Family Search for PF06110 (TXD17-like_Trx)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

PF06110 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q9VMQ9 pyrimidodiazepine synthase (EC 1.5.4.1) from Drosophila melanogaster (see paper)
NP_001260098 clot, isoform B from Drosophila melanogaster
Aligns to 6:124 / 126 (94.4%), covers 100.0% of PF06110, 188.7 bits

• The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily.
  Giordano, Molecular genetics and genomics : MGG 2003 (PubMed)
  • GeneRIF: Clot protein is an essential component of a glutathione redox system required for the final step in the biosynthetic pathway for drosopterins. Cloning, molecular organization and sequence alterations associated with the alleles cl(1) and cl(2)

NP_080835 thioredoxin domain-containing protein 17 from Mus musculus
Q9CQM5 Thioredoxin domain-containing protein 17 from Mus musculus
Aligns to 8:122 / 123 (93.5%), covers 99.2% of PF06110, 176.2 bits

• Control of protein function through oxidation and reduction of persulfidated states.
  Dóka, Science advances 2020
  • GeneRIF: Control of protein function through oxidation and reduction of persulfidated states.
• TRP14 inhibits osteoclast differentiation via its catalytic activity.
  Hong, Molecular and cellular biology 2014
  • GeneRIF: Results suggest that TRP14 regulates osteoclasts differentiation and bone resorption through its catalytic activity and that enhancing TRP14 may present a new strategy for preventing bone resorption diseases.
• Thioredoxin and ventricular remodeling.
  Ago, Journal of molecular and cellular cardiology 2006
  • GeneRIF: In this review, we will summarize the cardiac effects of thioredoxin and the mechanisms by which thioredoxin mediates inhibition of ventricular remodeling.
• Thymic Microenvironment Is Modified by Malnutrition and Leishmania infantum Infection
  Losada-Barragán, Frontiers in cellular and infection microbiology 2019
  • “...Pgk1 Down O08997 7315.65 2 13 0.499 1.6 0.005 Copper transport protein ATOX1 Atox1 Down Q9CQM5 13987.73 2 14 0.738 2.1 0.009 Thioredoxin domain-containing protein 17 Txndc17 Down P99024 49620.96 2 15 1.344 3.8 0.005 Tubulin beta-5 chain Tubb5 Down P27773 56624.67 3 15 0.521 1.7...”
• Proteomic Analysis Provides Insights Into the Therapeutic Effect of GU-BEN-FANG-XIAO Decoction on a Persistent Asthmatic Mouse Model.
  Liu, Frontiers in pharmacology 2019
  • “...Q7TQ48 SRL Sarcalumenin 1.924 K3W4R6 TNNT2 Troponin T2, cardiac type 1.6 Q62348 TSN Translin 1.595 Q9CQM5 TXNDC17 Thioredoxin domain containing 17 1.93 Q78IK2 USMG5 Up-regulated during skeletal muscle growth 5 homolog (mouse) 1.707 P68510 YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Analysis of Proteomic Data via...”

B0K010 Thioredoxin domain-containing protein 17 from Rattus norvegicus
Aligns to 8:122 / 123 (93.5%), covers 99.2% of PF06110, 171.2 bits

• Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration
  Kwong, International journal of molecular sciences 2023
  • “...P14881-2 Cryba1 Beta-crystallin A3 1.83 0.87 0.88 0.00 P02770 Alb Albumin 1.81 0.86 0.85 0.02 B0K010 Txndc17 Thioredoxin domain-containing protein 17 1.81 0.86 0.70 0.02 A0A0G2JZ73 Serpina1 Alpha-1-antiproteinase 1.78 0.83 0.82 0.01 A0A0G2K376 Fip1l1 Pre-mRNA 3-end-processing factor FIP1 1.75 0.80 0.70 0.01 Q6PDU6 Hbb-b1 Beta-glo 1.70...”
• Peptidome analysis reveals critical roles for peptides in a rat model of intestinal ischemia/reperfusion injury.
  Zhang, Aging 2023
  • “...2399 0.092 0.00032739 Q10758 Krt8 KLEVDPNIQAV 1833 0.098 1.01E-05 A0A0H2UHM5 Pdia3 TADGIVSHL 1216 0.106 8.29E-06 B0K010 Txndc17 ITAVPTLLK 1563 0.111 0.00014108 P34058 Hsp90ab1 KHLEINPDHPIVETLR 2518 0.111 8.69E-05 P63269 Actg2 GVMVGMGQKDSYVG 2051 0.112 0.00107894 A0A0H2UHM7 LOC100909441 YAPVISAEK 1585 0.114 2.36E-06 Q10758 Krt8 KLEVDPNIQA 1734 0.115 2.81E-06 P63269...”
• Identification of protein targets for the antidepressant effects of Kai-Xin-San in Chinese medicine using isobaric tags for relative and absolute quantitation.
  Dong, Neural regeneration research 2020
  • “...Q8CFC9, O88656, Q9EPH2, P05964, P63312, F1LRP7, M0R4A0, G3V6L0, M0R5F8, Q9WV63, P20760, Q4QR75, Q5XII8, F1LQ96, F1M3M0, B0K010, P13668, Q9WUD2, Q9EPJ0, P13437, Q9QX67, Q5PPP3, Q66H40, Q02293, M0RBL8, D3ZNX9, M0RBE5, F1LU13, F1LQJ1, D3ZIX4, Q6AYK1, Q5BJP2, G3V6N7, Q05175, D3ZJJ7, O35147, Q642A9, Q5M7T2, P60841, D3ZH00, H9KVF3, Q925G0, D4A3J3, F1M9X4, Q8VID1, G3V8R0,...”
  • “...P63055, Q9R1R4, D3ZXK6, G3V7B0, Q923J6, D3ZIX4, D3ZBT2, Q05175, M0R734, D3ZMG1, Q9QX67, P62634, Q3MID9, F1LWR6, Q924S1, B0K010, D4A0W4, M0RBK9, G3V795, F1M9F9, D4A7Q3, D3ZP34, Q8VID1, Q3B8N7, Q8CFC9 ,F1M208, D3ZXY8, Q4QQW3, M0R9P1,O3534, F1LNP1, Q497A9, P18757, Q80XX4, W4VSR4, D4A1C1, D3ZS15, P04550, F1M0N1, Q712U5, D4A2D8, D3ZFB6, F1M8Y2, D3ZIV3, D4A8N1, P07936 O88600,...”
• Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair
  Devaux, Molecular & cellular proteomics : MCP 2016
  • “...G3V913 P55051 P85972 Q5RKI0 Q5XFX0 Q63610-2 Q6JE36 Q9WVR7 B0K010 C0JPT7 D3ZHA0 D3ZQP6 G3V852 G3V8L3 G3V940 Q5XI38 Cluster 2 B0BNN3 P01048 P02091 P02680-2 P04639...”
  • “...Q63041 Q63610-2 Q66HA8 Q68FQ2 Q6JE36 Q9QX79 Q9QZA2 Q9WVR7 B0K010 C0JPT7 D3ZHA0 D3ZQP6 F1LM84 F1LRZ7 G3V7K3 G3V7U4 G3V852 G3V8L3 G3V940 Q6PDW1 M0RBF1 O54854...”

Q5REA8 Thioredoxin domain-containing protein 17 from Pongo abelii
Aligns to 8:122 / 123 (93.5%), covers 99.2% of PF06110, 158.9 bits

• Endogenous HIV-1 Vpr-mediated apoptosis and proteome alteration of human T-cell leukemia virus-1 transformed C8166 cells.
  He, Apoptosis : an international journal on programmed cell death 2009
  • “...+2.3 11 215 PO9382 Galectin-1 15 5.34 K.SFVLNLGK.D K.LPDGYEFK.F K.DSNNLCLHFNPR.F R.LNLEAINYMAADGDFK.I R.EAVFPFQPGSVAEVCITFDQANLTVK.L +45.6 12 245 Q5REA8 Thioredoxin domain-containing protein 17 14 5.40 K.TIFAYFTGSK.D K.NLKVTAVPTLLK.Y K.TIFAYFTGSKDAGGK.S K.VTAVPTLLKYGTPQK.L K.SWCPDCVQAEPVVR.E R.YEEVSVSGFEEFHR.A +10.3 Note: a Only proteins with significant Mascot database matches ( P <0.05) and scores (>68) are listed....”

TXD17_HUMAN / Q9BRA2 Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; TRP14; Protein 42-9-9; Thioredoxin-like protein 5 from Homo sapiens (Human) (see 2 papers)
Q9BRA2 cystine reductase (EC 1.8.1.6) from Homo sapiens (see paper)
NP_116120 thioredoxin domain-containing protein 17 from Homo sapiens
Aligns to 8:122 / 123 (93.5%), covers 99.2% of PF06110, 158.9 bits

• function: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
  subunit: Interacts with TRXR1 and DYNLL1/DNCL1.
• Characterization of human oxidoreductases involved in aldehyde odorant metabolism.
  Boichot, Scientific reports 2023
  • “...15, 1) Alcohol dehydrogenase 1B (ADH1B) P00325 16 (17, 10, 2) Thioredoxin domain-containing protein 17 Q9BRA2 5 (14, 8, 5) Aldehyde dehydrogenase, mitochondrial (ALDH2) P05091 16 (11, 15, 0) Aldose reductase (AKR1B1) P15121 8 (15, 10, 1) Sepiapterin reductase P35270 11 (15, 11, 0) Cytosolic 10-formyltetrahydrofolate...”
• Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS.
  Zafarullah, International journal of molecular sciences 2023
  • “...0.004467 0.7106443 71 P12109 COL6A1 Collagen alpha-1(VI) chain 0.001902 0.8530394 0.0200518 0.292934 0.029598 0.9623254 72 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0.0045339 0.8419097 0.020576 0.278214 0.115543 0.8520701 73 Q8N386 LRRC25 Leucine-rich repeat-containing protein 25 0.0349695 0.0514834 0.000297 0.433359 0.574902 0.5565245 74 P51884 LUM Lumican 0.0119658 0.502447...”
  • “...antigen CD47 117 Q9NVZ3 NECAP2 0.6 13.39 0.001083 0.020052 Adaptin ear-binding coat-associated protein 2 118 Q9BRA2 TXNDC17 0.65 13.95 0.001121 0.020576 Thioredoxin domain-containing protein 17 119 Q16401 PSMD5 0.55 12.83 0.001208 0.021994 26S proteasome non-ATPase regulatory subunit 5 120 P14625 HSP90B1 0.22 13.99 0.001298 0.023421 Endoplasmin...”
• Ellagic Acid Triggers the Necrosis of Differentiated Human Enterocytes Exposed to 3-Nitro-Tyrosine: An MS-Based Proteomic Study
  Díaz-Velasco, Antioxidants (Basel, Switzerland) 2022
  • “...P51648 Thioredoxin domain-containing protein 17 TXNDC17 3.91 10 6 2.19 Disulfide reductase with peroxidase activity Q9BRA2 Glycine dehydrogenase (decarboxylating), mitochondrial GLDC 2.17 10 5 2.23 Catalyzes the degradation of glycine P23378 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.009 2.42 Involved in the interconnexion between the urea and tricarboxylic...”
• Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1.
  Ryaboshapkina, Molecular & cellular proteomics : MCP 2022
  • “...P32119 PRDX2 86 P07900 HSP90AA1 136 P35527 KRT9 37 P61457 PCBD1 87 Q15631 TSN 137 Q9BRA2 TXNDC17 38 P26583 HMGB2 88 Q13526 PIN1 138 P68036 UBE2L3 39 Q04760 GLO1 89 Q13404 UBE2V1 139 P25789 PSMA4 40 P60866 RPS20 90 P62316 SNRPD2 140 P63173 RPL38 41 P00492...”
• The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells
  Brochard, BMC complementary medicine and therapies 2021
  • “...false P60953 0.63 CDC42 Cell division control protein 42 homolog true 0 0 19 true Q9BRA2 0.63 TXNDC17 Thioredoxin domain-containing protein 17 false 1 1 0 false Q9BRF8 0.63 CPPED1 Serine/threonine-protein phphatase CPPED1 false 2 0 0 false Q07666 0.64 KHDRBS1 KH domain-containing RNA-binding signal transduction-associated...”
• Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment
  Stevenson, NPJ breast cancer 2021
  • “...RCC2 2 70.92 136.35 0.94 0.04 P01833 Polymeric immunoglobulin receptor 4 70.64 136.73 0.95 0.006 Q9BRA2 Thioredoxin domain-containing protein 17 3 70.62 136.70 0.95 0.05 P55786 Puromycin-sensitive aminopeptidase 25 69.06 138.65 1.01 0.05 Q9Y646 Carboxypeptidase Q 3 68.80 139.00 1.01 0.02 Q12765 Secernin-1 6 68.36 139.53...”
• Cytoprotective Effect of Ascorbic Acid and Rutin against Oxidative Changes in the Proteome of Skin Fibroblasts Cultured in a Three-Dimensional System
  Gęgotek, Nutrients 2020
  • “...sepin (A0A024R6I7, A0A0G2JRN3), UDP-glucose 6-dehydrogenase (E7ER95), importin (Q14974), actin-related protein 3 (B4DXW1), thioredoxin (P83876, Q99757, Q9BRA2), and glutaredoxin (O76003); Isoforms of nuclear ribonucleoprotein A/B (D6RD18, Q53F64, D6RBZ0, D6R9P3), annexin (H0YNB8, H0YKN4), filamin (E7EN95), glucose-6-phosphate dehydrogenase (Q0PHS3), ATP-citrate synthase (P53396), proline/glutamine-rich splicing factor (Q86VG2, P23246), cathepsin D...”
• Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
  Li, The EPMA journal 2020
  • “...K7EJH0 Kinetochore protein Spc24 SPC24 2 20.70 15.97 140 0 7 91,278,000 196,000,000 0.43 6.67 Q9BRA2 Thioredoxin domain-containing protein 17 TXNDC17 4 38.20 13.94 123 0 38 745,240,000 1,838,200,000 0.43 13.73 P15531 Nucleoside diphosphate kinase A NME1 1 69.70 17.15 152 0 20 312,380,000 966,090,000 0.43...”
• More
• Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.
  Chatterji, The international journal of biochemistry & cell biology 2021 (PubMed)
  • GeneRIF: Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.
• TXNDC17 promotes paclitaxel resistance via inducing autophagy in ovarian cancer.
  Zhang, Autophagy 2015
  • GeneRIF: TXNDC17, through participation of BECN1, induces autophagy and consequently results in paclitaxel resistance in ovarian cancer
• Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.
  Pader, Proceedings of the National Academy of Sciences of the United States of America 2014
  • GeneRIF: The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols.
• Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
  Jung, The Journal of biological chemistry 2008
  • GeneRIF: LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state.
• Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.
  Jeong, The Journal of biological chemistry 2004 (PubMed)
  • GeneRIF: TRP14 is a thioredoxin-related protein with roles in tumor necrosis factor-alpha signaling pathways
• Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function.
  Jeong, The Journal of biological chemistry 2004 (PubMed)
  • GeneRIF: TRP14 is a thioredoxin-related protein of 14 kDa
• Structural basis of cellular redox regulation by human TRP14.
  Woo, The Journal of biological chemistry 2004 (PubMed)
  • GeneRIF: Data report the crystal structure of human thioredoxin-related protein 14 determined at 1.8-angstrom resolution.

AT5G42850 hypothetical protein from Arabidopsis thaliana
Aligns to 1:132 / 134 (98.5%), covers 88.2% of PF06110, 154.3 bits

• Barley Root Proteome and Metabolome in Response to Cytokinin and Abiotic Stimuli
  Berka, Frontiers in plant science 2020
  • “...protein AT1G05260 NR NR NR HORVU3Hr1G037720 Peroxiredoxin-2D AT3G06050 NR NR HORVU7Hr1G046280 Thioredoxin domain-containing protein 17 AT5G42850 Signaling HORVU1Hr1G001850 12-oxophytodienoate reductase 2 AT1G17990 NR HORVU5Hr1G067710 Jasmonate-induced protein AT3G21380 NR HORVU1Hr1G045630 Membrane steroid binding protein 1 AT5G52240 NR NR Storage protein HORVU1Hr1G008130 11S seed storage protein AT2G28680 NR...”
• Extra Large G-Protein Interactome Reveals Multiple Stress Response Function and Partner-Dependent XLG Subcellular Localization
  Liang, Frontiers in plant science 2017
  • “...3.9E-15 Y2H ROOT XLG1 At5g06350 Rix1 complex component domain-containing protein 0.124 2.8E-17 Y2H GLUC XLG1 At5g42850 Thioredoxin-like protein Clot 0.024 1.1E-01 Y2H SAL XLG1 At5g54760 Translation initiation factor SUI1 family protein 0.106 9.7E-14 Y2H SAL XLG1 At5g57740 E3 ubiquitin-protein ligase XBAT32 0.013 4.0E-01 Y2H SAL XLG1...”

TXD17_EPICO / T1SH39 Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; TRP14 from Epinephelus coioides (Orange-spotted grouper) (Epinephelus nebulosus) (see paper)
Aligns to 8:122 / 123 (93.5%), covers 100.0% of PF06110, 142.4 bits

• function: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:23994424). Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity). May function as an antioxidant involved in response to viral infection (PubMed:23994424).

Q5Z9Z3 Thioredoxin-like protein Clot from Oryza sativa subsp. japonica
A2YCB4 Thioredoxin domain-containing protein from Oryza sativa subsp. indica
Aligns to 9:137 / 139 (92.8%), covers 84.0% of PF06110, 103.6 bits

• Floral Nectary Morphology and Proteomic Analysis of Nectar of Liriodendron tulipifera Linn
  Zhou, Frontiers in plant science 2016
  • “...Q0JNS6 Calmodulin-1 181 37 16.88/4.11 ELGTVMR HVMTNLGEK LTDEEVDEMIR DTDSEEELKEAFR VFDKDQNGFISAAELR Oryza sativa Japonica Group 44 Q5Z9Z3 Thioredoxin-like protein Clot 219 7 15.34/4.88 LTGVPTLIR FRLTGVPTLIR Oryza sativa Japonica Group The numerical value of Mw and pI just represent the accession, not the experimental value. Although it has...”
• iTRAQ-Based Quantitative Proteomics Analysis on Rice Anther Responding to High Temperature
  Mu, International journal of molecular sciences 2017
  • “...0.15 1.78 0.20 Signaling A2Y8H4 Aldo/keto reductase domain containing protein 1.54 0.06 1.59 0.13 Metabolic A2YCB4 Thioredoxin fold domain containing protein 1.57 0.09 1.78 0.19 Redox A2YI28 Reticulon-like protein 1.59 0.26 2.02 0.20 Endoplasmic reticulum, ER A2YM28 Thiamine thiazole synthase, chloroplastic 1.55 0.12 1.8 0.31 Starch...”

B6TP19 Thioredoxin-like protein 5 from Zea mays
Aligns to 9:135 / 138 (92.0%), covers 84.9% of PF06110, 100.6 bits

• Proteomic comparison of basal endosperm in maize miniature1 mutant and its wild-type Mn1
  Silva-Sanchez, Frontiers in plant science 2013
  • “...subunit alpha 1.21 0.01 1.60 0.00 B8A1M2 Similar to thioredoxin-like proteon 5 from Zea mays (B6TP19) 1.22 0.01 1.79 0.06 C0HF77 Putative uncharacterized protein 1.22 0.05 1.35 0.01 B6UAU9 Rhicadhesin receptor 1.23 0.04 1.47 0.02 B6UAK0 6-phosphogluconolactonase 1.28 0.06 1.71 0.00 Q8W2B6 UDP-glucosyltransferase BX9 1.28 0.04...”

B8A1M2 Thioredoxin domain-containing protein from Zea mays
Aligns to 9:135 / 138 (92.0%), covers 84.9% of PF06110, 99.4 bits

• Proteomic comparison of basal endosperm in maize miniature1 mutant and its wild-type Mn1
  Silva-Sanchez, Frontiers in plant science 2013
  • “...1.18 0.04 1.38 0.03 B6SXW8 RuBisCO large subunit-binding protein subunit alpha 1.21 0.01 1.60 0.00 B8A1M2 Similar to thioredoxin-like proteon 5 from Zea mays (B6TP19) 1.22 0.01 1.79 0.06 C0HF77 Putative uncharacterized protein 1.22 0.05 1.35 0.01 B6UAU9 Rhicadhesin receptor 1.23 0.04 1.47 0.02 B6UAK0 6-phosphogluconolactonase...”

I3L3M7 Thioredoxin domain-containing protein 17 from Homo sapiens
Aligns to 8:80 / 80 (91.2%), covers 60.5% of PF06110, 91.8 bits

• Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses.
  Özcan, Aging 2016
  • “...Q5JP53 metabolic processes ox-redox factors Peroxiredoxin 6 Protein deglycase DJ-1 (PARK7) TXNDC5 (ERP46) P30041 Q99497 I3L3M7 regulators of gene expression Major vault protein 14-3-3 protein epsilon Proteasome subunit beta type 4 Q14764 P62258 P28070 miscellaneous Aminopeptidase N (CD13) Cathepsin D P15144 P07339 Venn analysis allowed the...”

M7XZL4 Thioredoxin-like protein 5 from Rhodotorula toruloides (strain NP11)
Aligns to 10:122 / 131 (86.3%), covers 78.2% of PF06110, 57.0 bits

• Adaptation of Proteome and Metabolism in Different Haplotypes of Rhodosporidium toruloides during Cu(I) and Cu(II) Stress
  Cavelius, Microorganisms 2023
  • “...2.05 down up n.d. Thioredoxin-like_fold domain-containing protei A0A0K3C742 n.d. 2.09 down up Thioredoxin-like protein 5 M7XZL4 down up 5.00 2.33 Thioredoxin-domain-containing protein A0A2T0ABL4 n.d. n.d. 0.41 n.d. Thioredoxin domain-containing protein A0A2T0AIM8 2.02 2.23 6.25 n.d. Thioredoxin-like fold A0A2S9ZX64 up n.d. 2.94 down Thioredoxin-like protein A0A2T0A3T0 down...”

YOSC_SCHPO / Q9P7L1 Thioredoxin domain-containing protein C21C3.12c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 4:116 / 124 (91.1%), covers 78.2% of PF06110, 53.2 bits

HMU14090 putative thioredoxin TrxA from Helicobacter mustelae 12198
Aligns to 14:103 / 103 (87.4%), covers 55.5% of PF06110, 33.8 bits

• Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
  O'Toole, BMC genomics 2010
  • “...21 0.46 0.98 28 HMU12860 sodB superoxide dismutase (Fe) 24,576 231 23 0.46 0.98 29 HMU14090 putative thioredoxin 11,796 138 30 0.46 0.98 30 HMU11370 undefined product; no putative conserved domains detected, hypothetical protein Abu_2077 [Arcobacter butzleri RM4018]: 37% 7,677 92 26 0.46 0.98 31 HMU05010...”
  • “...0.81 22 HMU04730 oorB OORB subunit of 2-oxoglutarate:acceptor oxidoreductase 30,613 423 28 0.74 0.81 23 HMU14090 putative thioredoxin 11,796 267 39 0.730 0.8 24 HMU04740 oorA OORA subunit of 2-oxoglutarate:acceptor oxidoreductase 40,773 554 36 0.70 0.77 25 HMU02170 cheY chemotaxis regulatory protein 13,894 208 25 0.70...”

HP1458 thioredoxin from Helicobacter pylori 26695
O25996 Thioredoxin from Helicobacter pylori (strain ATCC 700392 / 26695)
Aligns to 3:100 / 104 (94.2%), covers 62.2% of PF06110, 30.5 bits

• Effect of environmental salt concentration on the Helicobacter pylori exoproteome
  Caston, Journal of proteomics 2019
  • “...1.92 2.18 2.90 2.34 1718 HP1454* Lpp20 domain containing protein 2.39 3.54 5.03 3.65 1920 HP1458 thioredoxin-2 (Trx 2) 1.69 1.40 1.79 1.63 - HP1561* iron(III) ABC transporter, periplasmic iron-binding protein (CeuE1) 2.52 2.89 3.09 2.83 3132 HP1562* iron(III) ABC transporter, periplasmic iron-binding protein (CeuE2) 2.62...”
  • “...0.54 HP1118 gamma-glutamyltranspeptidase (Ggt) 0.49 HP1186 carbonic anhydrase 1.85 HP1299 methionine amino peptidase (Map) 0.54 HP1458 thioredoxin-2 (Trx2) 0.43 HP1469 outer membrane protein (Omp31, HorJ) 0.59 a H. pylori was grown in Brucella broth containing either 0.5% or 1.25% NaCl. RNA-seq was performed as described in...”
• Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization
  Marcus, Helicobacter 2018
  • “...0.12 0.02 1.71 0.18 0.06 1.58 0.10 0.02 thioredoxin reductase ( trxR2, trxB ) HPG27_RS07230 HP1458 1.14 0.20 0.40 1.15 0.14 0.35 1.66 0.12 0.02 thioredoxin ( trx2 ) Motility class 3 flagellar genes HPG27_RS01995 HP1051 2.73 0.32 0.03 2.66 0.47 0.07 1.37 0.07 0.02 hypothetical...”
• Comment on "Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics"
  Kazakos, World journal of gastroenterology 2017
  • “...the authors[ 1 ], several other genes coding for transmembrane ABC transporters ( glnP, dppF, hp1458, hp1486 ), efflux proteins ( hp0656, hp0946 ), multidrug and toxic extrusion proteins were found to be significantly up-regulated, thereby indicating their prominent role in the cellular response to hDs...”
• Carbon Fixation Driven by Molecular Hydrogen Results in Chemolithoautotrophically Enhanced Growth of Helicobacter pylori
  Kuhns, Journal of bacteriology 2016
  • “...proteins HP0515 HP1317 HP0370 HP1152 HP1460 HP1430 HP0163 HP1458 HP0466 HP0306 HP0138 HP0088 HP0742 HP1182 Heat shock protein (HslV) 50S ribosomal protein L23...”
• Oxidative and nitrosative stress defences of Helicobacter and Campylobacter species that counteract mammalian immunity
  Flint, FEMS microbiology reviews 2016
  • “...comigratory protein BCP Thioredoxins Trx1, Trx2 hp0136 hp1458, hp0824 H2 O2 and organic peroxide detoxification Oxidative stress NADPH-specific quinone...”
• Growth phase-dependent composition of the Helicobacter pylori exoproteome
  Snider, Journal of proteomics 2016
  • “...toxin VacA; cell binding factor 2 or HP0175; hypothetical protein HP1286; and thioredoxin TrxC or HP1458) were reported to be selectively released into the extracellular space in all three of the previous proteomic studies. The previous proteomic studies provided valuable insights into the exoproteome of H....”
• Comparative Roles of the Two Helicobacter pylori Thioredoxins in Preventing Macromolecule Damage
  Kuhns, Infection and immunity 2015
  • “...Trx, namely, TrxA (KEGG accession number HP0824) and TrxC (HP1458), but only a single gene that encodes the reductase TrxR (HP0825) (13). The first known...”
  • “...contains part of the hp1459 gene and part of the hp1458 and cat (Cmr) genes. Next, primers trxC-3 and trxC-4 were used to PCR amplify a 409-bp region containing...”
• Aconitase Functions as a Pleiotropic Posttranscriptional Regulator in Helicobacter pylori
  Austin, Journal of bacteriology 2015
  • “...3= 13 HP1427 Histidine-rich protein (Hpn) CAGUG 5= 36 HP1458 Thioredoxin (Trx2) CUGUG CAGUG GGGAG 3= 3= 3= 292 215 354 HP1522 ATP-dependent DNA helicase (RecG)...”
• More
• Outer Membrane Vesicles Secreted by Helicobacter pylori Transmitting Gastric Pathogenic Virulence Factors
  Wei, ACS omega 2022
  • “...P48370 gyrA 229 O25080 pgdA 230 O25276 Cag22 231 O25157 HP_0396 232 O25773 proC 233 O25996 HP_1458 234 O25424 ansA 235 P56020 rpsM 236 O25283 accA 237 O25342 ispG 238 O25442 HP_0746 239 P56038 rplM 240 P56009 rpsB 241 O25771 Omp25 242 P56011 rpsD 243 O25001...”
• Structural and functional aspects of the Helicobacter pylori secretome
  Zanotti, World journal of gastroenterology 2014
  • “...O25229 P66928 P56431 P77872 P56086 O25776 P56087 O25825 O25856 O25996 O25997 O24968 O25001 O25021 O25103 O25728 Q7X5D6 O25345 O25742 O25749 z b', z z a, f, q,...”

jhp1351 putative THIOREDOXIN from Helicobacter pylori J99
Aligns to 6:98 / 104 (89.4%), covers 62.2% of PF06110, 30.3 bits

• pH-regulated gene expression of the gastric pathogen Helicobacter pylori
  Merrell, Infection and immunity 2003
  • “...HP1175 HP0310 HP1285 HP1178 JHP0048 JHP0661 JHP1351 JHP1027 JHP0805 -1-pyrroline-5-carboxylate dehydrogenase, putA II energy metabolism, ansB Thioredoxin...”

HPG27_RS07230 thioredoxin family protein from Helicobacter pylori G27
Aligns to 3:100 / 104 (94.2%), covers 61.3% of PF06110, 29.8 bits

• Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization
  Marcus, Helicobacter 2018
  • “...1.73 0.12 0.02 1.71 0.18 0.06 1.58 0.10 0.02 thioredoxin reductase ( trxR2, trxB ) HPG27_RS07230 HP1458 1.14 0.20 0.40 1.15 0.14 0.35 1.66 0.12 0.02 thioredoxin ( trx2 ) Motility class 3 flagellar genes HPG27_RS01995 HP1051 2.73 0.32 0.03 2.66 0.47 0.07 1.37 0.07 0.02...”

HCD_00885 thioredoxin family protein from Helicobacter cetorum MIT 99-5656
Aligns to 9:98 / 104 (86.5%), covers 58.0% of PF06110, 28.2 bits

• Comparative analysis of prophage-like elements in Helicobacter sp. genomes
  Fan, PeerJ 2016
  • “...of phiHCD_1 is 24.8 kb, which renders it a full-length prophage. Prophage phiHCD_1, inserted between HCD_00885 (thioredoxin-encoding) and HCD_01020 (transposase-encoding) in the genome of Helicobacter cetorum MIT 99-5656, contains twenty-eight ORFs ( Fig. 3 ). The prophage has identical 13 bp attL and attR sites (...”

Or search for genetic data about PF06110 in the Fitness Browser