Family Search for PF08878 (HamA)
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Running HMMer for PF08878
PF08878 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
SSA_1888 hypothetical protein from Streptococcus sanguinis SK36
Aligns to 36:288 / 311 (81.4%), covers 99.6% of PF08878, 195.1 bits
F4NA83 Uncharacterized protein from Staphylococcus aureus
Aligns to 35:284 / 304 (82.2%), covers 99.6% of PF08878, 175.4 bits
UC7_RS13845 DUF1837 domain-containing protein from Enterococcus caccae ATCC BAA-1240
Aligns to 40:295 / 317 (80.8%), covers 100.0% of PF08878, 167.8 bits
AbpA / b2628 CP4-57 prophage; anti-bacteriophage protein from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ABPA_ECOLI / P52127 Anti-bacteriophage protein A from Escherichia coli (strain K12) (see 2 papers)
NP_417117 anti-bacteriophage protein from Escherichia coli str. K-12 substr. MG1655
b2628 CP4-57 prophage; predicted protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 294:520 / 538 (42.2%), covers 99.6% of PF08878, 142.3 bits
- function: Part of an antiviral system composed of AbpA and AbpB; when both are expressed from a plasmid they confer resistance to phages T2, T4, T7 and lambda but not RB32 or RB69. Resistance is temperature dependent, it can be seen at 30 degrees Celsius but not at 37 or 42 degrees Celsius. The system impairs phage but not bacterial DNA synthesis (shown for T4, T7 and lambda). Partially suppressed by mutations in T4 gene 41, a replicative helicase.
subunit: Interacts with AbpB.
disruption phenotype: About 20% increase in T4 progeny; the phenotype is the same in a double abpA-abpB deletion. - AbpA and AbpB provide anti-phage activity in Escherichia coli.
Yasui, Genes & genetic systems 2014 (PubMed)- GeneRIF: AbpA and AbpB target DNA replication of phages to block phage propagation
- Phage single-stranded DNA-binding protein or host DNA damage triggers the activation of the AbpAB phage defense system
Sasaki, mSphere 2023 - “...LB plates without KM. AbpA and AbpB structure prediction and alignment Three-dimensional AbpA (UniProt ID: P52127) and AbpB (UniProt ID: P52126) model structures were obtained from the AlphaFold Protein Structure Database ( https://alphafold.ebi.ac.uk/ ) ( 36 , 37 ). AbpA and AbpB structural homologs were searched...”
- Common and specific characteristics of the high-pathogenicity island of Yersinia enterocolitica
Rakin, Infection and immunity 1999 - “...67, 1999 5269 hypothetical proteins YfjK (P52126) and YfjL (P52127) clustered in the alpA-gabD region of the E. coli K-12 chromosome. ORF21 and ORF22 are...”
- “...E. coli (P52126) Unknown 22% to YfjL of E. coli (P52127) 24% to ComE integral protein of Bacillus subtilis (P39695) 43% to uracyl hydrolase of E. coli (P39219)...”
- Directional RNA-seq reveals highly complex condition-dependent transcriptomes in E. coli K12 through accurate full-length transcripts assembling
Li, BMC genomics 2013 - “...strand is documented as an operon in RegulonDB, there is no TSS documented for gene b2628 . We predicted a potential TSS in the upstream intergenic region of b2628 (2,763,486) in five samples (Additional file 1 : Figure S5). The remaining 1,968 predicted TSSs appeared only...”
WP_055648496 Hachiman antiphage defense system protein HamA from Shewanella sp. Sh95
Aligns to 59:271 / 291 (73.2%), covers 74.8% of PF08878, 56.7 bits
HAMA_BACCE / P0DW39 Hachiman protein HamA from Bacillus cereus (see paper)
Aligns to 45:235 / 271 (70.5%), covers 73.0% of PF08878, 55.9 bits
- function: Component of antiviral defense system Hachiman, composed of HamA and HamB. Expression of Hachiman in B.subtilis (strain BEST7003) confers resistance to phages phi105, phi29, phi3T, rho14, SBSphiJ, SpBeta and SPR.
disruption phenotype: When this gene is missing the Hachiman system does not confer SpBeta resistance in B.subtilis.
Or search for genetic data about PF08878 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory