Family Search for PF05303 (GSKIP_dom)
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Running HMMer for PF05303
PF05303 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q22757 GSKIP domain-containing protein from Caenorhabditis elegans
Aligns to 42:147 / 156 (67.9%), covers 99.0% of PF05303, 126.4 bits
GSKIP_RAT / Q5PPI3 GSK3B-interacting protein; GSKIP from Rattus norvegicus (Rat) (see paper)
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 120.1 bits
- function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta- catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity).
subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971). Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (By similarity).
GSKIP_MOUSE / Q8BGR8 GSK3B-interacting protein; GSKIP from Mus musculus (Mouse) (see paper)
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 119.5 bits
- function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta- catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204).
subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin. Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity.
disruption phenotype: Knockout Gskip mice die at birth. At 18.5 dpc, embryos are still alive but rapidly die within 5 to 30 min after casarean section. Embryos obtained at 18.5 dpc are cyanotic, suffer from respiratory distress, and fail to initiate breathing properly.
NP_848728 GSK3B-interacting protein from Mus musculus
Aligns to 38:138 / 144 (70.1%), covers 100.0% of PF05303, 119.4 bits
GSKIP_HUMAN / Q9P0R6 GSK3B-interacting protein; GSKIP; GSK3beta interaction protein from Homo sapiens (Human) (see 5 papers)
NP_057556 GSK3B-interacting protein from Homo sapiens
Aligns to 33:133 / 139 (72.7%), covers 100.0% of PF05303, 117.6 bits
- function: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702).
subunit: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta- catenin degradation through GSK3B-induced phosphorylation of beta- catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971, PubMed:25920809, PubMed:27484798). Interacts with GSK3B; induces GSK3B- mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (PubMed:16981698, PubMed:25920809). - A specific selenium-chelating peptide isolated from the protein hydrolysate of Grifola frondosa
Xiong, RSC advances 2021 - “...= Homo sapiens GN = C2orf54 PE = 2 SV = 2 447 1.235443 0.008035 Q9P0R6 GSK3-beta interaction protein OS = Homo sapiens GN = GSKIP PE = 1 SV = 2 139 1.234663 0.034995 A0A0A0MSV9 Tapasin OS = Homo sapiens GN = TAPBP PE =...”
- Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms.
Pegliasco, Leukemia 2022 (PubMed)- GeneRIF: Germline ATG2B/GSKIP-containing 14q32 duplication predisposes to early clonal hematopoiesis leading to myeloid neoplasms.
- Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size.
Sakai, Molecular and cellular biology 2022 - GeneRIF: Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size.
- High expression of GSKIP is associated with poor prognosis in meningioma.
Cheng, Medicine 2022 - GeneRIF: High expression of GSKIP is associated with poor prognosis in meningioma.
- ATG2B/GSKIP in de novo acute myeloid leukemia (AML): high prevalence of germline predisposition in French West Indies.
Pegliasco, Leukemia & lymphoma 2021 (PubMed)- GeneRIF: ATG2B/GSKIP in de novo acute myeloid leukemia (AML): high prevalence of germline predisposition in French West Indies.
- The origin of GSKIP, a multifaceted regulatory factor in the mammalian Wnt pathway.
Chou, Biochimica et biophysica acta. Molecular cell research 2018 (PubMed)- GeneRIF: Findings support the idea that in addition to its reported role in modulating Drp1, Ser637 phosphorylation causing mitochondrial elongation, GSKIP acts as a scavenger to take GSK3beta away from the beta-catenin destruction complex or as a competitor for GSK3beta binding in the Wnt pathway.
- The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.
Dema, The Journal of biological chemistry 2016 - GeneRIF: findings highlight an essential compartmentalization of both PKA and GSK3beta by GSKIP, and ascribe a function to a cytosolic AKAP-PKA interaction as a regulatory factor in the control of canonical Wnt signaling.
- Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies.
Saliba, Nature genetics 2015 (PubMed)- GeneRIF: demonstrate that overexpression of ATG2B and GSKIP enhances hematopoietic progenitor differentiation, including of megakaryocytes, by increasing progenitor sensitivity to thrombopoietin
- Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation.
Tang, Biopolymers 2011 (PubMed)- GeneRIF: analysis of the GSK3beta-GSKIPtide complex structure and the X-ray crystal structures of GSK3beta-FRATide and GSK3beta-AxinGID complexes suggests that the hydroxyl group of Y288 is crucial to maintaining a hydrogen bond network in GSK3beta-FRATide
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CG11523 uncharacterized protein from Drosophila melanogaster
Aligns to 18:134 / 158 (74.1%), covers 100.0% of PF05303, 116.5 bits
- Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach
Hall, Aging 2019 - “...regions extended into 5 Kb of flanking sequences had identified several top-ranked genes including the CG11523 and Neprilysin 1 . The former was found to have a GSK3 interaction domain that is a crucial component of the TOR pathway in human cell lines [ 20 ];...”
- Longevity GWAS Using the Drosophila Genetic Reference Panel
Ivanov, The journals of gerontology. Series A, Biological sciences and medical sciences 2015 - “...of the top-ranking genes from the gene-based associations are plausible candidate genes affecting lifespan determination. CG11523 is predicted to have a GSK3 interaction domain (GSKIP; InterPro term: IPR023231). The human ortholog (GSKIP) protein interacts in vitro and in vivo with GSK3 and inhibits the GSK3 activity...”
- “...boxes starting with c_ represent complexes; yellow boxes represent putative genes part of the IIS (CG11523) or TOR (RpS9) pathways; genes circled in red represent genes found in the top-ranked genes in the gene-based analysis; black horizontal line represents a symbolic separation between the TOR and...”
- Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis
Germain, Developmental biology 2015 - “...; however, unknown at the time, there is another gene between Ddx1 and CSP , CG11523 . A subsequent report showed that disrupted CG11523 is associated with a lethal phenotype ( CG11523 GD7321 ) ( Mummery-Widmer et al., 2009 ). It is, therefore, likely that the...”
- A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing
Cruz, Genetics 2009 - “...CG32180 (Eip74EF) CG13698 CG14080 (Mkp3) CG10580 ( fng) CG11523 CG10712 (Chro) CG31529 CG2244 (MTA1-like) CG9755 (pum) CG9366 (RhoL) CG6203 (Fmr1) CG5361 CGh...”
- “...CG4379 (Pka-C1) CG9591 CG4993 (PRL 1) CG3619 (Dl) CG11523 CG4644 CG2849 (Rala) CG15015 (Cip4) CG6477 (RhoGAP54D) CG9968 (Anxb11) Gen 39 CG4954 (eIF3-S8) CG6818...”
- Quantitative genomics of aggressive behavior in Drosophila melanogaster
Edwards, PLoS genetics 2006 - “...in H males). Finally, six transcripts demonstrated antagonism between the C and L groups ( CG11523 was up-regulated in L males and down-regulated in L females; twin of eyeless, CG15825, CG8093, CG7598, and CG4199 were up-regulated in L females but down-regulated in L males). These probe...”
Q9XWX6 GSKIP domain-containing protein from Caenorhabditis elegans
Aligns to 83:188 / 244 (43.4%), covers 97.1% of PF05303, 109.0 bits
Q9XU41 GSKIP domain-containing protein from Caenorhabditis elegans
Aligns to 142:247 / 253 (41.9%), covers 99.0% of PF05303, 108.8 bits
Smp_136320 hypothetical protein from Schistosoma mansoni
Aligns to 27:140 / 154 (74.0%), covers 99.0% of PF05303, 108.7 bits
- Screening of a Library of Recombinant Schistosoma mansoni Proteins With Sera From Murine and Human Controlled Infections Identifies Early Serological Markers
Crosnier, The Journal of infectious diseases 2022 - “...51 Smp_128590 K21-S260 69 Laminin gamma3 Low 52 Smp_135210 I21-Q1584 220 EGF-domain-containing protein Low 53 Smp_136320 H21-K154 48 GSK3beta-interacting protein Low 54 Smp_144130 L26-V553 118 Septate junction protein Low 55 Smp_154760 Q30-M2155 298 EGF-domain-containing protein Low 56 Smp_171780 Q19-K260 61 SPARC High 57 Smp_178740 Q31-V533 97...”
- Systematic screening of 96 Schistosoma mansoni cell-surface and secreted antigens does not identify any strongly protective vaccine candidates in a mouse model of infection
Crosnier, Wellcome open research 2019 - “...100-20-20 379,757 49 Smp_035040 40 - 100-20-20 62,272 50 Smp_052660 51 Smp_128590 52 Smp_135210 53 Smp_136320 24 - 100-20-20 72,442 54 Smp_144130 118 + 100-20-20 129,754 55 Smp_154760 274 - 100-20-20 356,003 56 Smp_171780 37 - 100-20-20 158,384 57 Smp_178740 58 Smp_180600 48 - 100-20-20 489,748/347,980...”
B0XA92 GSKIP domain-containing protein from Culex quinquefasciatus
Aligns to 20:101 / 124 (66.1%), covers 78.1% of PF05303, 53.8 bits
P34466 Clustered mitochondria protein homolog from Caenorhabditis elegans
Aligns to 224:303 / 1247 (6.4%), covers 69.5% of PF05303, 35.2 bits
CLU_DROME / A1ZAB5 Protein clueless; Clustered mitochondria protein homolog from Drosophila melanogaster (Fruit fly) (see paper)
NP_611095 clueless, isoform A from Drosophila melanogaster
Aligns to 319:395 / 1448 (5.3%), covers 63.8% of PF05303, 26.8 bits
- function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
disruption phenotype: Causes mitochondria to cluster within cells. - Clueless forms dynamic, insulin-responsive bliss particles sensitive to stress.
Sheard, Developmental biology 2020 - GeneRIF: Clueless forms dynamic, insulin-responsive bliss particles sensitive to stress.
- Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.
Wang, Human molecular genetics 2016 - GeneRIF: Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance.
- Clueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.
Sen, Disease models & mechanisms 2015 - GeneRIF: Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.
- Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.
Sen, PloS one 2013 - GeneRIF: The results suggest Clu functions upstream of electron transport and oxidative phosphorylation, has a role in suppressing oxidative damage in the cell, and that lack of Clu's specific function causes mitochondria to mislocalize.
- Clueless regulates aPKC activity and promotes self-renewal cell fate in Drosophila lgl mutant larval brains.
Goh, Developmental biology 2013 (PubMed)- GeneRIF: Clueless (clu) is a novel regulator of aPKC activity.
- Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.
Cox, Disease models & mechanisms - GeneRIF: strong clu mutations resemble park mutations in their effects on mitochondrial function and that the two genes interact genetically
CLU_DICDI / O15818 Clustered mitochondria protein homolog from Dictyostelium discoideum (Social amoeba) (see paper)
XP_629429 150 kDa protein from Dictyostelium discoideum AX4
Aligns to 283:356 / 1320 (5.6%), covers 66.7% of PF05303, 26.2 bits
NP_001190068 tetratricopeptide repeat (TPR)-containing protein from Arabidopsis thaliana
Aligns to 258:362 / 1419 (7.4%), covers 69.5% of PF05303, 24.1 bits
AT3G52140 tetratricopeptide repeat (TPR)-containing protein from Arabidopsis thaliana
Aligns to 258:362 / 1403 (7.5%), covers 69.5% of PF05303, 24.1 bits
- FRIENDLY (FMT) is an RNA binding protein associated with cytosolic ribosomes at the mitochondrial surface
Hemono, The Plant journal : for cell and molecular biology 2022 - “...isolated or in large clusters of approximately 10 organelles. The involved mutation was localized in AT3G52140 locus, and the encoded protein was called FRIENDLY or FMT (Logan etal., 2003 ). FMT was subsequently shown to play a role in mediating intermitochondrial association and could be involved...”
- “...The most enriched proteins among the 63 are two cytosolic proteins: VCS (AT3G13300) and FMT (AT3G52140). VCS forms an mRNA decapping complex with DCP1 and DCP2 in processing bodies (Pbodies) (Xu & Chua, 2011 ). However, neither DCP1 (AT1G08370), nor DCP2 (AT5g13570) could be identified in...”
- Submergence of the filamentous Zygnematophyceae Mougeotia induces differential gene expression patterns associated with core metabolism and photosynthesis
Fürst-Jansen, Protoplasma 2022 - “...2.24637151 6.5626E-06 Mousp15175_c0_g1_i6 AT2G14610 pathogenesis-related protein 1 2.24594398 0.000030745 Mousp17901_c2_g3_i1 none none 2.24550218 0.000023275 Mousp16876_c0_g5_i2 AT3G52140 tetratricopeptide repeat (TPR)-containing protein 2.22759061 0.000030632 Mousp17754_c1_g2_i1 AT5G41460 transferring glycosyl group transferase (DUF604) 2.22550195 1.2101E-10 Mousp10496_c0_g1_i1 AT4G33880 ROOT HAIR DEFECTIVE 6-LIKE 2 2.21640294 7.7321E-10 Mousp14422_c0_g1_i6 AT1G14870 PLANT CADMIUM RESISTANCE 2...”
- FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana
Ayabe, Plant cell reports 2021 (PubMed)- “...fusion vector constructs and plant transformation FMT (AT3G52140) cDNA was amplified from cDNA RAFL04-20-A10 obtained from RIKEN BRC (https: //www....”
- Genome-wide (ChIP-seq) identification of target genes regulated by WRKY33 during submergence stress in Arabidopsis
Zhang, BMC genomic data 2021 - “...AT3G41768 rRNA 10.2 AT3G41979 5.8SrRNA 6.8 AT3G42130 glycine-rich protein 6.2 AT3G45755 transposable element gene 6.1 AT3G52140 tetratricopeptide repeat (TPR)-containing protein 6.2 AT4G10030 Alpha/beta hydrolase domain containing protein involved in lipid biosynthesis 5.3 AT4G20360 Nuclear transcribed, plastid localized EF-Tu translation elongation factor 5.2 AT4G32700 helicases;ATP-dependent helicases;nucleic acid...”
- QTL and candidate genes associated with leaf anion concentrations in response to phosphate supply in Arabidopsis thaliana
El-Soda, BMC plant biology 2019 - “...that contains a noncatalytic carbohydrate-binding module as well as a dual specificity protein phosphatase domain AT3G52140 - AT3G52170 5 AT5G10180 3194 0.32 4.8 0.56 0.10 ARABIDOPSIS SULFATE TRANSPORTER 68, AST68, SULFATE TRANSPORTER 2;1, SULTR2;1. Encodes a low-affinity sulfate transporter expressed in the root cap and central...”
- Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis
Osman, The Plant journal : for cell and molecular biology 2018 - “...), with the identifier PXD006042. The following lines were used for mutant analysis: At5g46070, SALK_016366; At3g52140, SALK_046271; At5g42220, SALK_151742; At5g59210, GABI_094G05; mcm2 (At1g44900), SALK_023429; icu21 (At5g67100), N329; spo1114 (At3g13170), WiscDsLox461464J19 (Roberts 2010 ); asy4 (At2g33793), SAIL_886_D04. Conflicts of interest The authors declare no known conflicts of...”
- Nitric Oxide Regulates Seedling Growth and Mitochondrial Responses in Aged Oat Seeds
Mao, International journal of molecular sciences 2018 - “...0.76 ns Not assigned W5BQ98 AT4G22310 Mitochondrial pyruvate carrier Triticum aestivum 1.31 ns ns Q6ZGV8 AT3G52140 Clustered mitochondria protein homolog Oryza sativa subsp. japonic a ns 1.68 1.91 Q0JDA2 AT1G47420 Succinate dehydrogenase subunit 5, mitochondrial Oryza sativa subsp. japonic a ns 1.32 1.23 B6SPH3 AT5G08040 Mitochondrial...”
- A Microsomal Proteomics View of H₂O₂- and ABA-Dependent Responses
Alqurashi, Proteomes 2017 - “...Chaperonin 60 family protein 0.041 2.1 ns AT5G56030 Heat shock protein 81-2 0.012 0.4 ns AT3G52140 Tetratricopeptide repeat-containing protein 0.04 5.3 ns 7. Transporters AT4G38580 Farnesylated protein 6 0.017 0.4 ns AT3G15660 Glutaredoxin 4 0.011 ns 6.0 AT1G27950 Glycosylphosphatidylinositol-anchored lipid protein transfer 1 0.027 16.0 44.0...”
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CLU_ARATH / F4J5S1 Clustered mitochondria protein; Friendly mitochondria protein from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Aligns to 258:362 / 1407 (7.5%), covers 69.5% of PF05303, 24.1 bits
- function: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria (By similarity) (PubMed:14617080). Together with REC2, REC3 and FMT/CLU, contributes to the establishment of the cellular volume devoted to the chloroplast compartment (PubMed:26862170).
disruption phenotype: Causes mitochondria to cluster within cells (PubMed:14617080). Reduced proportion of the cellular volume devoted to chloroplasts leading to an abnormal chloroplasts distributions (PubMed:26862170). Lower levels of chlorophyll, especially in plants lacking REC1, REC2, REC3 and FMT/CLU (PubMed:26862170).
A7ENU3 Clustered mitochondria protein homolog from Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Aligns to 208:298 / 1311 (6.9%), covers 68.6% of PF05303, 23.4 bits
Or search for genetic data about PF05303 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory