Family Search for PF02656 (DUF202)

PF02656.15 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Rv2272 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN (NCBI) from Mycobacterium tuberculosis H37Rv
Aligns to 17:84 / 122 (55.7%), covers 98.5% of PF02656, 64.4 bits

• Nonclassical T cells and their antigens in tuberculosis
  De, Cold Spring Harbor perspectives in medicine 2014
  • “...proteins, namely of 1-deoxy-D-xylulose 5-phosphate synthase 2 and Rv2272 protein, which activated gd T cells from pulmonary TB patients (Xi et al. 2013)....”
• Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones
  De, Frontiers in Immunology 2014
  • “...IPP, HMBPP ( 43 45 ) Tetanus toxoid ( 30 , 31 ) DXS2 or Rv2272 peptides ( 40 ) V1 clones HLA-A24, HLA-A2 ( 9 , 10 ) V4V1 HLA-B27 ( 32 ) V3V2 Histidyl-tRNA synthetase ( 39 ) MOUSE Hybridoma G8 T10, T22, T27...”
  • “...isopentenyl pyrophosphate; MICA or MICB, MHC class I chain-related protein A or B; NP, 4-hydroxy-3-nitrophenylacetyl; Rv2272, mycobacterium transmembrane protein; T10, T22, or T27, MHC class Ib proteins; PE, algae protein phycoerythrin . CD1 molecules have been found to interact with the human TCR. The first isolated...”
• Molecules and Mechanisms Implicated in the Peculiar Antigenic Activation Process of Human Vγ9Vδ2 T Cells
  Harly, Frontiers in immunology 2014
  • “...characterized which led to the identification of new protein/peptides of mycobacterial origin (e.g., OXYS, DXS2, Rv2272) ( 94 , 95 ) that can interact with V9V2 TCRs and activate a large fraction of V9V2 T cells isolated from peripheral blood of tuberculosis infected patients but not...”
• Identification of a new tuberculosis antigen recognized by γδ T cell receptor
  Xi, Clinical and vaccine immunology : CVI 2013
  • “...The extracellular region (extracellular peptide [EP]) of Rv2272, a TP2-matched mycobacterial transmembrane protein, was also shown to activate T cells from...”
  • “...transmembrane region of the unknown transmembrane protein (Rv2272). Statistical analysis. Statistical comparisons were performed using the Student t test....”
• Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
  Das, BMC genomics 2013
  • “...tuberculosis [ 19 ]. In case of F99 several trans-membrane protein coding genes, such as Rv2272 and Rv2273 were missing. Although we have considered repeat regions by realigning short reads with multiple matches, a number of prophage proteins (phiRV2) were not mapped. Prophage proteins are quite...”
• Genomic signatures of the haarlem lineage of Mycobacterium tuberculosis: implications of strain genetic variation in drug and vaccine development
  Cubillos-Ruiz, Journal of clinical microbiology 2010
  • “...exemplified here by deletion of the transmembrane proteins Rv2272 and Rv2273 as part of HSD2. Consequently, vaccine candidates should be effective against...”
• Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments
  Cubillos-Ruiz, BMC research notes 2008
  • “...643 PE-PGRS33 2365930 1774 helZ (Helicase) Rv2102 (Conserved hypothetical protein) 2546849 6480 Rv2271 (Hypothetical protein) Rv2272 (Probable conserved transmembrane protein) Rv2273 (Probable conserved transmembrane protein) Rv2274c (Hypothetical protein) Rv2275 (Hypothetical protein) cyp121 (Cytochrome P450) Rv2277c (Probable glycerolphosphodiesterase) 2792261 170 PE-PGRS42 3117314 439 Repeat region (DR) Intergenic...”

YidH / b3676 conserved inner membrane protein YidH from Escherichia coli K-12 substr. MG1655 (see 2 papers)
Aligns to 13:80 / 115 (59.1%), covers 98.5% of PF02656, 59.6 bits

FGR18 putative uncharacterized protein from Candida albicans (see paper)
Aligns to 1:80 / 120 (66.7%), covers 92.6% of PF02656, 59.2 bits

• CharProtDB CGD description: Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly spurious ORF (Annotation Working Group prediction)

XP_846013 vacuolar transporter chaperone, putative from Trypanosoma brucei brucei TREU927
Aligns to 62:127 / 180 (36.7%), covers 95.6% of PF02656, 58.5 bits

• Ablation of a small transmembrane protein of Trypanosoma brucei (TbVTC1) involved in the synthesis of polyphosphate alters acidocalcisome biogenesis and function, and leads to a cytokinesis defect.
  Fang, The Biochemical journal 2007
  • GeneRIF: PP(i)-driven H+ pumping deficiency induced by ablation of TbVTC1 induces changes in the protonmotive force of acidocalcisomes, resulting in deficient fusion or budding of the organelles, decreased H+ and Ca2+ content, and decreased synthesis of poly P.

cg0135 putative inner membrane protein (RefSeq) from Corynebacterium glutamicum ATCC 13032
Aligns to 21:88 / 122 (55.7%), covers 98.5% of PF02656, 57.2 bits

• Target genes, consensus binding site, and role of phosphorylation for the response regulator MtrA of Corynebacterium glutamicum
  Brocker, Journal of bacteriology 2011
  • “...2017 by University of California, Berkeley cg0133 cg0134 cg0135 cg0136 cg0282 cg0689 cg0715 cg0859 cg0862 cg0896 cg0909 cg1016 cg1037 cg1085 cg1210 cg1213...”

VTC1_SCHPO / Q9UR17 Vacuolar transporter chaperone 1; Negative regulator of cdc42 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
nrf1 GTPase regulator Nrf1 from Schizosaccharomyces pombe (see 3 papers)
Aligns to 24:86 / 122 (51.6%), covers 98.5% of PF02656, 53.9 bits

• function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (By similarity). Involved in the control of cell polarity.
  subunit: The VTC complex is an integral membrane heterooligomer composed of at least vtc1, vtc2 and vtc4 (By similarity). Interacts with GTP-bound Ras-like cdc42, which is subsequently inactivated.
• CharProtDB Source (per GeneDB): GeneDB_Spombe

VTC1_YEAST / P40046 Vacuolar transporter chaperone 1; Negative regulator of CDC42 protein 1; Phosphate metabolism protein 4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YER072W Vacuolar transporter chaperon (VTC) involved in distributing V-ATPase and other membrane proteins; together with other VTC proteins, forms a heterotetrameric complex that associates with the SNARE Nyv1p and the V0 sector of the V-ATPase (RefSeq) from Saccharomyces cerevisiae
Aligns to 24:86 / 129 (48.8%), covers 97.1% of PF02656, 53.4 bits

• function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.
  subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1.
• The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization
  Kim, The Journal of biological chemistry 2009
  • “...APS3 (YJL024C) APM3 (YBR288C) RAV2 (YDR202C) VTC1 (YER072W) ARL1 (YBR164C) AVL9P (YLR114C) COG8 (YML071C) GYP1 (YOR070C) SEC28 (YIL076W) ARR4/GET3 (YDL100C)...”
  • “...vesicle Golgi component component VTC1 vesicle vacuole (YER072W) component sorting CMK2 stress (YOL016C) calcium CAJ1 stress (YER048C) cochaperone intracellular...”
• Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae
  Namy, Genetics 2002 (secret)
• New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
  Ogawa, Molecular biology of the cell 2000
  • “...of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4 single mutants and the phm1 phm2 double mutant...”
  • “...Table 2). Three of these genes (YPL019c, YJL012c and YER072w) had levels of differential expression similar to PHO5 and PHO84, in nearly all of the eight...”
• Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe
  Murray, Genetics 2000 (secret)
• Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
  Zhang, Nucleic acids research 2000
  • “...YCR022c YER066c-a YHR218w-a YLR050c YNL176c YPR100w YCR025c YER072w YIL012w YLR064w YNL179c YPR114w YCR043c YER091c-a YIL025c YLR111w YNL203c YPR151c YCR062w...”

XP_001690865 vacuolar transport chaperone-like protein from Chlamydomonas reinhardtii
Aligns to 45:119 / 158 (47.5%), covers 97.1% of PF02656, 49.8 bits

• Critical function of a Chlamydomonas reinhardtii putative polyphosphate polymerase subunit during nutrient deprivation.
  Aksoy, The Plant cell 2014
  • GeneRIF: Data show that introduction of the VACUOLAR TRANSPORTER CHAPERONE1 (VTC1) gene, which encodes a component of a polyphosphate polymerase complex, specifically complements the ars76 mutant phenotypes.

AFUA_2G09040, Afu2g09040 vacuolar transporter chaperone (Vtc4), putative from Aspergillus fumigatus Af293
Aligns to 677:740 / 801 (8.0%), covers 97.1% of PF02656, 48.2 bits

• Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach
  Kaltdorf, Frontiers in molecular biosciences 2016
  • “...protein AFUA_2G17650 0.523 2.921 2.795 DUF907 domain protein AFUA_2G17300 n.s. 4.050 1.057 GSH Glutathione S-transferase AFUA_2G09040 n.s. 1.360 1.053 Vacuolar transporter chaperone (Vtc4) AFUA_2G04010 n.s. 1.125 1.182 SUC Alpha,alpha-trehalose-phosphate synthase subunit ESSENTIAL GENES AFUA_3G14440 0.916 1.174 n.s. Cytochrome c oxidase family protein AFUA_4G10480 n.s. 2.375 1.812...”
  • “...protein AFUA_2G17300 261 220 481 14 Glutathione S-transferase AFUA_1G17010 261 220 481 14 Glutathione S-transferase AFUA_2G09040 307 195 502 15 Vacuolar transporter chaperone (Vtc4) AFUA_2G04010 220 302 522 16 Alpha, alpha-trehalose-phosphate synthase subunit AFUA_6G12950 220 302 522 16 Trehalose-phosphate synthase/phosphatase complex subunit Tps1, putative B I...”
• Functional characterization of the Aspergillus fumigatusPHO80 homologue
  de, Fungal genetics and biology : FG & B 2008 (PubMed)
  • “...(phoDPHO84), Afu7g06350 (phoEPHO89), Afu4g06020 (phoCPHO81), and Afu2g09040 (vacuolar transporter Vtc4) as more expressed both in the phoBPHO80 mutant...”
  • “...Afu4g03610 Phosphate:H + symporter ( phoD PHO84 ) Afu2g09040 Vacuolar transporter chaperone Vtc4 Afu4g06020 Cyclin dependent kinase inhibitor, Nuc2 ( phoC PHO81...”

cg0136 hypothetical protein (RefSeq) from Corynebacterium glutamicum ATCC 13032
Aligns to 6:71 / 105 (62.9%), covers 95.6% of PF02656, 47.8 bits

• Target genes, consensus binding site, and role of phosphorylation for the response regulator MtrA of Corynebacterium glutamicum
  Brocker, Journal of bacteriology 2011
  • “...by University of California, Berkeley cg0133 cg0134 cg0135 cg0136 cg0282 cg0689 cg0715 cg0859 cg0862 cg0896 cg0909 cg1016 cg1037 cg1085 cg1210 cg1213 cg1227...”

Rv2273 PROBABLE CONSERVED TRANSMEMBRANE PROTEIN (NCBI) from Mycobacterium tuberculosis H37Rv
Aligns to 10:73 / 109 (58.7%), covers 98.5% of PF02656, 47.5 bits

• Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
  Das, BMC genomics 2013
  • “...19 ]. In case of F99 several trans-membrane protein coding genes, such as Rv2272 and Rv2273 were missing. Although we have considered repeat regions by realigning short reads with multiple matches, a number of prophage proteins (phiRV2) were not mapped. Prophage proteins are quite often present...”
• Genomic signatures of the haarlem lineage of Mycobacterium tuberculosis: implications of strain genetic variation in drug and vaccine development
  Cubillos-Ruiz, Journal of clinical microbiology 2010
  • “...by deletion of the transmembrane proteins Rv2272 and Rv2273 as part of HSD2. Consequently, vaccine candidates should be effective against challenge not only...”
• Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments
  Cubillos-Ruiz, BMC research notes 2008
  • “...(Helicase) Rv2102 (Conserved hypothetical protein) 2546849 6480 Rv2271 (Hypothetical protein) Rv2272 (Probable conserved transmembrane protein) Rv2273 (Probable conserved transmembrane protein) Rv2274c (Hypothetical protein) Rv2275 (Hypothetical protein) cyp121 (Cytochrome P450) Rv2277c (Probable glycerolphosphodiesterase) 2792261 170 PE-PGRS42 3117314 439 Repeat region (DR) Intergenic between Rv2813 and Rv2814 3192481...”
• Mycobacterium tuberculosis genes induced during infection of human macrophages
  Dubnau, Infection and immunity 2002
  • “...infC nirA dut Unknown Rv0036c, Rv0406c, Rv0811c, Rv1778c, Rv2273, Rv2468c, Rv2632c, Rv2717c, Rv3427c, Rv3493c, Rv3717 a The Rv number is the number assigned to...”

An12g04710 vacuolar transporter chaperone 4 from Aspergillus niger CBS 513.88
Aligns to 688:751 / 808 (7.9%), covers 97.1% of PF02656, 45.9 bits

• Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics
  Meyer, Eukaryotic cell 2009
  • “...Other signaling processes An15g01560 An04g01500 An08g07090 An16g07890 An12g04710 (3.21) 2.98 0.06 0.04 0.29 0.029 0.044 0.054 0.037 0.031 GTPase-activating...”
  • “...reference 83). Interestingly, we found a downregulation of An12g04710, which displays similarity to the yeast Vtc1p and Nrf1p proteins, which are negative...”

VTC2_YEAST / P43585 Vacuolar transporter chaperone 2; Phosphate metabolism protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YFL004W Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 686:752 / 828 (8.1%), covers 97.1% of PF02656, 44.3 bits

• function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
  subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1.
• Non-coding RNA prediction and verification in Saccharomyces cerevisiae
  Kavanaugh, PLoS genetics 2009
  • “...file. Figure S7 Regions producing Z-scores 3.5 for intergenic sequence between SEC4 (YFL005W) and VTC1 (YFL004W). Positions along the 828 bp sequence are shown on the scale at the top of the figure. All windows producing a Z-score 3.5 are plotted below the scale as a...”
  • “...The first column provides the sequence name. This region lies between SEC4 (YFL005W) and VTC2 (YFL004W) and is 828 bp long. The sequence name ends with the boundary values for the window being evaluated. The second column (Pos) specifies the beginning position of the window. The...”
• Expression evolution in yeast genes of single-input modules is mainly due to changes in trans-acting factors
  Wang, Genome research 2007
  • “...the promoter regions of YCR075C, YDL137W, YEL052W, YEL053C, YFL004W, YGR157W, YLR438W, YML075C, YOR306C, and YPL157W between BY and RM. After the replacement of...”
  • “...Ratio Swap/BY (95% CI) Effect YCR075C YDL137W YEL052W YEL053C YFL004W YGR157W YLR438W YML075C YOR306C YPL157W 0.74 1.27 0.83 0.84 0.68 0.66 1.31 1.97 0.58 0.93...”
• New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
  Ogawa, Molecular biology of the cell 2000
  • “...phosphate metabolism. The amino acid sequences of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4...”
  • “...proteins encoded by these three genes share homology with YFL004w as described later (Figure 3A). The expression of YFL004w was also regulated by the PHO...”

VTC3_YEAST / Q02725 Vacuolar transporter chaperone 3; Phosphate metabolism protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YPL019C Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 698:765 / 835 (8.1%), covers 97.1% of PF02656, 42.9 bits

• function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for LMA1 release prior to membrane fusion (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
  subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1.
• The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease
  Dobson, Molecular and cellular biology 2005
  • “...BamHI restriction fragment containing the YPL020C/ULP1 gene and YPL019C (an uncharacterized open reading frame [ORF] flanking ULP1) was amplified by PCR from...”
  • “...clones, containing the YPL026C/STS1, YPL022W/RAD1, YPL018W/CTF19, YPL019C and YPL020C/ULP1 genes, respectively, were tested for their ability to complement...”
• Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA box-binding protein (TBP)
  Kobayashi, Nucleic acids research 2003
  • “...for CAM1, TK2117/TK2118 for PMT4, TK2119/TK2431 for YPL019C, TK2121/TK2432 for PHO5, TK2125/TK2126 for YDL124W, TK2294/ TK2295 for TRX1, TK2296/TK2297 for WTM2...”
  • “...the expression levels of SAGA-dependent genes, that is, PHO84, YPL019C, PHO5, YHB1 and YDL124W (35), in these three taf12 mutants (Fig. 3A, right panel). The...”
• New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
  Ogawa, Molecular biology of the cell 2000
  • “...The amino acid sequences of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4 single mutants and...”
  • “...(Figure 2B and Table 2). Three of these genes (YPL019c, YJL012c and YER072w) had levels of differential expression similar to PHO5 and PHO84, in nearly all of...”

CNAG_01263 vacuolar transporter chaperone 4 from Cryptococcus neoformans var. grubii H99
Aligns to 762:829 / 864 (7.9%), covers 98.5% of PF02656, 40.8 bits

• Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans
  Kretschmer, Infection and immunity 2014
  • “...membrane Polyphosphate storage and processing Vtc4 Ppx1 Ppn1 CNAG_01263 CNAG_04354 CNAG_07629 VTC4 XPP1 EPP1 e155 2e24 1e76 64 26 43 80 44 61 Vacuolar...”
  • “...to the yeast vacuolar transport chaperone Vtc4 (CNAG_01263) for polyphosphate synthesis, as well as candidate orthologs for endopolyphosphatases (EPP1) and...”

YidG / b3675 putative inner membrane protein from Escherichia coli K-12 substr. MG1655 (see 2 papers)
Aligns to 12:74 / 120 (52.5%), covers 82.4% of PF02656, 39.0 bits

VTC4_YEAST / P47075 Vacuolar transporter chaperone 4; Phosphate metabolism protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
NP_012522 Vtc4p from Saccharomyces cerevisiae S288C
NP_012522, YJL012C Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion (RefSeq) from Saccharomyces cerevisiae
Aligns to 622:684 / 721 (8.7%), covers 97.1% of PF02656, 36.4 bits

• function: Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion (PubMed:12584253, PubMed:11102525, PubMed:11823419). Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106). Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106).
  subunit: The VTC complex is an integral membrane heterooligomer composed of VTC1, VTC2, VTC3 and VTC4. The complex interacts with the v-SNARE NYV1 and with the V(0) subunit of V-ATPase VPH1.
• The macro domain as fusion tag for carrier-driven crystallization
  Wild, Protein science : a publication of the Protein Society 2017
  • “...cerevisiae Vtc3; Q02725) and ScVtc4 (S. cerevisiae Vtc4; P47075) and including a secondary structure assignment calculated with the program DSSP48 and based on...”
• Positively-charged semi-tunnel is a structural and surface characteristic of polyphosphate-binding proteins: an in-silico study
  Wei, PloS one 2015
  • “...three-subunit components with actin-like structure. not reported PPK4 (vacuolar transporter chaperone, VTC4) Saccharomyces cerevisiae (NP_012522.2, P47075) membrane transport and vesicular traffic. one SPX domain (IPR004331) at the N terminus, DUF202 (IPR003807) and VTC domain (IPR018966). polyP-winding tunnel-shaped pocket with nucleotide-and phosphate-binding structures, formed mainly by antiparallel...”
• Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.
  Hothorn, Science (New York, N.Y.) 2009 (PubMed)
  • GeneRIF: results define Vtc4p* as a polyP-synthesizing enzyme
• Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases
  Lonetti, The Journal of biological chemistry 2011
  • “...2). It has recently been found that Vtc4 (YJL012C; also known as Phm3), corresponding to subunit four of the vacuolar transporter chaperone complex, functions...”
• Proteome-wide identification of proteins and their modifications with decreased ambiguities and improved false discovery rates using unique sequence tags
  Shen, Analytical chemistry 2008
  • “...S.SSANK.L (from YKR092) cannot be distinguished from D.SSAGGK.Q (from YJL012C) due to the isobaric segment GG for N as one cannot get guarantee the MS/MS...”
• The vtc4 gene influences polyphosphate storage, morphogenesis, and virulence in the maize pathogen Ustilago maydis
  Boyce, Eukaryotic cell 2006
  • “...cerevisiae (64% identity and 78% similarity; accession number NP_012522). Deletion of vtc4 confers a filamentous cellular morphology. The coding region of the...”
• Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae
  Schüller, Molecular biology of the cell 2004
  • “...YKR093W YBR043C YLR372W YAL059W YDR492W YGR175C YGR189C YJL012C YBL039C YOR153W YFR055W YOR303W YDR038C YER091C YBR033W YDR497C YNL142W YBL003C YHR007C...”
• Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii
  Brachat, Genome biology 2003
  • “...262 YGL045W 229 540 3FS AFR108W 549 YGR272C 152 YGR271C-A 63 233 FS ABR143C 214 YJL012C VTC4 648 YJL012C-A 65 721 FS AGR316C 714 Resequenced YJL017W 325 YJL016W 171 561 FS AGR313W 471 Resequenced YJL019W MPS3 620 YJL018W 102 682 FS AGR312W 617 Resequenced YJL020C BBC1...”
• Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns
  Kirschner, Molecular and cellular biology 2002
  • “...genes of the second (PHO84, PHO5, SPL2, YHB1, and YJL012C), four genes in the third (AAH1, FAR1, TABLE 2. Total gene expression analysisa TAFII25 mutant Del. 72...”
• Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors
  Kirchner, Molecular and cellular biology 2001
  • “...depend upon SAGA (YHB1, PHO84, YDL124W, and YJL012C). The third represented genes whose transcription was reduced in an undefined temperature-sensitive taf25...”
  • “...familya SAGA TFIID TAF25p Total poly (A) mRNA YHB1 PHO84 YJL012C YDL124W PMT4 WSC2 TRX1 GIC2 YOR248W FAS2 Wild type G101E TAF25N TAF25C TAF25NC 86A 88A 89A 90A...”
• New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis
  Ogawa, Molecular biology of the cell 2000
  • “...amino acid sequences of PHM1 (YFL004w), PHM2 (YPL019c), PHM3 (YJL012c), and PHM4 (YER072w) are 32-56% identical. The phm3 and phm4 single mutants and the phm1...”
  • “...2B and Table 2). Three of these genes (YPL019c, YJL012c and YER072w) had levels of differential expression similar to PHO5 and PHO84, in nearly all of the...”
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