Family Search for PF05853 (BKACE)

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PF05853 hits 43 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

PS417_07250 2-deoxy-3-keto-D-ribonoate cleavage enzyme from Pseudomonas simiae WCS417
Aligns to 6:302 / 310 (95.8%), covers 100.0% of PF05853, 376.0 bits

• mutant phenotype: # Specifically important in carbon source 2-Deoxy-D-Ribose; carbon source 2-Deoxy-D-ribonic acid lithium salt; this is a beta keto acid cleavage enzyme, see PMID:24240508

kce / Q8RHX2 3-keto,5-aminohexanoate cleavage enzyme subunit (EC 2.3.1.247) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see 2 papers)
KCE_FUSNN / Q8RHX2 3-keto-5-aminohexanoate cleavage enzyme; EC 2.3.1.247 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see 2 papers)
Q8RHX2 3-keto-5-aminohexanoate cleavage enzyme (EC 2.3.1.247) from Fusobacterium nucleatum subsp. nucleatum (see 2 papers)
Aligns to 4:270 / 272 (98.2%), covers 100.0% of PF05853, 367.4 bits

• function: Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety. It can also use beta-alanyl-CoA as substrate.
  catalytic activity: (5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3- aminobutanoyl-CoA + acetoacetate (RHEA:31555)
  subunit: Homotetramer.

H281DRAFT_00641 2-deoxy-3-keto-D-ribonate cleavage enzyme from Paraburkholderia bryophila 376MFSha3.1
Aligns to 7:304 / 312 (95.5%), covers 100.0% of PF05853, 367.0 bits

• mutant phenotype: Important for utilization of deoxyribose and deoxyribonate. This is expected to be the next step after the oxidation of deoxyribonate. It would release glyceryl-CoA and acetoacetate.

KCE_CLOAI / B0VHH0 3-keto-5-aminohexanoate cleavage enzyme; EC 2.3.1.247 from Cloacimonas acidaminovorans (strain Evry) (see paper)
B0VHH0 3-keto-5-aminohexanoate cleavage enzyme (EC 2.3.1.247) from Candidatus Cloacimonas acidaminovorans (see paper)
Aligns to 3:274 / 276 (98.6%), covers 100.0% of PF05853, 349.3 bits

• function: Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety.
  catalytic activity: (5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3- aminobutanoyl-CoA + acetoacetate (RHEA:31555)
  cofactor: Zn(2+)
  subunit: Homotetramer.

Pf6N2E2_4692 dehydrocarnitine cleavage enzyme (EC 2.3.1.-) from Pseudomonas fluorescens FW300-N2E2
Aligns to 4:291 / 295 (97.6%), covers 99.6% of PF05853, 331.4 bits

• mutant phenotype: Specifically important for: Carnitine Hydrochloride. Similar to CdhC = PA5387

cdhC / Q9HTH7 3-dehydrocarnitine cleavage enzyme from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Aligns to 4:291 / 294 (98.0%), covers 99.6% of PF05853, 329.2 bits

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