Family Search for PF11819 (CUPID)

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Running HMMer for PF11819

PF11819 hits 9 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

FRM4A_HUMAN / Q9P2Q2 FERM domain-containing protein 4A from Homo sapiens (Human) (see 2 papers)
Aligns to 356:491 / 1039 (13.1%), covers 99.3% of PF11819, 201.2 bits

• function: Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754).
  subunit: Interacts (via coiled-coil domain) with CYTH1 (via coiled-coil domain). Interacts with PARD3 (via coiled-coil domain). Found in a complex with PARD3, CYTH1 and FRMD4A. Interacts with CYTH2. Interacts with CYTH3.

FRM4A_MOUSE / Q8BIE6 FERM domain-containing protein 4A from Mus musculus (Mouse) (see paper)
Aligns to 341:476 / 1020 (13.3%), covers 99.3% of PF11819, 200.9 bits

• function: Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4B in epithelial polarization (PubMed:20080746). May regulate MAPT secretion by activating ARF6- signaling (By similarity).
  subunit: Interacts (via coiled-coil domain) with CYTH1 (via coiled-coil domain) (PubMed:20080746). Interacts with PARD3 (via coiled-coil domain) (PubMed:20080746). Found in a complex with PARD3, CYTH1 and FRMD4A (PubMed:20080746). Interacts with CYTH2 (PubMed:20080746). Interacts with CYTH3 (PubMed:20080746).

FRM4B_MOUSE / Q920B0 FERM domain-containing protein 4B; GRP1-binding protein GRSP1; Golgi-associated band 4.1-like protein; GOBLIN from Mus musculus (Mouse) (see 2 papers)
Aligns to 395:529 / 1035 (13.0%), covers 100.0% of PF11819, 185.8 bits

• function: Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (PubMed:20080746). Plays a redundant role with FRMD4A in epithelial polarization (PubMed:20080746).
  subunit: Interacts with CYTH3 (PubMed:11445584, PubMed:20080746). Interacts with PARD3 (PubMed:20080746). Interacts with CYTH1.

INAVA_MOUSE / Q7TN12 Innate immunity activator protein from Mus musculus (Mouse) (see paper)
Aligns to 87:216 / 663 (19.6%), covers 100.0% of PF11819, 182.3 bits

• function: Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1- dependent ARF6 activation (PubMed:29420262).
  subunit: Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation. Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion. Interacts (via N- terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin- protein ligase complexes (By similarity).
  disruption phenotype: After infection with Citrobacter rodentium, mutants show significantly increased bacterial loads at day 5 compared to wild-types. They are able to control the infection by day 12 post- infection, they exhibit significantly shortened colon length. They don't have impaired cytokine response (PubMed:29420262). Mutants also exhibit impaired recovery from dextran sodium sulfate-induces colitis, they show increased body weight loss and reduced colon length (PubMed:29420262).

INAVA_HUMAN / Q3KP66 Innate immunity activator protein from Homo sapiens (Human) (see 3 papers)
Aligns to 87:216 / 663 (19.6%), covers 100.0% of PF11819, 181.6 bits

• function: Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1- dependent ARF6 activation (PubMed:29420262).
  subunit: Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation (PubMed:28436939). Interacts with YWHAQ/14- 3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion (PubMed:28436939). Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains) (PubMed:29420262). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (PubMed:29420262).

CC120_HUMAN / Q96HB5 Coiled-coil domain-containing protein 120 from Homo sapiens (Human) (see 2 papers)
Aligns to 2:141 / 630 (22.2%), covers 99.3% of PF11819, 153.1 bits

• function: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.
  subunit: Interacts with NIN and CEP170; leading to recruit them to centrosomes (PubMed:28422092). Directly interacts with CYTH2; this interaction stabilizes CCDC120, possibly by preventing ubiquitination.

CC120_MOUSE / A2AEV7 Coiled-coil domain-containing protein 120 from Mus musculus (Mouse) (see paper)
Aligns to 2:141 / 629 (22.3%), covers 98.5% of PF11819, 147.0 bits

• function: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity).
  subunit: Interacts with NIN and CEP170; leading to recruit them to centrosomes (By similarity). Interacts with CYTH2; this interaction is direct and stabilizes CCDC120, possibly by preventing ubiquitination (By similarity).

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