Family Search for PF05608 (DUF778)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF05608 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

RTE1_ARATH / F4ITL6 Protein REVERSION-TO-ETHYLENE SENSITIVITY1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
NP_180177 protein REVERSION-TO-ETHYLENE SENSITIVITY-like protein (DUF778) from Arabidopsis thaliana
AT2G26070 RTE1 (REVERSION-TO-ETHYLENE SENSITIVITY1) from Arabidopsis thaliana
Aligns to 60:195 / 250 (54.4%), covers 100.0% of PF05608, 216.4 bits

• function: Acts at an early step in the ethylene signaling pathway. Positively regulates ETR1, leading to the negative regulation of ethylene responses.
  subunit: Interacts with ETR1 through a region corresponding to its ethylene-binding domain.
  disruption phenotype: Enhanced ethylene sensitivity.
• Molecular association of Arabidopsis RTH with its homolog RTE1 in regulating ethylene signaling.
  Zheng, Journal of experimental botany 2017
  • GeneRIF: the regulatory function of Arabidopsis RTH via its homolog RTE1 in the ethylene signaling pathway
• HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis.
  Xu, PLoS genetics 2015
  • GeneRIF: Gene expression involved in ethylene signaling suppression was not reduced by the hpr1-5 mutation, which indicates selectivity of HPR1 for RTE1 expression affecting the consequent ethylene response.
• Association of cytochrome b5 with ETR1 ethylene receptor signaling through RTE1 in Arabidopsis.
  Chang, The Plant journal : for cell and molecular biology 2014
  • GeneRIF: Cb5 and RTE1 are functional partners in promoting ETR1-mediated repression of ethylene signaling.
• Arabidopsis RTE1 is essential to ethylene receptor ETR1 amino-terminal signaling independent of CTR1.
  Qiu, Plant physiology 2012
  • GeneRIF: The roles of CTR1 and RTE1 in ETR1 N-terminal signaling, were evaluated.
• Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1.
  Dong, The Journal of biological chemistry 2010
  • GeneRIF: a high affinity association of RTE1 and ETR1 is important in the regulation of ETR1.
• ETR1-specific mutations distinguish ETR1 from other Arabidopsis ethylene receptors as revealed by genetic interaction with RTE1.
  Rivarola, Plant physiology 2009
  • GeneRIF: Dominant etr1 mutations that require RTE1 to confer ethylene insensitivity are essentially silent when transferred to the identical conserved postitions in other ethylene receptor genes.
• Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a regulatory role for RTE1 in ETR1 ethylene signaling.
  Dong, The Plant journal : for cell and molecular biology 2008
  • GeneRIF: we demonstrated the subcellular co-localization of RTE1 and ETR1. These findings support and enhance the genetic model that RTE1 plays a role in regulating ETR1.
• Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis.
  Resnick, The Plant journal : for cell and molecular biology 2008
  • GeneRIF: RTE1 targets the ethylene-binding domain of ETR1 and positively regulates the ethylene receptor, independent of RAN1 activity.
• More
• High-resolution imaging as a tool for identifying quantitative trait loci that regulate photomorphogenesis in Arabidopsis thaliana
  Deslauriers, AoB PLANTS 2021
  • “...seedling growth ( Hsia and Callis 2010 ); skotomorphogenesis ( Clouse and Sasse 1998 ) AT2G26070 (RTE1) Regulation of ethylene responses ( Zhou et al. 2007 ) AT2G26330 (Erecta) Auxin-dependent cell elongation ( Woodward et al. 2005 ); hypocotyl growth in darkness and blue light (...”
• Genome-Wide Identification and Analysis of the Cytochrome B5 Protein Family in Chinese Cabbage (Brassica rapa L. ssp. Pekinensis)
  Zheng, International journal of genomics 2019
  • “...Bra035720 AT4G32360, NADP adrenodoxin-like ferredoxin reductase Bra023065 AT3G16340, PDR1; ATPase Bra017241 AT2G36380, PDR6; ATPase Bra007769 AT2G26070, RTE1 (Reversion-to-Ethylene Sensitivity1) Bra026434 AT4G26455, WIP1 (WPP-Domain Interacting Protein 1) Bra013361 AT4G18910, NIP1, 2 (NOD26-Like Intrinsic Protein 1, 2) Bra012567 Bra038838 AT2G19080, metaxin-related Bra038562 Bra038877 AT3G51040, RTH (RTE1-Homolog) Bra009383 AT5G09420,...”
• Light Modulates Ethylene Synthesis, Signaling, and Downstream Transcriptional Networks to Control Plant Development
  Harkey, Frontiers in plant science 2019
  • “...(SAUR76) 3.61 2.61 2.75 2.99 YES AT2G19590 ACC OXIDASE 1 (ACO1) 2.67 2.23 3.28 2.73 AT2G26070 REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1) 3.00 1.09 2.92 2.33 YES AT3G23150 ETHYLENE RESPONSE 2 (ETR2) 2.21 1.80 2.79 2.27 YES YES AT3G25730 ETHYLENE RESPONSE DNA BINDING FACTOR3 (EDF3) 2.22 1.54 2.15 1.97...”
• Characterization of the genome of a phylogenetically distinct tospovirus and its interactions with the local lesion-induced host Chenopodium quinoa by whole-transcriptome analyses
  Chou, PloS one 2017
  • “...in leaves and responses to ET and methyl JA. SA represses gene expression. CqRTE1 5059 AT2G26070 14.1362 29.3949 0.08 Reversion-to-ethylene sensitivity 1, negative regulation of ET-activated signaling pathway CqSNAP33 2069 AT5G61210 33.3194 192.761 1.34 MAPK cascade CqSOBIR1 3807 AT2G31880 22.7079 142.605 1.41 A putative leucine-rich repeat...”
• Identification of conserved drought-adaptive genes using a cross-species meta-analysis approach
  Shaar-Moshe, BMC plant biology 2015
  • “...loc_os03g42130 (AT3G19000, oxidoreductase) Ethylene loc_os01g32780 (AT1G68300, USP family protein), loc_os12g36640 (AT2G47710, UPS family protein), loc_os01g51430 (AT2G26070, RTE1) Response to stimulus Abiotic and biotic stress Heat, drought loc_os02g32520 (AT5G51070, ERD1), loc_os05g44340 (AT1G74310, HSP101), loc_os03g16030, loc_os01g04380 (AT5G59720, HSP18.2), loc_os03g11910 (AT2G32120, HSP70T-2), loc_os03g31300 (AT5G15450, APG6), loc_os05g38530 (AT3G12580, HSP70), loc_os11g47760...”
• Characterization of transcriptome remodeling during cambium formation identifies MOL1 and RUL1 as opposing regulators of secondary growth
  Agusti, PLoS genetics 2011
  • “...3.31 this work AT5G39340 AHP3 1.84 3.17 no probe [71] AT5G57110 ACA8 1.56 2.94 [46] AT2G26070 RTE1 1.83 2.89 - [48] AT3G45590 ATSEN1 1.72 2.85 no probe [72] AT2G27040 AGO4 1.46 2.61 [73] AT5G57130 unknown protein 1.33 2.56 AT1G11130 SCM 1.72 2.30 [45] AT2G41070 ATBZIP12 1.47...”
  • “...(AT5G57110), (B) AT2G41230, (C) AT2G47180, (D) AT1G02850, (E) MOL1 (AT5G51350), (F) PXY (AT5G61480), (G) RTE (AT2G26070), (H) RUL1 (AT5G05160), (I) SCM (AT1G11130), (J) AT5G54690, (K) WOX4 (AT1G46480). Values obtained by qRT-PCR are in grey, values obtained by microarray analysis are in black. For sample labeling, see...”
• REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis
  Resnick, Proceedings of the National Academy of Sciences of the United States of America 2006
  • “...a single-nucleotide mutation in the ORF of gene At2g26070 (GenBank NP180177); rte1-1 carries a G-to-A missense mutation, and rte1-2 lacks a single nucleotide...”
  • “...mutant with a 4.33-kb genomic DNA fragment of wild-type At2g26070 (comprising 2.66 kb upstream and 0.80 kb downstream of the predicted start and stop codons,...”
• Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling
  Barry, Proceedings of the National Academy of Sciences of the United States of America 2006
  • “...homologous proteins in plants, two from Arabidopsis (At2G26070 and At3G51040), and three from rice (GenBank accession nos. NP916598, AAV59409, and AAO37528)....”
  • “...53%, 51%, and 37% amino acid identity with GRL1, At2G26070, and GRL2, respectively. Alignment of GR with several homologous proteins reveals divergence at the N...”

XP_019070581 green ripe-like 1 isoform X2 from Solanum lycopersicum
Aligns to 52:187 / 243 (56.0%), covers 100.0% of PF05608, 204.5 bits

• Differential control of ethylene responses by GREEN-RIPE and GREEN-RIPE LIKE1 provides evidence for distinct ethylene signaling modules in tomato.
  Ma, Plant physiology 2012
  • GeneRIF: Data provides evidence for the expansion and subfunctionalization of the ethylene signaling pathway in tomato and supports the hypothesis of the existence of distinct ethylene signaling modules in tomato that operate through SlGR and SlGRL1. [SlGRL1]

NP_190673 RTE1-homolog from Arabidopsis thaliana
AT3G51040 RTH (RTE1-HOMOLOG) from Arabidopsis thaliana
Aligns to 38:175 / 231 (59.7%), covers 100.0% of PF05608, 196.2 bits

• Molecular association of Arabidopsis RTH with its homolog RTE1 in regulating ethylene signaling.
  Zheng, Journal of experimental botany 2017
  • GeneRIF: the regulatory function of Arabidopsis RTH via its homolog RTE1 in the ethylene signaling pathway
• Highly conserved proteins that modify plant ethylene responses
  Klee, Proceedings of the National Academy of Sciences of the United States of America 2006
• Genome-Wide Identification and Analysis of the Cytochrome B5 Protein Family in Chinese Cabbage (Brassica rapa L. ssp. Pekinensis)
  Zheng, International journal of genomics 2019
  • “...Bra013361 AT4G18910, NIP1, 2 (NOD26-Like Intrinsic Protein 1, 2) Bra012567 Bra038838 AT2G19080, metaxin-related Bra038562 Bra038877 AT3G51040, RTH (RTE1-Homolog) Bra009383 AT5G09420, ATTOC64-V Bra032473 AT1G05270, TraB family protein Bra039818 AT2G14750, Adenylyl-sulfate kinase Bra017872 Bra013120 Bra007769 AT2G26070, RTE1 (Reversion-to-Ethylene Sensitivity1) Bra013376 AT4G19150, ankyrin repeat family protein Bra023091 AT2G37020, sequence-specific...”
• REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis
  Resnick, Proceedings of the National Academy of Sciences of the United States of America 2006
  • “...copy in Arabidopsis, which we have named RTE1-HOMOLOG (RTH) (At3g51040, GenBank NP190673), encodes a protein of 231 amino acids with 51% identity to RTE1 over...”
• Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling
  Barry, Proceedings of the National Academy of Sciences of the United States of America 2006
  • “...in plants, two from Arabidopsis (At2G26070 and At3G51040), and three from rice (GenBank accession nos. NP916598, AAV59409, and AAO37528). Numerous related...”

XP_015621003 protein REVERSION-TO-ETHYLENE SENSITIVITY1 from Oryza sativa Japonica Group
Aligns to 51:186 / 241 (56.4%), covers 100.0% of PF05608, 195.4 bits

• Modulation of ethylene responses by OsRTH1 overexpression reveals the biological significance of ethylene in rice seedling growth and development.
  Zhang, Journal of experimental botany 2012
  • GeneRIF: OsRTH1(Os01g0711600) overexpression prevented ethylene-induced alterations in growth and development.

XP_010324172 green ripe isoform X1 from Solanum lycopersicum
Aligns to 52:187 / 243 (56.0%), covers 100.0% of PF05608, 180.1 bits

• Differential control of ethylene responses by GREEN-RIPE and GREEN-RIPE LIKE1 provides evidence for distinct ethylene signaling modules in tomato.
  Ma, Plant physiology 2012
  • GeneRIF: Data provides evidence for the expansion and subfunctionalization of the ethylene signaling pathway in tomato and support the hypothesis of the existence of distinct ethylene signaling modules in tomato that operate through SlGR and SlGRL1. [SlGR]

TM222_HUMAN / Q9H0R3 Transmembrane protein 222 from Homo sapiens (Human) (see paper)
2 alignments in 61:178 / 208 (56.7%), covering up to 43.4% of PF05608, 143.5 bits

• Comprehensive study of altered proteomic landscape in proximal renal tubular epithelial cells in response to calcium oxalate monohydrate crystals
  Wang, BMC urology 2020
  • “...SV=3 ZNF146 Q15072 2.23 0.000 Zinc finger protein OZF OS=Homo sapiens GN=ZNF146 PE=1 SV=2 TMEM222 Q9H0R3 2.17 0.002 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 ZNF574 A0A0C4DFM2 2.16 0.000 HCG1643764, isoform CRA_b OS=Homo sapiens GN=ZNF574 PE=1 SV=1 TSHZ1 Q6ZSZ6 2.11 0.006 Teashirt homolog 1 OS=Homo...”
• Phyllanthus Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NFκB, and Hypoxia).
  Tang, Evidence-based complementary and alternative medicine : eCAM 2013
  • “...2.01 1.97 22 P41221 Protein Wnt-5a 1.75 1.87 1.87 1.92 1.74 1.84 1.85 2.01 23 Q9H0R3 Transmembrane protein 222 1.57 1.52 1.57 1.42 1.47 1.62 1.57 1.46 24 Q5MJ09 Sperm protein associated with the nucleus on the X chromosome N3 1.45 1.57 1.57 1.57 1.34 1.45...”

Q8BVA2 Transmembrane protein 222 from Mus musculus
2 alignments in 61:178 / 208 (56.7%), covering up to 43.4% of PF05608, 139.4 bits

• Improved global protein homolog detection with major gains in function identification.
  Kilinc, Proceedings of the National Academy of Sciences of the United States of America 2023
  • “...predicted by AlphaFold2 ( 29 ) for H3BPM6 ( L e f t ) and Q8BVA2 ( R i g h t ). The alignment of these structures has a FATCAT p-value of 2.91e-03 and a 0.47 TM-Score. ( C ) Sequence alignments of C11orf53 and...”
  • “...sequence identity. ( D ) Sequence alignments of human MKRN2 opposite strand protein (H3BPM6) and Q8BVA2 have 16.4% sequence identity. A protein with PROST hits was the human chromosome 20 open reading frame 204 (C20orf204). For this protein, BLAST and PHMMER fail to identify homologous sequences...”

Bm1_15855 D4Ertd196e protein, putative from Brugia malayi
2 alignments in 32:148 / 178 (65.7%), covering up to 44.9% of PF05608, 117.8 bits

• Operons are a conserved feature of nematode genomes
  Pettitt, Genetics 2014
  • “...Tsp_09103 Tsp_09102 t35569 t35568 snu-23 ZK686.3 3452 Bm1_13735 Bm1_13740 Tsp_09506 a Nonoperonic H20J04.6 mog-2 2124 Bm1_15855 Bm1_15860 Tsp_09539 a Nonoperonic E02H1.5 E02H1.6 2436 Bm1_24720 Bm1_24715 Tsp_10673 Tsp_10674 t34344.1 t34344.2 B0491.1 B0491.7 2532 Bm1_10780 Bm1_10785 Tsp_10698 Tsp_10702 Nonoperonic trpp-8 vha-10 1264 Bm1_12140 Bm1_12135 Tsp_10959 a Nonoperonic ubxn-2...”

Tsp_09506 U2 small nuclear ribonucleo protein A from Trichinella spiralis
2 alignments in 92:208 / 530 (22.1%), covering up to 45.6% of PF05608, 117.5 bits

• Operons are a conserved feature of nematode genomes
  Pettitt, Genetics 2014
  • “...t05596 sel-1 mrps-5 5365 Bm1_45745 Bm1_45750 Tsp_09103 Tsp_09102 t35569 t35568 snu-23 ZK686.3 3452 Bm1_13735 Bm1_13740 Tsp_09506 a Nonoperonic H20J04.6 mog-2 2124 Bm1_15855 Bm1_15860 Tsp_09539 a Nonoperonic E02H1.5 E02H1.6 2436 Bm1_24720 Bm1_24715 Tsp_10673 Tsp_10674 t34344.1 t34344.2 B0491.1 B0491.7 2532 Bm1_10780 Bm1_10785 Tsp_10698 Tsp_10702 Nonoperonic trpp-8 vha-10 1264...”

Or search for genetic data about PF05608 in the Fitness Browser