Family Search for PF04190 (GET4)

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PF04190 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

GET4_ASPFU / Q4WDK4 Golgi to ER traffic protein 4 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 2 papers)
Aligns to 38:314 / 346 (80.1%), covers 100.0% of PF04190, 293.9 bits

• function: Component of the get4/get5/sgt2 sorting complex involved in the GET (guided entry of TA proteins) pathway that leads to the insertion of tail-anchored (TA) proteins into the endoplasmic reticulum (PubMed:21832041, PubMed:22262836). Get4 and get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from sgt2 to the cytosolic targeting factor which then targets the TA protein to the ER membrane via get1/get2 (PubMed:21832041, PubMed:22262836).
  subunit: Component of the get4/get5/sgt2 sorting complex.

GET4_YEAST / Q12125 Golgi to ER traffic protein 4; Guided entry of tail-anchored proteins 4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
Aligns to 46:308 / 312 (84.3%), covers 100.0% of PF04190, 276.9 bits

• function: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
  subunit: Interacts with MDY2/GET5.

GET4_HUMAN / Q7L5D6 Golgi to ER traffic protein 4 homolog; Conserved edge-expressed protein; Transmembrane domain recognition complex 35 kDa subunit; TRC35 from Homo sapiens (Human) (see 7 papers)
Aligns to 56:306 / 327 (76.8%), covers 98.4% of PF04190, 260.5 bits

• function: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post- translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail- anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).
  subunit: Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303, PubMed:29042515, PubMed:25535373).

GET4_SCHPO / O74432 Golgi to ER traffic protein 4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 33:290 / 303 (85.1%), covers 100.0% of PF04190, 247.8 bits

• function: May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.

GET4_ARATH / Q6GKV1 Protein GET4; AtGET4; Guided entry of tail-anchored proteins 4 homolog from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 46:320 / 324 (84.9%), covers 99.6% of PF04190, 242.1 bits

• function: Involved in the regulation of root hair growth.
  subunit: Interacts with GET3A.
  disruption phenotype: Strong reduction of root hair length.

Or search for genetic data about PF04190 in the Fitness Browser