Family Search for PF08550 (DUF1752)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF08550 hits 46 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

AREA_ASPOR / O13415 Nitrogen regulatory protein areA from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
Aligns to 99:126 / 866 (3.2%), covers 100.0% of PF08550, 49.0 bits

• function: Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.

AREA_EMENI / P17429 Nitrogen regulatory protein areA from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 6 papers)
Aligns to 105:132 / 876 (3.2%), covers 96.4% of PF08550, 49.0 bits

• function: Transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. Activates the transcription of uapA.
  subunit: Interacts with nmrA.

NIT2_NEUCR / P19212 Nitrogen catabolic enzyme regulatory protein; Nitrogen regulatory protein 2; NIT2 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see paper)
Aligns to 169:196 / 1036 (2.7%), covers 100.0% of PF08550, 47.8 bits

• function: Major nitrogen regulatory protein. During conditions of nitrogen limitation it turns on the expression of genes for enzymes which are required for the use of a variety of secondary nitrogen sources, including nitrates, purines, amino acids, and proteins.
  subunit: Interacts with nmr.

YIDF_SCHPO / Q9UTC4 Uncharacterized protein C227.15 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
Aligns to 314:341 / 873 (3.2%), covers 100.0% of PF08550, 44.1 bits

REG1_YEAST / Q00816 Resistance to glucose repression protein 1; Protein HEX2; Second-site suppressor of the rna1-1 mutation 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 173:204 / 1014 (3.2%), covers 100.0% of PF08550, 40.7 bits

• function: Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.
  subunit: Interacts with SAK1.

GAT1_YEAST / P43574 Transcriptional regulatory protein GAT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 58:85 / 510 (5.5%), covers 100.0% of PF08550, 34.4 bits

• function: Positive regulator of multiple nitrogen catabolic genes

GAT1_CANAL / Q5A432 Transcriptional regulatory protein GAT1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
Aligns to 1:25 / 688 (3.6%), covers 85.7% of PF08550, 33.1 bits

• function: Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model.

GRA3_GIBZE / I1S490 Gramillins biosynthetic cluster protein FGSG_11657 from Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) (see paper)
Aligns to 482:508 / 740 (3.6%), covers 89.3% of PF08550, 30.8 bits

• function: Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).

REG2_YEAST / P38232 Protein REG2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 131:153 / 338 (6.8%), covers 75.0% of PF08550, 26.4 bits

• function: Regulatory subunit, binds to type-1 protein phosphatase. Functions with HEX2/REG1 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.

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