Family Search for PF04402 (SIMPL)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF04402 hits 70 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BP26_BRUA1 / Q44642 26 kDa periplasmic immunogenic protein from Brucella abortus (strain S19) (see paper)
Aligns to 40:247 / 250 (83.2%), covers 100.0% of PF04402, 184.4 bits

YggE / b2922 DUF541 domain-containing protein YggE from Escherichia coli K-12 substr. MG1655 (see 12 papers)
Aligns to 30:230 / 246 (81.7%), covers 100.0% of PF04402, 171.5 bits

IKBP1_MOUSE / Q9ESJ7 Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; ActA-binding protein 70; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; SIMPL from Mus musculus (Mouse) (see 4 papers)
Aligns to 52:247 / 259 (75.7%), covers 95.6% of PF04402, 96.1 bits

• function: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
  subunit: Interacts with IRAK1 and RELA. Interacts with HSPA8 and HSPA1. May interact with Listeria monocytogenes actA.

Or search for genetic data about PF04402 in the Fitness Browser