Family Search for PF05600 (DUF773)

PF05600.12 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

CK5P3_MOUSE / Q99LM2 CDK5 regulatory subunit-associated protein 3 from Mus musculus (Mouse) (see paper)
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 640.0 bits

• function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2- dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1.
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2. Interacts with RELA. Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis. Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:21494687). Interacts with DDRGK1. Interacts with MAPK14. Interacts with CCNB1. Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).

CK5P3_HUMAN / Q96JB5 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; Protein HSF-27 from Homo sapiens (Human) (see 14 papers)
Aligns to 4:503 / 506 (98.8%), covers 99.8% of PF05600, 635.2 bits

• function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
  function: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).
  subunit: (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry.

XP_011523599 CDK5 regulatory subunit-associated protein 3 isoform X1 from Homo sapiens
Aligns to 29:528 / 531 (94.2%), covers 99.8% of PF05600, 634.9 bits

• Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
  Lin, World journal of gastroenterology 2018
  • GeneRIF: Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients.
• CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
  Wang, Cancer letters 2017 (PubMed)
  • GeneRIF: CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms.
• Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope.
  Wu, Cell research 2013
  • GeneRIF: C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture.
• Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
  Hořejší, Journal of cellular physiology 2012 (PubMed)
  • GeneRIF: Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage
• Interaction of LHBs with C53 promotes hepatocyte mitotic entry: A novel mechanism for HBV-induced hepatocellular carcinoma.
  Lei, Oncology reports 2012 (PubMed)
  • GeneRIF: our results strongly suggest that the binding of hepatitis viral pre-S2 LHBs with C53 is a novel negative regulator of the checkpoint response
• CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.
  Mak, PloS one 2012
  • GeneRIF: our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF).
• LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
  An, PloS one 2011
  • GeneRIF: the ability of LZAP to alter p38 phosphorylation depended, at least partially, on the p38 phosphatase, Wip1
• Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.
  Mak, Cancer research 2011 (PubMed)
  • GeneRIF: Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation.
• More

CK5P3_RAT / Q9JLH7 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53 from Rattus norvegicus (Rat) (see 2 papers)
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 630.5 bits

• function: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2- dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1.
  subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:10721722). Interacts with RELA. Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis. Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53. Interacts with UFL1; the interaction is direct. Interacts with DDRGK1. Interacts with MAPK14. Interacts with CCNB1. Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).

NP_001295112 CDK5 regulatory subunit-associated protein 3 isoform 2 from Mus musculus
Aligns to 1:389 / 392 (99.2%), covers 78.3% of PF05600, 433.3 bits

• Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53.
  Yin, International journal of molecular medicine 2005 (PubMed)
  • GeneRIF: Results suggest that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development.

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