Family Search for PF06388 (DUF1075)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF06388 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

F162A_RAT / Q4QQV3 Protein FAM162A; E2-induced gene 5 protein homolog from Rattus norvegicus (Rat) (see paper)
Aligns to 1:155 / 155 (100.0%), covers 100.0% of PF06388, 250.9 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition.
• Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics.
  Zhang, Molecules (Basel, Switzerland) 2022
  • “...68 Kelch-like protein 22 Klhl22 A0A0G2KA06 0.57 a 0.75 0.43 a 69 Protein FAM162A Fam162a Q4QQV3 0.57 a 1.06 0.61 a 70 SCY1-like pseudokinase 2 Scyl2 D4A1Y0 0.58 a 1.05 0.61 a 71 Ras GTPase-activating protein 2 Rasa2 Q63713 0.61 a 0.69 0.42 a 72 Chromatin-modifying...”
• Myocardial proteomic profile in pulmonary arterial hypertension.
  Hołda, Scientific reports 2020
  • “...isomerase, mitochondrial 1.11 Q4V8F9 Hsdl2 Hydroxysteroid dehydrogenase-like protein 2 1.29 P07943 Akr1b1 Aldose reductase 1.11 Q4QQV3 Fam162a Protein FAM162A 1.33 P11507 Atp2a2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1.12 P41350 Cav1 Caveolin-1 1.48 P39069 Ak1 Adenylate kinase isoenzyme 1 1.12 Figure 2 Heat map presentation of a...”
• Integrative proteomics and pharmacogenomics analysis of methylphenidate treatment response
  da, Translational psychiatry 2019
  • “...D4A193 Receptor expression-enhancing protein Reep1 1.004 0.0222 A2RRU1 Glycogen [starch] synthase, muscle Gys1 1.003 0.0374 Q4QQV3 Protein FAM162A Fam162a 1.001 0.0055 Q6PST4 Atlastin-1 Atl1 1.001 0.0484 MPH methylphenidate, Log2FC log base 2 transformed fold-change a Not detected by the proteomic technique in any biological replicate from...”
• Preliminary quantitative profile of differential protein expression between rat L6 myoblasts and myotubes by stable isotope labeling with amino acids in cell culture.
  Cui, Proteomics 2009
  • “...361207 Transmembrane protein 109 precursor IPI00372499.1 2.21NA 1 Q6AYQ4 361732 LOC360721 protein IPI00608138.1 2.87NA 1 Q4QQV3 360721 Up-regulated during skeletal muscle growth protein 5 IPI00202111.1 2.28 0.00 2 Q9JJW3 171069 WD-containing protein IPI00205633.6 2.30NA 1 Q9R037 246152 Table 2 The List of Proteins with the Ratio...”

F162A_MOUSE / Q9D6U8 Protein FAM162A; E2-induced gene 5 protein homolog; Growth and transformation-dependent protein; HGTD-P from Mus musculus (Mouse) (see 2 papers)
Aligns to 1:155 / 155 (100.0%), covers 99.4% of PF06388, 248.0 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997).
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (By similarity). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (By similarity).
• Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
  Feng, Frontiers in neurology 2022
• Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA
  Key, Cells 2021
  • “...Echs1 0.0352 1.23 Q9CYT3;Q99N15;A2AFQ2;O08756 Hsd17b10 0.0374 1.21 A2AP32;A2AP31;Q3UIU2 Ndufb6 0.042 1.42 Q9WTP7;Q9D8W6 Ak3 0.0423 1.13 Q9D6U8 Fam162a 0.0427 1.36 Q9D0K2;Q3UK61;Q3U9P7;Q3UJQ9;Q9CRF4 Oxct1 0.0475 1.20 Q8K009;D3Z6B9 Aldh1l2 0.0496 1.38 Upregulations Majority Protein IDs Gene Names p -Value Fold Change with Imputation Previous Mammalian Substrates PMID P38647 Hspa9 2E-07...”
• A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.
  Bledzka, Journal of molecular and cellular cardiology 2021
  • “...beta subcomplex subunit 8, mitochondrial Q9D6J5 Ndufb8 3 15 0 Ln6 only 17 Protein FAM162A Q9D6U8 Fam162a 3 14 0 Ln6 only Table 3 Summary for GRK2 IP Protein Accession Gene Area Spectral Counts SC Ratio ID Ln10 Ln12 Ln12/10 1 26S proteasome non-ATPase regulatory subunit...”
• Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle.
  Murphy, Data in brief 2018
  • “...4 96.3 6.76E-04 2.1 O35114 Scarb2 Lysosome membrane protein 2 3 3 186.0 3.26E-04 2.1 Q9D6U8 Fam162a Protein FAM162A 2 2 4.0 5.57E-04 2.1 Q9DBH5 Lman2 Vesicular integral-membrane protein VIP36 7 7 188.6 9.85E-06 2.1 Q05144 Rac2 Ras-related C3 botulinum toxin substrate 2 2 2 49.7...”

Q2NKR7 Protein FAM162A from Bos taurus
Aligns to 1:156 / 156 (100.0%), covers 99.4% of PF06388, 243.7 bits

• Growth Traits and Sperm Proteomics Analyses of Myostatin Gene-Edited Chinese Yellow Cattle
  Zhao, Life (Basel, Switzerland) 2022
  • “...NFS1 0.015 3.98 UP F1MEM9 Tetratricopeptide repeat domain 19 GN = TTC19 0.044 6.31 UP Q2NKR7 Protein FAM162A GN = FAM162A 0.001 8.70 UP E1BGC1 Methylcrotonoyl-CoA carboxylase 1 GN = MCCC1 0.019 7.12 UP Q3ZBU7 Tubulin beta-4A chain GN = TUBB4A 0.044 6.27 UP E1B8W3 Outer...”
• Isotope coded protein labeling coupled immunoprecipitation (ICPL-IP): a novel approach for quantitative protein complex analysis from native tissue.
  Vogt, Molecular & cellular proteomics : MCP 2013

F162A_HUMAN / Q96A26 Protein FAM162A; E2-induced gene 5 protein; Growth and transformation-dependent protein; HGTD-P from Homo sapiens (Human) (see 3 papers)
NP_055182 protein FAM162A from Homo sapiens
Aligns to 1:154 / 154 (100.0%), covers 99.4% of PF06388, 241.3 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (PubMed:16698020). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (PubMed:15082785).
• Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy.
  Nakagawa, Scientific reports 2023
  • “...class I histocompatibility antigen, alpha chain F HLA-F ENSG00000204642 P30511 24.9 Protein FAM162A FAM162A ENSG00000114023 Q96A26 23.9 Latent-transforming growth factor beta-binding protein 2 LTBP2 ENSG00000119681 Q14767 21.7 LEM domain-containing protein 2 LEMD2 ENSG00000161904 Q8NC56 20.9 Angiopoietin-related protein 7 ANGPTL7 ENSG00000171819 O43827 18.8 Sodium/nucleoside cotransporter 1 SLC28A1...”
• Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players
  Orrù, International journal of environmental research and public health 2022
  • “...NAP1L4 1.48 Q9UKU7 Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 1.48 P15088 Mast cell carboxypeptidase A CPA3 1.48 Q96A26 Protein FAM162A FAM162A 1.48 Q15555 Microtubule-associated protein RP/EB family member 2 MAPRE2 1.48 P21817 Ryanodine receptor 1 RYR1 1.44 a Rsc represents the log 2 ratio between the protein expression...”
• Alignment of virus-host protein-protein interaction networks by integer linear programming: SARS-CoV-2.
  Llabrés, PloS one 2020
  • “...0.249 0.722 Q9HCD5 P11940 0.055 0.869 0.868 A9UHW6 Q8WVC6 0.141 P08949 Q96DA6 0.372 0.539 P50583 Q96A26 0.826 0.968 P20290 P51148 0.521 0.666 0.138 P62879 P62873 0.455 0.981 0.879 Q99426 P62820 0.289 0.761 Q16548 P61006 0.381 0.702 Q92843 P11233 0.485 0.727 Q56VL3 O43169 0.869 (f) Non-structural protein...”
  • “...protein orf6 (P59634, P0DTC6) SARS-CoV-1 SARS-CoV-2 BPO CCO MFO P10415 Q9NQT5 0.323 0.887 0.234 P50583 Q96A26 0.826 0.968 Q07817 Q9Y3A6 0.299 0.806 Q16548 P61006 0.381 0.702 Q92843 P11233 0.485 0.727 O43765 Q7Z4Q2 0.489 0.531 (c) Accessory protein orf7a (P59635, P0DTC7) SARS-CoV-1 SARS-CoV-2 BPO CCO MFO P08708...”
• Identification of Candidate Protein Markers in Skeletal Muscle of Laminin-211-Deficient CMD Type 1A-Patients
  Kölbel, Frontiers in neurology 2019
  • “...COX5A ) Mito-chondria 0.49 1.02 This is the heme A-containing chain of cytochrome c oxidase Q96A26 4/4 0.04 Protein FAM162A ( F162A ) Mito-chondria 0.48 1.04 Involved in hypoxia-induced cell death of neuronal cells Q16555 18/13 0.01 Dihydropyrimidinase-related protein 2 ( DPYSL2 ) Cytoplasm 0.48 1.04...”
• Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.
  Samanta, Asian journal of andrology 2019
  • “...19.3 5.0 0.0 40S ribosomal protein S8 P62241 24 29.0 4.3 2.0 0.0 Protein FAM162A Q96A26 17 28.7 18.0 16.0 12.3 Ras-related protein Rab-18 Q9NP72 23 28.0 7.0 0.7 0.0 Erlin-1 O75477 39 27.7 21.7 11.7 8.7 26S protease regulatory subunit 10B P62333 46 27.3 20.3...”
• Quantitative proteomics reveal the anti-tumour mechanism of the carbohydrate recognition domain of Galectin-3 in Hepatocellular carcinoma.
  Wang, Scientific reports 2017
  • “...0.66 7 5 P09972 ALDOC 0.64 0.62 9 10 P28332 ADH6 0.65 0.69 9 10 Q96A26 FAM162A 0.66 0.65 6 4 Q6UWM9 UGT2A3 0.67 0.48 8 6 Data mining of differentially expressed proteins To obtain a biological view of 190 differentially expressed proteins, Gene Ontology (GO)...”
• Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk.
  Nuebel, Biochimica et biophysica acta 2016
  • “...Protein FAM136A FAM136A 26.8 CX 9 C, CX 3 CC, triple CX 3 C No Q96A26 Protein FAM162A FAM162A, C3orf28 17.3 CX 3 C No Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 FKBP10 FPR2 64.2 CX 15 C Yes [4] Q9NRV9 Heme-binding protein 1 HEBP1, HBP 21.1 Cytosol...”
• Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates.
  Johnson, Biomedical engineering and computational biology 2013
  • “...1.16E-01 Q6ZRP7 Sulfhydryl oxidase 2 8 GVDFSSLD 1.09E-01 A0PJX4 Protein shisa-3 homolog 50 PEDFDTLD 9.03E-02 Q96A26 Protein FAM162A 17 TVSLEMLD 7.63E-02 UDP-glucuronosyltransferase 1 family (combined) 37 PLDLAVFW 7.42E-02 P60509 HERV-R(b)_3p24.3 provirus ancestral env polyprotein 40 NISLALED 7.41E-02 Q4ADV7 Protein RIC1 homolog 35 DENFSTLS 6.68E-02 Q3SXP7 Uncharacterized...”
• More
• Expression and clinicopathological significance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer.
  Cho, Histopathology 2010
  • GeneRIF: Expression and clinicopathological significance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson, PloS one 2010
  • GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
• Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma.
  Cho, Human pathology 2009 (PubMed)
  • GeneRIF: human growth and transformation-dependent protein expression is a common occurrence during the progression from a normal gastric mucosa to an intestinal-type carcinoma and may be associated with tumor cell proliferation activity
• Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades.
  Kim, FEBS letters 2006 (PubMed)
  • GeneRIF: Heat shock protein 90 physically interacts with HGTD-P.
• Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway.
  Lee, Molecular and cellular biology 2004
  • GeneRIF: Data indicate that HGTD-P is a new hypoxia-inducible factor 1 alpha-responsive proapoptotic molecule that activates mitochondrial apoptotic cascades.

F8W7Q4 Protein FAM162A from Homo sapiens
Aligns to 1:144 / 144 (100.0%), covers 93.0% of PF06388, 231.3 bits

• Integrative analysis reveals marker genes for intestinal mucosa barrier repairing in clinical patients.
  Zhao, iScience 2023
  • “...Aquaporin-8 AQP8 Q53GF6 7.86 2.56 Protein-arginine deiminase type-2 PADI2 A0A024RA98 16.12 2.38 Protein FAM162A FAM162A F8W7Q4 12.91 2.22 Estradiol 17-beta-dehydrogenase 2 HSD17B2 Q53GD0 12.22 2.22 Sulfotransferase; Sulfotransferase 1A1 SULT1A1; hCG_1993905 A0A024QZB4 12.85 1.96 Sulfurtransferase; Thiosulfate sulfurtransferase TST Q53EW8 14.02 1.00 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS...”

NP_001078949 protein FAM162B from Homo sapiens
Q5T6X4 Protein FAM162B from Homo sapiens
Aligns to 3:160 / 162 (97.5%), covers 98.7% of PF06388, 220.5 bits

• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose, Molecular medicine (Cambridge, Mass.)
  • GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
• Mechanisms Underlying Adaptation to Life in Hydrogen Sulfide-Rich Environments.
  Kelley, Molecular biology and evolution 2016
  • “...P10620 Microsomal glutathione S-transferase 1 mgst1.2 1 TCONS_00006640 P52294 Importin subunit alpha-5 kpna1 1 TCONS_00006715 Q5T6X4 Protein FAM162B fam162a 3 TCONS_00007401 B7ZAP0 RAB GTPase activating protein 1-like rabgap1l2 1 TCONS_00008470 P15121 Aldose reductase akr1b1 1 TCONS_00010008 O00483 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex ndufa4l2 1 TCONS_00010278...”

LOC102037655 protein FAM162B-like from Geospiza fortis
Aligns to 12:149 / 151 (91.4%), covers 70.9% of PF06388, 149.4 bits

• Genetic and ecological drivers of molt in a migratory bird
  Contina, Scientific reports 2023
  • “...associations were identified on chromosome 4A, situated within the coding region of an uncharacterized protein (LOC102037655), and on chromosome 2, located in the regulatory region approximately 15 kbp downstream from the HEPACAM2 gene. The multi-locus approach identified 5 additional genes associated with the molt-migration strategy (Fig....”
  • “...identified with high effect sizes were CSPG4, PDGF-B, CNOT9, ARHGAP26 , and two uncharacterized proteins (LOC102037655 and LOC102037327). Figure 3 ( A ) Manhattan plot of genome-wide association results of molt-migration behavior grouping in Painted Buntings using the mrMLM v4.0 software. Orange highlights the candidate genes...”

Or search for genetic data about PF06388 in the Fitness Browser