Family Search for PF07773 (TCTN_DUF1619)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF07773
PF07773 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
NP_001167446 tectonic-1 isoform 4 from Homo sapiens
Aligns to 22:331 / 531 (58.4%), covers 100.0% of PF07773, 319.9 bits
- microRNA-216a-5p inhibits the development of gastric cancer through target combination with TCTN1.
Xu, Minerva medica 2023 (PubMed)- GeneRIF: microRNA-216a-5p inhibits the development of gastric cancer through target combination with TCTN1.
- Function and transcriptional regulation of TCTN1 in oral squamous cell carcinoma.
Bai, Oncology reports 2022 - GeneRIF: Function and transcriptional regulation of TCTN1 in oral squamous cell carcinoma.
- [Diagnosis of two cases from one family with Joubert syndrome caused by novel mutations of TCTN1 gene by whole exome sequencing].
Wang, Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2019 (PubMed)- GeneRIF: Two novel TCTN1 mutations were identified in a family with Joubert syndrome
- Knockdown of TCTN1 Strongly Decreases Growth of Human Colon Cancer Cells.
Dai, Medical science monitor : international medical journal of experimental and clinical research 2017 - GeneRIF: Flow cytometry analysis showed that depletion of TCTN1 could cause cell cycle arrest at the G2/M phase. This indicates that TCTN1 may be crucial for CRC cell growth.
- Expanding the allelic disorders linked to TCTN1 to include Varadi syndrome (Orofaciodigital syndrome type VI).
Al-Qattan, American journal of medical genetics. Part A 2017 (PubMed)- GeneRIF: we describe the phenotype of a patient with Varadi syndrome who is homozygous for a previously reported mutation in TCTN1 (NM_001082538.2:c.342-2A>G, p.Gly115Lysfs*8) and suggest that allelic disorders linked to TCTN1 include Varadi syndrome, in addition to Joubert syndrome and Meckel-Gruber syndrome.
- Lentivirus-Mediated Knockdown of TCTN1 Inhibits Glioma Cell Proliferation.
Li, Applied biochemistry and biotechnology 2015 (PubMed)- GeneRIF: These data suggest TCTN1 is essential for glioma cell viability, and dysregulation of TCTN1 may play a key role in glioma tumorigenesis.
- Tectonic‑1 contributes to the growth and migration of prostate cancer cells in vitro.
Wang, International journal of molecular medicine 2015 - GeneRIF: These findings confirmed the direct association between the TCTN1 gene and prostate cancer growth in vitro.
- Expression and prognostic significance of TCTN1 in human glioblastoma.
Meng, Journal of translational medicine 2014 - GeneRIF: TCTN1 may serve as a novel prognostic factor and a potential therapeutic target for glioblastoma.
- More
NP_001076007 tectonic-1 isoform 1 precursor from Homo sapiens
Aligns to 78:387 / 592 (52.4%), covers 100.0% of PF07773, 319.5 bits
TECT1_HUMAN / Q2MV58 Tectonic-1 from Homo sapiens (Human) (see paper)
Aligns to 78:387 / 587 (52.8%), covers 100.0% of PF07773, 319.5 bits
- function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).
subunit: Part of the tectonic-like complex (also named B9 complex). - A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation.
Zhang, Clinical proteomics 2017 - “...cell motility -Actin-like protein 2 ACTBL2 Q562R1 Major constituent of the contractile apparatus Tectonic-1 TCTN1 Q2MV58 Cilium assembly Hemoglobin subunit HBB P68871 Oxygen transport; contributes to haptoglobin binding Potassium voltage-gated channel subfamily G member 1 KCNG1 Q9IUX4 Potassium channel activity Differentially expressed proteins with the normalized...”
TECT1_MOUSE / Q8BZ64 Tectonic-1 from Mus musculus (Mouse) (see 3 papers)
NP_001034242 tectonic-1 precursor from Mus musculus
Aligns to 82:395 / 593 (53.0%), covers 100.0% of PF07773, 319.5 bits
- function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
subunit: Part of the tectonic-like complex (also named B9 complex).
disruption phenotype: Null animals show disruption of nodal flow, laterality defects, and neural tube dorsalization. Basal bodies dock to the cellular plasma membrane, but fail to extend axonemes. However, cilia are present in the notochord, early gut epithelium, and mesenchymal cells surrounding the neural tube and in the limb bud. Null embryos develop an extra preaxial digit on 1 or both hindlimbs. Although sonic hedgehog (Shh) expression is normal, downstream signaling is disturbed, suggesting that Tctn1 is required for cilium- dependent Shh signal transduction. - Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.
Wang, Developmental biology 2017 - GeneRIF: These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing.
- A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo, Nature genetics 2011 - GeneRIF: Loss of Tctn1 is associated with ciliopathies.
- Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
Reiter, Genes & development 2006 - GeneRIF: During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Tectonic plays an additional role in repressing Hh pathway activity.
TECT3_HUMAN / Q6NUS6 Tectonic-3 from Homo sapiens (Human) (see 2 papers)
NP_056446 tectonic-3 isoform a precursor from Homo sapiens
Aligns to 90:390 / 607 (49.6%), covers 100.0% of PF07773, 297.0 bits
- function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
subunit: Part of the tectonic-like complex (also named B9 complex). - Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates.
Johnson, Biomedical engineering and computational biology 2013 - “...acid receptor 1 32 EVFMETST 2.65E-02 P0C6S8 Leucine-rich repeat neuronal protein 2 40 DTYFATLT 2.56E-02 Q6NUS6 Tectonic-3 43 EVSLTTLV 2.56E-02 Q8IYS5 Osteoclast-associated immunoglobulin-like receptor 48 EFFLEEVT 2.47E-02 Q9H5V8 CUB domain-containing protein 1 16 DLLFSVTL 2.34E-02 Q15399 Toll-like receptor 1 41 QVSSEVLE 2.29E-02 Q9Y2C9 Toll-like receptor 6...”
- Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
Platova, International journal of molecular sciences 2022 - “...++ + tctn NP_608998 Human NP_001076007 TCTN2 ++ + x Human NP_079085 TCTN3 x Human NP_056446 MKS1 ++ + NP_572804 Human NP_060247 CC2D2A ++ + NP_611229 Human NP_001365544 B9D1 ++ + NP_650470 Human NP_056496 TMEM17 ++ + x Human NP_938017 TMEM107 ++ + x Human NP_115730...”
TECT3_MOUSE / Q8R2Q6 Tectonic-3 from Mus musculus (Mouse) (see paper)
NP_080536 tectonic-3 isoform 1 precursor from Mus musculus
Aligns to 78:379 / 595 (50.8%), covers 100.0% of PF07773, 287.5 bits
TECT2_HUMAN / Q96GX1 Tectonic-2 from Homo sapiens (Human) (see 3 papers)
NP_079085 tectonic-2 isoform 1 precursor from Homo sapiens
Aligns to 171:444 / 697 (39.3%), covers 100.0% of PF07773, 242.5 bits
- function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity).
subunit: Part of the tectonic-like complex (also named B9 complex). - Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
Platova, International journal of molecular sciences 2022 - “...NP_995911 Human NP_003315 TCTN1 ++ + tctn NP_608998 Human NP_001076007 TCTN2 ++ + x Human NP_079085 TCTN3 x Human NP_056446 MKS1 ++ + NP_572804 Human NP_060247 CC2D2A ++ + NP_611229 Human NP_001365544 B9D1 ++ + NP_650470 Human NP_056496 TMEM17 ++ + x Human NP_938017 TMEM107 ++...”
TECT2_MOUSE / Q2MV57 Tectonic-2 from Mus musculus (Mouse) (see 4 papers)
NP_080762 tectonic-2 precursor from Mus musculus
Aligns to 171:442 / 700 (38.9%), covers 100.0% of PF07773, 239.7 bits
- function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction.
subunit: Part of the tectonic-like complex (also named B9 complex).
disruption phenotype: Mice have ventricular septal defects and can display right-sided stomach. The embryos exhibit microphthalmia, cleft palate and polydactyly. Embryos lack also nodal cilia. Cilia in neural tubes are scarce and morphologically defective, and failed to elongate axonemes. Basal bodies dock to the plasma membrane in Tctn2 null neural epithelium. No Arl13b ciliary staining in defective Tctn2 embryos perineural mesenchyme suggesting that, as in Tctn1 null mutants, defective Tctn2 cilia lack Arl13b. Tctn1 and Tctn2 share a common function, with both affecting ciliogenesis in a tissue-specific manner. - Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2.
Li, Tissue & cell 2022 (PubMed)- GeneRIF: Max interacting protein 1 induces IL-17-producing T helper/regulatory T imbalance in osteoarthritis by upregulating tectonic family member 2.
- Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.
Wang, Developmental biology 2017 - GeneRIF: These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing.
- A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo, Nature genetics 2011 - GeneRIF: Loss of Tctn2 is associated with ciliopathies.
NP_001074251 tectonic-2 precursor from Rattus norvegicus
Aligns to 171:442 / 700 (38.9%), covers 100.0% of PF07773, 238.1 bits
TECT_DROME / Q9VMH0 Tectonic; dTectonic from Drosophila melanogaster (Fruit fly) (see paper)
NP_608998 tectonic from Drosophila melanogaster
Aligns to 117:403 / 657 (43.7%), covers 100.0% of PF07773, 193.0 bits
- function: Probable component of the tectonic-like complex (also named MKS complex), a complex localized at the transition zone of primary cilia (PubMed:27646273). Has a role in ciliary structure and function (PubMed:27646273).
subunit: Probable component of the tectonic-like complex (also named MKS complex), composed of B9d1, B9d2, Cc2d2a, Mks1 and tctn.
disruption phenotype: Simultaneous knockout of B9d2 and tctn is viable and does not show sensory behavioral defects (PubMed:27646273). Males produce motile sperm and show only slightly reduced fertility (PubMed:27646273). Sperm flagella show weak ultrastructural defects including broken and disorganised structure (PubMed:27646273). Length of the transition zone is decreased and recruitment of the tectonic- like complex compromised (PubMed:27646273). - Gotta Go Slow: Two Evolutionarily Distinct Annelids Retain a Common Hedgehog Pathway Composition, Outlining Its Pan-Bilaterian Core
Platova, International journal of molecular sciences 2022 - “...+ x Human NP_065080 TULP3 ++ + ktub NP_995911 Human NP_003315 TCTN1 ++ + tctn NP_608998 Human NP_001076007 TCTN2 ++ + x Human NP_079085 TCTN3 x Human NP_056446 MKS1 ++ + NP_572804 Human NP_060247 CC2D2A ++ + NP_611229 Human NP_001365544 B9D1 ++ + NP_650470 Human NP_056496...”
NP_001137445 tectonic-3 isoform b precursor from Homo sapiens
2 alignments in 90:218 / 459 (28.1%), covering up to 24.9% of PF07773, 120.9 bits
Or search for genetic data about PF07773 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory