Family Search for PF08213 (COX24_C)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF08213 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q6PI41 Small ribosomal subunit protein mS38 (Fragment) from Homo sapiens
Aligns to 90:122 / 162 (20.4%), covers 97.0% of PF08213, 47.8 bits
5mrc11 / P32344 of the yeast mitochondrial ribosome - Class A (see paper)
Aligns to 1:32 / 34 (94.1%), covers 93.9% of PF08213, 47.7 bits
Q9DCJ7 Small ribosomal subunit protein mS38 from Mus musculus
NP_079614 aurora kinase A-interacting protein from Mus musculus
Aligns to 128:160 / 200 (16.5%), covers 97.0% of PF08213, 47.5 bits
AKIP_HUMAN / Q9NWT8 Small ribosomal subunit protein mS38; 28S ribosomal protein S38, mitochondrial; MRP-S38; Aurora kinase A-interacting protein; AURKA-interacting protein from Homo sapiens (Human) (see 4 papers)
NP_060370 small ribosomal subunit protein mS38 from Homo sapiens
Aligns to 127:159 / 199 (16.6%), covers 97.0% of PF08213, 47.4 bits
- function: May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation
subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051). - AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.
Tian, Cell death & disease 2023 - GeneRIF: AURKAIP1 actuates tumor progression through stabilizing DDX5 in triple negative breast cancer.
- Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase.
Szklarczyk, Genome biology 2012 - GeneRIF: Encodes a mitochondrial protein
- Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.
Huh, Nutrition and cancer 2011 (PubMed)- GeneRIF: Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin.
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson, PloS one 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.
Wysong, Cell cycle (Georgetown, Tex.) 2009 (PubMed)- GeneRIF: Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents.
- AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-3beta.
Fumoto, Oncogene 2008 (PubMed)- GeneRIF: GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP.
- Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
Chan, Chromosoma 2008 - GeneRIF: Plk1 controls Aurora A localization and function by regulating cellular levels of hBora.
- Antizyme1 mediates AURKAIP1-dependent degradation of Aurora-A.
Lim, Oncogene 2007 (PubMed)- GeneRIF: We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation.
- More
- Mitochondria-derived vesicles and their potential roles in kidney stone disease.
Chaiyarit, Journal of translational medicine 2023 - “...(Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) 46 ATRNL1 Q5VV63 Attractin-like protein 1 47 AURKAIP1 Q9NWT8 Aurora kinase A-interacting protein (AURKA-interacting protein) (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Mitochondrial small ribosomal subunit protein mS38) 48 CD72 P21854 B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72) 49...”
- Deciphering the mechanoresponsive role of β-catenin in keratoconus epithelium.
Amit, Scientific reports 2020 - “...protein ARC 27 Q7LC44 33 Musculin MSC 22 O60682 32 Aurora kinase A-interacting AURKAIP1 22 Q9NWT8 32 Collagen alpha1 XVI COL16A1 157 Q07092 32 Serine/threonine-protein kinase STK 11 STK11 55 Q15831 32 Basal cell adhesion molecule BCAM 67 P50895 31 Oxysterol binding protein 1 OSBP 89...”
- Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome.
Koc, Frontiers in physiology 2013 - “...Protein Human Bovine Mouse Fly Worm MRPS37 CHCHD1 Q96BP2 Q2HJE8 XP_852408 ABJ16982 AAB88317 MRPS38 AURKAIP1 Q9NWT8 Q0VCJ1 XM_843641 Q8IML6 Y54G9A MRPS39 PTCD3 Q96EY7 Q2KI62 XP_532975 A1Z9A8 AAF60413 MRPL58 ICT1 Q14197 Q3T116 XP_533118 CAL26738 AAL06045 MRPL59 CRIF1 Q8TAE8 A1A4P4 XP_533898 AAM29650 CAB03171 To confirm the subunit distribution...”
- Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles.
Peterson, Proteomics 2008
COX24_SCHPO / Q9P7H5 Small ribosomal subunit protein mS38; Mitochondrial mRNA-processing protein cox24 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 143:175 / 175 (18.9%), covers 97.0% of PF08213, 47.2 bits
- function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS38 is also involved in the splicing of the COX1 mRNA.
subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and at least 32 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and at least 45 different proteins.
Q0VCJ1 Small ribosomal subunit protein mS38 from Bos taurus
Aligns to 127:159 / 199 (16.6%), covers 97.0% of PF08213, 46.9 bits
ML2428A ML2428A. Orthologue of M. tuberculosis Rv0500B. Conserved hypothetical protein, strongly basic. Also similar to Streptomyces coelicolor SCE68.25c, hypothetical protein, len : 32 aa; unknown function, possible small, lysine-rich protein. FASTA score: gp|AL079345|AL079345_25 Streptomyces coelicolor (32 aa) E(): 1.7e-07; 93.103% identity in 29 aa overlap from Mycobacterium leprae TN
A0QR10 Conserved domain protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
P9WKT5 Uncharacterized protein Rv0500B from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Rv0500B hypothetical protein from Mycobacterium tuberculosis H37Rv
MRA_RS02635 AURKAIP1/COX24 domain-containing protein from Mycolicibacterium smegmatis MC2 155
Aligns to 1:33 / 33 (100.0%), covers 100.0% of PF08213, 46.2 bits
- Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae
Vedithi, Frontiers in molecular biosciences 2021 - “...Crystal Structure of Translation Initiation Factor 1 from Mycobacterium tuberculosis * Hatzopoulos and Mueller-Dieckmann, 2010 ML2428A 5O61 The complete structure of the Mycobacterium smegmatis 70S ribosome* Hentschel et al., 2017 ML1485 4WKW Crystal Structure of a Conserved Hypothetical Protein from Mycobacterium leprae Determined by Iodide SAD...”
- Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences
Chandra, FEMS microbiology reviews 2014 - “...), 5766 ( ML0986 ), 5866 ( ML1027 ), 6030 ( ML1041 ). One ( ML2428A ) was similar to SCO3327 , but did not give a reciprocal blastp best hit, and another ( ML0899 ) was absent from S. coelicolor , but present in S....”
- Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers.
Li, Protein & cell 2018 - “...mycobacterial protein database indeed located the identity and sequence of this unannotated protein (UniProt # A0QR10 for M . smegmatis and UniProt # P9WKT5 for M. tuberculosis ). The flexible C-terminus points to the 50S subunit. We propose to change the name of protein eL41 to...”
- Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers
Li, Protein & cell 2018 - “...sequence of this unannotated protein (UniProt # A0QR10 for M . smegmatis and UniProt # P9WKT5 for M. tuberculosis ). The flexible C-terminus points to the 50S subunit. We propose to change the name of protein eL41 to uL41, because it is no longer a eukaryote-specific...”
- The global responses of Mycobacterium tuberculosis to physiological levels of copper
Ward, Journal of bacteriology 2008 - “...Chaperone Rv0350 (dnaK) Hypothetical Rv0057 Rv0140 Rv0190 Rv0430 Rv0500B Rv0968 Rv2466c Rv3463 Change (fold) with 500 M Cu 4.9 Putative transposase (fragment)...”
- The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c
Chen, Frontiers in cellular and infection microbiology 2019 - “...These results were consistent with the proteome results. Meanwhile, the genes with diminished expression were MRA_RS02635, MRA_0731, MRA_1749, MRA_2046, rnpB, Novel 00016 (a novel transcript) and sRNA00033 . MRA_0565 (Rv0558 in H37Rv, MenG, demethylmenaquinone methyltransferase) is responsible for the conversion of demethylmenaquinone (DMK9) to menaquinone (MK9)...”
- “...12.11 MRA_0566 1743.06733236726 170.115689602463 Hypothetical protein <0.0001 10.25 MRA_0567 5670.52178636248 100.346019520407 Benzoquinone methyltransferase <0.0001 56.51 MRA_RS02635 51.6032290442103 124.251165444936 AURKAIP1/COX24 domain-containing protein <0.0001 2.41 MRA_0731 151.780801949601 306.041461196588 50S ribosomal protein L15 <0.0001 2.02 MRA_1749 1451.28472640206 2966.73979595929 Hypothetical protein <0.0001 2.04 MRA_2046 733.214576158605 1518.25473302068 Alpha-crystallin <0.0001 2.07 MRA_2366...”
7pnv3 / Q9DCJ7 7pnv3 (see paper)
Aligns to 1:32 / 72 (44.4%), covers 93.9% of PF08213, 46.0 bits
7l08A3 / Q9NWT8 structure of the human 55S mitoribosome-RRFmt complex. (see paper)
Aligns to 1:32 / 72 (44.4%), covers 93.9% of PF08213, 45.9 bits
3jd5n / Q0VCJ1 Cryo-em structure of the small subunit of the mammalian mitochondrial ribosome (see paper)
Aligns to 1:32 / 72 (44.4%), covers 90.9% of PF08213, 45.7 bits
COX24_YEAST / P32344 Small ribosomal subunit protein mS38; Mitochondrial mRNA-processing protein COX24 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
NP_013305 Qri5p from Saccharomyces cerevisiae S288C
NP_013305, YLR204W Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA from Saccharomyces cerevisiae
Aligns to 77:109 / 111 (29.7%), covers 97.0% of PF08213, 45.6 bits
- function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081). mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141).
subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins. - COX24 codes for a mitochondrial protein required for processing of the COX1 transcript.
Barros, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: Cox24p has a role in splicing and in translation of the COX1 mRNA
- Systematic analysis of nuclear gene function in respiratory growth and expression of the mitochondrial genome in S. cerevisiae
Stenger, Microbial cell (Graz, Austria) 2020 - “...MRPL32 YCR003W PET111 YMR257C IFM1 YOL023W MRPL38 YKL170W PET112 YBL080C IMG2 YCR071C MRPL6 YHR147C QRI5 YLR204W MHR1 YDR296W MRPL9 YGR220C RSM7 YJR113C MRF1 YGL143C MRPS5 YBR251W MRM1 YOR201C MSE1 YOL033W Respiratory chain components and assembly factors ATP15 YPL271W ATP7 YKL016C ATP17 YDR377W SDH4 YDR178W Other mitochondrial...”
- morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring
Wagner, BMC bioinformatics 2014 - “...( M. mulatta ) NP_001244714 Yes 99% COX23 NP_011984 Sequence CHCHD7 NP_077276 Yes 91% COX24 NP_013305 HMM AURKAIP1 NP_060370 No Only found with S. japonicus, finds S. cerevisiae Pet20 (NP_015166) as ortholog 100% (98%) COA1 NP_012109 HMM COA1 NP_060694 Yes S. pombe 100% (100%) COA3 NP_076894...”
- Spatio-temporal dynamics of yeast mitochondrial biogenesis: transcriptional and post-transcriptional mRNA oscillatory modules
Lelandais, PLoS computational biology 2009 - “...A YJR034W PET191 RCCasm4 19.1 Yes I A YLL009C COX17 RCCasm4 30.9 Yes I A YLR204W COX24 RCCasm4 13 Yes I / YML129C COX14 RCCasm4 22.6 Yes I A YOR266W PNT1 RCCasm4 33.6 Yes I A YPL132W COX11 RCCasm4 59.2 Yes I A YPL172C COX10 RCCasm4...”
- The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
Osman, The Journal of cell biology 2009 - “...IM SL YME1 YPR024w IM SL OXA1 YER154w IM GD COX6 YHR051w IM GD COX24 YLR204w IM GD ATP7 YKL016c IM GD ATP10 a YLR292w IM GD ATP17 YDR377w IM GD ATP23 a YNR020c IMS GD COQ1 YBR003w MA GD Mitochondrial morphology/-barrel assembly MMM1 a b...”
- Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data
Bryan, BMC genomics 2008 - “...mitochondrial genome loss YKL137W Mutation results in growth defect on a non-fermentable (respiratory) carbon source YLR204W Mitochondrial inner membrane protein YLR218C Growth defects on a non-fermentable carbon source YML030W Localizes to mitochondria Null mutant is viable & displays decreased frequency of mitochondrial genome loss YMR157C detected...”
- “...ORFs, consistently predicted by annotated biclusters across the Hughes and Gasch datasets is YDR493W, YKL137W, YLR204W, YLR218C, YML030W, YMR157C. These annotated biclusters were highly enriched in Mitochondrial (42.16) and Ribosomal Proteins (12.01.01) with significances of 2.48 10 -53 & 5.88 10 -40 and 1.23 10 -36...”
- Gene function prediction using labeled and unlabeled data
Zhao, BMC bioinformatics 2008 - “...dna processing GO:0007067 GO:0006260 GO:0006281 YDR106W YGL168W YER038C YDR168W YER038C 11 transcription GO:0006364 GO:0006396 YLR196W YLR204W YLR196W 12 protein synthesis GO:0043037 YFR032C YLR287C YFR032C YLR287C 14 protein fate GO:0006457 YNL310C YNL310C 20 cellular transport GO:0006888 YDL099W YDL099W 32 cell rescue, defense and virulence GO:0006974 GO:0006950 GO:0006979...”
- dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae
Pan, Methods (San Diego, Calif.) 2007 - “...for optimal growth YLR074C BUD20 Low spore viability YLR204W QRI5 Requires uracil for optimal growth YLR357W RSC2 Might need uracil for optimal growth YLR410W...”
- COX24 codes for a mitochondrial protein required for processing of the COX1 transcript
Barros, The Journal of biological chemistry 2006 (PubMed)- “...of cytochrome oxidase. COX24 corresponds to reading frame YLR204W and was previously named QRI5 (32). The phenotype of cox24 mutants and characterization of...”
- “...low molecular weight protein product of open reading frame YLR204W, for which we propose the name COX24, is also involved in processing of COX1 RNA...”
- More
5aj3n / A0A0M3KL57 Structure of the small subunit of the mammalian mitoribosome (see paper)
Aligns to 1:32 / 72 (44.4%), covers 90.9% of PF08213, 44.3 bits
8crxX 8crxX (see paper)
Aligns to 1:32 / 32 (100.0%), covers 97.0% of PF08213, 44.2 bits
SCO3327 hypothetical protein from Streptomyces coelicolor A3(2)
Aligns to 1:32 / 32 (100.0%), covers 90.9% of PF08213, 38.4 bits
- Deciphering the regulon of Streptomyces coelicolor AbrC3, a positive response regulator of antibiotic production
Rico, Applied and environmental microbiology 2014 - “...SCO1550 SCO1839 SCO2113/bfr SCO2779/acdH SCO3218 SCO3327 SCO3328/bdtA SCO4425/afsS SCO5240/wblE SCO5915 SCO6205 SCO6992/absR1 Hydroxylacyl-CoA dehydrogenase...”
- “...regulated by BldD and forms an operon with SCO3327 [22, 23]), were also significantly downregulated. The acdH gene (SCO2779), encoding an acyl-coenzyme A...”
- Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences
Chandra, FEMS microbiology reviews 2014 - “...5866 ( ML1027 ), 6030 ( ML1041 ). One ( ML2428A ) was similar to SCO3327 , but did not give a reciprocal blastp best hit, and another ( ML0899 ) was absent from S. coelicolor , but present in S. avermitilis ( SAV1313 ) and...”
- Genome-wide transcriptomic analysis of the response to nitrogen limitation in Streptomyces coelicolor A3(2)
Lewis, BMC research notes 2011 - “...the GlnR regulon whose expression is induced in response to nitrogen limitation. We also note SCO3327 which encodes a small protein (32 amino acid residues) unusually rich in the basic amino acids lysine (31.25%) and arginine (25%) is significantly differentially expressed in the nitrogen limited cultures....”
- “...differentially expressed in low nitrogen culture conditions, including a putative nitrogen storage protein encoded by SCO3327. Our list includes several genes whose expression patterns are similar to up-regulated members of the GlnR regulon and are induced in response to nitrogen limitation. These genes represent likely targets...”
6yw522 / Q7SHR6 structure of the small subunit of the mitoribosome from Neurospora crassa (see paper)
Aligns to 1:32 / 33 (97.0%), covers 90.9% of PF08213, 36.5 bits
COX24_NEUCR / Q7SHR6 Small ribosomal subunit protein mS38 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
NCU02548 hypothetical protein from Neurospora crassa OR74A
Aligns to 311:343 / 344 (9.6%), covers 97.0% of PF08213, 32.3 bits
- function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
subunit: Component of the mitochondrial small ribosomal subunit (mt- SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. - Experimental Evolution of Multidrug Resistance in Neurospora crassa under Antifungal Azole Stress
Zhou, Journal of fungi (Basel, Switzerland) 2022 - “...knockout mutants of eight mutated genes ( NCU08055 , NCU01997 , NCU09308 , NCU02036 , NCU02548 , NCU03491 , NCU03641 and NCU02243 ) in 30thK2. The mutants for NCU03641 (beta-glucosidase 2), NCU08055 (glycoside hydrolase family 3 protein ZIP-1), and NCU02243 (hp) showed the WT sensitivity to...”
- “...transporter) and NCU09308 (glycoprotease) were more resistant to Terb than WT; and the mutants for NCU02548 (hp) and NCU03491 (RNA splicing factor) were more resistant to KTC than WT ( Figure S4 , Tables S5 and S6 ). In addition, the NCU02548 deletion mutant was more...”
LOC105207451 uncharacterized protein LOC105207451 from Solenopsis invicta
Aligns to 122:154 / 232 (14.2%), covers 93.9% of PF08213, 32.3 bits
8a22BC 8a22BC (see paper)
Aligns to 1:31 / 31 (100.0%), covers 69.7% of PF08213, 23.3 bits
Or search for genetic data about PF08213 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory