Family Search for PF05527 (DUF758)
PF05527.11 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
TFIP8_HUMAN / O95379 Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 from Homo sapiens (Human) (see 4 papers)
NP_055165 tumor necrosis factor alpha-induced protein 8 isoform a from Homo sapiens
Aligns to 16:196 / 198 (91.4%), covers 99.4% of PF05527, 265.2 bits
XP_006254771 tumor necrosis factor alpha-induced protein 8 isoform X3 from Rattus norvegicus
Aligns to 6:186 / 188 (96.3%), covers 99.4% of PF05527, 262.9 bits
NP_001171230 tumor necrosis factor alpha-induced protein 8 isoform 2 from Mus musculus
Aligns to 6:186 / 188 (96.3%), covers 99.4% of PF05527, 261.6 bits
- Effect of tumor necrosis factor-α-induced protein 8 on the immune response of CD4+ T lymphocytes in mice following acute insult.
Yu, Molecular medicine reports 2018 (PubMed)- GeneRIF: TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice.
- TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells.
Liu, Oncology reports 2018 (PubMed)- GeneRIF: Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation.
- Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection.
Porturas, Journal of immunology (Baltimore, Md. : 1950) 2015 - GeneRIF: TNFAIP8 regulates RAC1 signaling during TNF-alphaR activation and L. monocytogenes invasion of cells and that this regulation is crucial for controlling cell death and lethal L. mono-cytogenes infection of mice.
- Exacerbated experimental colitis in TNFAIP8-deficient mice.
Sun, Journal of immunology (Baltimore, Md. : 1950) 2015 - GeneRIF: TIPE plays an important role in maintaining colon homeostasis and in protecting against colitis.
- A preliminary X-ray study of murine Tnfaip8/Oxi-α.
Lee, International journal of molecular sciences 2014 - GeneRIF: Data indicate that mutant Tnfaip8/Oxi-alpha has been crystallized and X-ray data have been collected to 1.8 A using synchrotron radiation.
- Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.
Woodward, Cell death and differentiation 2010 (PubMed)- GeneRIF: Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes
- TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.
Laliberté, Journal of cellular physiology 2010 - GeneRIF: Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation.
- Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
Ahn, PLoS pathogens 2010 - GeneRIF: Tnfaip8 expression is associated with susceptibility to Staphylococcus aureus sepsis.
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Q921Z5 Tumor necrosis factor alpha-induced protein 8 from Mus musculus
Aligns to 16:196 / 198 (91.4%), covers 99.4% of PF05527, 261.3 bits
- A preliminary X-ray study of murine Tnfaip8/Oxi-α.
Lee, International journal of molecular sciences 2014 - “...forward strand and 5-GTTCTTCTCCTTTGCGCCCCTACAGCTGGCCGAACAGCCAAC-3 for the reverse strand. The gene harboring murine Tnfaip8/Oxi- (UniProt ID: Q921Z5) was amplified by PCR using 80 ng of the plasmid-cDNA [ 3 ] and 50 M of primers with Deep Vent Polymerase (New England Biolabs, Inc., Beverly, MA, USA). The...”
TP8L3_HUMAN / Q5GJ75 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Homo sapiens (Human) (see 2 papers)
NP_997264 tumor necrosis factor alpha-induced protein 8-like protein 3 isoform 1 from Homo sapiens
Aligns to 110:290 / 292 (62.0%), covers 99.4% of PF05527, 258.7 bits
- function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
- The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Kim, Scientific reports 2017 - “...), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3 from Homo sapiens (hTIPE3). Figure 4 Structural comparison of ( a ) mTnfaip8, ( b ) hTIPE2 and ( c ) hTIPE3. The surface of the protein is...”
- The genomic environment around the Aromatase gene: evolutionary insights
Castro, BMC evolutionary biology 2005 - “...Fr Fugu rubripes ; Tn Tetraodon nigroviridis . SSC-S2 The ORF identified in Ensembl as NP_997264 (FLJ41287 protein), presents significant sequence similarity to three other GenBank entries. One of those is a novel tumor necrosis factor- inducible gene, SSC-S2 [ 25 ], which maps to HSA5....”
- “...(figure 2 ). These are annotated as follows: AP4-E1 [GenBank: NP_031373 ], FLJ41287 (SSC-2SC) [GenBank: NP_997264 ], Collomin [GenBank: NP_861454 ], DMXL2 [GenBank: NP_056078 ], SCGIII [GenBank: NP_037375 ], MGC35274 [GenBank: NP_699205 ], TMOD2 [GenBank: NP_055363 ], and TMOD3 [GenBank: NP_055362 ] (figure 2 ). In...”
- Ulcerative colitis: functional analysis of the in-depth proteome.
Schniers, Clinical proteomics 2019 - “...Sulfate transporter SLC26A2 P50443 18.52 0.26 Tumor necrosis factor alpha-induced protein 8-like protein 3 TNFAIP8L3 Q5GJ75 5.42 0.29 Carbonic anhydrase 2 HEL-76;CA2 V9HW21 12.09 0.30 Selenium-binding protein 1 HEL-S-134P;SELENBP1 V9HWG1 15.36 0.33 cAMP-dependent protein kinase inhibitor beta PKIB Q5T0Z6 7.57 0.34 Chloride anion exchanger SLC26A3;DKFZp686P10213 P40879...”
TP8L3_MOUSE / Q3TBL6 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Mus musculus (Mouse) (see 2 papers)
NP_001028707 tumor necrosis factor alpha-induced protein 8-like protein 3 from Mus musculus
Aligns to 22:202 / 204 (88.7%), covers 99.4% of PF05527, 252.0 bits
- function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
disruption phenotype: Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3-methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice. - The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Kim, Scientific reports 2017 - “...(hTIPE1), EDL38778 for mTIPE2 ( Mus musculus ), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3 from Homo sapiens (hTIPE3). Figure 4 Structural comparison of ( a ) mTnfaip8, ( b ) hTIPE2 and ( c )...”
- Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.
Cui, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015 - GeneRIF: Tnfaip8l3 expression was almost identical in most organs from human and mice. Tnfaip8l3 is a cytoplasmic protein expressed preferentially in epithelial-derived cells with secretory functions.
NP_078851 tumor necrosis factor alpha-induced protein 8-like protein 2 from Homo sapiens
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 247.8 bits
- TIPE2 suppressed cisplatin resistance by inducing autophagy via mTOR signalling pathway.
Guo, Experimental and molecular pathology 2020 (PubMed)- GeneRIF: aberrant TIPE2 expression may contribute to the occurrence of chemoresistance by interfering with autophagy in non-small-cell lung cancer in an mTOR-dependent manner.
- Reduced TIPE2 expression is inversely associated with proinflammatory cytokines and positively correlated with bone mineral density in patients with osteoporosis.
Jiang, Life sciences 2019 (PubMed)- GeneRIF: Reduced TIPE2 expression is inversely associated with proinflammatory cytokines and positively correlated with bone mineral density in patients with osteoporosis
- TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.
Gao, Human molecular genetics 2019 (PubMed)- GeneRIF: our results indicate that a reduction of TIPE2 expression is observed in dystrophic skeletal muscle, when compared to WT and more importantly that TIPE2 gene delivery may provide as a novel anti-inflammatory therapy to alleviate the muscle weakness in DMD patients.
- Tumour necrosis factor-α-induced protein 8-like 2 is a novel regulator of proliferation, migration, and invasion in human rectal adenocarcinoma cells.
Wu, Journal of cellular and molecular medicine 2019 - GeneRIF: High TIPE2 expression is associated with proliferation, migration, and invasion in rectal adenocarcinoma.
- TIPE2 in dendritic cells inhibits the induction of pTregs in the gut mucosa.
Liu, Biochemical and biophysical research communications 2019 (PubMed)- GeneRIF: in addition to acting as a negative regulator of pathogen-induced immune response, TIPE2 in DCs is also capable of promoting immune response under homeostatic condition through the suppression of peripheral tolerance.
- TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway.
Zhu, Journal of translational medicine 2018 - GeneRIF: TIPE2 suppressed progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/beta-catenin pathway.
- Inflammatory cytokine TNF-α promotes corneal endothelium apoptosis via upregulating TIPE2 transcription during corneal graft rejection.
Wang, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2018 (PubMed)- GeneRIF: Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.
- TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway.
Wang, Molecular medicine reports 2018 - GeneRIF: The results of the present study indicated that TIPE2 acts as an inhibitor of hepatocellular carcinoma cell growth and aggressiveness, and promotes apoptosis, thus suggesting that TIPE2 may inhibit the metastasisassociated PI3K/AKT signaling cascade and may arrest the tumor cell cycle.
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NP_001014061 tumor necrosis factor alpha-induced protein 8-like protein 2 from Rattus norvegicus
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 247.6 bits
TP8L2_MOUSE / Q9D8Y7 Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2 from Mus musculus (Mouse) (see paper)
XP_006502103 tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1 from Mus musculus
NP_081482 tumor necrosis factor alpha-induced protein 8-like protein 2 from Mus musculus
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 244.2 bits
- function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
subunit: May interact with CASP8; however, such result is unclear
disruption phenotype: Multiorgan inflammation, splenomegaly and premature death. Mice are hypersensitive to septic shock. - TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.
Gao, Human molecular genetics 2019 (PubMed)- GeneRIF: our results indicate that a reduction of TIPE2 expression is observed in dystrophic skeletal muscle, when compared to WT and more importantly that TIPE2 gene delivery may provide as a novel anti-inflammatory therapy to alleviate the muscle weakness in DMD patients.
- TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells.
Wang, The Journal of infectious diseases 2019 (PubMed)- GeneRIF: TIPE2 promoted host resistance to Pseudomonas aeruginosa Keratitis by suppressing corneal inflammation via regulating TAK1 signaling negatively and inhibiting the infiltration of inflammatory cells.
- TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury.
Wu, Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019 - GeneRIF: Our study shows that the increased expression of AAV-mediated TIPE2 in the lungs of mice inhibits acute inflammation and apoptosis and suppresses the activation of NF-kappaB and JNK in a murine model of acute lung injury (ALI). Our results indicate that TIPE2 might be useful as a potential therapeutic target for sepsis-induced ALI.
- Tumor Necrosis Factor-α-Induced Protein 8-like 2 Downregulation Reduces CD4⁺ T Lymphocyte Apoptosis in Mice with Thermal Injury.
Huang, Medical science monitor : international medical journal of experimental and clinical research 2019 - GeneRIF: Downregulation of TIPE2 in vivo can reduce the apoptosis of CD4 T lymphocytes following thermal damage, and activate the TGFss downstream signaling of Smad2/Smad3, upregulating Bim, and downregulating Bcl-2.
- TIPE2 governs macrophage polarization via negative regulation of mTORC1.
Jiang, Molecular medicine reports 2018 - GeneRIF: TIPE2 serves an important role in orchestrating the differential polarization status of macrophages, via negative regulation of mTORC1 activation and accelerated conversion of arginine to urea.
- TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells.
Xu, Biochemical and biophysical research communications 2018 (PubMed)- GeneRIF: TIPE-2 held a protective effect on liver fibrosis and could be a potential therapeutic target.
- Inflammatory cytokine TNF-α promotes corneal endothelium apoptosis via upregulating TIPE2 transcription during corneal graft rejection.
Wang, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2018 (PubMed)- GeneRIF: Our study identifies the molecular mechanisms underlying the interplay of TNF-alpha, TIPE2, and apoptosis during allograft rejection, and it suggests that both TNF-alpha and TIPE2 might be potential targets for the successfully grafted corneal endothelium.
- Egress of murine regulatory T cells from the thymus requires TIPE2.
Fan, Biochemical and biophysical research communications 2018 (PubMed)- GeneRIF: TIPE2 enhances the cytoskeleton remodeling and promotes the thymus egress of Regulatory T cells.
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- The genomic environment around the Aromatase gene: evolutionary insights
Castro, BMC evolutionary biology 2005 - “...H. sapiens ENSMUSP00000034810 M. musculus ENSGALP00000007631 G. gallus ENSXETP00000044865 X. tropicalis B NP_078851 H. sapiens NP_081482 M. musculus ENSXETP00000017843 X. tropicalis SINFRUP00000149825 F. rubripes GSTENT00011674001 T. nigroviridis C NP_997264 H. sapiens ENSMUSP00000034810 M. musculus ENSGALP00000007631 G. gallus ENSXETP00000044865 X. tropicalis SINFRUT00000165316 annotated as pseudogene F. rubripes...”
TP8L1_MOUSE / Q8K288 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress regulated gene-beta; Oxy-beta from Mus musculus (Mouse) (see 3 papers)
NP_079842 tumor necrosis factor alpha-induced protein 8-like protein 1 from Mus musculus
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 242.8 bits
XP_013852617 tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1 from Sus scrofa
Aligns to 19:197 / 199 (89.9%), covers 100.0% of PF05527, 242.0 bits
TP8L1_HUMAN / Q8WVP5 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress-regulated gene-beta; Oxy-beta from Homo sapiens (Human) (see 2 papers)
NP_001161414 tumor necrosis factor alpha-induced protein 8-like protein 1 from Homo sapiens
NP_689575 tumor necrosis factor alpha-induced protein 8-like protein 1 from Homo sapiens
XP_011525982 tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1 from Homo sapiens
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 238.9 bits
- function: Acts as a negative regulator of mTOR activity.
subunit: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination. - In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.
Durrant, Blood advances 2017 - “...O95379 TNFAIP8 Tumor necrosis factor induced protein 8 1.12e+6 0.9 4.0 1 1 2 No Q8WVP5 TNFAIP8L1 Tumor necrosis factor induced protein 8like protein 1/TIPE1 3.18e+5 4.1 14.3 2 2 2 No Q9BPZ7 MAPKAP1 Target of rapamycin complex 2 subunit MAPKAP1/SIN1 2.93e+5 0.9 2.1 1 1...”
- The Tnfaip8-PE complex is a novel upstream effector in the anti-autophagic action of insulin
Kim, Scientific reports 2017 - “...(mTnfaip8), AAH07014 for Tnfaip8 from Homo sapiens (hTnfaip8), BC032199.1 for TIPE1 from Mus musculus (mTIPE1), NP_001161414 for TIPE1 from Homo sapiens (hTIPE1), EDL38778 for mTIPE2 ( Mus musculus ), NP_078851 for TIPE2 from Homo sapiens (hTIPE2), NP_001028707 for TIPE3 from Mus musculus (mTIPE3), NP_997264 for TIPE3...”
- The genomic environment around the Aromatase gene: evolutionary insights
Castro, BMC evolutionary biology 2005 - “...G. gallus ENSXETP00000044865 X. tropicalis SINFRUT00000165316 annotated as pseudogene F. rubripes GSTENT00018057001 T. nigroviridis D NP_689575 H. sapiens ENSMUSP00000076961 M. musculus ENSGALP00000006772 G. gallus SINFRUP00000156999 F. rubripes GSTENT00028868001 T. nigroviridis Colmedin CG6867 NP_573262 D. melanogaster COF-2 AY494975 C. elegans unc-122 AY494976 C. elegans COL1 NP_861454 H....”
- TIPE1 accelerates atherogenesis by inducing endothelial dysfunction in response to oxidative stress.
Shao, Biochimica et biophysica acta. Molecular basis of disease 2020 (PubMed)- GeneRIF: Excessive ROS induced by the overexpression of TIPE1 in endothelial cells accelerated the process of atherogenesis.
- TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration.
Chen, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2019 (PubMed)- GeneRIF: our results demonstrate the anti-tumor role of TIPE1 in osteosarcoma
- TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome.
Zhao, Carcinogenesis 2019 (PubMed)- GeneRIF: High TIPE1 expression is associated with repression of p53 acetylation and cervical cancer.
- TIPE1 suppresses the invasion and migration of breast cancer cells and inhibits epithelial-to-mesenchymal transition primarily via the ERK signaling pathway.
Qiu, Acta biochimica et biophysica Sinica 2019 (PubMed)- GeneRIF: These results suggested that TIPE1 might suppress the invasion and migration of breast cancer cells and inhibit epithelial-to-mesenchymal transition primarily via the ERK signaling pathway.
- TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer.
Liu, Journal of cellular and molecular medicine 2018 - GeneRIF: the levels of TIPE1 were significantly reduced and inversely correlated with differentiation status and distant metastasis in primary gastric cancer tissues.
- TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.
Zhang, Oncogene 2015 (PubMed)- GeneRIF: TIPE1 induced apoptosis in HCC cells by negatively regulating Rac1 pathway
- Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.
Ha, Journal of neurochemistry 2014 (PubMed)- GeneRIF: oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2
- The expression of TIPE1 in murine tissues and human cell lines.
Cui, Molecular immunology 2011 (PubMed)- GeneRIF: high levels of TIPE1 (TNFAIP8-like 1) mRNA were detected in most human carcinoma cell lines, especially in cells transformed with viral genomes
NP_001273746 tumor necrosis factor alpha-induced protein 8 isoform d from Homo sapiens
Aligns to 1:164 / 166 (98.8%), covers 90.1% of PF05527, 234.7 bits
- SCC-S2 Facilitates Tumor Proliferation and Invasion via Activating Wnt Signaling and Depressing Hippo Signaling in Colorectal Cancer Cells and Predicts Poor Prognosis of Patients.
Yang, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2019 - GeneRIF: SCC-S2 Facilitates Tumor Proliferation and Invasion via Activating Wnt Signaling and Depressing Hippo Signaling in Colorectal Cancer Cells and Predicts Poor Prognosis of Patients
- TNFAIP8 regulates Hippo pathway through interacting with LATS1 to promote cell proliferation and invasion in lung cancer.
Han, Molecular carcinogenesis 2018 (PubMed)- GeneRIF: TNFAIP8 regulates Hippo pathway through interacting with LATS1 to promote cell proliferation.
- Two Genetic Variants Associated with Plantar Fascial Disorders.
Kim, International journal of sports medicine 2018 (PubMed)- GeneRIF: The indel chr5:118704153:D, located within TNFAIP8, showed an association with plantar fascial disorders at genome-wide significance (p<5x10(-8)) with small effects (odds ratios=0.93 and 1.07 per allele, respectively).
- TNFAIP8 promotes the proliferation and cisplatin chemoresistance of non-small cell lung cancer through MDM2/p53 pathway.
Xing, Cell communication and signaling : CCS 2018 - GeneRIF: role of TNFAIP8 in NSCLC proliferation and cisplatin chemoresistance that is mediated through the MDM2/p53 pathway
- Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8).
Niture, Cells 2018 - GeneRIF: this review focused on the expression, regulation, structural aspects, modifications/interactions, and oncogenic role of TNFAIP8 proteins in human cancers. [Review]
- Tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus.
Garcia, Veterinary and comparative oncology 2017 (PubMed)- GeneRIF: expression associated with cell survival and death in cancer cell lines infected with canine distemper virus
- Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression.
Day, Methods in molecular biology (Clifton, N.J.) 2017 (PubMed)- GeneRIF: TNFAIP8 seems to regulate the cell survival and cancer progression processes in a multifaceted manner. (Review)
- The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.
Lowe, Cell death and differentiation 2017 - GeneRIF: TNFAIP8 v2 may contribute to both carcinogenesis and chemotherapeutic resistance by broadly suppressing p53 activity, thus offsetting p53-dependent tumor suppression.
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Q55BQ2 PH domain-containing protein from Dictyostelium discoideum
Aligns to 123:305 / 310 (59.0%), covers 96.1% of PF05527, 124.0 bits
Or search for genetic data about PF05527 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory