Family Search for PF02696 (SelO)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF02696 hits 24 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
UTI89_C1899 hypothetical protein YdiU from Escherichia coli UTI89
Aligns to 1:451 / 478 (94.4%), covers 99.1% of PF02696, 512.3 bits
YdiU / b1706 UPF0061 family protein YdiU from Escherichia coli K-12 substr. MG1655 (see 4 papers)
selO / P77649 protein adenylyltransferase SelO (EC 2.7.7.108) from Escherichia coli (strain K12) (see 4 papers)
SELO_ECOLI / P77649 Protein adenylyltransferase SelO; Selenoprotein O homolog; SelO; EC 2.7.7.108 from Escherichia coli (strain K12) (see paper)
ydiU / RF|NP_416221 UPF0061 protein ydiU from Escherichia coli K12 (see paper)
b1706 hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 1:451 / 478 (94.4%), covers 99.1% of PF02696, 511.1 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). Cannot use GTP, CTP or UTP as cosubstrate. AMPylates SucA at 'Thr-405' and GrxA on 'Tyr-13'. Regulates protein S-glutathionylation levels probably by AMPylation of deglutathionylation enzymes such as GrxA. Probably involved in redox homeostasis.
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
disruption phenotype: Moderate decrease in global protein S- glutathionylation. - 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013
6k20A / P77649 Structure of apo ydiu
Aligns to 1:449 / 465 (96.6%), covers 98.9% of PF02696, 508.2 bits
- Ligand: magnesium ion (6k20A)
VC1931 conserved hypothetical protein from Vibrio cholerae O1 biovar eltor str. N16961
Aligns to 23:479 / 508 (90.0%), covers 98.3% of PF02696, 501.0 bits
- Impact of Gene Repression on Biofilm Formation of Vibrio cholerae
Pombo, Frontiers in microbiology 2022 - “...protein 1 VC1784 Neuraminidase, sialidase 1 VC1832 Hypothetical protein 2 VC1911 Orotidine 5-phosphate decarboxylase 1 VC1931 Hypothetical protein 1 VC1956-1957 VC1956 Lytic murein transglycosylase, membrane-bound lytic murein transglycosylase B 1 VC1965-1966 VC1966 Hypothetical protein 1 VC2037 Na + /H + antiporter, NhaC 1 VC2058-2069 VC2067 MinD-like...”
6eacA / Q87VB1 Pseudomonas syringae selo (see paper)
Aligns to 4:459 / 476 (95.8%), covers 98.9% of PF02696, 500.3 bits
- Ligands: magnesium ion; calcium ion; phosphoaminophosphonic acid-adenylate ester (6eacA)
SELO_PSESM / Q87VB1 Protein adenylyltransferase SelO; EC 2.7.7.108 from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) (see paper)
Aligns to 3:458 / 487 (93.6%), covers 98.9% of PF02696, 500.2 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+)
PA5023 hypothetical protein from Pseudomonas aeruginosa PAO1
Aligns to 3:457 / 486 (93.6%), covers 98.9% of PF02696, 490.4 bits
FMP40 / Q08968 protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.108) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 7 papers)
SELO_YEAST / Q08968 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
YPL222W Fmp40p from Saccharomyces cerevisiae
Aligns to 48:649 / 688 (87.5%), covers 99.1% of PF02696, 486.2 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation) (PubMed:30270044). Involved in redox homeostasis by regulating the cellular response to oxidative stress (PubMed:30270044). Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins (PubMed:30270044).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
cofactor: Mg(2+)
disruption phenotype: Reduced growth and survival in presence of oxygen reactive species. - From complete genome sequence to 'complete' understanding?
Galperin, Trends in biotechnology 2010 - “...Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis Predicted RNA-modifying enzyme [ 80 ] ydiU YPL222w SELO PF02696 0397 n/a Selenoprotein O, in yeast localized to mitochondria; not found in archaea No news Modified from Table 3 from Ref [ 39 ] with permission from Oxford...”
- Saccharomyces cerevisiae signature genes for predicting nitrogen deficiency during alcoholic fermentation
Mendes-Ferreira, Applied and environmental microbiology 2007 - “...Gene name YNL270c YMR280c YGL166w YOR180c YKR076w YPL222w YDL222c YMR250w YDL223c YOR391c YLR174w YML128c YPL134c YDR313c YDL204w YIL113w YDR238c YMR175w...”
- 'Conserved hypothetical' proteins: prioritization of targets for experimental study
Galperin, Nucleic acids research 2004 - “...1690 01205 1739 03853 0062 02410 0799 01784 0327 01709 0217 YPL222w SELO 02696 0397 2542 3274 3326 3140 3833 3299 2585 3212 4131 2972 n/a n/a n/a n/a 1UC2 1VI7...”
- Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast
Infante, Genetics 2003 - “...YML042W, -043C YNL289W YNL125C YOR173W YOR374W, -376W YPL250C, -252C YPL222W, -223C YPL092W YPR036W, -037C YPR063C YPR151C IX IX IX IX X X X XII XIII XIII XIV...”
PBPRA2020 hypothetical protein from Photobacterium profundum SS9
Aligns to 11:493 / 522 (92.5%), covers 99.4% of PF02696, 459.9 bits
- Protein evolution in deep sea bacteria: an analysis of amino acids substitution rates
Campanaro, BMC evolutionary biology 2008 - “...q (%) 1 Putative Phosphate ABC Transporter, Permease Protein PBPRA1392 0581P 4.3 2 Hypothetical Protein PBPRA2020 - 4.8 3 Hypothetical Phosphoribosylaminoimidazole Carboxylase, Catalytic Subunit PBPRA3574 0041F 0.0 4 Dithiobiotin Synthetase PBPRA2326 0132H 8.3 5 Putative Xanthine/Uracil Permease PBPRA0186 2233F 8.3 6 Hypothetical TonB Protein PBPRA2103 0810M...”
BPSL1422 conserved hypothetical protein from Burkholderia pseudomallei K96243
Aligns to 24:496 / 525 (90.1%), covers 97.8% of PF02696, 447.1 bits
- The Burkholderia pseudomallei intracellular 'TRANSITome'
Heacock-Kang, Nature communications 2021 - “...Fig. 4b ). Of these 11 genes, four, BPSL0097 , BPSL0636 , BPSL1126 , and BPSL1422 , have not been identified in the literature to our knowledge while seven have had some reference. BpeT and BpeS, regulators of the RND efflux pump BpeEF-OprC, responsible for co-trimoxizole...”
- “...to wild type (Supplementary Table 1 ). Six mutants, BPSL0097 , BPSL1126 , BPSL1390 , BPSL1422 , BPSL2714 , and BPSS0015 , showed defects in intracellular replication between 2 and 6h post infection, ranging from 17 to 75% wild-type replication while eight mutants, BPSL0097 , BPSL0636...”
Galf_2424 YdiU family protein from Gallionella capsiferriformans ES-2
Aligns to 18:486 / 518 (90.5%), covers 97.2% of PF02696, 423.2 bits
AT5G13030 hypothetical protein from Arabidopsis thaliana
NP_196807 selenoprotein O from Arabidopsis thaliana
Aligns to 114:601 / 633 (77.1%), covers 96.1% of PF02696, 422.0 bits
- Proteomic and Metabolomic Analysis of the Quercus ilex-Phytophthora cinnamomi Pathosystem Reveals a Population-Specific Response, Independent of Co-Occurrence of Drought
Hernández-Lao, Biomolecules 2024 (no snippet) - The plastidial Arabidopsis thaliana NFU1 protein binds and delivers [4Fe-4S] clusters to specific client proteins
Roland, The Journal of biological chemistry 2020 - “...AT3G12930 AT3G62910 ATCG00180 ATCG00190 ATCG00740 AT5G13030 AT1G32900 AT5G24300 AT5G43780 AT3G21200 AT1G22940 AT3G06730 AT4G29670 AT5G65840 AT2G42220 2...”
- Small RNA and PARE sequencing in flower bud reveal the involvement of sRNAs in endodormancy release of Japanese pear (Pyrus pyrifolia 'Kosui')
Bai, BMC genomics 2016 (no snippet) - A genome-scale mining strategy for recovering novel rapidly-evolving nuclear single-copy genes for addressing shallow-scale phylogenetics in Hydrangea
Granados, BMC evolutionary biology 2015 - “...were randomly selected from the pool for primer design: AT1G10840, AT1G63900, AT2G17975, AT3G54170, AT4G35850, AT5G12040, AT5G13030, AT5G48470, AT5G57410 and AT5G64860. These genes were subsequently aligned to the A. thaliana full length genomic sequence obtained from TAIR ( http://www.arabidopsis.org/ ). Alignments were screened for regions with high...”
- SELENOPROTEIN O is a chloroplast protein involved in ROS scavenging and its absence increases dehydration tolerance in Arabidopsis thaliana.
Fichman, Plant science : an international journal of experimental plant biology 2018 (PubMed)- GeneRIF: The study elucidates SELO as a PSI-related component involved in regulating ROS levels and stress responses.
TTHERM_00852990 selenoprotein O from Tetrahymena thermophila SB210
Aligns to 39:602 / 634 (89.0%), covers 96.3% of PF02696, 418.1 bits
KT99_20194 hypothetical protein from Shewanella benthica KT99
Aligns to 7:484 / 513 (93.2%), covers 98.7% of PF02696, 409.5 bits
An07g10280 uncharacterized protein from Aspergillus niger
Aligns to 49:584 / 618 (86.7%), covers 95.7% of PF02696, 404.6 bits
FGSG_05197 hypothetical protein from Fusarium graminearum PH-1
Aligns to 83:624 / 668 (81.1%), covers 95.9% of PF02696, 400.3 bits
- Fusarium graminearum Ste3 G-Protein Coupled Receptor: A Mediator of Hyphal Chemotropism and Pathogenesis
Sharma, mSphere 2022 - “...Mitochondria FGSG_12693 Altered inheritance of mitochondria 32 7.087 0.0005160525821 FGSG_01639 Enoyl-delta isomerase mitochondrial 2.685 0.0001528329539 FGSG_05197 Fmp40 found in mitochondrial proteome 2.611 9.19E05 FGSG_11231 MOSC mitochondrial 2.073 2.44E05 With relevance to chemotropism, a wider variety of genes and their homologues involved in cellular development and cell...”
- “...functions in redox quality control ( 52 ). Additionally, two mitochondrial carrier proteins: Fmp40 ( FGSG_05197 ), which is found in the mitochondrial proteome, and enoyl delta isomerase ( FGSG_01639 ) were both upregulated. Although it is hard to predict in which morphogenetic changes these mitochondrial...”
BP1090 conserved hypothetical protein from Bordetella pertussis Tohama I
Aligns to 5:458 / 487 (93.2%), covers 98.3% of PF02696, 396.9 bits
- Genomic epidemiology of Iranian Bordetella pertussis: 50 years after the implementation of whole cell vaccine
Safarchi, Emerging microbes & infections 2019 - “...isolates Different provinces Genic (25) 13 nsSNPs: BP0194, BP0292, BP0518, BP0854 ( nuoN ), BP0891, BP1090, BP1261, BP1471, BP2249 ( bscI ), BP2485 Deletions: BP0880 (8), BP2946 (31), fim2 p (5) 11 sSNPs: BP0184, BP0215 ( ppc ), BP0505, BP0507, BP0678 ( prfA ), BP1054 (...”
- Mutations in the bvgA gene of Bordetella pertussis that differentially affect regulation of virulence determinants
Stibitz, Journal of bacteriology 1994 - “...cross the mutant alleles into BP953 to create BP1090 and BP1091, respectively, essentially as described previously (29). Mutagenesis and screening of BP953....”
- “...Tohama I BP953 BP1056 BP1060 BP1074 BP1078 BP1079 BP1090 BP1091 B. PERTUSSIS bvgA MUTATIONS AFFECT VIRULENCE REGULATION VOL. 176, 1994 TABLE 2. TABLE 3....”
SPAC20G4.05c UPF0061 family protein from Schizosaccharomyces pombe
Aligns to 35:534 / 568 (88.0%), covers 98.3% of PF02696, 395.1 bits
Q9DBC0 Protein adenylyltransferase SelO, mitochondrial from Mus musculus
Aligns to 79:625 / 667 (82.0%), covers 94.0% of PF02696, 394.2 bits
SELENOO / Q9BVL4 protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.108) from Homo sapiens (see 4 papers)
SELO_HUMAN / Q9BVL4 Protein adenylyltransferase SelO, mitochondrial; Selenoprotein O; SelO; EC 2.7.7.-; EC 2.7.7.108 from Homo sapiens (Human) (see 2 papers)
NP_113642 protein adenylyltransferase SelO, mitochondrial from Homo sapiens
Aligns to 76:624 / 669 (82.1%), covers 95.5% of PF02696, 388.0 bits
- function: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) (PubMed:30270044). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein (PubMed:24751718).
catalytic activity: ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L- tyrosyl-[protein] (RHEA:54288)
catalytic activity: ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl- [protein] + diphosphate (RHEA:54292)
catalytic activity: ATP + L-seryl-[protein] = 3-O-(5'-adenylyl)-L-seryl-[protein] + diphosphate (RHEA:58120)
cofactor: Mg(2+) - Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein.
Han, PloS one 2014 - GeneRIF: SelO is a redox-active mitochondrial selenoprotein.
- Serum lipid and lipoprotein levels in Japanese patients with familial hypercholesterolemia.
Mabuchi, Atherosclerosis 1979 (PubMed)- GeneRIF: The SELO protein has a protein domain with significant albeit remote sequence similarity to protein kinase-like proteins.
- Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation
Heid, Computational and structural biotechnology journal 2024 - “...IDs of the error causing sequences were: Q8NHP1, P22352, P59796, P18283, P07203, Q9C0D9, P36969, Q8IZQ5, Q9BVL4, Q9BQE4, Q8WWX9, P49908, P62341, P59797, Q9NZV5, P63302, Q9Y6D0, O60613, Q99611, Q9NNW7, Q86VQ6, Q8WZ42, P49895, Q92813, P55073, Q9NZV6, Q16881. A filter was applied based on the length of aggregation prone -stretches,...”
- Serum Autoantibodies in Patients with Dry and Wet Age-Related Macular Degeneration
Korb, Journal of clinical medicine 2023 - “...Sec1 family domain containing 1, isoform CRA_b vesicle transport-related protein isoform b [Homo sapiens] VTI-B Q9BVL4 73.5 Selenoprotein O Homo sapiens selenoprotein O (SELO) mRNA SELO Q6PJ21 39.4 SPRY domain-containing SOCS box protein 3 SPRY domain-containing SOCS box protein SSB-3 SPRX P35611 81.0 Alpha-adducin adducin 1...”
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.
Chaiyarit, Journal of translational medicine 2023 - “...(PEST phosphatase-interacting protein 2) 178 PSMG4 Q5JS54 Proteasome assembly chaperone 4 (PAC-4) (hPAC4) 179 SELENOO Q9BVL4 Protein adenylyltransferase SelO, mitochondrial (EC 2.7.7.-) (EC 2.7.7.n1) (Selenoprotein O) (SelO) 180 ATOH1 Q92858 Protein atonal homolog 1 (Class A basic helix-loop-helix protein 14) (bHLHa14) (Helix-loop-helix protein hATH-1) (hATH1) 181...”
- Proteomics Reveals that Methylmalonyl-CoA Mutase Modulates Cell Architecture and Increases Susceptibility to Stress
Costanzo, International journal of molecular sciences 2020 - “...UP 1.7 Q14790 Caspase-8 CASP8 UP 1.8 Q86UT6 NLR family member X1 NLRX1 UP 2.1 Q9BVL4 Selenoprotein O SELO UP 2.4 Q6PML9 Zinc transporter 9 SLC30A9 UP 2.4 O95139 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 UP 2.7 A8MXV4 Nucleoside diphosphate-linked moiety X motif...”
- Oral Glucose Mobilizes Triglyceride Stores From the Human Intestine
Xiao, Cellular and molecular gastroenterology and hepatology 2019 - “...light chain FTL 0.8169 .0124 Ion transport P02794 Ferritin heavy chain FTH1 0.8959 .0144 Mitochondria/redox Q9BVL4 Selenoprotein O b SELENOO 5.0987 .0002 Mitochondria/redox Q9HB07 UPF0160 protein MYG1; mitochondrial b C12orf10 5.9843 5.8E-16 Mitochondria/redox P22090 40S ribosomal protein S4 b RPS4Y1 6.7537 .0018 Transcription/RNA processing/translation Q9P003 Protein...”
- Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Bar-Peled, Cell 2017 - “...C66 No Q99757 TXN2 Yes C90 Yes P00352 ALDH1A1 Yes Yes Q9BRX8 FAM213A Yes Yes Q9BVL4 SELO ^ Yes Yes P78417 GSTO1 Yes Yes Q5TFE4 NT5DC1 Yes Yes Q9H7Z7 PTGES2 Yes Yes ^ Contains conserved functional (seleno)cysteine residue * Competed defined as showing R value 2.5...”
- Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver.
Engelken, Molecular biology and evolution 2016 - “...SELK SELK (Q9Y6D0) Targeted Quantified rs13317328 c SELM SELM (Q8WWX9) Quantified rs8135353 c SELO SELO (Q9BVL4) Quantified Quantified rs4838862 c VIMP SELS (Q9BQE4) Quantified Quantified rs34713741 x SELT SELT (P62341) Targeted Quantified rs7639294 k SEP15 SEP15 (O60613) Targeted Quantified rs17129522 c , rs5845 y SEPHS1 SPS1...”
RSP_2375 hypothetical protein from Rhodobacter sphaeroides 2.4.1
Aligns to 1:451 / 481 (93.8%), covers 98.7% of PF02696, 375.8 bits
- Convergence of the transcriptional responses to heat shock and singlet oxygen stresses
Dufour, PLoS genetics 2012 - “...Energy metabolism Amino acids and amines RSP_3957 Electron transport RSP_0296, RSP_0610, RSP_1194, RSP_1489, RSP_1529, RSP_1576, RSP_2375, RSP_2685, RSP_2945 Glycolysis/gluconeogenesis RSP_0361 Fatty acid and cell envelope Biosynthesis RSP_0720, RSP_0929, RSP_2776 Biosynthesis and degradation of murein sacculus and peptidoglycan RSP_1240 Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides...”
thalar_00489 YdiU family protein from Litoreibacter arenae DSM 19593
Aligns to 6:447 / 476 (92.9%), covers 80.4% of PF02696, 344.7 bits
CC3334 conserved hypothetical protein, interruption from Caulobacter crescentus CB15
Aligns to 8:160 / 160 (95.6%), covers 30.5% of PF02696, 168.0 bits
LOC101880049 LOW QUALITY PROTEIN: protein adenylyltransferase SelO-like from Melopsittacus undulatus
Aligns to 12:224 / 224 (95.1%), covers 40.0% of PF02696, 96.6 bits
Or search for genetic data about PF02696 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory