Family Search for PF10164 (BRI3)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF10164

PF10164 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BRI3_MOUSE / P28662 Membrane protein BRI3; Brain protein I3 from Mus musculus (Mouse)
Aligns to 28:124 / 125 (77.6%), covers 100.0% of PF10164, 121.4 bits

• function: Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity).
  subunit: Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By similarity).

NP_001009604 brain protein I3 isoform 1 from Rattus norvegicus
Aligns to 28:124 / 125 (77.6%), covers 100.0% of PF10164, 120.8 bits

• MicroRNA-323 regulates ischemia/reperfusion injury-induced neuronal cell death by targeting BRI3.
  Yang, International journal of clinical and experimental pathology 2015
  • GeneRIF: miR-323 might regulate ischemia/reperfusion-induced rat neuronal cell death via targeting BRI3.

BRI3_HUMAN / O95415 Membrane protein BRI3; Brain protein I3; pRGR2 from Homo sapiens (Human) (see 4 papers)
Aligns to 28:124 / 125 (77.6%), covers 100.0% of PF10164, 118.5 bits

• function: Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055).
  subunit: [Isoform 1]: Interacts with BRI3BP (PubMed:11860200, PubMed:30983867). Interacts with MGAT1 and IFITM3 (PubMed:30983867).
  subunit: [Isoform 2]: Interacts with BRI3BP, MGAT1 and IFITM3; the interactions are weaker than with isoform 1.
• The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles.
  do, Biochimica et biophysica acta. Molecular cell research 2022
  • “...al., 2020 (dataset S1) 140 Q96HP0 Dedicator of cytokinesis protein 6 38.59 0.5 1.7 141 O95415 Brain protein I3 38.40 0.7 <140 aa 142 O95248 Myotubularin-related protein 5 37.47 0.7 2.37 Hardenberg et al., 2020 (dataset S1) *HTS 143 O76050 E3 ubiquitin-protein ligase NEURL1 37.46 0.2...”
• SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
  Karami, Frontiers in immunology 2021
  • “...polyprotein P19021 AMD Peptidyl-glycine alpha-amidating monooxygenase precursor 973 ENSP00000306100 KLIKEPGSGVPVVLITTL 860-867 13 RYPANSIV ORF1ab polyprotein O95415 BRI3 Brain protein I3 125 ENSP00000313601 SRTVTRYPANSIVVVGGC 66-73 14 GPPGTGKS ORF1ab polyprotein O75351 VPS4B Vacuolar protein sorting-associated protein 4B 444 ENSP00000297290 GILLFGPPGTGKSYLAKA 174-181 Q7Z333 SETX Probable helicase senataxin 2677 ENSP00000238497...”

NP_001157181 brain protein I3 isoform 2 from Mus musculus
Aligns to 26:120 / 121 (78.5%), covers 66.0% of PF10164, 118.0 bits

• bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death.
  Wu, Biochemical and biophysical research communications 2003 (PubMed)
  • GeneRIF: bri3 appears to play an important role in TNF-induced cell death and may be localized to lysosome and function through lysosome.

NP_001152963 membrane protein BRI3 isoform b from Homo sapiens
Aligns to 28:93 / 98 (67.3%), covers 61.3% of PF10164, 31.3 bits

• NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.
  Yasukawa, Cell reports 2020 (PubMed)
  • GeneRIF: NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta Production by Targeting BRI2 and BRI3 for Degradation.
• Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.
  Kavak, Cellular signalling 2010 (PubMed)
  • GeneRIF: In the context of hepatocellular carcinoma cells, BRI3 is a target of WNT signaling.
• BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
  Matsuda, The Journal of biological chemistry 2009
  • GeneRIF: BRI3 inhibits the various processing of amyloid protein precursor by blocking the access of alpha- and beta-secretases.
• BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.
  Gong, BMB reports 2008 (PubMed)
  • GeneRIF: Possible roles of BRI3 in the process of neuronal differentiation.
• A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients.
  Bandrés, Oncology reports 2007 (PubMed)
  • GeneRIF: BRI3 RNA is expressed less in stage 3 colon cancer in comparison to stage 2 colon cancer, and it is among 8 genes which can be used as a gene signature to differentiate colon cancer stages.
• Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain.
  Ye, Acta crystallographica. Section F, Structural biology and crystallization communications 2005
  • GeneRIF: An X-ray data set was collected to 1.6 A resolution using synchrotron radiation, of a ligandin recombinant fusion protein.

Or search for genetic data about PF10164 in the Fitness Browser