Family Search for PF10179 (NDNF)
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PF10179 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
NDNF_HUMAN / Q8TB73 Protein NDNF; Neuron-derived neurotrophic factor from Homo sapiens (Human) (see 3 papers)
NP_078850 protein NDNF precursor from Homo sapiens
Aligns to 192:335 / 568 (25.4%), covers 100.0% of PF10179, 144.1 bits
- function: Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).
subunit: Binds heparin and chondroitin sulfate. - Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
Messina, American journal of human genetics 2020 - GeneRIF: Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
- Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.
Zhang, JCI insight 2019 - GeneRIF: Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer.
- Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.
Ohashi, The Journal of biological chemistry 2014 - GeneRIF: NDNF acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms
- A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi, Human molecular genetics 2010 - GeneRIF: Observational study of gene-disease association. (HuGE Navigator)
- Mosaicism for terminal deletion of 4q.
Utine, Genetic counseling (Geneva, Switzerland) 2006 (PubMed)- GeneRIF: direct duplication of chromosome 4q27q31.3 de novo results in partial trisomy of its long arm.
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
- Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.
Messina, American journal of human genetics 2020 - Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.
Schira, Molecular & cellular proteomics : MCP 2015
NDNF_DANRE / F1QPX0 Protein NDNF from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 192:340 / 574 (26.0%), covers 100.0% of PF10179, 139.9 bits
- function: Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (By similarity).
disruption phenotype: Morpholino knockdown of the protein alters the migration of gonadotropin-releasing hormone (GnRH) expressing neurons.
NDNF_MOUSE / Q8C119 Protein NDNF; Epidermacan; Neuron-derived neurotrophic factor from Mus musculus (Mouse) (see 4 papers)
NP_765987 protein NDNF precursor from Mus musculus
Aligns to 192:335 / 568 (25.4%), covers 99.2% of PF10179, 139.2 bits
NDNF_DROME / Q9W192 Protein NDNF; Neuron-derived neurotrophic-like factor; Protein Nord from Drosophila melanogaster (Fruit fly) (see 2 papers)
NP_611900 nord from Drosophila melanogaster
Aligns to 208:333 / 587 (21.5%), covers 99.2% of PF10179, 113.6 bits
- function: Secretory protein that acts as a feedback regulator of dpp/BMP, wg and hh signaling pathways (PubMed:35609633, PubMed:35037619). In the developing wing, is a dosage-dependent modulator of dpp/BMP signaling involved in wing growth and crossvein patterning; low levels promote and high levels inhibit dpp/BMP signaling (PubMed:35609633, PubMed:35037619). In the early pupal wing, inhibits dpp/BMP signaling activity to prevent the formation of ectopic crossveins in the posterior compartment (PubMed:35609633, PubMed:35037619). Binds to dpp and gbb to modulate their release and activity decreasing dpp/BMP signaling in the responding cells (PubMed:35609633, PubMed:35037619). During wing development regulates dpp/BMP coreceptor dally availability on the cell surface (PubMed:35609633). Might have a role in testis development (PubMed:35609633).
subunit: Binds heparin (PubMed:35609633). Interacts with dally; the interaction promotes dally degradation (PubMed:35609633). Interacts with dpp and gbb (PubMed:35037619). - The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Yang, eLife 2022 - GeneRIF: The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
- Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development
Kuang, BMC neuroscience 2010 - “...Methods Protein sequence analysis Human (NP_078850), mouse (NP_765987), bovine (XP_597721), chicken (XP_420627), frog (NP_001085901), fly (NP_611900) and nematode (NP_500282) protein sequences were used in this study. In addition, the rat NDNF protein sequence was acquired by homology comparison. A sequence alignment software program, Clustalw 2.0, was...”
LOC101887233 uncharacterized protein LOC101887233 from Musca domestica
Aligns to 307:430 / 692 (17.9%), covers 98.4% of PF10179, 98.1 bits
NP_500282 Protein NDNF C-terminal domain-containing protein from Caenorhabditis elegans
Aligns to 220:271 / 536 (9.7%), covers 37.0% of PF10179, 77.7 bits
Or search for genetic data about PF10179 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory