Family Search for PF04577 (DUF563)

PF04577.14 hits 33 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

PBN151_4312 glycosyltransferase family 61 protein from Paenibacillus sp. NAIST15-1
Aligns to 128:332 / 361 (56.8%), covers 98.6% of PF04577, 153.1 bits

• Surface Sensing for Paenibacillus sp. NAIST15-1 Flagellar Gene Expression on Solid Medium
  Kobayashi, Applied and environmental microbiology 2017
  • “...motility. Of these, disruption of degSU, wsfP, or PBN151_4312 resulted in 26 complete loss of flagellin synthesis. Analysis of flagellar gene promoter activity...”
  • “...important for 148 motility in Paenibacillus sp. 149 PBN151_4312 is a cytoplasmic protein of unknown function that is conserved in many 150 bacteria. PBN151_4312...”

EOGT_DROME / Q9VQB7 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Drosophila melanogaster (Fruit fly) (see paper)
Q9VQB7 protein O-GlcNAc transferase (EC 2.4.1.255) from Drosophila melanogaster (see paper)
AAF51259.1 [protein] EGF20 O-β-N-acetylglucosaminyltransferase (Eogt;EOGT;CG9867) (EC 2.4.1.255) (see protein)
NP_608678 EGF-domain O-GlcNAc transferase, isoform A from Drosophila melanogaster
Aligns to 232:458 / 520 (43.7%), covers 98.6% of PF04577, 114.9 bits

• function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp).
  catalytic activity: L-seryl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl- [protein] + H(+) + UDP (RHEA:48904)
  catalytic activity: L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L- threonyl-[protein] + H(+) + UDP (RHEA:48908)
  cofactor: a divalent metal cation
  disruption phenotype: Defects in apical extracellular matrix. Embryos show defects in the formation of the innermost layer of the apical extracellular matrix and its attachment to the epidermis. Most larvae die during second-instar or second/third- instar interface, but some survive until early third-instar. Surviving larvae display cuticle defect and irregular tracheal morphology. Ultrastructural analysis of larval epidermis reveals disruption of the deposition zone of the endocuticle, leading to separation of the epidermis from the chitin layers.
• EOGT and O-GlcNAc on secreted and membrane proteins.
  Varshney, Biochemical Society transactions 2017 (PubMed)
  • GeneRIF: Studies provide evidence that EOGT plays important roles in drosophila, especially in its development.[review]
• The EGF repeat-specific O-GlcNAc-transferase Eogt interacts with notch signaling and pyrimidine metabolism pathways in Drosophila.
  Müller, PloS one 2013
  • GeneRIF: Data suggest that Eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation.

EOGT_MOUSE / Q8BYW9 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Mus musculus (Mouse) (see 2 papers)
XP_006505321 EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1 from Mus musculus
Aligns to 245:472 / 527 (43.3%), covers 99.0% of PF04577, 99.3 bits

• function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
  catalytic activity: L-seryl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl- [protein] + H(+) + UDP (RHEA:48904)
  catalytic activity: L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L- threonyl-[protein] + H(+) + UDP (RHEA:48908)
• O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.
  Sakaidani, Biochemical and biophysical research communications 2012 (PubMed)
  • GeneRIF: the characterization of A130022J15Rik, a mouse gene homolog of Drosophila Eogt (Eogt 1), was reported.

EOGT_HUMAN / Q5NDL2 EGF domain-specific O-linked N-acetylglucosamine transferase; Extracellular O-linked N-acetylglucosamine transferase; EC 2.4.1.255 from Homo sapiens (Human) (see 2 papers)
Q5NDL2 protein O-GlcNAc transferase (EC 2.4.1.255) from Homo sapiens (see paper)
Aligns to 245:472 / 527 (43.3%), covers 99.0% of PF04577, 96.6 bits

• function: Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
  catalytic activity: L-seryl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl- [protein] + H(+) + UDP (RHEA:48904)
  catalytic activity: L-threonyl-[protein] + UDP-N-acetyl- alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L- threonyl-[protein] + H(+) + UDP (RHEA:48908)

CC_0632 hypothetical protein (NCBI ptt file) from Caulobacter crescentus CB15
Aligns to 116:314 / 350 (56.9%), covers 99.0% of PF04577, 95.0 bits

• Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus
  Cabeen, Journal of bacteriology 2010
  • “...further. However, a Himar1 insertion in the gene cc_0632 of hypothetical function produced cells with normal lengths but with a considerable reduction of cell...”
  • “...should have no effect on the expression of cc_0632. Additionally, the cc_0632::Himar1 cell shape defect could be rescued with a plasmid bearing the cc_0631...”

HMPREF1204_03307 glycosyltransferase family 61 protein from Bacteroides fragilis HMW 615
Aligns to 148:365 / 395 (55.2%), covers 94.3% of PF04577, 88.5 bits

• Novel large-scale chromosomal transfer in Bacteroides fragilis contributes to its pan-genome and rapid environmental adaptation
  Husain, Microbial genomics 2017
  • “...outer membrane associated proteins. Fig. 6. PSF exchange mediated by tetQ2 435 and tetQ2 482. HMPREF1204_03307, is a gene from the PSF operon of B. fragilis HMW615 (within tetQ2 435 ). BF638R_1544, BF638R_1548, BF638R_1552, and BF638R_1556 are genes within the PSF operon of B. fragilis 638R....”
  • “...HMW615 genome. a: Lane 1: MW Standard, Lanes 26: Template B. fragilis HMW615. Primers for HMPREF1204_03307, BF638R_1544, BF638R_1548, BF638R_1552, and BF638R_1556, respectively. Lanes 711: Template BF 638R. Primers for HMPREF1204_03307, BF638R_1544, BF638R_1548, BF638R_1552, and BF638R_1556, respectively. Lanes 1216: Template BF638R ::tetQ2 435 . Primers for HMPREF1204_03307,...”

XAX1_ORYSJ / Q6Z7I3 Beta-1,2-xylosyltransferease XAX1; Protein XYLOSYL ARABINOSYL SUBSTITUTION OF XYLAN 1; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Aligns to 280:507 / 566 (40.3%), covers 91.9% of PF04577, 84.2 bits

• function: Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:23027943). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone (PubMed:23027943).
  disruption phenotype: Dwarf phenotype, decreased levels of xylose, ferulic acid and coumaric acid in leaves, and increased saccharification efficiency.

CC0631, CC_0631 hypothetical protein (NCBI ptt file) from Caulobacter crescentus CB15
Aligns to 133:337 / 394 (52.0%), covers 98.1% of PF04577, 83.3 bits

• Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus
  Cabeen, Journal of bacteriology 2010
  • “...(Fig. 2A, lane 5). These data indicate that the CC0631 protein plays a role in LPS biosynthesis in C. crescentus and that defects in LPS production are...”
  • “...gene of a predicted operon encompassing cc_0635 to cc_0631 (Fig. 1B), suggesting a potential polar effect on the downstream cc_0631 gene. Consistent with this...”
  • “...m1) was found to have a point mutation in cc_0631 (Fig. 1A, panel v). A cosmid (cos1-10-A) containing Downloaded from http://jb.asm.org/ on February 11, 2017 by...”

AAQ73546.1 β-1,2-xylosyltransferase (EC 2.4.2.38) (see protein)
Aligns to 235:490 / 511 (50.1%), covers 97.1% of PF04577, 82.6 bits

NP_775925 EGF domain-specific O-linked N-acetylglucosamine transferase isoform b precursor from Homo sapiens
Aligns to 190:388 / 443 (44.9%), covers 75.1% of PF04577, 81.5 bits

• The Glycosyltransferase EOGT Regulates Adropin Expression in Decidualizing Human Endometrium.
  Muter, Endocrinology 2018 (PubMed)
  • GeneRIF: Analysis of midluteal endometrial biopsies revealed an inverse correlation between endometrial EOGT and ENHO expression and body mass index. obesity impairs the EOGT-adropin axis in decidual cells, which in turn points toward a mechanistic link between metabolic disorders and adverse pregnancy outcome.
• O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.
  Sawaguchi, eLife 2017
  • GeneRIF: Eogt resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. Combined deficiency of different Notch1 mutant alleles exacerbated the abnormalities in Eogt(-/-) retina, and Notch target gene expression was decreased in Eogt(-/-)endothelial cells.
• EOGT and O-GlcNAc on secreted and membrane proteins.
  Varshney, Biochemical Society transactions 2017 (PubMed)
  • GeneRIF: Studies provide evidence that mutations in EOGT lead to autosomal recessive Adams-Oliver Syndrome. [review]
• Autosomal recessive Adams-Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase.
  Cohen, European journal of human genetics : EJHG 2014
  • GeneRIF: c.1074delA mutation segregates with Adams-Oliver syndrome in the Bedouin family.
• Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome.
  Shaheen, American journal of human genetics 2013
  • GeneRIF: Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome.

XYLT_ARATH / Q9LDH0 Beta-1,2-xylosyltransferase; AtXYLT; EC 2.4.2.38 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
Q9LDH0 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Arabidopsis thaliana (see 4 papers)
Q9LDH0 β-1,2-xylosyltransferase (EC 2.4.2.38) from Arabidopsis thaliana (see 4 papers)
CAB90610.1 core β-1,2-xylosyltransferase (XylT;AtXYLT;At5g55500) (EC 2.4.2.38) (see protein)
NP_568825 beta-1,2-xylosyltransferase from Arabidopsis thaliana
AT5G55500 XYLT (ARABIDOPSIS THALIANA BETA-1,2-XYLOSYLTRANSFERASE); xylosyltransferase (RefSeq) from Arabidopsis thaliana
Aligns to 247:513 / 534 (50.0%), covers 98.1% of PF04577, 81.4 bits

• function: Glycosyltransferase involved in the xylosylation of N- glycans (PubMed:10781814, PubMed:12943552, PubMed:15013764, PubMed:15686448). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the core beta-linked mannose of N-glycans (PubMed:10781814, PubMed:12943552, PubMed:15013764, PubMed:15686448). Involved in the biosynthesis of glycoprotein bound N-glycans (PubMed:15686448, PubMed:22024534). Does not require metal ions for its activity (PubMed:15686448).
  catalytic activity: N(4)-{beta-D-GlcNAc-(1->2)-alpha-D- Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man- (1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-xylose = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D- Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl- (1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L- asparaginyl-[protein] + UDP (RHEA:10612)
• Arabidopsis β1,2-xylosyltransferase: substrate specificity and participation in the plant-specific N-glycosylation pathway.
  Kajiura, Journal of bioscience and bioengineering 2012 (PubMed)
  • GeneRIF: AtXYLT acts on protein-bound N-glycans prior to alpha1,3-fucosyltransferase and mannosidase II.
• An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes.
  Bakker, Proceedings of the National Academy of Sciences of the United States of America 2006
  • GeneRIF: Data show that expression of a hybrid enzyme of Arabidopsis thaliana xylosyltransferase and human beta-1,4-galactosyltransferase I in tobacco causes a reduction of N-glycans with potentially immunogenic core-bound xylose and fucose residues.
• Arabidopsis thaliana beta1,2-xylosyltransferase: an unusual glycosyltransferase with the potential to act at multiple stages of the plant N-glycosylation pathway.
  Bencúr, The Biochemical journal 2005
  • GeneRIF: The substrate specificity of XylT permits the enzyme to act at multiple stages of the plant N-glycosylation pathway.
• Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi
  Wang, Scientific reports 2017
  • “...other plants 31 89 90 . Domain PF04577 was identified in Arabidopsis XylT peptide sequence (AT5G55500). Genes containing the domain PF04577 were not identified in fungi. Only 13 genes were present in each animal genome, while in plants, genes are abundant (as many as over 30...”
  • “...PF07748 CL0158 n/a CL0103 GnTII A. thaliana AT2G05320 GT16 PF05060 CL0110 plants 1,2-XylT A. thaliana AT5G55500 GT61 PF04577 n/a 1,3-FucT A. thaliana AT3G19280 GT10 PF00852 n/a 1,3-GalT A. thaliana AT1G26810 GT31 PF00337 PF01762 CL0004 CL0110 1,4-FucT A. thaliana AT1G71990 GT10 PF00852 n/a animals 1,4-GalT H. sapiens...”
• XAX1 from glycosyltransferase family 61 mediates xylosyltransfer to rice xylan
  Chiniquy, Proceedings of the National Academy of Sciences of the United States of America 2012
  • “...represented by only a single sequence per genome (At5G55500 and Os08g39380 in Arabidopsis and rice, respectively). One member of this clade, At5g55500, has been...”
• Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase
  Bakker, The Journal of biological chemistry 2009
  • “...able to act on xylosides when transferase (AtXylT; AT5G55500) (32) was isolated from the same provided at high concentration but not on the endogenous...”

CAI11448.1 β-1,2-xylosyltransferase (Xt1) (EC 2.4.2.38) (see protein)
Aligns to 238:494 / 515 (49.9%), covers 97.1% of PF04577, 80.6 bits

PMGT2_HUMAN / Q8NAT1 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Homo sapiens (Human) (see 2 papers)
Q8NAT1 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.312) from Homo sapiens (see paper)
XP_005265572 protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 isoform X1 from Homo sapiens
Aligns to 162:395 / 580 (40.3%), covers 96.7% of PF04577, 80.5 bits

• function: O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that transfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
  catalytic activity: O(3)-(alpha-D-mannosyl)-L-threonyl- [protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-(N- acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl- [protein] + UDP (RHEA:37663)
• Protein O-Linked Mannose β-1,4-N-Acetylglucosaminyl-transferase 2 (POMGNT2) Is a Gatekeeper Enzyme for Functional Glycosylation of α-Dystroglycan.
  Halmo, The Journal of biological chemistry 2017
  • GeneRIF: POMGNT2 when two of the conserved amino acids are replaced. These findings begin to define the selectivity of POMGNT2 and suggest that this enzyme functions as a gatekeeper enzyme to prevent the vast majority of O-mannosylated sites on proteins from becoming modified with glycan structures functional for binding laminin globular domain-containing proteins
• GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.
  Ogawa, Biochemical and biophysical research communications 2013 (PubMed)
  • GeneRIF: GTDC2 generates CTD110.6 antibody-reactive N-acetylglucosamine epitopes on the O-mannosylated alpha-dystroglycan.
• Exome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndrome.
  Manzini, American journal of human genetics 2012
  • GeneRIF: Using WES in consanguineous WWS-affected families, we found multiple deleterious mutations in GTDC2 (also known as AGO61). .

CAI70375.1 β-1,2-xylosyltransferase (PoXYL1) (EC 2.4.2.38) (see protein)
Aligns to 191:447 / 468 (54.9%), covers 97.1% of PF04577, 80.3 bits

NP_705768 protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 precursor from Mus musculus
Aligns to 162:395 / 580 (40.3%), covers 97.1% of PF04577, 80.2 bits

• AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.
  Yagi, Scientific reports 2013
  • GeneRIF: AGO61-KO mice lacked laminin-binding glycans and exhibited phenotypes similar to those of known dystroglycanopathy mutants, as reflected by abnormalities in neural migration and basal lamina formation.

PMGT2_MOUSE / Q8BW41 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Mus musculus (Mouse) (see 2 papers)
Aligns to 162:395 / 605 (38.7%), covers 97.1% of PF04577, 80.1 bits

• function: O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that transfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity). Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:24256719).
  catalytic activity: O(3)-(alpha-D-mannosyl)-L-threonyl- [protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-(N- acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl- [protein] + UDP (RHEA:37663)
  disruption phenotype: Newborn are slightly smaller and die within the first day of birth due to abnormal basal lamina formation and neuronal migration defects. Defects are due to a lack of laminin- binding glycans.

AT3G18180 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 186:404 / 470 (46.6%), covers 90.4% of PF04577, 79.8 bits

• Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi
  Wang, Scientific reports 2017
  • “...as a putative xylosyltransferase which was recently characterized as MUCI21, while the genes AT3G18170 and AT3G18180 are expressed highly in a heteroxylan containing mucilaginous tissues, which indicated that the genes in this group are related to mucilage production in terrestrial plants 94 95 . 1,3-fucose transferase...”
• Altered Expression of Genes Implicated in Xylan Biosynthesis Affects Penetration Resistance against Powdery Mildew
  Chowdhury, Frontiers in plant science 2017
  • “...largely of uncharacterised genes and forms a sister clade to the Arabidopsis genes AT3G18170 and AT3G18180 (Figure S3 ). The importance of GT61 family in penetration resistance is strengthened further by enhanced RSI upon TIGS of two additional GT61-family members. The fact that no reciprocal infection...”
• Discovery of diversity in xylan biosynthetic genes by transcriptional profiling of a heteroxylan containing mucilaginous tissue
  Jensen, Frontiers in plant science 2013
  • “...c 12 DPA Stem M01000012733 AT5G61840 IRX10L CAZy GT47 104 508 4919 8557 0 M01000017653 AT3G18180 CAZy GT61 2958 3787 3620 1093 0 M01000032237 AT3G02230 RGP1, UAM CAZy GT75 5063 7559 3561 4548 142 M01000025200 AT3G18170 CAZy GT61 2001 3189 3433 926 0 M01000012668 AT3G18180 CAZy...”
  • “...509 590 1702 2828 0 M01000025204 AT3G18170 CAZy GT61 1694 2058 1702 647 0 M01000017654 AT3G18180 CAZy GT61 1479 1361 1672 304 2 M01000025153 AT2G32750 CAZy GT47 18 180 1200 588 0 M01000026523 AT3G18170 CAZy GT61 6 197 1092 1759 0 M01000007355 AT1G54940 GUX5 CAZy GT8...”
• Glycosyl transferases in family 61 mediate arabinofuranosyl transfer onto xylan in grasses
  Anders, Proceedings of the National Academy of Sciences of the United States of America 2012
  • “...in dicots. Expression levels of the Arabidopsis representatives, At3g18180 and At3g18170, are low and they are not coexpressed with secondary cell wall genes...”
• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)

RCN11_ORYSJ / Q6ZFH6 Beta-1,2-xylosyltransferase RCN11; OsXylT; Protein REDUCED CULM NUMBER 11; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Q6ZFH6 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Oryza sativa (see paper)
BAD09279.1 [N-glycan] β-1,2-xylosyltransferase (RCN11;Xt;Os08g0503800) (EC 2.4.2.38) (see protein)
Aligns to 259:512 / 533 (47.7%), covers 97.1% of PF04577, 78.9 bits

• function: Glycosyltransferase involved in the xylosylation of N- glycans (PubMed:26025522). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the core beta- linked mannose of N-glycans (PubMed:26025522). Beta-1,2-linked xylose residues on N-glycans are critical for seed germination and plant development and growth under conditions of abiotic stress (PubMed:26025522).
  disruption phenotype: Reduced number of tillers and reduced biomass.

AT3G18170 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 101:322 / 384 (57.8%), covers 89.5% of PF04577, 78.5 bits

• Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi
  Wang, Scientific reports 2017
  • “...was demonstrated as a putative xylosyltransferase which was recently characterized as MUCI21, while the genes AT3G18170 and AT3G18180 are expressed highly in a heteroxylan containing mucilaginous tissues, which indicated that the genes in this group are related to mucilage production in terrestrial plants 94 95 ....”
• Altered Expression of Genes Implicated in Xylan Biosynthesis Affects Penetration Resistance against Powdery Mildew
  Chowdhury, Frontiers in plant science 2017
  • “...that consists largely of uncharacterised genes and forms a sister clade to the Arabidopsis genes AT3G18170 and AT3G18180 (Figure S3 ). The importance of GT61 family in penetration resistance is strengthened further by enhanced RSI upon TIGS of two additional GT61-family members. The fact that no...”
• Discovery of diversity in xylan biosynthetic genes by transcriptional profiling of a heteroxylan containing mucilaginous tissue
  Jensen, Frontiers in plant science 2013
  • “...3620 1093 0 M01000032237 AT3G02230 RGP1, UAM CAZy GT75 5063 7559 3561 4548 142 M01000025200 AT3G18170 CAZy GT61 2001 3189 3433 926 0 M01000012668 AT3G18180 CAZy GT61 153 762 3178 2195 0 M01000021834 AT3G18170 CAZy GT61 153 541 1889 2009 8 M01000033105 AT4G32290 GT14R 509 590...”
  • “...1479 1361 1672 304 2 M01000025153 AT2G32750 CAZy GT47 18 180 1200 588 0 M01000026523 AT3G18170 CAZy GT61 6 197 1092 1759 0 M01000007355 AT1G54940 GUX5 CAZy GT8 350 467 1072 314 0 M01000007434 AT5G05170 CESA3 CAZy GT2 270 377 944 221 1217 M01000021804 AT4G32410 CESA1...”
• Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus
  Wright, PLoS biology 2013
  • “...glycosyltransferase metabolic enzyme ( www.phytozome.net ). This protein has greatest homology to A. thaliana gene AT3G18170, which attaches glyosyl groups to N-linked glycan molecules critical for construction of plant cell membranes [31] . The second flanking gene, MGV1A026627M, is located 41 kb from Nec1 and encodes...”
• Glycosyl transferases in family 61 mediate arabinofuranosyl transfer onto xylan in grasses
  Anders, Proceedings of the National Academy of Sciences of the United States of America 2012
  • “...Expression levels of the Arabidopsis representatives, At3g18180 and At3g18170, are low and they are not coexpressed with secondary cell wall genes (Fig. S6). We...”
• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)

XAT3_ORYSJ / Q10I20 Alpha-1,3-arabinosyltransferase XAT3; Xylan arabinosyltransferase 3; OsXAT3; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
AAK50581.1 xylan α-1,3-arabinofuranosyltransferase (OsXAT3; Os03g0567600 or Os03g37010) (EC 2.4.2.-) (see protein)
Aligns to 289:513 / 576 (39.1%), covers 96.2% of PF04577, 77.9 bits

• function: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:22215597). Possesses alpha-1,3-arabinosyltransferase activity, ttransferring an arabinofuranose residue to the xylan backbone (PubMed:22215597).

CCA61105.1 xylan α-1,3-arabinofuranosyltransferase (TaGT61_1) (EC 2.4.2.-) (see protein)
Aligns to 209:435 / 506 (44.9%), covers 89.5% of PF04577, 77.0 bits

AT4G33600 hypothetical protein (RefSeq) from Arabidopsis thaliana
Aligns to 177:404 / 470 (48.5%), covers 96.7% of PF04577, 76.8 bits

• Identification of ZOUPI Orthologs in Soybean Potentially Involved in Endosperm Breakdown and Embryogenic Development
  Zhang, Frontiers in plant science 2017
  • “...Target Genes The expression of presumed ZOU target genes, including ALE1. At3g06890. At5g03820 , and At4g33600 ( Kondou et al., 2008 ; Yang et al., 2008 ; Xing et al., 2013 ) were detected in the GmZOUs transgenic lines ( Figure 6 ). The ZOU target...”
  • “...GmZOU-2 transgenic lines as detected by qPCR. The expression of ALE1. At3g06890. At5g03820 , and At4g33600 , which are the AtZOU presumed target genes, decreased in the Atzou-4 mutant and showed partial recovery in the GmZOU-1 transgenic lines, but not in the GmZOU-2 transgenic lines. These...”

XAT2_ORYSJ / Q6ZFR0 Alpha-1,3-arabinosyltransferase XAT2; Xylan arabinosyltransferase 2; OsXAT2; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
BAD15592.1 xylan α-1,3-arabinofuranosyltransferase (OsXAT2; Os02g22480 or Os02g0330200) (EC 2.4.2.-) (see protein)
Aligns to 296:520 / 583 (38.6%), covers 96.2% of PF04577, 76.4 bits

• function: Glycosyltransferase involved in the arabinosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:22215597). Possesses alpha-1,3-arabinosyltransferase activity, transferring an arabinofuranose residue to the xylan backbone (PubMed:22215597).

AT2G03370 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 159:384 / 452 (50.0%), covers 95.7% of PF04577, 76.3 bits

• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)

CCC14964.1 xylan α-1,3-arabinofuranosyltransferase (TaGT61_2) (EC 2.4.2.-) (see protein)
Aligns to 292:516 / 578 (38.9%), covers 95.2% of PF04577, 72.8 bits

PMGT2_DANRE / Q5NDE5 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; EC 2.4.1.312 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 161:394 / 578 (40.5%), covers 97.1% of PF04577, 72.1 bits

• function: O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that transfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity).
  catalytic activity: O(3)-(alpha-D-mannosyl)-L-threonyl- [protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + O(3)-(N- acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl- [protein] + UDP (RHEA:37663)

NP_001012384 protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 from Danio rerio
Aligns to 168:401 / 585 (40.0%), covers 97.1% of PF04577, 72.0 bits

• Exome sequencing and functional validation in zebrafish identify GTDC2 mutations as a cause of Walker-Warburg syndrome.
  Manzini, American journal of human genetics 2012
  • GeneRIF: We found that gtdc2 knockdown in zebrafish replicates all WWS features (hydrocephalus, ocular defects, and muscular dystrophy), strongly suggesting that GTDC2 mutations cause WWS.

Q2UVB3 glycoprotein 2-beta-D-xylosyltransferase (EC 2.4.2.38) from Zea mays (see paper)
CAJ47425.1 β-1,2-xylosyltransferase (Xt1;XylT) (EC 2.4.2.38) (see protein)
Aligns to 238:491 / 512 (49.6%), covers 97.6% of PF04577, 71.1 bits

NP_187643 Glycosyltransferase family 61 protein from Arabidopsis thaliana
AT3G10320 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 197:431 / 494 (47.6%), covers 96.7% of PF04577, 68.1 bits

• Highly Branched Xylan Made by IRREGULAR XYLEM14 and MUCILAGE-RELATED21 Links Mucilage to Arabidopsis Seeds.
  Voiniciuc, Plant physiology 2015
  • GeneRIF: MUCI21, a member of an uncharacterized clade of the GT61 family, and IRX14 (GT43 protein) are essential for the synthesis of highly branched xylan in seed coat epidermal cells.
• Evolution of protein N-glycosylation process in Golgi apparatus which shapes diversity of protein N-glycan structures in plants, animals and fungi
  Wang, Scientific reports 2017
  • “...( Supplementary Figure S14 ). In this group, although no genes were definitely identified enzymatically, AT3G10320 was demonstrated as a putative xylosyltransferase which was recently characterized as MUCI21, while the genes AT3G18170 and AT3G18180 are expressed highly in a heteroxylan containing mucilaginous tissues, which indicated that...”
• Expression of ROS-responsive genes and transcription factors after metabolic formation of H(2)O(2) in chloroplasts
  Balazadeh, Frontiers in plant science 2012
  • “...1.10 0.76 0.47 0.18 3.05 1.71 At3g09410 0.28 0.27 0.22 0.81 0.22 1.66 1.46 0.32 At3g10320 0.36 0.84 2.31 1.49 3.05 2.85 6.78 3.90 At3g10930 0.72 4.25 1.97 3.89 3.08 5.28 7.56 5.90 At3g11840 1.19 1.22 1.67 0.87 0.88 1.81 3.81 2.49 At3g12580 1.37 1.54 2.02...”
• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)

XYXT1_ORYSJ / Q5Z8T8 Beta-1,2-xylosyltransferase XYXT1; Xylan xylosyltransferase 1; EC 2.4.2.- from Oryza sativa subsp. japonica (Rice) (see paper)
Aligns to 180:384 / 465 (44.1%), covers 88.5% of PF04577, 68.0 bits

• function: Glycosyltransferase involved in the xylosylation of xylan, the major hemicellulose (non-cellulosic component) of primary and secondary walls of angiosperms (PubMed:29325159). Possesses beta-1,2-xylosyltransferase activity, transferring xylose from UDP-xylose to the xylan backbone (PubMed:29325159). Catalyzes the addition of 2-O-xylosyl side chains to the xylan backbone (PubMed:29325159).

AT2G41640 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 194:426 / 500 (46.6%), covers 61.7% of PF04577, 66.4 bits

• GWAS with Heterogeneous Data: Estimating the Fraction of Phenotypic Variation Mediated by Gene Expression Data
  Sasaki, G3 (Bethesda, Md.) 2018
  • “...0.53 FLC * AT1G65480 0.54 2.64E-11 0.37 FT * AT2G45660 0.47 1.35E-08 0.22 SOC1 * AT2G41640 0.42 7.03E-07 0.20 Glycosyl- transferase AT3G57920 0.39 3.28E-06 0.17 SPL15 AT1G04400 0.38 5.24E-06 0.15 CRY2 * AT5G52310 0.38 5.39E-06 0.14 RD29A AT1G69440 0.38 5.53E-06 0.18 AGO7 AT3G13100 0.38 7.71E-06 0.10...”
• Cell growth and homeostasis are disrupted in arabidopsis rns2-2 mutants missing the main vacuolar RNase activity
  Morriss, Annals of botany 2017 (secret)
• Expression of ROS-responsive genes and transcription factors after metabolic formation of H(2)O(2) in chloroplasts
  Balazadeh, Frontiers in plant science 2012
  • “...unknown function At4g18880 * 1.6 6.5 4.0 1.9 4.6 2.4 Heat stress-type transcription factor (HsfA4a/HSF21) At2g41640 1.1 4.0 3.7 2.2 6.0 2.7 Protein of unknown function At1g28190 * 1.1 3.9 3.5 2.4 5.6 2.3 Protein of unknown function At5g57220 2.8 9.1 3.3 1.3 6.9 5.2 Cytochrome...”
  • “...0.11 0.23 0.71 1.09 1.44 1.20 At2g41380 0.19 0.27 2.95 2.64 3.26 4.41 5.92 4.88 At2g41640 0.12 2.02 0.91 1.01 1.17 2.59 2.84 2.49 At2g43820 0.50 0.11 1.38 0.24 0.09 0.68 3.02 3.05 At2g47000 0.15 0.22 0.59 2.57 0.55 4.43 7.60 6.33 At3g02800 0.14 2.31 0.32...”
• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)
• Identification of unstable transcripts in Arabidopsis by cDNA microarray analysis: rapid decay is associated with a group of touch- and specific clock-controlled genes
  Gutierrez, Proceedings of the National Academy of Sciences of the United States of America 2002
  • “...and two genes of unknown function (At1g72450 and At2g41640). Although the functional significance of these sequences remains to be determined, these transcripts...”

AT3G57380 transferase, transferring glycosyl groups (RefSeq) from Arabidopsis thaliana
Aligns to 196:426 / 504 (45.8%), covers 46.9% of PF04577, 62.3 bits

• The Arabidopsis transcription factor IIB-related protein BRP4 is involved in the regulation of mitotic cell-cycle progression during male gametogenesis
  Qin, Journal of experimental botany 2014
  • “...Liu et al. , 1995 ), and found that a T-DNA segment was inserted between At3g57380 and At3g57370 ( BRP4 ), 1014bp upstream of the start codon of BRP4 ( Fig. 1E ). RT-PCR analysis showed that the expression of BRP4 was highly upregulated in smo3-D...”
  • “...BRP4 locus in smo3-D . The coding regions of both At3g57370 ( BRP4 ) and At3g57380 are indicated as black arrows, and the intermediate genomic sequence is indicated as a black line. T-DNA was inserted in the promoter region of BRP4 , 1014bp upstream of ATG....”
• A large rearrangement involving genes and low-copy DNA interrupts the microcollinearity between rice and barley at the Rph7 locus
  Brunner, Genetics 2003 (secret)

GRMZM2G105221 glycosyltransferase from Zea mays
Aligns to 223:455 / 529 (44.0%), covers 43.5% of PF04577, 45.5 bits

• Comparative RNA-Seq Analysis Reveals That Regulatory Network of Maize Root Development Controls the Expression of Genes in Response to N Stress
  He, PloS one 2016
  • “...pyrophosphate synthase (GRMZM2G058404), splicing factor U2af subunit isoform (GRMZM2G031827), isocitrate lyase (GRMZM2G056369), beta-glucanase (GRMZM2G473711), glycosyltransferase (GRMZM2G105221), and aldose 1-epimerase (GRMZM2G125233). In contrast, rtcs showed larger dynamic changes in gene expression under N-deficiency stress, and 804 co-modulated DEGs were detected ( S10 Table ). More N-deficiency-induced genes...”

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