Family Search for PF06454 (THH1_TOM1-3_dom)

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PF06454 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TOM3_TOBAC / Q402F3 Tobamovirus multiplication protein 3; NtTOM3 from Nicotiana tabacum (Common tobacco) (see paper)
Aligns to 22:294 / 294 (92.9%), covers 99.3% of PF06454, 498.4 bits

• function: Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
  disruption phenotype: Reduced efficiency of intracellular multiplication of tobamoviruses (e.g. TMV-L, ToMV, PMMoV, and TMGMV), characterized by a reduced accumulation of viral coat protein (CP) and reduced amplification of TMV-related RNAs.

TOM3_ARATH / Q9ZUM2 Tobamovirus multiplication protein 3; AtTOM3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 31:303 / 303 (90.1%), covers 99.6% of PF06454, 495.2 bits

• function: Contributes to the intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
  subunit: Constituent of tobamovirus replication complex. Interacts with the helicase domain of tobamovirus-encoded replication proteins.
  disruption phenotype: When associated with TOM1 disruption, reduced efficiency of intracellular multiplication of tobamoviruses (e.g. crucifer strain TMV-Cg), characterized by a reduced accumulation of viral coat protein (CP) and reduced amplification of TMV-related RNAs.

THH1_ARATH / Q948R8 Protein TOM THREE HOMOLOG 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 21:293 / 293 (93.2%), covers 99.3% of PF06454, 495.0 bits

• function: Contributes to the intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
  subunit: Constituent of tobamovirus replication complex.
  disruption phenotype: When associated with TOM1 disruption, reduced efficiency of intracellular multiplication of tobamoviruses (e.g. crucifer strain TMV-Cg), characterized by a reduced accumulation of viral coat protein (CP) and reduced amplification of TMV-related RNAs.

TOM1_ARATH / Q9FEG2 Tobamovirus multiplication protein 1; AtTOM1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Aligns to 19:291 / 291 (93.8%), covers 99.6% of PF06454, 475.3 bits

• function: Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
  subunit: Constituent of tobamovirus replication complex. Interacts with TOM2A and with the helicase domain of tobamovirus-encoded replication proteins.
  disruption phenotype: Reduced efficiency of intracellular multiplication of tobamoviruses (e.g. crucifer strain TMV-Cg), characterized by a reduced accumulation of viral coat protein (CP) and reduced amplification of TMV-related RNAs.

TOM1_TOBAC / Q402F4 Tobamovirus multiplication protein 1; NtTOM1 from Nicotiana tabacum (Common tobacco) (see 2 papers)
Aligns to 16:288 / 288 (94.8%), covers 98.9% of PF06454, 471.7 bits

• function: Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.
  subunit: Constituent of tobamovirus replication complex. Interacts with TOM2A and with the helicase domain of tobamovirus-encoded replication proteins.
  disruption phenotype: Reduced efficiency of intracellular multiplication of tobamoviruses (e.g. TMV-L, ToMV, PMMoV, and TMGMV), characterized by a reduced accumulation of viral coat protein (CP) and reduced amplification of TMV-related RNAs.

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