Family Search for PF09755 (DUF2046)
PF09755.9 hits 2 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
XP_006514339 coiled-coil domain-containing protein 6 isoform X1 from Mus musculus
Aligns to 25:330 / 412 (74.3%), covers 94.7% of PF09755, 497.7 bits
CCDC6_HUMAN / Q16204 Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4 from Homo sapiens (Human) (see paper)
NP_005427 coiled-coil domain-containing protein 6 from Homo sapiens
Aligns to 42:337 / 474 (62.4%), covers 94.4% of PF09755, 490.2 bits
- Genome sequencing for nonsmall-cell lung cancer identifies a basis for nintedanib sensitivity.
Takeda, Annals of oncology : official journal of the European Society for Medical Oncology 2016 (PubMed)- GeneRIF: Our findings nevertheless suggest that CCDC6-RET fusions identified by multiplex testing are potential targets for nintedanib therapy.
- Antitumor effect of FGFR inhibitors on a novel cholangiocarcinoma patient derived xenograft mouse model endogenously expressing an FGFR2-CCDC6 fusion protein.
Wang, Cancer letters 2016 - GeneRIF: FGFR inhibitors, particularly BGJ398, are therapeutic options for cholangiocarcinoma patients harboring FGFR2-CCDC6 fusions.
- New therapeutic perspectives in CCDC6 deficient lung cancer cells.
Morra, International journal of cancer 2015 (PubMed)- GeneRIF: CCDC6 levels provide valuable insight for OS.
- The cell cycle regulator CCDC6 is a key target of RNA-binding protein EWS.
Duggimpudi, PloS one 2015 - GeneRIF: Results show that RNA-binding protein EWS binds and regulates CCDC6 expression at RNA and protein levels.
- FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC.
Morra, Oncotarget 2015 - GeneRIF: we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications
- Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Suzuki, Cancer science 2013 (PubMed)- GeneRIF: Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.
- Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors.
Staibano, BMC cancer 2013 - GeneRIF: the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.
- RET, ROS1 and ALK fusions in lung cancer.
Takeuchi, Nature medicine 2012 (PubMed)- GeneRIF: we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas
- More
- β-Catenin Knockdown Affects Mitochondrial Biogenesis and Lipid Metabolism in Breast Cancer Cells
Vergara, Frontiers in Physiology 2017 - “...7 70.8 SAFB Scaffold attachment factor B1 Q15424 9 16.6 CCDC6 Coiled-coil domain-containing protein 6 Q16204 7 17.7 FSCN1 Fascin Q16658 16 41.2 LRRFIP1 Leucine-rich repeat flightless-interacting protein 1 Q32MZ4 10 17 MYH14 Myosin-14 Q7Z406 42 28 KTN1 Kinectin Q86UP2 46 41.9 NMD3 60S ribosomal export...”
Or search for genetic data about PF09755 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory