Family Search for PF06736 (TMEM175)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF06736
PF06736 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
8dhmA / Q9BSA9 Human tmem175 in complex with 4-aminopyridine (see paper)
2 alignments in 6:247 / 367 (51.0%), covering up to 100.0% of PF06736, 150.4 bits
- Ligand: 4-aminopyridine (8dhmA)
8fy5A / Q9BSA9 Human tmem175-lamp1 full-length complex (see paper)
2 alignments in 6:267 / 387 (48.3%), covering up to 100.0% of PF06736, 150.2 bits
TM175_HUMAN / Q9BSA9 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; hTMEM175 from Homo sapiens (Human) (see 12 papers)
TC 1.A.78.1.1 / Q9BSA9 Endosomal/Lysosomal K+ channel of 504 aas and 12 TMSs with two 6 TMS repeat units, KEL or TMEM175 from Homo sapiens
2 alignments in 35:356 / 504 (37.1%), covering up to 100.0% of PF06736, 149.2 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034, PubMed:35333573, PubMed:37390818). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (PubMed:35750034). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:32267231). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32228865, PubMed:32267231, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer (PubMed:28723891, PubMed:32228865, PubMed:35608336). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (PubMed:37390818). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (PubMed:37390818). - substrates: K+
tcdb comment: A mutation in the encoding gene is associated with Parkinson's disease (Jing et al. 2015). It forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion (Lee et al. 2017). TMEM175 plays a direct and critical role in lysosomal and mitochondrial functions as well as Parkinson's Disease (PD) pathogenesis (Jinn et al. 2017). The 3-D structures of the open and closed channels are known (Oh et al. 2020) - Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease
Tang, Biomolecules 2023 - “..., E4TN31; Cb, Chryseobacterium sp., A0A086F3E3; Sc, Streptomyces collinus , S5VBU1; h: Homo sapiens , Q9BSA9; Gg, Gorilla gorilla , G3R453; Mm, Mus musculus , Q9CXY1; Dr, Danio rerio , A5PN43. The Clustal Omega sequence alignment program was used to align amino acid sequences and the...”
- Computational analysis of five neurodegenerative diseases reveals shared and specific genetic loci.
Maselli, Computational and structural biotechnology journal 2023 - “...PILRA Alzheimer's disease Q9UKJ1 R78G rs202122669 CYP2R1 Parkinson's disease Q6VVX0 P36L rs34311866 TMEM175 Parkinson's disease Q9BSA9 M393T The Uniprot code for the KIF5A protein is Q12840. A SNP identified in our analysis is SNP rs113247976, which leads to P986L and P986R mutations. This SNP is considered...”
- “...P36L mutation and is associated with PD. The Uniprot code for the TMEM175 protein is Q9BSA9. SNP identified is SNP rs34311866, resulting in the M393T mutation, and it is considered one of the possible causes of PD. We analyzed 4 out of 5 proteins through the...”
- Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration.
O'Day, Current issues in molecular biology 2022 - “...A GPT110 Q99497 Lewy Body Dementia 1510 TMEM175/ 172IQRS A HRA L YRRH V LGIVL190 Q9BSA9 114 172IQRS A HRALYRRHVLGI V L190 110 172IQRSAHR A LYRRHVLG I VL190 112 172IQRSAHR A LYRRHVLGIV L 190 110 172IQRSAHRA L YRRHVLGI V L190 112 GBA/ 249ARYF V KFLDAYAEHK L...”
- Structural basis for ion selectivity in TMEM175 K+ channels
Brunner, eLife 2020 - “...Gene ( Marivirga tractuosa) MtTMEM175 DSM 4126 E4TN31 Gene ( Homo sapiens ) hTMEM175 Sourcebioscience Q9BSA9, IRAUp969F1019D Gene ( Streptomyces collinus ) scTMEM175 Synthesized by GenScript S5VBU1 Recombinant DNA reagent pBXC3H Dutzler lab Addgene # 47068 Recombinant DNA reagent pcDXC3M Dutzler lab Addgene #49030 Recombinant DNA...”
- Finnish Parkinson's disease study integrating protein-protein interaction network data with exome sequencing analysis
Siitonen, Scientific reports 2019 - “...P10636 MAPT 29 Q13501 SQSTM1 12 P03886 MT-ND1 30 O43426 SYNJ1 13 P03897 MT-ND3 31 Q9BSA9 TMEM175 14 P03915 MT-ND5 32 Q96A57 TMEM230 15 Q8N183 NDUFAF2 33 P09936 UCHL1 16 Q5TEU4 NDUFAF5 34 P55072 VCP 17 O43181 NDUFS4 35 Q709C8 VPS13C 18 O75251 NDUFS7 36 Q96QK1...”
G3R453 Endosomal/lysosomal proton channel TMEM175 from Gorilla gorilla gorilla
2 alignments in 35:356 / 504 (37.1%), covering up to 100.0% of PF06736, 147.9 bits
- Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease
Tang, Biomolecules 2023 - “...A0A086F3E3; Sc, Streptomyces collinus , S5VBU1; h: Homo sapiens , Q9BSA9; Gg, Gorilla gorilla , G3R453; Mm, Mus musculus , Q9CXY1; Dr, Danio rerio , A5PN43. The Clustal Omega sequence alignment program was used to align amino acid sequences and the sequence alignment result was shown...”
TM175_RAT / Q6AY05 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175 from Rattus norvegicus (Rat) (see paper)
NP_001014013 endosomal/lysosomal proton channel TMEM175 from Rattus norvegicus
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.8 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (By similarity). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (By similarity). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (By similarity). Constitutes the pore- forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (By similarity). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (By similarity). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:32799888) (Probable).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer. Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel. Interacts with LAMP1; inhibiting the proton channel activity of TMEM175. Interacts with LAMP2; inhibiting the proton channel activity of TMEM175. - TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
Zhang, Molecular brain 2020 - GeneRIF: TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion.
- TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Jinn, Proceedings of the National Academy of Sciences of the United States of America 2017 - GeneRIF: TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation.
TM175_MOUSE / Q9CXY1 Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175; mTMEM175 from Mus musculus (Mouse) (see 3 papers)
XP_006535293 endosomal/lysosomal proton channel TMEM175 isoform X1 from Mus musculus
2 alignments in 32:353 / 499 (37.5%), covering up to 100.0% of PF06736, 144.5 bits
- function: Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH (PubMed:35750034). Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis (By similarity). Regulation of lumenal pH stability is required for autophagosome-lysosome fusion (PubMed:26317472). Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:33505021). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021).
catalytic activity: H(+)(in) = H(+)(out) (RHEA:34979)
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homodimer (By similarity). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021). Interacts with LAMP1; inhibiting the proton channel activity of TMEM175 (By similarity). Interacts with LAMP2; inhibiting the proton channel activity of TMEM175 (By similarity).
disruption phenotype: Mice display accelerated loss of dopaminergic neurons and impaired motor skills (PubMed:33505021). Knockout neurons show increased damage in response to insults and an accumulation of alpha-synuclein (PubMed:33505021, PubMed:35750034). The accumulation of alpha-synuclein leads to increased damage to the integrity of lysosomal membranes (PubMed:33505021, PubMed:35750034). - Lysosomal K+ channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
Qu, EMBO reports 2022 - GeneRIF: Lysosomal K(+) channel TMEM175 promotes apoptosis and aggravates symptoms of Parkinson's disease.
- Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
Pergel, International journal of molecular sciences 2021 - GeneRIF: Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds.
- TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.
Cang, Cell 2015 (PubMed)- GeneRIF: TMEM175 comprises a potassium (K) channel that underlies the molecular mechanism of lysosomal K(+) permeability.
- Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease
Tang, Biomolecules 2023 - “...S5VBU1; h: Homo sapiens , Q9BSA9; Gg, Gorilla gorilla , G3R453; Mm, Mus musculus , Q9CXY1; Dr, Danio rerio , A5PN43. The Clustal Omega sequence alignment program was used to align amino acid sequences and the sequence alignment result was shown and colored using MView. Figure...”
- Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome.
Di, Redox biology 2019 - “...A2APV2 2.0 1.1 1 7 Arginase-1 Q61176 3.3 5.2 1 9 Endosomal/lysomomal potassium channel (TMEM175) Q9CXY1 6.6 1.6 1 10 Crescerin-2 Q3TYG6 20 2.7 3 16 Serine/threonine-protein phosphatase 2A 65kDa regulatory subunit A alpha isoform (PP2A) Q76MZ3 9.1 5.43 3 Ts65Dn InRapa/Eu veh 2 Acyl-CoA dehydrogenase...”
TM175_CHRP1 / A0A086F3E3 Potassium channel HX13_20290 from Chryseobacterium sp. (strain P1-3) (see paper)
Aligns to 5:89 / 192 (44.3%), covers 100.0% of PF06736, 119.8 bits
- function: Potassium channel.
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891).
TM175_STRC3 / S5VBU1 Potassium channel B446_29190 from Streptomyces collinus (strain DSM 40733 / Tue 365) (see paper)
Aligns to 6:94 / 206 (43.2%), covers 100.0% of PF06736, 113.3 bits
- function: Potassium channel.
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891). - Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease
Tang, Biomolecules 2023 - “..., K9UJK2; Mt, Marivirga tractuosa , E4TN31; Cb, Chryseobacterium sp., A0A086F3E3; Sc, Streptomyces collinus , S5VBU1; h: Homo sapiens , Q9BSA9; Gg, Gorilla gorilla , G3R453; Mm, Mus musculus , Q9CXY1; Dr, Danio rerio , A5PN43. The Clustal Omega sequence alignment program was used to align...”
- Structural basis for ion selectivity in TMEM175 K+ channels
Brunner, eLife 2020 - “...sapiens ) hTMEM175 Sourcebioscience Q9BSA9, IRAUp969F1019D Gene ( Streptomyces collinus ) scTMEM175 Synthesized by GenScript S5VBU1 Recombinant DNA reagent pBXC3H Dutzler lab Addgene # 47068 Recombinant DNA reagent pcDXC3M Dutzler lab Addgene #49030 Recombinant DNA reagent pcDXC3GMS Dutzler lab Addgene #49031 Recombinant DNA reagent pBXNPHM3 Dutzler...”
- “...cloned from the strain DSM 4126. The TMEM175 cDNA of Streptomyces collinus (UniProt accession # S5VBU1) was synthesized by GenScript. For expression in MC1061 E. coli , TMEM175 genes were expressed from the FX-cloning plasmid pBXC3H ( Geertsma and Dutzler, 2011 ) (Addgene # 47068) with...”
TM175_CHAP6 / K9UJK2 Potassium channel Cha6605_3372; Transmembrane protein 175; CmTMEM175 from Chamaesiphon minutus (strain ATCC 27169 / PCC 6605) (see paper)
Aligns to 12:102 / 203 (44.8%), covers 100.0% of PF06736, 99.1 bits
- function: Potassium channel (PubMed:28723891). The channel is permeable for K(+), Rb(+) and Cs(+), while it is unable to conduct Na(+) (PubMed:28723891).
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer (PubMed:28723891).
CC0228 conserved hypothetical protein from Caulobacter crescentus CB15
Aligns to 32:118 / 223 (39.0%), covers 100.0% of PF06736, 82.4 bits
- Fur controls iron homeostasis and oxidative stress defense in the oligotrophic alpha-proteobacterium Caulobacter crescentus
da, Nucleic acids research 2009 - “...for each gene; however, some present more than one, such as genes CC0001, CC0029, CC0179, CC0228, CC0682, CC1063, CC1362, CC2193, CC2194, CC2367, CC3208 and CC3264 that possess two sites each and gene CC0028 with four putative Fur-binding sites in its promoter region (Table S2). It is...”
NP_001284356 endosomal/lysosomal proton channel TMEM175 isoform 3 from Homo sapiens
Aligns to 144:240 / 388 (25.0%), covers 100.0% of PF06736, 82.3 bits
- Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Zhang, Molecular cell 2023 - GeneRIF: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
- A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology.
Wie, Nature 2021 - GeneRIF: A growth-factor-activated lysosomal K(+) channel regulates Parkinson's pathology.
- Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.
Krohn, Annals of neurology 2020 (PubMed)- GeneRIF: Coding variants in TMEM175 are likely to be responsible for the association in the TMEM175/GAK/DGKQ locus, which could be mediated by affecting glucosylceramidase activity.
- Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.
Oh, eLife 2020 - GeneRIF: Gating and selectivity mechanisms for the lysosomal K(+) channel TMEM175.
- Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease.
Jinn, Human molecular genetics 2019 - GeneRIF: Data suggest that the TMEM175 p.M393T variant is responsible for the main signal in the chromosome 4p16.3 locus therefore conferring risk for Parkinson disease through its phosphorylation of alpha-synuclein.
- TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation.
Jinn, Proceedings of the National Academy of Sciences of the United States of America 2017 - GeneRIF: TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation.
- The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.
Lee, Nature 2017 - GeneRIF: structure of TMEM175 represents a novel architecture of a tetrameric cation channel whose ion selectivity mechanism appears to be distinct from that of the classical K(+) channel family
- Impact of Parkinson's disease risk loci on age at onset.
Lill, Movement disorders : official journal of the Movement Disorder Society 2015 (PubMed)- GeneRIF: Data indicated that GBA and TMEM175/GAK significantly alter age at onset in PD.
LOC100206560 endosomal/lysosomal potassium channel TMEM175 from Hydra vulgaris
2 alignments in 49:367 / 544 (33.8%), covering up to 100.0% of PF06736, 76.7 bits
lmo0419 similar to unknown protein from Listeria monocytogenes EGD-e
Aligns to 5:89 / 184 (46.2%), covers 100.0% of PF06736, 72.5 bits
- PadR-type repressors controlling production of a non-canonical FtsW/RodA homologue and other trans-membrane proteins
Hauf, Scientific reports 2019 - “...polymerase factor sigma C 139.319.3 8.610 7 lmo0420 hypothetical protein, HAD family hydrolase 54.910.2 0.0001 lmo0419 hypothetical protein 7.11.5 0.0035 lmo2773 putative transcription antiterminator 2.40.5 0.0035 lmo2050 excinuclease ABC subunit A 2.30.4 0.0037 downregulated in lstR lmo1597 hypothetical protein 0.50.04 0.0083 lmo0416 putative transcriptional regulator 0.50.01...”
- “...is the lmo0423-lstR-lmo0421 operon itself 26 . The two divergently transcribed and uncharacterized lmo0420 and lmo0419 genes located downstream of the sigC operon are also considerably overexpressed in the lstR mutant (Table 1 ). Transcriptional read-through could be an explanation for this. The remaining LstR-affected genes,...”
- Unraveling the evolution and coevolution of small regulatory RNAs and coding genes in Listeria
Cerutti, BMC genomics 2017 - “...lmo0082 , lmo0334 , lmo0550 and lmo2107 . For the three remaining coevolving genes ( lmo0419, lmo0017 and lmo2157 ) we did not identify a consistent interacting region. As illustrated in Fig. 5b , fifteen interacting regions were predicted between lmo0333 5UTR and rli133 . Two...”
- Intracellular gene expression profile of Listeria monocytogenes
Chatterjee, Infection and immunity 2006 - “...genes lmo0200 FC 3.45 10.82 7.33 9.12 lmo0257 lmo0419 3.06 3.44 lmo0445 2.04 lmo0750 lmo0751 lmo0752 3.31 2.55 2.79 lmo0838 4.58 lmo1083 lmo1084 lmo1100...”
- “...lmo0200 lmo0201 lmo0202 lmo0203 lmo0204 lmo0205 lmo0206 lmo0257 lmo0419 4.48 8.08 3.66 18.76 9.40 12.97 2.84 2.66 4.16 lmo0434 lmo0445 lmo0748 lmo0750 lmo0751...”
- Genome diversification in phylogenetic lineages I and II of Listeria monocytogenes: identification of segments unique to lineage II populations
Zhang, Journal of bacteriology 2003 - “...strains. PCR analysis using primers within the flanking lmo0419 and lmo0424 genes yielded an expected 3.9-kb product from all Downloaded from http://jb.asm.org/...”
NCDO2118_0727 TMEM175 family protein from Lactococcus lactis subsp. lactis NCDO 2118
Aligns to 6:91 / 203 (42.4%), covers 100.0% of PF06736, 71.2 bits
gbs0300 unknown from Streptococcus agalactiae NEM316
Aligns to 7:89 / 234 (35.5%), covers 100.0% of PF06736, 65.7 bits
LACR_1506 Predicted integral membrane protein from Lactococcus lactis subsp. cremoris SK11
Aligns to 14:99 / 193 (44.6%), covers 100.0% of PF06736, 65.1 bits
- Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis
Dijkstra, PloS one 2016 - “...2.9 LACR_0452 ABC-type multidrug transport system, ATPase component positive 5.2 LACR_0381 hypothetical protein positive 0.5 LACR_1506 hypothetical protein positive 0.3 LACR_0744 lysophospholipase L1 related esterase positive 1.5 LACR_2167 N-acetylmuramoyl-L-alanine amidase positive 4.5 LACR_0347 ABC-type multidrug transport system, ATPase and permease component positive 4.4 LACR_1291 Beta-xylosidase positive...”
LACR_0140 Predicted integral membrane protein from Lactococcus lactis subsp. cremoris SK11
Aligns to 9:78 / 172 (40.7%), covers 77.3% of PF06736, 59.8 bits
- Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis
Dijkstra, PloS one 2016 - “...hypothetical protein negative 4.4 LACR_1523 DNA-binding response regulator positive 5.0 LACR_0804 hypothetical protein positive 2.2 LACR_0140 hypothetical protein positive 0.1 LACR_0505 hypothetical protein negative 0.4 LACR_1362 transcriptional regulator positive 1.8 LACR_C28 dienelactone hydrolase family protein positive 14.6 LACR_2274 hypothetical protein positive 12.9 LACR_1031 lactose transport regulator...”
TM175_MARTH / E4TN31 Potassium channel Ftrac_2467; Transmembrane protein 175; MtTMEM175 from Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter tractuosus) (see paper)
Aligns to 24:105 / 247 (33.2%), covers 96.6% of PF06736, 50.7 bits
- function: Potassium channel; forms a potassium-permeable leak-like channel with weak selectivity for potassium (PubMed:32267231). The channel is permeable for K(+), Rb(+) and Cs(+) (PubMed:32267231).
catalytic activity: K(+)(in) = K(+)(out) (RHEA:29463)
subunit: Homotetramer. - Transmembrane Protein 175, a Lysosomal Ion Channel Related to Parkinson's Disease
Tang, Biomolecules 2023 - “...for these TMEM175 proteins are shown. Cm, Chamaesiphon minutus , K9UJK2; Mt, Marivirga tractuosa , E4TN31; Cb, Chryseobacterium sp., A0A086F3E3; Sc, Streptomyces collinus , S5VBU1; h: Homo sapiens , Q9BSA9; Gg, Gorilla gorilla , G3R453; Mm, Mus musculus , Q9CXY1; Dr, Danio rerio , A5PN43. The...”
- Structural basis for ion selectivity in TMEM175 K+ channels
Brunner, eLife 2020 - “...resource Designation Source or reference Identifiers Additional information Gene ( Marivirga tractuosa) MtTMEM175 DSM 4126 E4TN31 Gene ( Homo sapiens ) hTMEM175 Sourcebioscience Q9BSA9, IRAUp969F1019D Gene ( Streptomyces collinus ) scTMEM175 Synthesized by GenScript S5VBU1 Recombinant DNA reagent pBXC3H Dutzler lab Addgene # 47068 Recombinant DNA...”
- “...either on the N- or C-terminus. The TMEM175 gene of Marivirga tractuosa (UniProt accession # E4TN31) was cloned from the strain DSM 4126. The TMEM175 cDNA of Streptomyces collinus (UniProt accession # S5VBU1) was synthesized by GenScript. For expression in MC1061 E. coli , TMEM175 genes...”
Or search for genetic data about PF06736 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory