIF2 YML097C VPS9 YML020W YML020W YLR138W NHA1 YIL153W...”
- Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
Yu, PloS one 2008 - “...* YHR215W VTC4 YJL012C PHO86 * YJL117W PHO84 * YML123C PHM7 YOL084W CTF19 YPL018W VTC3 YPL019C KRE29 YER038C SWC3 YAL011W YAR069C YAR069C YAR070C YAR070C KRE2 YDR483W MNN1 YER001W ARO9 YHR137W REC107 YJR021C YJR039W YJR039W NUP85 YJR042W PTK2 YJR059W CDA1 YLR307W YLR402W YLR402W YML089C YML089C YMR291W YMR291W...”
- The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease
Dobson, Molecular and cellular biology 2005 - “...BamHI restriction fragment containing the YPL020C/ULP1 gene and YPL019C (an uncharacterized open reading frame [ORF] flanking ULP1) was amplified by PCR from...”
- “...clones, containing the YPL026C/STS1, YPL022W/RAD1, YPL018W/CTF19, YPL019C and YPL020C/ULP1 genes, respectively, were tested for their ability to complement...”
- Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP)
Kobayashi, Nucleic acids research 2003 - “...for CAM1, TK2117/TK2118 for PMT4, TK2119/TK2431 for YPL019C, TK2121/TK2432 for PHO5, TK2125/TK2126 for YDL124W, TK2294/ TK2295 for TRX1, TK2296/TK2297 for WTM2...”
- “...the expression levels of SAGA-dependent genes, that is, PHO84, YPL019C, PHO5, YHB1 and YDL124W (35), in these three taf12 mutants (Fig. 3A, right panel). The...”
- New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
Ogawa, Molecular biology of the cell 2000 - “...The amino acid sequences of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4 single mutants and...”
- “...(Figure 2B and Table 2). Three of these genes (YPL019c, YJL012c and YER072w) had levels of differential expression similar to PHO5 and PHO84, in nearly all of...”
XP_002295322 predicted protein from Thalassiosira pseudonana CCMP1335
Aligns to 475:541 / 589 (11.4%), covers 94.1% of PF02656, 41.8 bits
CNAG_01263 vacuolar transporter chaperone 4 from Cryptococcus neoformans var. grubii H99
Aligns to 762:829 / 864 (7.9%), covers 98.5% of PF02656, 40.8 bits
YidG / b3675 putative inner membrane protein from Escherichia coli K-12 substr. MG1655 (see 2 papers)
Aligns to 12:74 / 120 (52.5%), covers 82.4% of PF02656, 39.0 bits
VTC4_YEAST / P47075 Vacuolar transporter chaperone 4; Phosphate metabolism protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
NP_012522 Vtc4p from Saccharomyces cerevisiae S288C
NP_012522, YJL012C Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 622:684 / 721 (8.7%), covers 97.1% of PF02656, 36.4 bits
- function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:12584253, PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1. - The macro domain as fusion tag for carrier-driven crystallization
Wild, Protein science : a publication of the Protein Society 2017 - “...cerevisiae Vtc3; Q02725) and ScVtc4 (S. cerevisiae Vtc4; P47075) and including a secondary structure assignment calculated with the program DSSP48 and based on...”
- Positively-charged semi-tunnel is a structural and surface characteristic of polyphosphate-binding proteins: an in-silico study
Wei, PloS one 2015 - “...three-subunit components with actin-like structure. not reported PPK4 (vacuolar transporter chaperone, VTC4) Saccharomyces cerevisiae (NP_012522.2, P47075) membrane transport and vesicular traffic. one SPX domain (IPR004331) at the N terminus, DUF202 (IPR003807) and VTC domain (IPR018966). polyP-winding tunnel-shaped pocket with nucleotide-and phosphate-binding structures, formed mainly by antiparallel...”
- Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
Hothorn, Science (New York, N.Y.) 2009 (PubMed)- GeneRIF: results define Vtc4p* as a polyP-synthesizing enzyme
- The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
Olaisen, FEBS open bio 2018 - “...Cox23 Cytochrome c oxidaseassembly factor Cox23 2 YHR137W Aro9 Aromatic amino acid aminotransferase 2 1 YJL012C Vtc4 Vacuolar transporter chaperone 4 42 YJL090C Dpb11 DNA replication regulator Dpb11 10 YKL028W Tfa1 Transcription initiation factor IIE subunit alpha 11 YKL103C Ape1 Vacuolar aminopeptidase 1 14 YKR026C Gcn3...”
- Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins
Margulis, Traffic (Copenhagen, Denmark) 2016 - “...21 30 Plasma membrane H+-ATPase YOR270C Vph1 7 22 Subunit a of vacuolar-ATPase V0 domain YJL012C Vtc4 5 20 Vacuolar membrane polyphosphate polymerase YDR135C Ycf1 0 11 Vacuolar glutathione S-conjugate transporter...”
- The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast
Chesi, PloS one 2012 - “...SAP190 YIL054W YIL054W YBR231C SWC5 YIL040W APQ12 YER072W VTC1 YLL044W YLL044W YJL004C SYS1 YJR074W MOG1 YJL012C VTC4 YOR199W YOR199W YKL081W TEF4 YMR031W-A YMR031W-A YHR135C YCK1 YIL145C PAN6 YOL018C TLG2 YDR089W YDR089W YDL095W PMT1 YKR001C VPS1 YDR295C HDA2 YLL030C RRT7 YJL029C VPS53 YPR179C HDA3 YIL047C SYG1 YPL019C...”
- High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome
Yu, BMC genomics 2012 - “...- 3.98 - - - - - 3.63 - - - - - - P YJL012C VTC4 B - - - - - - 8.45 - - - - 6.10 - - P YER072W VTC1 B - - - - - - 8.94 - - -...”
- Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases
Lonetti, The Journal of biological chemistry 2011 - “...2). It has recently been found that Vtc4 (YJL012C; also known as Phm3), corresponding to subunit four of the vacuolar transporter chaperone complex, functions...”
- Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16
Yu, PloS one 2008 - “...HIS1 YER055C HOR2 YER062C VTC1 YER072W VTC2 YFL004W SPL2 * YHR136C PHO12 * YHR215W VTC4 YJL012C PHO86 * YJL117W PHO84 * YML123C PHM7 YOL084W CTF19 YPL018W VTC3 YPL019C KRE29 YER038C SWC3 YAL011W YAR069C YAR069C YAR070C YAR070C KRE2 YDR483W MNN1 YER001W ARO9 YHR137W REC107 YJR021C YJR039W YJR039W...”
- Proteome-wide identification of proteins and their modifications with decreased ambiguities and improved false discovery rates using unique sequence tags
Shen, Analytical chemistry 2008 - “...S.SSANK.L (from YKR092) cannot be distinguished from D.SSAGGK.Q (from YJL012C) due to the isobaric segment GG for N as one cannot get guarantee the MS/MS...”
- The vtc4 gene influences polyphosphate storage, morphogenesis, and virulence in the maize pathogen Ustilago maydis
Boyce, Eukaryotic cell 2006 - “...cerevisiae (64% identity and 78% similarity; accession number NP_012522). Deletion of vtc4 confers a filamentous cellular morphology. The coding region of the...”
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Or search for genetic data about PF02656 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory