Family Search for PF05600 (DUF773)
PF05600.12 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
F1RWH6 CDK5 regulatory subunit-associated protein 3 isoform b from Sus scrofa
Aligns to 4:502 / 505 (98.8%), covers 99.8% of PF05600, 652.4 bits
CK5P3_MOUSE / Q99LM2 CDK5 regulatory subunit-associated protein 3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 640.0 bits
- function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (By similarity). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (By similarity). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (By similarity). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (By similarity). May also play a role in the rupture of the nuclear envelope during apoptosis (By similarity). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (PubMed:30635284).
subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (By similarity). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:21494687, PubMed:30635284). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity).
disruption phenotype: Prenatal lethality, probably caused by severe liver hypoplasia (PubMed:30635284). E16.5 mutant embryos also show defects in definitive erythropoiesis (PubMed:30635284). Conditional knockout mice lacking Cdk5rap3 in hepatocytes causes lethality after weaning -specific Cdk5rap3 display liver hypoplasia and die after weaning (PubMed:30635284). - Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
Lemaire, PloS one 2011 - “...5.2 E1 enzyme of UFM1 (Komatsu et al, 2004) CDK5RAP3; CDK5 regulatory subunit-associated protein 3 Q99LM2 57 4 3 6.4 tumor suppressor (Wang et al, 2007); substrate of Ufm1 (this paper) 7 HSPA5/BiP; 78 kDa glucose-regulated protein precursor P20029 72 3 3 4.7 ER stress, chaperone...”
NP_001002105 CDK5 regulatory subunit-associated protein 3 from Danio rerio
Aligns to 4:504 / 507 (98.8%), covers 99.8% of PF05600, 638.7 bits
- Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly
Liu, Developmental dynamics : an official publication of the American Association of Anatomists 2011 - “...al., 1995 ). Cloning of Zebrafish lzap cDNA and Sequence Analysis A zebrafish Lzap ortholog (NP_001002105) was identified by NCBI Blink search using the sequence of the mouse Lzap ortholog (NP_084524.1). Total RNA was isolated from 1-cell to 120 hours post fertilization (hpf) wild-type embryos in...”
- “...the Clustal W algorithm. Hs, Homo sapiens (NP_788276.1); Mm, Mus musculus (NP_084524.1); Dr, Danio rerio (NP_001002105.1). () identical; () conserved; (:) semi-conserved. C: Pairwise comparison of amino acid conservation between human (H. sapiens), mouse (M. musculus), and zebrafish (D. rerio) Lzap. Fig. 2 lzap is Expressed...”
Q3U506 Uncharacterized protein from Mus musculus
Aligns to 4:500 / 503 (98.8%), covers 99.8% of PF05600, 638.4 bits
NP_077814 CDK5 regulatory subunit-associated protein 3 from Rattus norvegicus
Q642E3 CDK5 regulatory subunit associated protein 3, isoform CRA_b from Rattus norvegicus
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 636.1 bits
CK5P3_HUMAN / Q96JB5 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein; Protein HSF-27 from Homo sapiens (Human) (see 15 papers)
Aligns to 4:503 / 506 (98.8%), covers 99.8% of PF05600, 635.2 bits
- function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (PubMed:23152784, PubMed:30635284). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). Required for liver development (By similarity).
function: (Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:12737517). Interacts with RELA (PubMed:17785205). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (PubMed:19223857). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (PubMed:16173922). Interacts with UFL1; the interaction is direct (PubMed:20164180, PubMed:20228063). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Interacts with DDRGK1 (PubMed:20228063). Interacts with MAPK14 (PubMed:21283629). Interacts with CCNB1 (PubMed:15790566). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (PubMed:21465471).
subunit: (Microbial infection) Interacts with hepatitis B virus large envelope protein mutant pre-s2; promotes mitotic entry. - Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer
Bouchal, Molecular & cellular proteomics : MCP 2015 - “...N1-2/N0 Q96JY6 G1: N1-2/N0 G1: N1-2/N0 G3: N1-2/N0 P63313 Q96JB5 G1: N1-2/N0 Q04206 Q9NZT2 G1: N1-2/N0 G1: N1-2/N0 Q9Y592 G1: N1-2/N0 G1: N1-2/N0 P31947 Q96BH1...”
- A proteomic study of potential VEGF-C-associated proteins in bladder cancer T24 cells.
Zhang, Medical science monitor : international medical journal of experimental and clinical research 2012 - “...No. Protein Accession * Protein MW(Da) PI Sequence coverage (%) Score Ratio ** Functions 662 Q96JB5 Isoform 2 of CDK5 regulatory subunit-associated protein 3 46664 4.56 5 71 1.62 Involved in cell proliferation 683 P02545 Isoform ADelta 10 of Lamin-A/C 70903 8.55 32 188 1.69 Structural...”
XP_011523599 CDK5 regulatory subunit-associated protein 3 isoform X1 from Homo sapiens
Aligns to 29:528 / 531 (94.2%), covers 99.8% of PF05600, 634.9 bits
- Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.
Lin, Oncology reports 2019 - GeneRIF: Study demonstrated that CDK5RAP3/C53 isoform d (IC53d) was upregulated in gastric cancer tissues and was associated with tumor Tstage. Furthermore, overexpression of IC53d promoted the proliferation, colony formation and G1/S phase transition of gastric cancer cells, leading to enhancement of tumorigenesis in vitro and in vivo.
- C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
Chen, Journal of molecular and cellular cardiology 2019 - GeneRIF: The current findings advance innovation in drug discovery and highlight C53 as a novel pGC-B activator with sustained in vivo activity and anti-fibrotic actions in vitro.
- CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer.
Li, Disease markers 2019 - GeneRIF: CDK5RAP3 is associated with autophagy and down-regulated in renal cancer.
- CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer.
Zheng, Journal of experimental & clinical cancer research : CR 2018 - GeneRIF: Our results demonstrated that CDK5RAP3 negatively regulates the Wnt/beta-catenin signaling pathway by repressing AKT phosphorylation, which leads to better survival of patients with gastric cancer.
- Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Lin, World journal of gastroenterology 2018 - GeneRIF: Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients.
- CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.
Wang, Cancer letters 2017 (PubMed)- GeneRIF: CDK5RAP3 negatively regulates the beta-catenin signaling pathway by repressing GSK-3beta phosphorylation in gastric neoplasms.
- Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope.
Wu, Cell research 2013 - GeneRIF: C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture.
- Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.
Hořejší, Journal of cellular physiology 2012 (PubMed)- GeneRIF: Nuclear gamma-tubulin interacts with tumor suppressor protein C53 that is involved in regulation of DNA damage
- More
CK5P3_RAT / Q9JLH7 CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53 from Rattus norvegicus (Rat) (see 3 papers)
Aligns to 4:501 / 504 (98.8%), covers 99.8% of PF05600, 630.5 bits
- function: Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, in response to endoplasmic reticulum stress (By similarity). Negatively regulates NF- kappa-B-mediated gene transcription through the control of RELA phosphorylation. Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May also play a role in the rupture of the nuclear envelope during apoptosis. May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (By similarity). Required for liver development (By similarity).
subunit: Interacts with CDK5R1; competes with CDK5RAP1 and CDK5RAP2 (PubMed:10721722). Interacts with RELA (By similarity). Interacts with CHEK1; may negatively regulate CHEK1 and thereby stimulate entry into mitosis (By similarity). Interacts with CDKN2A/ARF and MDM2; forms a ternary complex involved in regulation of p53/TP53 (By similarity). Interacts with UFL1; the interaction is direct (PubMed:20531390). Interaction with UFL1 anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (PubMed:20531390). Interacts with DDRGK1 (By similarity). Interacts with MAPK14 (By similarity). Interacts with CCNB1 (By similarity). Interacts with TUBG1; may regulate CDK5RAP3 in mitotic G2/M transition checkpoint (By similarity). - Acupuncture as a multifunctional neuroprotective therapy ameliorates cognitive impairment in a rat model of vascular dementia: A quantitative iTRAQ proteomics study.
Yang, CNS neuroscience & therapeutics 2018
NP_001295112 CDK5 regulatory subunit-associated protein 3 isoform 2 from Mus musculus
Aligns to 1:389 / 392 (99.2%), covers 78.3% of PF05600, 433.3 bits
Smp_127510 putative myosin XV from Schistosoma mansoni
Aligns to 2040:2325 / 2339 (12.2%), covers 43.3% of PF05600, 90.9 bits
Or search for genetic data about PF05600 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory