Family Search for PF03478 (DUF295)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF03478 hits 132 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

KIB4_ARATH / Q9SRV0 F-box protein KIB4; Protein KINK SUPPRESSED IN BZR1-1D 4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 59:359 / 393 (76.6%), covers 99.2% of PF03478, 172.0 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
  disruption phenotype: Abolished brassinosteroid (BR)-induced ASK7/BIN2/SK21 degradation, and BR-insensitivity. Suppression of the constitutive BR-response phenotype in the dominant mutant bzr1-1D, and accumulation of phosphorylated BZR1.

SKI23_ARATH / Q3EBZ2 F-box protein SKIP23; SKP1-interacting partner 23 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 46:364 / 407 (78.4%), covers 98.5% of PF03478, 169.0 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
  subunit: Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1.

KIB1_ARATH / Q9SU05 F-box/kelch-repeat protein KIB1; Protein KINK SUPPRESSED IN BZR1-1D 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 69:342 / 382 (71.7%), covers 99.6% of PF03478, 164.0 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
  subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Binds directly to several GSK3 family proteins such as SKP1A/ASK1, ASK1/SK11, ASK3/SK12, ASK5/SK13, ASK7/BIN2/SK21, ASK9/SK22 and ASK6/SK23. Interacts with ASK7/BIN2/SK21 in a brassinosteroid (BR)- dependent manner.
  disruption phenotype: Abolished brassinosteroid (BR)-induced ASK7/BIN2/SK21 degradation, and severe BR-insensitivity. Suppression of the constitutive BR-response phenotype in the dominant mutant bzr1-1D, and accumulation of phosphorylated BZR1.

KIB3_ARATH / Q9ZW91 F-box protein KIB3; Protein KINK SUPPRESSED IN BZR1-1D 3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 59:356 / 450 (66.2%), covers 99.2% of PF03478, 157.3 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
  disruption phenotype: Abolished brassinosteroid (BR)-induced ASK7/BIN2/SK21 degradation, and BR-insensitivity. Suppression of the constitutive BR-response phenotype in the dominant mutant bzr1-1D, and accumulation of phosphorylated BZR1.

KIB2_ARATH / Q9SU04 F-box protein KIB2; Protein KINK SUPPRESSED IN BZR1-1D 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 109:405 / 442 (67.2%), covers 99.2% of PF03478, 152.8 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
  subunit: Interacts with ASK7/BIN2/SK21.
  disruption phenotype: Abolished brassinosteroid (BR)-induced ASK7/BIN2/SK21 degradation, and BR-insensitivity. Suppression of the constitutive BR-response phenotype in the dominant mutant bzr1-1D, and accumulation of phosphorylated BZR1.

FB111_ARATH / Q3EBY8 F-box protein At2g17690; Protein SUPPRESSOR OF DRM1 DRM2 CMT3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 57:401 / 421 (81.9%), covers 86.5% of PF03478, 107.6 bits

• function: Involved in heat stress response. Contributes to recovery from heat stress.

UFO_ARATH / Q39090 Protein UNUSUAL FLORAL ORGANS; F-box only protein 1; AtFBX1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
Aligns to 112:346 / 442 (53.2%), covers 78.8% of PF03478, 37.9 bits

• function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Considered as a meristem identity factor required for normal growth of the young floral meristem. Acts together with LEAFY to positively regulate the B class floral homeotic genes APETALA3 and PISTILLATA. In this way, operates as a region-specific regulator for petal and stamen development. Alternatively, may play a role as a negative regulator of the C class floral homeotic genes. Interacts together with the SKP1- like protein ASK1 to form a ubiquitin E3 ligase complex and could indirectly promote the ubiquitination and degradation of specific proteins controlling the floral primordia development like repressors of B class floral homeotic genes.
  subunit: Part of a putative SCF (ASK/Cullin/F-box) ubiquitin ligase complex. Interacts with SKP1A/ASK1, SKP1B/ASK2 and ASK11.

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