Family Search for PF06565 (DM10_dom)
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Running HMMer for PF06565
PF06565 hits 19 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
EFHC1_HUMAN / Q5JVL4 EF-hand domain-containing protein 1; Myoclonin-1 from Homo sapiens (Human) (see 9 papers)
3 alignments in 86:512 / 640 (51.4%), covering up to 100.0% of PF06565, 344.2 bits
- function: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization (PubMed:19734894, PubMed:28370826). Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581, PubMed:19734894, PubMed:22926142, PubMed:28370826). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189).
subunit: Interacts with the C-terminus of CACNA1E (PubMed:15258581). Interacts with alpha-tubulin (PubMed:19734894).
EFHC1_BOVIN / E1BKH1 EF-hand domain-containing protein 1; Myoclonin-1 from Bos taurus (Bovine) (see paper)
3 alignments in 86:512 / 640 (51.4%), covering up to 100.0% of PF06565, 344.1 bits
- function: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death (By similarity). Microtubule inner protein (MIP) part of the dynein- decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:34715025).
subunit: Interacts with the C-terminus of CACNA1E. Interacts with alpha-tubulin.
EFHC1_MOUSE / Q9D9T8 EF-hand domain-containing protein 1; Myoclonin-1 from Mus musculus (Mouse) (see 2 papers)
3 alignments in 86:512 / 648 (50.8%), covering up to 100.0% of PF06565, 341.2 bits
- function: Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis (PubMed:15258581). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
subunit: Interacts with the C-terminus of CACNA1E. InteractS with alpha-tubulin.
EFHC2_BOVIN / A0A3Q1N1R0 EF-hand domain-containing family member C2 from Bos taurus (Bovine) (see paper)
4 alignments in 54:515 / 733 (50.2%), covering up to 100.0% of PF06565, 333.8 bits
- function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
EFHC2_HUMAN / Q5JST6 EF-hand domain-containing family member C2 from Homo sapiens (Human) (see paper)
4 alignments in 68:530 / 749 (49.3%), covering up to 100.0% of PF06565, 320.1 bits
- function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Or search for genetic data about PF06565 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory