Family Search for PF05527 (DUF758)

PF05527.11 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

TFIP8_HUMAN / O95379 Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 from Homo sapiens (Human) (see 4 papers)
Aligns to 16:196 / 198 (91.4%), covers 99.4% of PF05527, 265.2 bits

• function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

XP_006254771 tumor necrosis factor alpha-induced protein 8 isoform X3 from Rattus norvegicus
Aligns to 6:186 / 188 (96.3%), covers 99.4% of PF05527, 262.9 bits

• Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy.
  Zhang, Biochimica et biophysica acta 2010 (PubMed)
  • GeneRIF: Findings demonstrate that TNFAIP8 is one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury.

NP_001171230 tumor necrosis factor alpha-induced protein 8 isoform 2 from Mus musculus
Aligns to 6:186 / 188 (96.3%), covers 99.4% of PF05527, 261.6 bits

• Effect of tumor necrosis factor-α-induced protein 8 on the immune response of CD4+ T lymphocytes in mice following acute insult.
  Yu, Molecular medicine reports 2018 (PubMed)
  • GeneRIF: TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice.
• TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells.
  Liu, Oncology reports 2018 (PubMed)
  • GeneRIF: Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation.
• Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection.
  Porturas, Journal of immunology (Baltimore, Md. : 1950) 2015
  • GeneRIF: TNFAIP8 regulates RAC1 signaling during TNF-alphaR activation and L. monocytogenes invasion of cells and that this regulation is crucial for controlling cell death and lethal L. mono-cytogenes infection of mice.
• Exacerbated experimental colitis in TNFAIP8-deficient mice.
  Sun, Journal of immunology (Baltimore, Md. : 1950) 2015
  • GeneRIF: TIPE plays an important role in maintaining colon homeostasis and in protecting against colitis.
• A preliminary X-ray study of murine Tnfaip8/Oxi-α.
  Lee, International journal of molecular sciences 2014
  • GeneRIF: Data indicate that mutant Tnfaip8/Oxi-alpha has been crystallized and X-ray data have been collected to 1.8 A using synchrotron radiation.
• Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.
  Woodward, Cell death and differentiation 2010 (PubMed)
  • GeneRIF: Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes
• TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.
  Laliberté, Journal of cellular physiology 2010
  • GeneRIF: Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation.
• Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
  Ahn, PLoS pathogens 2010
  • GeneRIF: Tnfaip8 expression is associated with susceptibility to Staphylococcus aureus sepsis.
• More

TP8L3_HUMAN / Q5GJ75 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Homo sapiens (Human) (see 2 papers)
NP_997264 tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1 from Homo sapiens
Aligns to 110:290 / 292 (62.0%), covers 99.4% of PF05527, 258.7 bits

• function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
• The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
  Kim, Scientific reports 2017
  • “...), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3 from Homo sapiens (hTIPE3). Figure 4 Structural comparison of ( a ) mTnfaip8, ( b ) hTIPE2 and ( c ) hTIPE3. The surface of the protein is...”
• The genomic environment around the Aromatase gene: evolutionary insights
  Castro, BMC evolutionary biology 2005
  • “...Fr Fugu rubripes ; Tn Tetraodon nigroviridis . SSC-S2 The ORF identified in Ensembl as NP_997264 (FLJ41287 protein), presents significant sequence similarity to three other GenBank entries. One of those is a novel tumor necrosis factor- inducible gene, SSC-S2 [ 25 ], which maps to HSA5....”
  • “...(figure 2 ). These are annotated as follows: AP4-E1 [GenBank: NP_031373 ], FLJ41287 (SSC-2SC) [GenBank: NP_997264 ], Collomin [GenBank: NP_861454 ], DMXL2 [GenBank: NP_056078 ], SCGIII [GenBank: NP_037375 ], MGC35274 [GenBank: NP_699205 ], TMOD2 [GenBank: NP_055363 ], and TMOD3 [GenBank: NP_055362 ] (figure 2 ). In...”

TP8L3_MOUSE / Q3TBL6 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Mus musculus (Mouse) (see 2 papers)
NP_001028707 tumor necrosis factor alpha-induced protein 8-like protein 3 from Mus musculus
Aligns to 22:202 / 204 (88.7%), covers 99.4% of PF05527, 252.0 bits

• function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
  disruption phenotype: Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3- methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice.
• The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
  Kim, Scientific reports 2017
  • “...(hTIPE1), EDL38778 for mTIPE2 ( Mus musculus ), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3 from Homo sapiens (hTIPE3). Figure 4 Structural comparison of ( a ) mTnfaip8, ( b ) hTIPE2 and ( c )...”
• Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.
  Cui, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015
  • GeneRIF: Tnfaip8l3 expression was almost identical in most organs from human and mice. Tnfaip8l3 is a cytoplasmic protein expressed preferentially in epithelial-derived cells with secretory functions.

NP_078851 tumor necrosis factor alpha-induced protein 8-like protein 2 from Homo sapiens
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 247.8 bits

• Inflammatory cytokine TNF-α promotes corneal endothelium apoptosis via upregulating TIPE2 transcription during corneal graft rejection.
  Wang, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2018 (PubMed)
  • GeneRIF: Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.
• TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway.
  Wang, Molecular medicine reports 2018
  • GeneRIF: The results of the present study indicated that TIPE2 acts as an inhibitor of hepatocellular carcinoma cell growth and aggressiveness, and promotes apoptosis, thus suggesting that TIPE2 may inhibit the metastasisassociated PI3K/AKT signaling cascade and may arrest the tumor cell cycle.
• The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
  Kim, Scientific reports 2017
  • “...(mTIPE1), NP_001161414 for TIPE1 from Homo sapiens (hTIPE1), EDL38778 for mTIPE2 ( Mus musculus ), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3 from Homo sapiens (hTIPE3). Figure 4 Structural comparison of ( a ) mTnfaip8, (...”
• Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity.
  Zhao, Human immunology 2017 (PubMed)
  • GeneRIF: this study shows that TIPE2 contributes to the pathogenesis of ankylosing spondylitis
• Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells.
  Wang, Oncology research 2017 (PubMed)
  • GeneRIF: TIPE2 expression was significantly decreased in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion of breast cancer cells through preventing the epithelial-to-mesenchymal transition (EMT) phenotype.
• Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition.
  Yin, Cancer gene therapy 2017 (PubMed)
  • GeneRIF: data provided the first evidence that TIPE2 inhibits gastric cancer cell migration, invasion and metastasis very probably via reversal of EMT, revealing that TIPE2 may be a novel therapeutic target for human gastric cancer EMT and metastasis.
• TIPE2 Inhibits the Expression of Asthma-Related Inflammatory Factors in Hyperstretched Bronchial Epithelial Cells Through the Wnt/β-Catenin Pathway.
  Sun, Inflammation 2017 (PubMed)
  • GeneRIF: TIPE2 inhibited the expression of asthma-related inflammatory factors in hyperstretched BEAS-2B cells by suppressing the Wnt/beta-catenin signaling pathway.
• Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is associated with immune phases of patients with chronic hepatitis B.
  Fan, Oncotarget 2017
  • GeneRIF: TIPE2 might be associated with immune clearance of patients with chronic hepatitis B.
• More

NP_001014061 tumor necrosis factor alpha-induced protein 8-like protein 2 from Rattus norvegicus
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 247.6 bits

• Tumor necrosis factor‑α‑induced protein‑8 like 2 regulates lipopolysaccharide‑induced rat rheumatoid arthritis immune responses and is associated with Rac activation and interferon regulatory factor 3 phosphorylation.
  Shi, Molecular medicine reports 2017 (PubMed)
  • GeneRIF: TIPE2 regulates lipopolysaccharide-induced rat rheumatoid arthritis immune responses and is associated with Rac1 activation and IRF3 phosphorylation.
• Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression.
  Liu, International journal of molecular medicine 2016
  • GeneRIF: Expression of tumor necrosis factor (TNF)alphainduced protein 8-like 2 (TIPE2), matrix metalloproteinase-9 (MMP-9) and heme oxygenase-1 (HO-1) and mitogen-activated protein kinase (MAPK) signaling was modulated by Xuebijing injection (XBJ).

TP8L2_MOUSE / Q9D8Y7 Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2 from Mus musculus (Mouse) (see paper)
XP_006502103 tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1 from Mus musculus
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 244.2 bits

• function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
  subunit: May interact with CASP8; however, such result is unclear
  disruption phenotype: Multiorgan inflammation, splenomegaly and premature death. Mice are hypersensitive to septic shock.
• TIPE2 governs macrophage polarization via negative regulation of mTORC1.
  Jiang, Molecular medicine reports 2018
  • GeneRIF: TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea.
• TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells.
  Xu, Biochemical and biophysical research communications 2018 (PubMed)
  • GeneRIF: TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target.
• Inflammatory cytokine TNF-α promotes corneal endothelium apoptosis via upregulating TIPE2 transcription during corneal graft rejection.
  Wang, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2018 (PubMed)
  • GeneRIF: Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.
• Egress of murine regulatory T cells from the thymus requires TIPE2.
  Fan, Biochemical and biophysical research communications 2018 (PubMed)
  • GeneRIF: TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells.
• Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway.
  Liu, PloS one 2017
  • GeneRIF: Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages.
• Gene delivery of TIPE2 inhibits breast cancer development and metastasis via CD8+ T and NK cell-mediated antitumor responses.
  Zhang, Molecular immunology 2017 (PubMed)
  • GeneRIF: TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8(+) T and NK cell-mediated antitumor immune responses
• Nicotine induces TIPE2 upregulation and Stat3 phosphorylation contributes to cholinergic anti-inflammatory effect.
  Sui, International journal of oncology 2017 (PubMed)
  • GeneRIF: the enhancement of stat3 phosphorylation and decrease of LPS-induced p65 translocation were achieved by nicotine treatment..this study revealed that TIPE2 upregulation and stat3 phosphorylation contribute to nicotine-mediated anti-inflammation effect, indicating that TIPE2 and stat3 might be potential molecules for dealing with inflammation-associated diseases.
• Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
  Fayngerts, Nature immunology 2017
  • GeneRIF: The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis.
• More

TP8L1_MOUSE / Q8K288 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress regulated gene-beta; Oxy-beta from Mus musculus (Mouse) (see 3 papers)
NP_079842 tumor necrosis factor alpha-induced protein 8-like protein 1 from Mus musculus
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 242.8 bits

• function: Acts as a negative regulator of mTOR activity.
  subunit: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
• TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
  Zhang, Oncogene 2015 (PubMed)
  • GeneRIF: TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
• The expression of TIPE1 in murine tissues and human cell lines.
  Cui, Molecular immunology 2011 (PubMed)
  • GeneRIF: TIPE1(TNFAIP8-like 1)protein was detected in a variety of tissues such as neurons, brain, hepatocytes, germ cells of female and male reproductive organs, muscular tissues and cells of epithelial origin it was not expressed in mature T or B lymphocytes

XP_013852617 tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1 from Sus scrofa
Aligns to 19:197 / 199 (89.9%), covers 100.0% of PF05527, 242.0 bits

• Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene.
  Li, Molecular genetics and genomics : MGG 2010 (PubMed)
  • GeneRIF: Findings provide an important basis for further understanding of porcine TNFAIP8L2 regulation and function in swine.

TP8L1_HUMAN / Q8WVP5 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress-regulated gene-beta; Oxy-beta from Homo sapiens (Human) (see 2 papers)
NP_001161414 tumor necrosis factor alpha-induced protein 8-like protein 1 from Homo sapiens
XP_011525982 tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 from Homo sapiens
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 238.9 bits

• function: Acts as a negative regulator of mTOR activity.
  subunit: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.
• The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
  Kim, Scientific reports 2017
  • “...(mTnfaip8), AAH07014 for Tnfaip8 from Homo sapiens (hTnfaip8), BC032199.1 for TIPE1 from Mus musculus (mTIPE1), NP_001161414 for TIPE1 from Homo sapiens (hTIPE1), EDL38778 for mTIPE2 ( Mus musculus ), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3...”
• TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
  Zhang, Oncogene 2015 (PubMed)
  • GeneRIF: TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
• Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.
  Ha, Journal of neurochemistry 2014 (PubMed)
  • GeneRIF: oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2
• The expression of TIPE1 in murine tissues and human cell lines.
  Cui, Molecular immunology 2011 (PubMed)
  • GeneRIF: high levels of TIPE1 (TNFAIP8-like 1) mRNA were detected in most human carcinoma cell lines, especially in cells transformed with viral genomes

NP_001273746 tumor necrosis factor alpha-induced protein 8 isoform d from Homo sapiens
Aligns to 1:164 / 166 (98.8%), covers 90.1% of PF05527, 234.7 bits

• Two Genetic Variants Associated with Plantar Fascial Disorders.
  Kim, International journal of sports medicine 2018 (PubMed)
  • GeneRIF: The indel chr5:118704153:D, located within TNFAIP8, showed an association with plantar fascial disorders at genome-wide significance (p<5x10(-8)) with small effects (odds ratios=0.93 and 1.07 per allele, respectively).
• Tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus.
  Garcia, Veterinary and comparative oncology 2017 (PubMed)
  • GeneRIF: expression associated with cell survival and death in cancer cell lines infected with canine distemper virus
• Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
  Day, Methods in molecular biology (Clifton, N.J.) 2017 (PubMed)
  • GeneRIF: TNFAIP8 seems to regulate the cell survival and cancer progression processes in a multifaceted manner. (Review)
• The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.
  Lowe, Cell death and differentiation 2017
  • GeneRIF: TNFAIP8 v2 may contribute to both carcinogenesis and chemotherapeutic resistance by broadly suppressing p53 activity, thus offsetting p53-dependent tumor suppression.
• Overexpression of TNFAIP8 is associated with tumor aggressiveness and poor prognosis in patients with invasive ductal breast carcinoma.
  Xiao, Human pathology 2017 (PubMed)
  • GeneRIF: TNFAIP8 overexpression is correlated with axillary lymph node metastasis and poor prognosis in invasive ductal breast carcinoma.
• MicroRNA-9 inhibits the gastric cancer cell proliferation by targeting TNFAIP8.
  Gao, Cell proliferation 2017 (PubMed)
  • GeneRIF: that MicroRNA-9-TNFAIP8 might represent a promising diagnostic biomarker for gastric cancer patients and could be a potential therapeutic target in the prevention and treatment of gastric cancer
• TNFAIP8 interacts with LATS1 and promotes aggressiveness through regulation of Hippo pathway in hepatocellular carcinoma.
  Dong, Oncotarget 2017
  • GeneRIF: TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
• TNFAIP8 overexpression: a potential predictor of lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.
  Sun, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 (PubMed)
  • GeneRIF: these findings suggest that TNFAIP8 overexpression is a potential biomarker to identify pN0 esophageal squamous cell carcinoma patients at higher risk of lymphatic recurrence who may benefit from adjuvant therapy.
• More

XP_016877658 tumor necrosis factor alpha-induced protein 8-like protein 3 isoform X3 from Homo sapiens
Aligns to 1:156 / 158 (98.7%), covers 85.6% of PF05527, 221.4 bits

• TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location.
  Wang, BMC cancer 2018
  • GeneRIF: High TIPE3 expression in the plasma membrane is associated with non-small-cell lung cancer.
• TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways.
  Lian, Oncotarget 2017
  • GeneRIF: TIPE3 protein was upregulated in breast cancer tissues and positively correlated to invasion and metastasis of human breast cancer cells by activating AKT and NF-kappaB signaling pathways.
• Molecular insights into the binding of phosphoinositides to the TH domain region of TIPE proteins.
  Antony, Journal of molecular modeling 2016 (PubMed)
  • GeneRIF: Further MD simulations confirmed the dynamic stability of these lipids in the TH domain. This computational analysis thus provides insight into the binding mode of phospholipids in the TH domain of the TIPE family of proteins.
• Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.
  Cui, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015
  • GeneRIF: TIPE3 protein is highly expressed in most human carcinoma cell lines. These results suggest that TIPE3 may play important roles in carcinogenesis and cell secretion.
• TIPE3 is the transfer protein of lipid second messengers that promote cancer.
  Fayngerts, Cancer cell 2014
  • GeneRIF: human cancers have markedly upregulated TIPE3 expression. Knocking out TIPE3 diminishes tumorigenesis, whereas enforced TIPE3 expression enhances it in vivo