Family Search for PF05300 (MIC19_MIC25)
April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)
Running HMMer for PF05300
PF05300 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
MIC25_HUMAN / Q9BRQ6 MICOS complex subunit MIC25; Coiled-coil-helix cristae morphology protein 1; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6 from Homo sapiens (Human) (see 5 papers)
NP_115719 MICOS complex subunit MIC25 isoform 2 from Homo sapiens
Aligns to 31:188 / 235 (67.2%), covers 100.0% of PF05300, 182.0 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:17624330, PubMed:22228767, PubMed:25781180, PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1 (PubMed:22228767). Interacts with DISC1 (PubMed:22228767). Interacts with IMMT/MIC60 (PubMed:22228767, PubMed:25997101).
subunit: (Microbial infection) Interacts with human cytomegalovirus protein UL37 isoform vMIA; this interaction rewires mitochondria by engaging the conserved MICOS complex. - A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Shang, Acta neuropathologica 2022 - GeneRIF: A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
- Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding, Scientific reports 2015 - GeneRIF: mitochondria exhibited lower cristae density in CHCHD6-knockout cells. CHCHD6 directly interacted with Sam50.
- CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
An, The Journal of biological chemistry 2012 - GeneRIF: CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka, Gut 2009 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11.
Xie, FEBS letters 2007 (PubMed)- GeneRIF: anti-mitofilin mAb immunocaptures its target protein in association with six other proteins, metaxins 1 and 2, SAM50, CHCHD3, CHCHD6 and DnaJC11, respectively
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
- Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls.
Cappelletti, Clinical proteomics 2022 - “...tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like DUS3L 1.14E07 5.93E05 2.660 22.773 1.476 25.446 0.966 23 10 0.186 0.202 Q9BRQ6 MICOS complex subunit MIC25 CHCHD6 1.04E07 5.93E05 4.215 21.766 0.898 26.389 2.373 20 4 0.174 0.091 Q7L8W6 Diphthineammonia ligase DPH6 2.76E07 1.31E04 1.913 21.418 0.980 23.404 0.962 7 2 0.183...”
- Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis
Dabbaghizadeh, PloS one 2018 - “...MICOS complex subunit MIC19 (Q9NX63) 1.34 0.38 4.16 0 1.44 MICOS complex subunit MIC 25 (Q9BRQ6) 0 0 4.16 0 Cytochrome b-c1 complex subunit 2, mitochondrial (P22695) 1 0 1.46 0.4 0.9 Cytochrome b-c1 complex subunit Rieske-like protein 1 (P47985) 0.24 0 0 0 Cytochrome c...”
Q9DA45 CHCH domain-containing protein from Mus musculus
Aligns to 16:211 / 258 (76.0%), covers 100.0% of PF05300, 179.3 bits
- Evidence for existence of thirty hypothetical proteins in rat brain.
Shin, Proteome science 2004 - “...(Q9D9F6) shows high homology with mitochondrial inner membrane protein (Fig 3 ) and 1700021B03Rik protein (Q9DA45) belongs to DUF 737 family containing uncharacterised protein. Figure 2 Graphical view of domains of two hypothetical proteins; Homo sapiens sequence 42 from patent wo0222660 and Homo sapiens sequence 33...”
- “...this protein is still unclear. Figure 4 Representative DUF 737 family proteins, including 1700021B03Rik protein (Q9DA45). Some of hypothetical proteins were detected in mouse hippocampus, human mesothelial, lymphocyte and bronchial cell lines (Table 1 see additional file 1 ). None of the listed hypothetical proteins were...”
Q91VN4 MICOS complex subunit Mic25 from Mus musculus
Aligns to 31:226 / 273 (71.8%), covers 100.0% of PF05300, 179.1 bits
- Proteomic Analysis of Mucopolysaccharidosis IIIB Mouse Brain
De, Biomolecules 2020 - “...M A0A0R4J0Q5 Lmnb2 Lamin-B2 1.4 0.03275 CK, N Q4FJX9 Sod2 Superoxide dismutase 1.4 0.01379 M Q91VN4 Chchd6 MICOS complex subunit Mic25 1.4 0.01573 C, M O88737 Bsn Protein bassoon 1.3 0.00915 C, GA Q3UWW9 Psmd11 Putative uncharacterized protein 1.3 0.01386 C, N O08788 Dctn1 Dynactin subunit...”
- Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2).
Stachowicz, International journal of molecular sciences 2017 - “...18 1.23 5 Spectrin chain, erythrocytic P15508 3 9 1.23 6 MICOS complex subunit Mic25 Q91VN4 2 3 1.21 7 Ubiquitin-60S ribosomal protein L40 P62984 4 51 1.21 8 Tubulin -1 chain A2AQ07 7 33 1.17 9 Tropomyosin -3 chain P21107 3 16 1.17 10 Paralemmin-1...”
- A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis.
Saintigny, Scientific reports 2016 - “...A1 P09651 17 1,51 Proteasome subunit beta type-1 O09061 18 1,70 MICOS complex subunit Mic25 Q91VN4 19 1,66 PINCH-1 Q99JW4 19 1,66 Peptidyl-prolyl cis-trans isomerase A P14851 20 1,30 Citrate synthase Q8VHF5 22 1,44 Adenylate kinase 4 Q9WUS0 23 1,71 Peptidyl-prolyl cis-trans isomerase B P24368 25...”
J3QTA6 Coiled-coil-helix-coiled-coil-helix domain containing 6 from Homo sapiens
Aligns to 31:189 / 256 (62.1%), covers 100.0% of PF05300, 177.4 bits
MIC19_HUMAN / Q9NX63 MICOS complex subunit MIC19; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 from Homo sapiens (Human) (see 8 papers)
NP_060282 MICOS complex subunit MIC19 isoform 2 from Homo sapiens
Aligns to 29:174 / 227 (64.3%), covers 100.0% of PF05300, 129.3 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101). This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:21081504, PubMed:22114354, PubMed:22228767, PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form (By similarity). Interacts with IMMT/MIC60.
subunit: (Microbial infection) Interacts with human cytomegalovirus protein UL13; this interaction alters cristae architecture. - Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
Tang, Cell death and differentiation 2020 - GeneRIF: Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
- Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins.
Pape, Proceedings of the National Academy of Sciences of the United States of America 2020 - GeneRIF: Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins.
- Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.
Sastri, Journal of cell science 2017 - GeneRIF: Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50.
- The Oxidation Status of Mic19 Regulates MICOS Assembly.
Sakowska, Molecular and cellular biology 2015 - GeneRIF: The findings suggest that Mic19 is a redox-dependent regulator of mitochondrial contact site and crista organizing system complex function.
- Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space.
Darshi, The Journal of biological chemistry 2012 - GeneRIF: both the myristoylation and the CHCH domain are essential for the import and mitochondrial localization of ChChd3. Once imported, ChChd3 binds to Mia40 for further folding and assembly into macromolecular complexes.
- ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
Darshi, The Journal of biological chemistry 2011 - GeneRIF: ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function.
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson, PloS one 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka, Gut 2009 (PubMed)- GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- More
- Skeletal muscle proteome analysis underpins multifaceted mitochondrial dysfunction in Friedreich's ataxia.
Indelicato, Frontiers in neuroscience 2023 - “...reticulum Ca2+ transporting 2 P16615 47,706 19,035 0.40 -1.33 0.004 CHCHD3 Coiled-coil-helix-coiled-coil-helix domain containing 3 Q9NX63 16,272 4,808 0.30 -1.76 0.001 -1.18 CPT1B Carnitine palmitoyltransferase 1B Q92523 3,977 1,440 0.36 -1.47 0.003 FXN Frataxin Q16595 3,523 2,215 0.63 -0.67 0.007 -1.86 GSTM4 Glutathione S-transferase mu 4...”
- Ellagic Acid Triggers the Necrosis of Differentiated Human Enterocytes Exposed to 3-Nitro-Tyrosine: An MS-Based Proteomic Study
Díaz-Velasco, Antioxidants (Basel, Switzerland) 2022 - “...CHCHD3 1.41 10 5 0.07 Component of the MICOS complex, maintenance of mitochondrial crista junctions Q9NX63 Histone H1.4 H1-4 1.00 10 4 0.08 Nucleosome assembly P10412 ATP synthase subunit alpha, mitochondrial ATP5F1A 0.010 0.17 Component of mitochondrial membrane ATP synthase P25705 60S ribosomal protein L13 RPL13...”
- Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells.
Xie, Kidney international 2022 - “...motif-containing protein, mitochondrial (LRPPRC) P42704 158 kDa 0 5 3.5 MICOS complex subunit MIC19 (CHCHD3) Q9NX63 26 kDa 0 5 3.5 Translational Statement Clinical evidence indicates that in a subset of diabetic patients, diabetic kidney disease (DKD) could progress to kidney failure in the absence of...”
- ARID1A downregulation promotes cell proliferation and migration of colon cancer via VIM activation and CDH1 suppression.
Baldi, Journal of cellular and molecular medicine 2022 - “...YBX3 P30626 SRI Q14532 KRT32 Q6P5R6 RPL22L1 Q9H444 CHMP4B P42167 TMPO Q15388 TOMM20 O75717 WDHD1 Q9NX63 CHCHD3 Q99935 OPRPN P25398 RPS12 P80188 LCN2 A8K2U0 A2ML1 O15144 ARPC2 Note : Results were obtained from HCT116 using COIP. 4 DISCUSSION The SWI/SNF chromatin remodelling complex is crucial in...”
- Quantification of FAM20A in human milk and identification of calcium metabolism proteins
Patel, Physiological reports 2021 - “...kinase 17 [CDK17_HUMAN] MFGM CID CDNF Q49AH0 Cerebral dopamine neurotrophic factor [CDNF_HUMAN] MFGM CID CHCHD3 Q9NX63 MICOS complex subunit MIC19 [MIC19_HUMAN] MFGM CID CNPY3 Q9BT09 Protein canopy homolog 3 [CNPY3_HUMAN] MFGM CID CNPY4 Q8N129 Protein canopy homolog 4 [CNPY4_HUMAN] MFGM CID COX5A P20674 Cytochrome c oxidase...”
- Proteomic Analysis of Placental Mitochondria Following Trophoblast Differentiation
Fisher, Frontiers in physiology 2019 - “...metabolism P51659 Peroxisomal multifunctional enzyme type 2 HSD17B4 26 40 0.658537 0.60266 0.04787 Cristae stabilization Q9NX63 MICOS complex subunit MIC19 CHCHD3 10 22 0.478261 1.06413 0.020945 Bolded font represents proteins chosen for western blot analysis. Western Blot and Activity Assay Analysis To validate findings from the...”
- Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.
Samanta, Asian journal of andrology 2019 - “...ribosomal protein S6 P62753 29 11.7 4.3 0.0 0.0 Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial precursor Q9NX63 26 11.7 6.0 5.3 4.3 Protein FAM166A Q6J272 36 11.7 6.0 0.0 0.0 Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1 Q96HS1 32 11.7 8.0 0.0 0.0 DnaJ homolog subfamily A member...”
- Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis
Dabbaghizadeh, PloS one 2018 - “...2.57 MICOS complex subunit MIC27 (Q6UXV4) 0.25 0 0 0.14 0 MICOS complex subunit MIC19 (Q9NX63) 1.34 0.38 4.16 0 1.44 MICOS complex subunit MIC 25 (Q9BRQ6) 0 0 4.16 0 Cytochrome b-c1 complex subunit 2, mitochondrial (P22695) 1 0 1.46 0.4 0.9 Cytochrome b-c1 complex...”
- More
C9JRZ6 Coiled-coil-helix-coiled-coil-helix domain containing 3 from Homo sapiens
Aligns to 29:179 / 232 (65.1%), covers 100.0% of PF05300, 124.9 bits
MIC19_MOUSE / Q9CRB9 MICOS complex subunit Mic19; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3 from Mus musculus (Mouse) (see paper)
NP_079612 MICOS complex subunit Mic19 from Mus musculus
Aligns to 29:174 / 227 (64.3%), covers 100.0% of PF05300, 124.4 bits
- function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.
subunit: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex (By similarity). Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form. - ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions
Bécares, Microbiology spectrum 2023 - “...Peptidyl-tRNA hydrolase 2, mitochondrial Ptrh2 0.55 2.33 P08074 Carbonyl reductase [NADPH] 2 Cbr2 0.88 5.70 Q9CRB9 MICOS complex subunit Mic19 Chchd3 0.89 5.15 P97450 ATP synthase-coupling factor 6, mitochondrial Atp5pf 1.05 2.80 Q5SUC9 Protein SCO1 homolog, mitochondrial Sco1 1.22 2.22 P47738 Aldehyde dehydrogenase, mitochondrial Aldh2 1.24...”
- Mass Spectrometric Profiling of Extraocular Muscle and Proteomic Adaptations in the mdx-4cv Model of Duchenne Muscular Dystrophy
Gargan, Life (Basel, Switzerland) 2021 - “...Destrin DSTN 9 0.03484 2.66 Q9D3D9 ATP synthase subunit delta, mitochondrial ATP5F1D 4 0.04228 2.71 Q9CRB9 MICOS complex subunit Mic19 CHCHD3 11 0.04353 2.90 Q9DBC7 cAMP-dependent protein kinase type I-alpha PRKAR1A 2 0.02217 2.91 The bioinformatic analysis of the proteomic survey of mdx-4cv EOMs is summarized...”
- Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.
Strong, mSphere 2021 - “...PE_PGRS47 Ras GTPase-activating-like protein IQGAP1 Q9JKF1 13 (13) 5 (5) 188.6 MICOS complex subunit Mic19 Q9CRB9 6 (6) 3 (3) 26.3 Endoplasmic reticulum chaperone BiP P20029 4 (3) 10 (9) 72.4 Erythrocyte band 7 integral membrane protein P54116 4 (4) 5 (5) 31.4 14-3-3 protein gamma...”
- MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract.
Aryal, Human genetics 2020 - “...Ubc12 None found 88 Jpt2 Q6PGH2 Jupiter microtubule associated homolog 2 None found 89 Chchd3 Q9CRB9 MICOS complex subunit Mic19 None found 90 Ywhah P68510 14-3-3 protein eta None found 91 Cfap36 Q8C6E0 Cilia- and flagella-associated protein 36 None found 92 Rps18 P62270 40S ribosomal protein...”
- “...2.8 7.1 3.0E-70 0.00000 108.9 15.3 Pon2 Q62086 2.5 6.3 6.0E-05 0.00018 5.3 0.8 Chchd3 Q9CRB9 2.4 5.7 1.0E-07 0.00000 9.2 1.6 Basp1 Q91XV3 2.4 5.3 5.0E-42 0.00000 68.6 12.8 Bcl2l13 P59017 2.2 4.8 2.0E-12 0.00000 17.5 3.6 Cxadr P97792 2.2 4.8 3.0E-06 0.00001 7.7 1.6...”
- Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles
Murphy, Proteomes 2015 - “...Selenium-binding protein 1 7 398.9 0.000733 2.35 P14152 Malate dehydrogenase, cytoplasmic 8 588.6 0.000441 2.33 Q9CRB9 Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial 2 191.9 0.008307 2.28 P70349 Histidine triad nucleotide-binding protein 1 6 504.1 0.004703 2.27 P11404 Fatty acid-binding protein, FABP3, heart 5 407.2 0.011413 2.21 Q01768...”
- TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria
Miller, The Journal of biological chemistry 2014 - “...Q8VEM8 P07759 Serpina3K (includes others) Q03265 P09542 Q8R4N0 Q9CRB9 Q8K2B3 Q03734 Serpina3K (includes others) P17182 Q9EQ20 Q8BH59 Q99PT1 P52480 P07724 Top 20...”
- Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.
McFarland, Molecular & cellular proteomics : MCP 2008 - Application of fluorescence two-dimensional difference in-gel electrophoresis as a proteomic biomarker discovery tool in muscular dystrophy research
Carberry, Biology 2013 - “...alpha, cardiac gi|387090 51 5.23 42,048 2 7 2.1 37 Coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial NP_079612 80 8.56 26,550 5 24 2.1 38 Cu/Zn superoxide dismutase 1513495A 147 6.03 15,926 5 41 2.1 39 Malate dehydrogenase mitochondrial NP_032643 256 8.93 36,053 12 45 2.1 40 Peroxiredoxin...”
D3Z0L4 Coiled-coil-helix-coiled-coil-helix domain containing 3 (Fragment) from Mus musculus
Aligns to 29:179 / 192 (78.6%), covers 100.0% of PF05300, 121.0 bits
- Cognitive impairment resulting from treatment with docetaxel, doxorubicin, and cyclophosphamide
Brown, Brain research 2021 - “...as meeting statistical significance for differential expression Protein Description Location Type Fold Change (log ratio) D3Z0L4 MICOS complex subunit Mitochondrion inner Membrane Other 6.79 A2AER7 Pqbpl protein Nucleus Other 4.49 B1AW58 Calcium/calmodulin-dependent protein kinase ID Nucleus Kinase 2.64 Q9CWB7 Glutaredoxin-like protein C5orf63 homolog Mitochondrion Other 2.46...”
D3ZUX5 Coiled-coil-helix-coiled-coil-helix domain containing 3 from Rattus norvegicus
Aligns to 39:170 / 223 (59.2%), covers 76.2% of PF05300, 112.2 bits
NP_001161208 MICOS complex subunit Mic25 isoform 2 from Mus musculus
Aligns to 31:179 / 245 (60.8%), covers 71.4% of PF05300, 99.1 bits
Or search for genetic data about PF05300 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory