Family Search for PF11081 (Adeno_L433K_22K)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF11081
PF11081 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
PKG2_ADE02 / P0DJX1 Packaging protein 2; Packaging protein 22K; L4-22K from Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) (see 7 papers)
Aligns to 1:178 / 195 (91.3%), covers 99.4% of PF11081, 339.7 bits
- function: Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 1 and 3, to the specific packaging sequence on the left end of viral genomic DNA and plays an active role in packaging of the viral genome into preformed capsids. Specifically binds to the 5'-TTTG-3' nucleotides of the repeats making up the packaging sequence. Forms a transcription factor called DEF-A through cooperative binding with packaging protein 1 (Probable). DEF-A binds to downstream elements of the major late promoter (MLP) and stimulates transcription from the MLP after initiation of viral DNA replication. Simultaneously suppresses early gene expression and is thus likely to participate in the early- late switch in the expression pattern of the late viral proteins. May as well enhance transcription from IVa2 and pIX promoters.
subunit: Part of a genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Self-assembles into higher-order structures.
SF33K_ADE02 / P24939 Protein 33K; L4-33K; Splicing factor 33K; Terminase, small subunit from Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) (see 4 papers)
Aligns to 1:225 / 228 (98.7%), covers 100.0% of PF11081, 322.4 bits
- function: Promotes alternative splicing of late transcripts by promoting splicing at weak 3' splice sites. Required for the temporal activation of major late pre-mRNA splicing at late times of infection. Induces the splicing and expression of the late capsid vertex protein.
function: Probably functions as the small terminase that is part of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. This motor is located at a unique vertex and comprises at least the IVa2 ATPase, the small terminase 33K and probably a portal. Forms a ring-like structure of about 17 nm in which genomic DNA is translocated into the capsid. Stimulates IVa2 ATPase activity in the presence of the viral genome. Once the DNA is packaged, the terminase detaches: the 33K protein is present in the empty particles, but not in the mature virions. Also involved in virion assembly.
subunit: Homooligomer. Interacts with DBP; this interaction occurs at a unique vertex during genome packaging. Interacts with IVa2; this interaction occurs at a unique vertex during genome packaging and seems to potentiate IVa2 and 33K oligomerization.
PKG2_ADE05 / Q2KS03 Packaging protein 2; Packaging protein 22K; L4-22K from Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) (see 4 papers)
Aligns to 1:179 / 196 (91.3%), covers 99.4% of PF11081, 311.0 bits
- function: Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 1 and 3, to the specific packaging sequence on the left end of viral genomic DNA and plays an active role in packaging of the viral genome into preformed capsids. Specifically binds to the 5'-TTTG-3' nucleotides of the repeats making up the packaging sequence. Forms a transcription factor called DEF-A through cooperative binding with packaging protein 1 (Probable). DEF-A binds to downstream elements of the major late promoter (MLP) and stimulates transcription from the MLP after initiation of viral DNA replication. Simultaneously suppresses early gene expression and is thus likely to participate in the early- late switch in the expression pattern of the late viral proteins. May as well enhance transcription from IVa2 and pIX promoters.
subunit: Part of a genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Self-assembles into higher-order structures.
SF33K_ADE05 / P24940 Protein 33K; L4-33K; Splicing factor 33K; Terminase, small subunit from Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) (see 6 papers)
Aligns to 1:226 / 229 (98.7%), covers 100.0% of PF11081, 294.1 bits
- function: Promotes alternative splicing of late transcripts by promoting splicing at weak 3' splice sites. Required for the temporal activation of major late pre-mRNA splicing at late times of infection. Induces the splicing and expression of the late capsid vertex protein.
function: Probably functions as the small terminase that is part of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. This motor is located at a unique vertex and comprises at least the IVa2 ATPase, the small terminase 33K and probably a portal. Forms a ring-like structure of about 17 nm in which genomic DNA is translocated into the capsid. Stimulates IVa2 ATPase activity in the presence of the viral genome. Once the DNA is packaged, the terminase detaches: the 33K protein is present in the empty particles, but not in the mature virions. Also involved in virion assembly.
subunit: Homooligomer. Interacts with DBP; this interaction occurs at a unique vertex during genome packaging. Interacts with IVa2; this interaction occurs at a unique vertex during genome packaging and seems to potentiate IVa2 and 33K oligomerization.
IV454_06250 phospholipase A from Massilia antarctica
Aligns to 29:204 / 357 (49.3%), covers 38.1% of PF11081, 21.7 bits
Or search for genetic data about PF11081 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory