Family Search for PF03653 (UPF0093)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF03653 hits 23 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

hemJ / P72793 protoporphyrinogen oxidase monomer (EC 1.3.3.4) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 3 papers)
HEMJ_SYNY3 / P72793 Protoporphyrinogen IX oxidase; PPO; Protox; EC 1.3.99.- from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
P72793 protoporphyrinogen oxidase (EC 1.3.3.4) from Synechocystis sp. (see paper)
Aligns to 16:164 / 210 (71.0%), covers 98.6% of PF03653, 172.3 bits

• function: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX. Is involved in the biosynthesis of tetrapyrrole molecules like heme and chlorophyll. Does not use oxygen or artificial electron acceptors such as menadione or benzoquinone. Is functionally coupled with coproporphyrinogen III oxidase (CPO) (PubMed:29925590). Is essential for growth (PubMed:20823222).
  catalytic activity: 3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX (RHEA:62000)
  cofactor: heme b (Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.)
  subunit: Homodimer. Can also form higher oligomers, most probably tetramers. Interacts with Sll1106, however it is unlikely that Sll1106 is required for PPO function.
  disruption phenotype: Attempts to disrupt this gene in the wild-type background of Synechocystis only allow to obtain heteroplasmic disruptants. These cells accumulate a substantial amount of protoporphyrin IX.

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