Family Search for PF11630 (Anti-LPS-SCYG)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF11630
PF11630 hits 11 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
LOC119576449 anti-lipopolysaccharide factor-like from Penaeus monodon
Aligns to 27:126 / 127 (78.7%), covers 100.0% of PF11630, 154.2 bits
XP_027206930 anti-lipopolysaccharide factor-like from Penaeus vannamei
Aligns to 23:122 / 122 (82.0%), covers 100.0% of PF11630, 152.6 bits
ALPS_SCYSE / B5TTX7 Anti-lipopolysaccharide factor; SsALF from Scylla serrata (Mud crab) (see 2 papers)
Aligns to 24:122 / 123 (80.5%), covers 100.0% of PF11630, 142.1 bits
- function: Binds to bacterial LPS and may specifically inhibit the LPS- mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria.
- Anti-inflammatory activities of arthropod peptides: a systematic review
Dos, The journal of venomous animals and toxins including tropical diseases 2021 - “...Scylla paramamosain Catalase D0EVW7 Antioxidant potential [ 105 , 106 ] Scylla serrata Anti-lipopolysaccharide factor B5TTX7 Charybdis natator Crab leg - Modulating the NF-kB pathway [ 107 ] Arachnid Titius obscurus Toxin To3 P60213 Suppression of TNF- and IL-1 [ 112 ] Toxin To4 P60215 Tityus...”
P07087 Anti-lipopolysaccharide factor from Tachypleus tridentatus
Aligns to 1:99 / 102 (97.1%), covers 99.0% of PF11630, 141.7 bits
ALPS_PORTR / C0KJQ4 Anti-lipopolysaccharide factor; PtALF from Portunus trituberculatus (Swimming crab) (Neptunus trituberculatus) (see 2 papers)
Aligns to 24:122 / 123 (80.5%), covers 100.0% of PF11630, 136.9 bits
- function: May bind to bacterial LPS and thus specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect especially on the growth of Gram-negative bacteria (By similarity).
- Anti-inflammatory activities of arthropod peptides: a systematic review
Dos, The journal of venomous animals and toxins including tropical diseases 2021 - “...reducing the release of pro-inflammatory cytokines [ 90 - 91 ] Portunus trituberculatus Anti-lipopolysaccharide factor C0KJQ4 Immunomodulatory activity [ 98 - 102 ] Anti-lipopolysaccharide factor isoform 4 H9MYY2 Anti-lipopolysaccharide factor isoform 5 - Antilipopolysaccharide factor isoform 8 - Scylla paramamosain Catalase D0EVW7 Antioxidant potential [ 105...”
P07086 Anti-lipopolysaccharide factor from Limulus polyphemus
Aligns to 1:98 / 101 (97.0%), covers 96.0% of PF11630, 134.1 bits
- Anti-inflammatory activities of arthropod peptides: a systematic review
Dos, The journal of venomous animals and toxins including tropical diseases 2021 - “...magnificca - P0CH47 Inhibition of the NF-kB pathway [ 84 ] Limulus polyphemus Anti-lipopolysaccharide factor P07086 Immunomodulatory activity [ 67 , 68 ] Penaeus monodon Anti-lipopolysaccharide factor B1NMC7 Disruption of the mitogen-activated protein (MAP) pathway by regulating and reducing the release of pro-inflammatory cytokines [ 90...”
- Functional divergence in shrimp anti-lipopolysaccharide factors (ALFs): from recognition of cell wall components to antimicrobial activity
Rosa, PloS one 2013 - “...shrimp and from the horseshoe crabs T. tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), L. polyphemus (LIMPO_ALF: P07086) and Carcinoscorpius rotundicauda (CARRO_ALF: CK086627). A total of 42 sequences were analyzed. A phylogenetic tree was generated from the sequence alignments with scygonadins [34] , another two cysteine-containing AMP family...”
- “...Chinese horseshoe crab Tachypleus tridentatus (TACTR_ALF: P07087; TACTR2_ALF: AAK00651), Atlantic horseshoe crab Limulus polyphemus (LIMPO_ALF: P07086) and Southeast Asian horseshoe crab Carcinoscorpius rotundicauda (CARRO_ALF: CK086627); (iii) Scygonadins (outgroup): giant mud crab Scylla serrata ( S serrata scygonadin: AAW57403; S serrata scygonadin-2: ABI96918; S serrata SSAP: ABM05493)...”
- Anti-lipopolysaccharide factors in the American lobster Homarus americanus: molecular characterization and transcriptional response to Vibrio fluvialis challenge
Beale, Comparative biochemistry and physiology. Part D, Genomics & proteomics 2008 - “...Japanese horseshoe crab Tachypleus tridentatus ( AF227150 ) and Atlantic horseshoe crab Limulus polyphemus ( P07086 ). Arrows indicate conserved cysteine residues participating in a disulfide bridge that forms a cationic loop in the protein. Figure 6 Neighbor-joining tree of representative arthropod anti-lipopolysaccharide protein sequences based...”
- Antilipopolysaccharide factor interferes with white spot syndrome virus replication in vitro and in vivo in the crayfish Pacifastacus leniusculus
Liu, Journal of virology 2006 - “...P07087), Limulus polyphemus (GenBank accession no. P07086), Litopenaeus stylirostris (GenBank accession no. AAY33769), Penaeus monodon, and Pacifastacus...”
XP_037782682 anti-lipopolysaccharide factor-like from Penaeus monodon
Aligns to 23:122 / 123 (81.3%), covers 99.0% of PF11630, 122.6 bits
- Marine Arthropods as a Source of Antimicrobial Peptides
Saucedo-Vázquez, Marine drugs 2022 - “...japonicus Anti-Gram negative Promotes the clearance of bacteria in vivo [ 164 ] F ALFPm10 (XP_037782682) Penaeus monodon Anti-Gram positive [ 46 ] [ 165 ] G ALFPm11 Penaeus monodon Broad spectrum antibacterial Antiviral [ 152 ] 3.6.4. Stylicins Structure These anionic AMPs are composed of...”
AMP1_SCYSE / A1YV58 Antimicrobial protein 1 from Scylla serrata (Mud crab) (see paper)
Aligns to 23:124 / 126 (81.0%), covers 99.0% of PF11630, 105.6 bits
- function: Has antibacterial activity against the Gram-positive bacteria E.coli (MIC<50 ug/ml) and P.aeruginosa (MIC<25 ug/ml), and the Gram- negative bacteria S.aureus (MIC<100 ug/ml) and S.pyogenes (MIC<50 ug/ml).
LOC127004138 anti-lipopolysaccharide factor-like from Eriocheir sinensis
Aligns to 23:119 / 120 (80.8%), covers 99.0% of PF11630, 104.5 bits
- Transcriptome and metabolomics analysis of adaptive mechanism of Chinese mitten crab (Eriocheir sinensis) to aflatoxin B1
Yang, PloS one 2023 - “...1.96 in L-C vs. L-30 m and 1.77 in L-C vs. L-60 m, respectively). Gene LOC127004138 could encode anti-lipopolysaccharide factor, which was widely used in aquaculture due to its strong antibacterial activity and broad antibacterial spectrum [ 27 ]. The expression level of LOC127004138 increased more...”
- “...enzymes related to regulatory effects encoded by DEGs ( LOC127004133 , LOC127005812 , LOC126997672 , LOC127004138 ) is related to the antibacterial and detoxification of the liver, and has also been mentioned in the literature [ 27 , 28 ]. Additionally, DEGs are also involved in...”
SCYG_SCYSE / Q5D710 Scygonadin from Scylla serrata (Mud crab) (see paper)
Aligns to 23:124 / 126 (81.0%), covers 99.0% of PF11630, 95.0 bits
- function: Has antibacterial activity against the Gram-positive bacterium M.luteus with an IC(90) of 125ug/ml. Has weak antibacterial activity against the Gram-negative bacterium A.hydrophila.
H9MYY2 Anti-lipopolysaccharide factor isoform 4 from Portunus trituberculatus
Aligns to 23:123 / 125 (80.8%), covers 98.0% of PF11630, 86.5 bits
- Anti-inflammatory activities of arthropod peptides: a systematic review
Dos, The journal of venomous animals and toxins including tropical diseases 2021 - “...trituberculatus Anti-lipopolysaccharide factor C0KJQ4 Immunomodulatory activity [ 98 - 102 ] Anti-lipopolysaccharide factor isoform 4 H9MYY2 Anti-lipopolysaccharide factor isoform 5 - Antilipopolysaccharide factor isoform 8 - Scylla paramamosain Catalase D0EVW7 Antioxidant potential [ 105 , 106 ] Scylla serrata Anti-lipopolysaccharide factor B5TTX7 Charybdis natator Crab leg...”
Or search for genetic data about PF11630 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory