Family Search for PF09755 (DUF2046)

PF09755.9 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

XP_006514339 coiled-coil domain-containing protein 6 isoform X1 from Mus musculus
Aligns to 25:330 / 412 (74.3%), covers 94.7% of PF09755, 497.7 bits

• Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity.
  Leone, Oncotarget 2015
  • GeneRIF: Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 activity and an increased expression of the CREB-1 regulated genes.
• Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.
  Staibano, BMC cancer 2013
  • GeneRIF: the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.

CCDC6_HUMAN / Q16204 Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4 from Homo sapiens (Human) (see paper)
NP_005427 coiled-coil domain-containing protein 6 from Homo sapiens
Aligns to 42:337 / 474 (62.4%), covers 94.4% of PF09755, 490.2 bits

• Genome sequencing for nonsmall-cell lung cancer identifies a basis for nintedanib sensitivity.
  Takeda, Annals of oncology : official journal of the European Society for Medical Oncology 2016 (PubMed)
  • GeneRIF: Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy.
• Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein.
  Wang, Cancer letters 2016
  • GeneRIF: FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions.
• New therapeutic perspectives in CCDC6 deficient lung cancer cells.
  Morra, International journal of cancer 2015 (PubMed)
  • GeneRIF: CCDC6 levels provide valuable insight for OS.
• The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS.
  Duggimpudi, PloS one 2015
  • GeneRIF: Results show that RNA-binding protein EWS binds and regulates CCDC6 expression at RNA and protein levels.
• FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.
  Morra, Oncotarget 2015
  • GeneRIF: we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications
• Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
  Suzuki, Cancer science 2013 (PubMed)
  • GeneRIF: Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.
• Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.
  Staibano, BMC cancer 2013
  • GeneRIF: the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.
• RET, ROS1 and ALK fusions in lung cancer.
  Takeuchi, Nature medicine 2012 (PubMed)
  • GeneRIF: we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas
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• β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
  Vergara, Frontiers in physiology 2017
  • “...7 70.8 SAFB Scaffold attachment factor B1 Q15424 9 16.6 CCDC6 Coiled-coil domain-containing protein 6 Q16204 7 17.7 FSCN1 Fascin Q16658 16 41.2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 Q32MZ4 10 17 MYH14 Myosin-14 Q7Z406 42 28 KTN1 Kinectin Q86UP2 46 41.9 NMD3 60S ribosomal export...”