Family Search for PF03661 (TMEM33_Pom33)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF03661
PF03661 hits 21 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
LOC659239 Krueppel homolog 2 from Tribolium castaneum
Aligns to 14:252 / 260 (91.9%), covers 97.9% of PF03661, 342.9 bits
Q9Z142 Transmembrane protein 33 from Rattus norvegicus
Aligns to 7:245 / 247 (96.8%), covers 97.5% of PF03661, 337.0 bits
- Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System
Tidmore, International journal of molecular sciences 2021 - “...P47863 P84092 Q5XIT1 Q9WV63 P04785 P48768 Q08602 Q62829 * Q9Z0W7 P07153 * P51635 Q32ZG1 Q63635 Q9Z142 P09895 P55051 Q3B8Q0 Q64591 Q9Z1N1 P0C5X8 P56536 Q499P2 Q66X93 P11232 P59215 Q4FZT2 Q68FP1 Fully mapped and annotated in UniProt. Bold font denotes only identified in this signature. Italic font denotes...”
TMM33_MOUSE / Q9CR67 Transmembrane protein 33; Protein DB83 from Mus musculus (Mouse) (see paper)
NP_001272381 transmembrane protein 33 isoform 1 from Mus musculus
Aligns to 7:245 / 247 (96.8%), covers 97.5% of PF03661, 336.8 bits
- function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (PubMed:31048699). Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (By similarity).
subunit: Interacts with EIF2AK3 (By similarity). Interacts with RTN1, RTN2, RTN3, RTN4 and ARL6IP1 (By similarity). Interacts with RNF5. Interacts with RNF26 (By similarity). Interacts with PKD2 (PubMed:31048699).
disruption phenotype: Deletion mice show renal protection against acute kidney injury (AKI). - LncRNA RUS shapes the gene expression program towards neurogenesis
Schneider, Life science alliance 2022 - “...1.82 No Nuclear pore Q91ZW3 Smarca5 3.74 1.30 No Q8C4J7 Tbl3 3.78 1.41 No Nucleolus Q9CR67 Tmem33 4.45 3.17 No Q921T2 Tor1aip1 4.20 1.88 Yes Nuclear lamin Q9JI13 Utp3 4.54 2.11 Yes Nucleolus Q9JJA4 Wdr12 3.75 1.37 No Nucleolus Q8BHB4 Wdr3 3.22 1.55 No Nucleolus Q6ZQL4...”
- Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
Feng, Frontiers in neurology 2022 - Dataset on the mass spectrometry-based proteomic profiling of the kidney from wild type and the dystrophic mdx-4cv mouse model of X-linked muscular dystrophy.
Dowling, Data in brief 2020 - “...Lap3 3 10.4237 0.02227 1.4 Q9DCY0 Glycine N-acyltransferase-like protein Keg1 Keg1 2 4.7402 0.00128 1.39 Q9CR67 Transmembrane protein 33 Tmem33 2 6.1302 0.00735 1.38 Q61207 Prosaposin Psap 2 5.1656 0.00022 1.37 Q8JZZ0 UDP-glucuronosyltransferase 3A2 Ugt3a2 2 6.4221 0.02672 1.37 Q9DBX3 Sushi domain-containing protein 2 Susd2 4...”
- Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis
Mugabo, The Journal of biological chemistry 2018 - “...P62267 D3Z148 P84084 O54724 E9Q132 O54890 O88477 P61750 Q9CR67 Q5XJF6 Q3THB3 Q6P5B5 D3Z6S1 P11152 Q9DCR2 P59999 P49312 P61358 O54734 Q07235 Q7TNV0 Q922B2 P62320...”
- TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
Arhatte, Nature communications 2019 - GeneRIF: Study shows that TMEM33 interacts with the ion channel polycystin-2 at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury.
TMM33_HUMAN / P57088 Transmembrane protein 33; Protein DB83; SHINC-3 from Homo sapiens (Human) (see 6 papers)
NP_060596 transmembrane protein 33 from Homo sapiens
F7H2H1 Transmembrane protein 33 from Macaca mulatta
Aligns to 7:245 / 247 (96.8%), covers 97.5% of PF03661, 334.2 bits
- function: Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity). Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671). Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696). Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377).
subunit: Interacts with EIF2AK3 (PubMed:26268696). Interacts with ARL6IP1, isoform RTN1-A of RTN1, isoform RTN2-B of RTN2, isoform 3 of RTN3 and isoform 3 of RTN4 (PubMed:25612671). Interacts with RNF5 (PubMed:34487377). Interacts with RNF26 (PubMed:32614325). Interacts with PKD2 (By similarity). - PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
Liu, The EMBO journal 2021 - GeneRIF: PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
- TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Sakabe, Breast cancer research and treatment 2015 - GeneRIF: TMEM33 is a novel regulator of the PERK-eIE2alpha-ATF4 and IRE1-XBP1 axes of the UPR signaling.
- Analysis of protein expression changes of the Vero E6 cells infected with classic PEDV strain CV777 by using quantitative proteomic technique.
Sun, Journal of virological methods 2015 - “...membrane cell communication; regulation of biological process; response to stimulus 1.51E02 0.82 57 Protein DB83 F7H2H1 membrane; cytoplasm 2.25E03 0.82 58 DORA reverse strand protein G7Q0P8 catalytic activity metabolic process 1.01E02 0.82 59 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing) G7PPY4 catalytic activity; nucleotide binding membrane metabolic...”
- A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
Choi, Scientific reports 2019 - “...GPR180 insoluble Q8TDY2 6.6 4.08E-04 183.1 RB1CC1 B/S e insoluble Q9NVH2 6.2 1.16E-08 106.8 INTS7 P57088 6.2 1.03E-06 28.0 TMEM33 S Q13371 6.2 5.62E-06 34.3 PDCL P43243 6.1 9.21E-07 94.6 MATR3 Q9Y6A5 6.0 2.72E-12 90.4 TACC3 P61978 5.9 8.39E-18 51.0 HNRNPK B/C Q04637 5.9 2.37E-08 175.5...”
- Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF
Marino, The Journal of biological chemistry 2019 - “...P62244 P18077 O95864 P61619 Q16643-3 P60842 Q99623 P57088 P61254 P04844-1 P62913 P51148-2 P60866-2 P62899-2 Q9UNF1 Q96CS3 P16615 P18085 Q9UBM7 Transcriptional...”
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
Choi, Science (New York, N.Y.) 2019 - “...10 31.4 97.83 Q143182 FKBP8 14 10 26.9 87.63 H3BS72 PTPLAD1 19 10 15.7 87.63 P57088 TMEM33 11 6 21.9 87.04 F8VZ44 AAAS 9 5 19.8 81.90 Q07065 CKAP4 30 17 35.9 79.54 Q96CS3 FAF2 (UBXDB8) 26 11 27.2 71.19 Q8WUM4 PDCD6IP 12 8 10.4 67.34...”
- The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.
Suárez-Arroyo, American journal of cancer research 2016 - Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases
Yang, Molecular & cellular proteomics : MCP 2015 - “...P07951 P08727 P11142 P12814 P36578 P42224 P42330 P57088 P62249 Tropomyosin alpha-3 chain-like protein Unconventional myosin-Ic Myosin regulatory light chain 12B...”
- Stable isotope labeling by amino acids in cell culture and differential plasma membrane proteome quantitation identify new substrates for the MARCH9 transmembrane E3 ligase.
Hör, Molecular & cellular proteomics : MCP 2009 - “...ADAM10 1.19 1 0.84 0.22 16.98 O14672 9 (10) TMM33 1.05 3 0.95 0.04 8.90 P57088 2 (2) CD99 a 1.19 1 0.84 0.07 5.40 P14209 1 (2) EVI2A a 1.05 1 0.95 0.35 8.19 P22794 1 (4) CD10 1.19 1 0.84 0.09 10.27 P08473 8...”
- Optimization of protein solubilization for the analysis of the CD14 human monocyte membrane proteome using LC-MS/MS.
Ye, Journal of proteomics 2009 - “...4 0.066 Endoplasmic reticulum membrane Q9BVC6 Transmembrane protein 109 precursor 5 0.541 Nucleus outer membrane P57088 Transmembrane protein 33 3 0.429 Membrane Q96CP4 Transporter 1, ATP-binding cassette, sub-family B 7 0.142 Integral to membrane Q6RW13 Type-1 angiotensin II receptor-associated protein 3 0.482 Endoplasmic reticulum membrane Q9H1C4...”
G1TD26 Transmembrane protein 33 from Oryctolagus cuniculus
Aligns to 7:245 / 246 (97.2%), covers 97.5% of PF03661, 333.5 bits
XP_017214478 transmembrane protein 33 isoform X1 from Danio rerio
Aligns to 11:250 / 252 (95.2%), covers 98.8% of PF03661, 332.7 bits
KRH2_DROME / Q9V447 Krueppel homolog 2; Protein Kr-h2 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 30:268 / 276 (86.6%), covers 97.5% of PF03661, 314.3 bits
- function: Member of the dosage-dependent hierarchy effective upon white gene expression.
D6RAA6 Transmembrane protein 33 (Fragment) from Homo sapiens
Aligns to 7:222 / 222 (97.3%), covers 87.9% of PF03661, 303.7 bits
Q9CWD1 Transmembrane protein 33 from Mus musculus
Aligns to 7:177 / 177 (96.6%), covers 68.8% of PF03661, 224.6 bits
CNAG_02753 endoplasmic reticulum protein from Cryptococcus neoformans var. grubii H99
Aligns to 6:249 / 278 (87.8%), covers 80.8% of PF03661, 133.5 bits
TTS1_SCHPO / Q9Y7Z5 Tetra-spanning protein 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
tts1 tetra spanning protein 1, Tts1 from Schizosaccharomyces pombe (see 4 papers)
SPBC1539.04 conserved eukaryotic protein from Schizosaccharomyces pombe
NP_596818 tetra-spanning protein 1 from Schizosaccharomyces pombe
Aligns to 5:258 / 279 (91.0%), covers 93.3% of PF03661, 119.7 bits
- function: Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator.
subunit: Interacts with RTN1 and YOP1. - CharProtDB Source (per GeneDB): GeneDB_Spombe
- Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe
Asakawa, Nucleus (Austin, Tex.) 2014 - “...69.3 100.32 2.89 spPom34 /Mug31 SPAC1002.02 25.8 94.83 2.73 spPom152 SPBC29A10.07 139.5 39.31 1.13 spTts1 SPBC1539.04 31.5 ND ND spEly5 SPBC29A10.06c 35.1 73.02 2.10 spNup37 SPAC4F10.18 42.7 86.60 2.49 spNup85 SPBC17G9.04c 78 69.54 2.00 spNup107 SPBC428.01c 93.2 29.75 0.86 spNup120 SPBC3B9.16c 129.7 77.40 2.23 spNup131 SPBP35G2.06c...”
- “...(West et al.) 26 e spPom34 /Mug31 SPAC1002.02 n n spPom152 SPBC29A10.07 n n spTts1 SPBC1539.04 n (Zhang et al.) 41 n spEly5 SPBC29A10.06c n (Bilokapic and Schwartz) 33 n n spNup37 SPAC4F10.18 n (Bilokapic and Schwartz) 33 n n spNup85 SPBC17G9.04c e (Ba et al.;...”
- Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function
He, Molecular biology of the cell 2014 - “...used in this study were cds1 (SPBC13A2.03), tgl4 (SPAC1A6.05c), dga1 (SPCC1235.15), lro1 (SPBC776.14), and tts1 (SPBC1539.04). S. japonicus mutagenesis screen The S . japonicus Rlc1-GFP Tts1-mCherryexpressing strain (parent) was mutagenized using ultraviolet light and grown at 24C on YES (yeast extract with supplements) medium agar plates...”
- Tts1, the fission yeast homologue of the TMEM33 family, functions in NE remodeling during mitosis.
Zhang, Molecular biology of the cell 2014 - GeneRIF: in addition to maintaining the cortical endoplasmic reticulum network, Tts1 also plays a role in nuclear envelope remodeling during mitosis
SMAC_00774 uncharacterized protein from Sordaria macrospora k-hell
Aligns to 6:268 / 286 (92.0%), covers 92.9% of PF03661, 110.7 bits
C0ND33 Endoplasmic reticulum protein from Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Aligns to 12:268 / 291 (88.3%), covers 93.3% of PF03661, 105.7 bits
TC 1.I.1.1.2 / G0S6T0 Nucleoporin POM33, component of Fungal Nuclear Pore Complex (NPC) with 29 components from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Aligns to 11:267 / 287 (89.5%), covers 90.8% of PF03661, 102.9 bits
- substrates: RNA, proteins
tcdb comment: Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015 presented the reconstitution of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. They proposed that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation (Stuwe et al. 2015)
POM33_YEAST / Q12164 Pore membrane protein of 33 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
NP_013077 nucleoporin POM33 from Saccharomyces cerevisiae S288C
YLL023C Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum from Saccharomyces cerevisiae
Aligns to 14:265 / 279 (90.3%), covers 95.4% of PF03661, 79.7 bits
- function: Contributes to proper distribution and/or efficient assembly of nuclear pores. Required for normal pore density in the daughter nucleus during telophase.
subunit: Interacts with RTN1. - Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...+ + Q12144 5 Pore and endoplasmic reticulum protein of 33 kDa PER33 + + Q12164 5 Pore membrane protein of 33 kDa POM33 + + P47154 4 CAAX prenyl protease 1 STE24 + + P35723 3 Endoplasmic reticulum transmembrane protein 1 YET1 + + Q07451...”
- Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding.
Floch, Journal of cell science 2015 (PubMed)- GeneRIF: combined impairment of lipid and Kap123 binding affects targeting of Pom33 to NPCs. These data highlight the requirement of multiple determinants and mechanisms for proper NPC localization of Pom33.
- Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
Hua, Cell systems 2018 - “...YDR307W, YDR297W, YNL190W, YDR503C, YBR177C, YGR266W, YER019C-A, YLR034C, YOR322C, YGR260W, YDR349C, YJR015W, YPL246C, YMR058W, YBR290W, YLL023C, YDR205W, YHR123W, YJL024C, YJL212C, YLR292C, YPL207W, YKR027W, YIL076W, YBR288C, YJL183W, YKL008C, YJL207C, YML067C, YGR089W, YOR291W, YNL111C, YEL043W, YPL234C, YLR056W, YKL096W-A, YGR157W, YHR060W, YLR039C, YHR079C DATA AND SOFTWARE AVAILABILITY The experimental...”
- Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
Srikumar, The Journal of cell biology 2013 - “...NPC componentsUlp1 localization NUP60 0.328 NUP133 0.228 nup145-R4 0.223 SRP1_damp 0.149 NUP84 0.113 GLE2 0.130 YLL023C 0.109 nup57-E17 0.094 NUP49_damp 0.091 Chromatin remodeling Histone chaperone ASF1 0.247 Chromatin silencing ESC2 0.294 RTT109 0.141 RAP1_damp 0.116 MOT3 0.110 YAP1 0.109 RIF1 0.099 Chromatin assembly factor (CAF-1) CAC2...”
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution
Chadrin, The Journal of cell biology 2010 - “...of the collection of nonessential gene deletions using the nup133 mutant as bait identified the YLL023c open reading frame (ORF), which encodes a 33 kD protein with several putative transmembrane helixes (subsequently termed Pom33, see the following paragraph). Although deletion of YLL023c/POM33 did not impair growth...”
- “...any temperature, its genetic interaction with NUP133 was confirmed by the enhanced growth defect of yll023c nup133 mutant cells as compared with nup133 , which was recorded at all temperatures tested (see Fig. 4 A ). Fluorescence microscopy analysis of Yll023c C-terminally tagged at its genomic...”
- Uncovering biological network function via graphlet degree signatures
Milenković, Cancer informatics 2008 - “...(YKL065C) 51 DIP 34 4 Cellular transport, transport facilities and transport routes 16 53.33% 0.00% YLL023C 22 DIP 17 2 Cellular transport, transport facilities and transport routes 10 66.67% 0.00% RAD33 (YML011C) 5 DIP 9 3 Metabolism 4 66.67% 0.00% YNL092W 29 DIP 3 1 Metabolism...”
- Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis
Rojas, BMC genomics 2008 - “...NMD3 SPE3 YHR214C-C DED1 MOG1 TPS2 YNL212W YIR035C NOP12 SPE4 YIL127C DYN1 MRPL35 TRR2 YOL101C YLL023C NOP58 SSF1 YJR027W EHT1 MSF1' TSL1 YOR009W YLR112W NPI46 SSP120 YJR029W ENO1 MTF2 TUF1 YOR022C YLR356W NPT1 STS1 YKL014C ENO2 NCE102 UGP1 YOR062C YMR178W NRD1 SUI1 YKL054C ERG11 NCR1 URA1...”
- Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
Arvas, BMC genomics 2006 - “...factor MBF1 13 3 1 17 HTA2 tre35558 histone H2A 9 4 1 2 16 YLL023C tre43299 putative ER membrane protein 10 5 15 pdi1 tre45146 ER-resident foldase 12 2 14 cip1 tre41957 esterase homologue 6 8 14 tre45203 Transcriptional coactivator p100 4 7 2 1...”
- A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation
Huang, Genetics 2005 - “...color) of the 12 wild-type controls (spo75, syn8, yll023c, yal068c, fun30, nup60, yal065c, tpo1, yll029w, yll020c, erv46, and cln3 (SGD, scope of this study,...”
- A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes
Stevenson, Proceedings of the National Academy of Sciences of the United States of America 2001 - “...content Stevenson et al. Phase increased TUB2 YCL028W YGR284C YIL041W YLL023C YLR057W YMR067C YNL224C Pre-M Early M Late M Late M Late M Late M None Late M %...”
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LOC104603094 transmembrane protein 33 homolog from Nelumbo nucifera
Aligns to 103:320 / 338 (64.5%), covers 75.4% of PF03661, 62.5 bits
- Gene Expression Profile in the Long-Living Lotus: Insights into the Heat Stress Response Mechanism
Liu, PloS one 2016 - “...LOC104587372 2.05 1.45E-02 glycine-rich cell wall structural protein - LOC104610879 2.82 5.88E-04 transmembrane protein Vacuole LOC104603094 1.74 8.42E-05 transmembrane protein Nucleus LOC104605640 2.49 3.68E-02 secretory carrier-associated membrane protein Plasma membrane LOC104608147 2.58 1.98E-02 extensin-2 Nucleus LOC104608452 3.73 1.99E-04 extensin-2 Secreted LOC104602657 1.80 1.83E-02 tetraspanin-6 Plasma membrane...”
Q9M898 AT3g02420/F16B3_5 from Arabidopsis thaliana
AT3G02420 hypothetical protein from Arabidopsis thaliana
Aligns to 112:326 / 348 (61.8%), covers 72.5% of PF03661, 56.5 bits
PER33_YEAST / Q12144 Pore and endoplasmic reticulum protein of 33 kDa from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YLR064W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR064W is not an essential gene from Saccharomyces cerevisiae
Aligns to 9:268 / 273 (95.2%), covers 92.9% of PF03661, 54.6 bits
- Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.
Rush, Current chemical biology 2015 - “...Manganese-transporting ATPase 1 SPF1 + + P38353 9 Sec sixty-one protein homolog SSH1 + + Q12144 5 Pore and endoplasmic reticulum protein of 33 kDa PER33 + + Q12164 5 Pore membrane protein of 33 kDa POM33 + + P47154 4 CAAX prenyl protease 1 STE24...”
- The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis
Koch, Nucleus (Austin, Tex.) 2020 - “...MAT a CSM4 YPL192C MAT a PRM3 YPL186C MAT a UIP4 YPL125W MAT a KAP120 YLR064W MAT a PER33 YBR273C MAT a UBX7 YCR045C MAT a RRT12 YCR086W MAT a CSM1 YKR082W MAT a NUP133 YLR450W MAT a HMG2 YER110C MAT a KAP123 YER120W MAT a...”
- Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits
Hua, Cell systems 2018 - “...YJL196C, YLL061W, YML101C, YDL232W, YOL030W, YMR054W, YDR410C, YBR273C, YLR120C, YHR110W, YOR044W, YDL137W, YJL171C, YOR285W, YMR029C, YLR064W, YPL137C, YOR092W, YBR159W, YGL083W, YNL156C, YDL128W, YBR296C, YOR175C, YJL198W, YOL101C, YHL019C, YJL117W, YGR263C, YML059C, YOR214C, YNR013C, YOR087W, YJL192C, YGR177C, YBL102W, YPL195W, YLL052C, YLR390W-A, YDR264C, YOR299W, YMR152W, YLL055W, YDR424C, YBR287W, YEL040W,...”
- A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations
Bojsen, Scientific reports 2016 - “...mms2 gyp1 arn1 sam3 ras2 sma2 ybr238c rho3 izh3 vht1 zrt1 Unknown ylr283w om45 dlt1 ylr064w ylr278c ybr255w ypl068c ecm27 pib2 ynl208w yal049c ylr125w rmd8 met12 mpa43 ytp1 ymr181c ylr407w ygr259c yor292c nrp1 ybr016w yor139c ybl081w tma16 asg1 ygr182c ygr190c yhr159w Mutants significantly more abundant in...”
- A genomic analysis of chronological longevity factors in budding yeast
Burtner, Cell cycle (Georgetown, Tex.) 2011 - “...YDL041W YDL041W Dubious ORF. Overlaps with SIR2/YDL042C YLR064W YLR064W Protein of unknown function YPL105C YPL105C Protein of unknown function ACO2 YJL200C...”
- Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution
Chadrin, The Journal of cell biology 2010 - “...Database analyses revealed that YLL023c/POM33 has a paralogue in S. cerevisiae , namely the nonessential YLR064w gene (subsequently termed PER33 ). Unlike Pom33-GFP, subcellular localization analysis of Ylr064w/Per33-GFP revealed a more typical ER localization, with no major enrichment at the nuclear periphery when compared with cortical...”
- “...the NE, with kinetics similar to those displayed by Sec61-GFP ( Fig. 2 ). Because Ylr064w can associate with NPCs, but unlike Pom33 is mainly associated with the ER/NE, YLR064w was renamed PER33 (pore and ER protein, 33 kD). A phylogenic analysis revealed that Pom33 and...”
- Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation
Higgins, Applied and environmental microbiology 2003 - “...YBR016w YDL038c YMR002w YOR062c YMR010w YBR113w YDL228c YLR064w YKR060w YPR022c YJL048c YEL070w YGR079w YDR492w YMR124w Gene description 4782 HIGGINS ET AL....”
- Recognition of protein coding genes in the yeast genome at better than 95% accuracy based on the Z curve
Zhang, Nucleic acids research 2000 - “...YHR218w-a YLR050c YNL176c YPR100w YCR025c YER072w YIL012w YLR064w YNL179c YPR114w YCR043c YER091c-a YIL025c YLR111w YNL203c YPR151c YCR062w YER097w YIL029c...”
S8EYA7 Family UPF0121 protein from Toxoplasma gondii (strain ATCC 50611 / Me49)
Aligns to 187:361 / 377 (46.4%), covers 65.8% of PF03661, 40.6 bits
- Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins
Li, Parasites & vectors 2022 - “...1.5632 S8GUI2 Membrane protein, putative LPYPVYSSL 0.7028 A0A125YP19 SAG-related sequence SRS30C SSNANEYTF 0.9631 HLA II S8EYA7 Uncharacterized protein (BLAST: family UPF0121 protein) IPIFLYFHLFRIRYS 1.2381 A0A125YIN1 Uncharacterized protein (BLAST: putative transmembrane protein) EDRLRLSAAALAAAR 0.841 S8F2A3 GpcrRhopsn4 domain-containing protein EQYHALAVMAAAIYV 0.5944 S8G829 Uncharacterized protein [BLAST: magnesium transporter nuclear-interacting...”
PVX_000960 secy-independent transporter protein, putative from Plasmodium vivax
Aligns to 85:309 / 315 (71.4%), covers 87.1% of PF03661, 34.2 bits
PF3D7_0405600 TMEM33 domain-containing protein, putative from Plasmodium falciparum 3D7
Aligns to 77:308 / 315 (73.7%), covers 89.2% of PF03661, 33.8 bits
Or search for genetic data about PF03661 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory