Family Search for PF11901 (DM9)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF11901 hits 37 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q7JZZ3 RE03883p from Drosophila melanogaster
2 alignments in 25:277 / 286 (78.3%), covering up to 100.0% of PF11901, 321.8 bits
XP_002061352 uncharacterized protein LOC6638414 isoform X2 from Drosophila willistoni
3 alignments in 24:278 / 287 (88.9%), covering up to 100.0% of PF11901, 316.9 bits
Q7Q5J5 AGAP006398-PA from Anopheles gambiae
XP_316431 uncharacterized protein LOC1277009 from Anopheles gambiae
2 alignments in 26:281 / 290 (77.2%), covering up to 99.1% of PF11901, 316.4 bits
Q8SZ28 RE21371p from Drosophila melanogaster
3 alignments in 24:277 / 286 (88.8%), covering up to 100.0% of PF11901, 297.2 bits
Q9W2M4 Farnesoic acid O-methyl transferase domain-containing protein from Drosophila melanogaster
CG10527, NP_611544 uncharacterized protein from Drosophila melanogaster
2 alignments in 152:287 / 296 (45.9%), covering up to 96.5% of PF11901, 200.0 bits
- Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins
Farkaš, PloS one 2014 - “...O46034 52.0 EGF signaling cell cortex, nuclear Cecropin A1 P14954 6.8 defense response secreted CG10527 Q9W2M4 31.6 basal metabolism cytoplasmic CG12140 Q7JWF1 66.0 basal metabolism cytoplasmic CG12236 Q9W458 60.8 DNA-binding nuclear CG 13993 Q9VMH8 14.7 co-chaperone endoplasmic reticulum CG15093 (Probable 3-hydroxyisobutyrate dehydrogenase) Q9V8M5 33.9 metabolism mitochondrial...”
- CgDM9CP-5-Integrin-MAPK Pathway Regulates the Production of CgIL-17s and Cgdefensins in the Pacific Oyster, Crassostrea gigas
Liu, Journal of immunology (Baltimore, Md. : 1950) 2023 - “...various downstream immune response processes. Three DM9CPs (CG3884, CG10527, and CG13321) from D. melanogaster were found to interact with other proteins to...”
- Genomic changes associated with adaptation to arid environments in cactophilic Drosophila species
Rane, BMC genomics 2019 - “...lethal (1) 1Bi ( l(1)1Bi ) Transcriptional regulator during larval and embryo stages DALD015521 FBgn0034583 CG10527 DUF3421; Farnesoic acid O-methyl transferase DALD011516 FBgn0034031 CG12963 NA DALD011555 FBgn0029518 CG13376 NA DALD014639 FBgn0038654 CG14298 Serine-type endopeptidase inhibitor activity DALD008141 FBgn0037244 CG14647 Transcriptional regulator of protein homo-oligomerisation DALD001586 FBgn0029686...”
- DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum
Jiang, Frontiers in immunology 2017 - “...after oral infection by entomopathogenic Pseudomonas entomophila ( 5 ), while another three DM9CPs (CG3884, CG10527, and CG13321) were revealed to be part of functional complexes involved in the engulfment of microbial pathogens, intracellular trafficking and phagosome modulation ( 6 , 7 ). In addition, the...”
- “...phagosome combined with the protein interaction network of D. melanogaster revealed that three DM9CPs (CG3884, CG10527, and CG13321) could interact with other proteins to form functional complexes involved in phagocytosis of microbial pathogens and phagosome modulation in the innate immunity ( 6 , 7 ). A...”
- Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis
Wen, PLoS genetics 2015 - “...DNA sequence of jhamt; FBgn0028841 (Flybase): jhamt CDS; AE0135995 (Genbank): the genomic DNA sequence of CG10527; FBgn0266450 (Flybase): kr-h1 CDS; FBgn0003964 (Flybase): USP CDS; FBgn0263782 (Flybase): hmgcr CDS. Data Availability All relevant data are within the paper and its Supporting Information files except for the accession...”
- “...DNA sequence of jhamt; FBgn0028841 (Flybase): jhamt CDS; AE0135995 (Genbank): the genomic DNA sequence of CG10527; FBgn0266450 (Flybase): kr-h1 CDS; FBgn0003964 (Flybase): USP CDS; FBgn0263782 (Flybase): hmgcr CDS. Introduction Juvenile hormones (JHs) are members of a family of sesquiterpenoid compounds synthesized primarily by the corpus allatum...”
- Transcriptome analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection
Kolliopoulou, PloS one 2015 - “...metabolism Ferritin Transferrin ribosomal proteins L11 P0 unknown LOC101735726 Protein KGM_04122 Protein KGM16290 Similar to CG10527 Similar to CG8927 Unknown secreted protein 30 kDa protein Only genes confirmed by qRT-PCR (more than 2-fold difference in response) are shown. Induced and repressed genes are marked with up...”
- Juvenile hormone biosynthesis gene expression in the corpora allata of honey bee (Apis mellifera L.) female castes
Bomtorin, PloS one 2014 - “...- XM_556135 NM_132467 XM_624031 5e-57 Crustacean Farnesoic acid O-methyltransferase homolog FAMET Function unclear - XP_318631 NP_611544 XM_623143 e-101 Bombyx JHA methyl transferase ortholog MT Transfers methyl group from AdoMet to farnesoic acid - XP_314173 NP_609793 XM_001119986 1e-40 Methyl farnesoate epoxidase (CYP15) MFE Oxidation of MF into...”
- Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins
Farkaš, PloS one 2014 - “...Cbl O46034 52.0 EGF signaling cell cortex, nuclear Cecropin A1 P14954 6.8 defense response secreted CG10527 Q9W2M4 31.6 basal metabolism cytoplasmic CG12140 Q7JWF1 66.0 basal metabolism cytoplasmic CG12236 Q9W458 60.8 DNA-binding nuclear CG 13993 Q9VMH8 14.7 co-chaperone endoplasmic reticulum CG15093 (Probable 3-hydroxyisobutyrate dehydrogenase) Q9V8M5 33.9 metabolism...”
- Partial venom gland transcriptome of a Drosophila parasitoid wasp, Leptopilina heterotoma, reveals novel and shared bioactive profiles with stinging Hymenoptera
Heavner, Gene 2013 - “...found within these hits, are Drosophila spp. sequences. The D. melanogaster homolog to 5A01 is CG10527 [GenBank NP_611544; E = 9e-55; 49% identity], a gene that is not necessary for JH production, but may be involved with JH pathways ( Zhang, 2010 ). CG10527 mutants are...”
- “...Y Wang S Lin X Liu Y Bendena W Li S Zhang YQ 2010 Drosophila CG10527 mutants are resistant to juvenile hormone and its analog methoprene Biochem Bioph Res Co 401 182 187 Zhu J-y Ye G-y Dong S-Z Fang Q Hu C 2009 Venom of...”
- “...these hits, are Drosophila spp. sequences. The D. melanogaster homolog to 5A01 is CG10527 [GenBank NP_611544; E = 9e-55; 49% identity], a gene that is not necessary for JH production, but may be involved with JH pathways ( Zhang, 2010 ). CG10527 mutants are resistant to...”
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LOC101739845 uncharacterized protein LOC101739845 from Bombyx mori
2 alignments in 315:450 / 458 (29.7%), covering up to 96.5% of PF11901, 193.2 bits
- Evolution of proteins involved in the final steps of juvenile hormone synthesis
Smykal, Journal of insect physiology 2023 - “...pfam12248DUF3421 and/or 2x pfam12248DUF3421 were acquired from GenBank and mapped to the corresponding gene model: LOC101739845 of B. mori and LOC111863761 of C. secundus . 3 Results 3.1 Functional Juvenile hormone acid Methyl transferases (JHAMTs) First, we aligned protein sequences of all JHAMTs with experimentally confirmed...”
- “...genes are arranged in tandem in the genome; the asterisk indicates alternative splicing of the LOC101739845 gene resulting in transcripts encoding versions with one or two pfam12248 copies, respectively. In LOC101739704, alternative splicing influences the N part of the predicted proteins, however, the only pfam12248 domain...”
- Comparative Proteomic Analysis Reveals Immune Competence in Hemolymph of Bombyx mori Pupa Parasitized by Silkworm Maggot Exorista sorbillans
Xu, Insects 2019 - “...peptide binding protein BGIBMGA010168-PA gi|112983896 50.01/6.33 30 11 3.17 - Extracellular region 5 uncharacterized protein LOC101739845 BGIBMGA002604-PA gi|512931715 49.40/5.42 15 6 2.94 - Farnesoic acid o-methyltransferase 6 antitrypsin BGIBMGA009953-PA gi|253809709 43.43/5.41 26 8 9.88 - Peptidase inhibitor activity 7 failed axon connections isoform X1 BGIBMGA000552-PA gi|512921311...”
LOC105228451 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 from Bactrocera dorsalis
2 alignments in 152:287 / 295 (46.1%), covering up to 96.5% of PF11901, 190.4 bits
NP_001091815 putative farnesoic acid O-methyl transferase from Bombyx mori
2 alignments in 73:223 / 232 (65.1%), covering up to 99.1% of PF11901, 168.8 bits
LOC102671476 uncharacterized protein LOC102671476 from Apis dorsata
Aligns to 25:136 / 145 (77.2%), covers 99.1% of PF11901, 161.2 bits
LOC726980 uncharacterized protein LOC726980 from Apis mellifera
Aligns to 25:136 / 145 (77.2%), covers 99.1% of PF11901, 159.6 bits
XP_023702164 natterin-3 from Cryptotermes secundus
Aligns to 24:135 / 144 (77.8%), covers 99.1% of PF11901, 158.9 bits
- Evolution of proteins involved in the final steps of juvenile hormone synthesis
Smykal, Journal of insect physiology 2023 - “...The DUF3421 domain (magenta) is also present alone in natterin3like proteins (represented by C. secundus XP_023702164). (B) Evolutionary reconstruction of the FAMeT proteins. The tree was inferred from the protein alignment using the LG+F+G4 model in IQ-TREE with 1000 ultrafast bootstrap replicates. The major taxonomic groups...”
LOC111863761 uncharacterized protein LOC111863761 from Cryptotermes secundus
Aligns to 317:427 / 436 (25.5%), covers 97.4% of PF11901, 157.5 bits
- Evolution of proteins involved in the final steps of juvenile hormone synthesis
Smykal, Journal of insect physiology 2023 - “...acquired from GenBank and mapped to the corresponding gene model: LOC101739845 of B. mori and LOC111863761 of C. secundus . 3 Results 3.1 Functional Juvenile hormone acid Methyl transferases (JHAMTs) First, we aligned protein sequences of all JHAMTs with experimentally confirmed function, that is their activities...”
A4H320 juvenile hormone-III synthase (EC 2.1.1.325) from Melipona scutellaris (see paper)
Aligns to 129:239 / 249 (44.6%), covers 97.4% of PF11901, 155.8 bits
A4H319 juvenile hormone-III synthase (EC 2.1.1.325) from Melipona scutellaris (see paper)
Aligns to 138:248 / 258 (43.0%), covers 97.4% of PF11901, 155.7 bits
B8X2Z4 juvenile hormone-III synthase (EC 2.1.1.325) from Nilaparvata lugens (see paper)
Aligns to 178:290 / 299 (37.8%), covers 97.4% of PF11901, 155.4 bits
Q7Q1W2 AGAP009604-PA from Anopheles gambiae
Aligns to 178:289 / 298 (37.6%), covers 98.3% of PF11901, 151.8 bits
XP_318631 uncharacterized protein LOC1278977 isoform X2 from Anopheles gambiae
Aligns to 178:289 / 298 (37.6%), covers 98.3% of PF11901, 151.5 bits
B2Z3X2 juvenile hormone-III synthase (EC 2.1.1.325) from Ceratitis capitata (see paper)
Aligns to 25:136 / 146 (76.7%), covers 99.1% of PF11901, 151.0 bits
G7YGH4 Uncharacterized protein from Clonorchis sinensis
Aligns to 28:145 / 156 (75.6%), covers 96.5% of PF11901, 147.0 bits
Smp_083240 hypothetical protein from Schistosoma mansoni
Aligns to 30:145 / 156 (74.4%), covers 95.7% of PF11901, 137.5 bits
Smp_167270 hypothetical protein from Schistosoma mansoni
Aligns to 28:140 / 152 (74.3%), covers 96.5% of PF11901, 135.2 bits
K1QRB6 Natterin-3 from Crassostrea gigas
2 alignments in 1:133 / 143 (93.0%), covering up to 98.3% of PF11901, 132.2 bits
5idaA / K1QRB6 Crystal structure of cgl1 from crassostrea gigas, mannose-bound form (cgl1/man) (see paper)
3 alignments in 1:141 / 142 (99.3%), covering up to 60.9% of PF11901, 130.9 bits
- Ligand: beta-d-mannopyranose (5idaA)
lpg0301 Hypothetical protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1
2 alignments in 7:149 / 181 (79.0%), covering up to 98.3% of PF11901, 120.9 bits
- New Global Insights on the Regulation of the Biphasic Life Cycle and Virulence Via ClpP-Dependent Proteolysis in Legionella pneumophila
Ge, Molecular & cellular proteomics : MCP 2022 - “...levels of various effectors varied depending on the phase: nine (Lpg1776, LegC8/Lgt2, Lpg0112, Lem28, LegC6, Lpg0301, Lpg2327, Lpg2888, and LnaB) were downregulated at both the RP and TP; two (MavD and LegA12) were downregulated at the RP but upregulated at the TP; eight (Lpg2207, LpnE, RalF,...”
- Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: the Legionella type II secretion paradigm
White, Microbial genomics 2019 - “...putative substrates of the T2SS (Table S2), there are four additional eukaryotic-like effectors [i.e. Lpw03931 (Lpg0301), Lpw10571 (Lpg0971), Lpw24081 (Lpg2222) and Lpw28361 (Lpg2588)]. This suggests that at least 17 % (i.e. 12/72) of the L. pneumophila T2SS substrates are eukaryotic-like in nature. Thus, eukaryotic-like effectors of...”
- “...not lsp mutant supernatants ( Table 1 ). The other 20 (i.e. Lpg0042, Lpg0165, Lpg0198, Lpg0301, Lpg0374, Lpg798, Lpg0957, Lpg1030, Lpg1233, LvrE, Lpg1318, Lpg1431, Lpg1645, Lpg1647, WipC, Lpg2220, Lpg2246, Lpg2275, Lpg2320 and Lpg2443) have been detected in wild-type strain Philadelphia-1 supernatants but have not yet been...”
- Life Stage-specific Proteomes of Legionella pneumophila Reveal a Highly Differential Abundance of Virulence-associated Dot/Icm effectors
Aurass, Molecular & cellular proteomics : MCP 2016 - “...assigned function (Lpg2220, Lpg1647, Lpg1645, Lpg0957, Lpg0301 Lpg1318, Lpg2206, Lpg2246), 5 T2SS substrates (chitinase ChiA, phospholipase A/acyltransferase...”
- Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease
Gomez-Valero, Genome biology 2014 - “...motif lpg0095 / lpp0109 llo3322 lmi1217 lha1000 lfa0120 Cytosolic IMP-GMP specific 5'-nucleotidase HAD-superfamily hydrolase, 5'-nucleotidase lpg0301 / lpp0379 lfa0312# Protein of unknown function DM9 repeat lpg0971 / lpp1033 Apyrase Nucleoside phosphatase lpg1328 a / lpp1283 lfa0766 Protein of unknown function Thaumatin lpg1798 a / lpp1761 llo0991...”
- Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes
Gomez-Valero, BMC genomics 2011 - “...Conserved exported protein of unknown function lpp0379 99.63 lpl0354 98.53 lpc0380 99.45 lpo0358 99.45 99.82 lpg0301 99.26 Phosphatidylcholine-hydrolyzing phospholipase C lpp0565 99.37 lpl0541 98.66 lpc2843 99.34 lpo0571 99.21 lpv0603 99.29 lpg0502 97.87 llo1329 Phytanoyl-CoA dioxygenase domain-containing protein 1 lpp0578 99.25 lpl0554 98.60 lpc2829 99.46 lpo0586 98.60...”
XP_011421715 uncharacterized protein LOC105324352 from Crassostrea gigas
3 alignments in 1:145 / 145 (100.0%), covering up to 50.4% of PF11901, 120.5 bits
lpl0354 hypothetical protein from Legionella pneumophila str. Lens
2 alignments in 6:149 / 181 (79.6%), covering up to 98.3% of PF11901, 115.2 bits
lpp0379 hypothetical protein from Legionella pneumophila str. Paris
2 alignments in 6:149 / 181 (79.6%), covering up to 98.3% of PF11901, 115.2 bits
CG16775 uncharacterized protein from Drosophila melanogaster
Aligns to 51:165 / 191 (60.2%), covers 98.3% of PF11901, 114.0 bits
- CgDM9CP-5-Integrin-MAPK Pathway Regulates the Production of CgIL-17s and Cgdefensins in the Pacific Oyster, Crassostrea gigas
Liu, Journal of immunology (Baltimore, Md. : 1950) 2023 - “...pathogens and PAMPs. For example, the expressions of DM9CP (CG16775) in D. melanogaster and AgPRS1 in the midgut and salivary gland of A. gambia were...”
- DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum
Jiang, Frontiers in immunology 2017 - “...proteins (DM9CPs) were discovered in both invertebrates and vertebrates. In D. melanogaster , a DM9CP (CG16775) was found to be significantly upregulated after oral infection by entomopathogenic Pseudomonas entomophila ( 5 ), while another three DM9CPs (CG3884, CG10527, and CG13321) were revealed to be part of...”
- “...of DM9 domain have been reported in several invertebrates and vertebrates. In invertebrates, a DM9CP (CG16775) from D. melanogaster was found specifically upregulated after oral infection by microbial pathogens but not septic injury with unknown functions ( 5 ). A system biology analysis of phagosome combined...”
- CHD1 contributes to intestinal resistance against infection by P. aeruginosa in Drosophila melanogaster
Sebald, PloS one 2012 - “...(flybase.org) or have reported relevance for gut immunity. For example, two very strongly activated genes, CG16775 and CG11765 , are predominantly expressed in the larval gut, and they have been found to undergo gene expression changes upon bacterial infection [31] , [32] . Other genes in...”
- Anopheles gambiae PRS1 modulates Plasmodium development at both midgut and salivary gland steps
Chertemps, PloS one 2010 - “...compatible with a function in vesicular trafficking or immune response. A fourth Drosophila DM9-containing protein (CG16775) was also described to be strongly up-regulated after oral infection of Drosophila larvae by an entomopathogenic Pseudomonas species [31] . Altogether, these data suggest that DM9-containing proteins are involved in...”
- Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins
McGraw, Genetics 2008 - “...greater decrease in transcript levels: CG7953, CG16758, and CG16775). At 12 hr post-mating, transcript levels of 128 genes were greater than in virgin females...”
- “...Jonah 25Bi Lethal (2) essential for life CG7953 CG16758 CG16775 1.36 1.54 1.21 1.26 2.15 1.00 1.16 1.01 1.07 Genes regulated at 12 hr post-mating CG15351...”
- Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species
Vodovar, Proceedings of the National Academy of Sciences of the United States of America 2005 - “...(CG15255) and four proteins of unknown function (CG6640, CG16775, CG14499, and CG13482) are up-regulated by 8-fold after infection by Ecc15 or Pe. Only 30...”
- Parasite-specific immune response in adult Drosophila melanogaster: a genomic study
Roxström-Lindquist, EMBO reports 2004 - “...desaturase 334 1.6 transportery CG7801 Glucose 857 1.7 CG16775 Unknown 208 3.2 CG8036 Transketolase 221 1.3 CG16834 Galactose-binding lectinw 118 2.3 CG8054...”
CNAG_00663 hypothetical protein from Cryptococcus neoformans var. grubii H99
2 alignments in 221:366 / 380 (38.4%), covering up to 98.3% of PF11901, 108.1 bits
- The copper regulon of the human fungal pathogen Cryptococcus neoformans H99
Ding, Molecular microbiology 2011 - “...1.34 Oxidoreductase CNAG_06424 1.04 Claudin family protein CNAG_03408 1.02 Unknown function CNAG_06668 0.97 Mitochondrial protein CNAG_00663 0.97 Unknown function CNAG_02933 0.90 Quinone oxidoreductase CNAG_00834 0.71 Phosphatidylserine decarboxylase CNAG_01255 0.60 Unknown function Low Cu CNAG_06208 0.73 Heat shock protein CNAG_06205 0.75 Unknown function CNAG_00110 0.79 Rho GTPase...”
CG5506 uncharacterized protein from Drosophila melanogaster
Aligns to 47:162 / 180 (64.4%), covers 97.4% of PF11901, 107.8 bits
- Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation
Everman, Genetics 2021 - “...implicated by the treatment-specific developmental viability QTL Q15. Two of the genes ( CG11878 and CG5506 ) identified in treatment cluster 2 were implicated by adult copper resistance-associated QTL intervals. One gene, CG5506 , was empirically demonstrated to interact with Fer2HCH ( Guruharsha et al. 2011...”
- Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome
Narayanasamy, Proteomics 2014 - “...threshold. Two proteins exceed doubling in abundance in both Sod2 knockdown versus control comparisons: FBgn0036766 (CG5506) and FBgn0031830 (CG11015). While little information is available for FBgn0036766 (protein BLAST can provide no functional annotation), FBgn0031830 has been annotated as cytochrome c oxidase subunit Vb. The observed relative...”
- Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis
Lebo, BMC genomics 2009 - “...2.5 sugar binding; carbohydrate biosynthesis CG6739 CG6739 2L 2.5 unknown CG13062 CG13062 3L 2.5 unknown CG5506 CG5506 3L 2.4 unknown dpr13 CG33996 2R 2.4 unknown CG7047 CG7047 3L 2.4 unknown CG9850 CG9850 2R 2.4 metallopeptidase activity; cell proliferation CG30101 CG30101 2R 2.4 unknown omega CG32145 3L...”
- Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster
Wittkopp, Genetics 2008 - “...-- -- -- -- -- CG10501 CG1644 CG18228 CG5506 CG6206 CG6462 CG6600 CG8707 Decarboxylase activity Electron carrier activity Unknown Unknown Mannosidase activity...”
- “...5.608 3.526 6 6 5 5 5 0.002 0.000 0.011 0.002 0.017 CG5506 F P B H R 0.479 0.420 0.068 0.287 0.146 0.629 1.863 0.633 1.624 0.491 0.356 0.347 2.130 0.491 0.767 6...”
- Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks
Bauer, BMC systems biology 2008 - “...CG4653 1.21 2.86E-11 1.38 1.92E-12 CG4734 1.62 9.69E-10 1.13 5.17E-07 CG4847 1.15 3.32E-05 1.64 1.82E-07 CG5506 1.13 1.66E-09 0.68 7.26E-06 CG6432 0.66 1.66E-05 0.80 1.08E-06 CG8562 0.68 4.98E-06 0.63 1.35E-05 CG8774 0.67 2.55E-05 0.66 2.96E-05 CG9080 0.62 3.00E-05 0.82 4.75E-07 CG9396 1.17 4.96E-09 0.73 1.13E-05 CG9672...”
Smp_167280 hypothetical protein from Schistosoma mansoni
Aligns to 1:68 / 79 (86.1%), covers 53.9% of PF11901, 83.0 bits
XP_015754265 natterin-4-like from Acropora digitifera
Aligns to 44:128 / 320 (26.6%), covers 61.7% of PF11901, 73.8 bits
D2A2I0 Uncharacterized protein from Tribolium castaneum
2 alignments in 15:147 / 182 (73.1%), covering up to 46.1% of PF11901, 67.4 bits
Q66S13 Natterin-4 from Thalassophryne nattereri
Aligns to 108:198 / 387 (23.5%), covers 81.7% of PF11901, 51.0 bits
- In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides from Thalassophryne nattereri Natterin Toxins
De, Pharmaceuticals (Basel, Switzerland) 2022 - “...natterin 1 (UniProt Q66S25), natterin 2 (UniProt Q66S21), natterin 3 (UniProt Q66S17), natterin 4 (UniProt Q66S13), and natterin P (UniProt Q66S08) were predicted using bioinformatics tools. AMPs were predicted using AMPA ( http://tcoffee.crg.cat/apps/ampa/do , accessed on 5 January 2022), CAMP algorithm ( http://www.camp.bicnirrh.res.in , accessed on...”
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function
Lima, Toxins 2021 - “...and Acanthochromis polyacanthus (XP_022070844.1) to compare with Natterin-1 (Q66S25), Natterin-2 (Q66S21), Natterin-3 (Q66S17), and Natterin-4 (Q66S13) of T. nattereri ( Figure 4 ). Natterin-1 and Natterin-2 contain six evolutionarily conserved motifs in the interval (241320 aa) GV, AGIP, QSY, VPVPP, MVA, and PFTATLIR. Natterin-3 shows eight...”
- The Toxins of Nemertean Worms.
Göransson, Toxins 2019 - “...Natterin-1 Notospermus geniculatus Ushimado Mar Inst Okayama Univ, Jpn Edema and nociception [ 15 ] Q66S13 Natterin-4 Lineus lacteus a Banyuls, Frjus, Fra [ 131 ] Edema and nociception [ 124 ] Q66S13 Natterin-4 Tubulanus polymorphus San Juan Island, WA, USA Edema and nociception [ 124...”
- Gene duplications are extensive and contribute significantly to the toxic proteome of nematocysts isolated from Acropora digitifera (Cnidaria: Anthozoa: Scleractinia)
Gacesa, BMC genomics 2015 - “...Disrupts haemostasis 4.0E-15 Q4PRC6 Snaclec 7 Daboia siamensis (Eastern Russels viper) adi_v1.18989 Disrupts haemostasis 6.00E-08 Q66S13 Fish venom Natterin-4 Thalassophryne nattereri (Niquim) adi_v1.19802 Disrupts haemostasis 1.0E-19 A7X3Z0 C-type lectin (Lectoxin-Thr1) Thrasops jacksonii (Jacksons black tree snake) adi_v1.06850 Disrupts haemostasis 9.0E-16 A8QZJ5 Cytotoxin-1 Millepora dichotoma (Net fire...”
- Nemertean toxin genes revealed through transcriptome sequencing.
Whelan, Genome biology and evolution 2014 (no snippet)
NATT3_THANI / Q66S17 Natterin-3; EC 3.4.-.- from Thalassophryne nattereri (Copper Joe toadfish) (see paper)
TC 1.C.4.6.1 / Q66S17 Natterin-3 precursor (venom gland protein) (see paper)
Aligns to 72:175 / 364 (28.6%), covers 93.0% of PF11901, 46.9 bits
- function: Shows nociceptive, edema-inducing and kininogenase activity with release of kallidin from low molecular weight kininogen. The cleavage occurs at Met-Lys bonds.
- substrates: small molecules
- In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides from Thalassophryne nattereri Natterin Toxins
De, Pharmaceuticals (Basel, Switzerland) 2022 - “...of BAPs BAPs from natterin 1 (UniProt Q66S25), natterin 2 (UniProt Q66S21), natterin 3 (UniProt Q66S17), natterin 4 (UniProt Q66S13), and natterin P (UniProt Q66S08) were predicted using bioinformatics tools. AMPs were predicted using AMPA ( http://tcoffee.crg.cat/apps/ampa/do , accessed on 5 January 2022), CAMP algorithm (...”
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function
Lima, Toxins 2021 - “...Epinephelus lanceolatus (XP_033476485.1), and Acanthochromis polyacanthus (XP_022070844.1) to compare with Natterin-1 (Q66S25), Natterin-2 (Q66S21), Natterin-3 (Q66S17), and Natterin-4 (Q66S13) of T. nattereri ( Figure 4 ). Natterin-1 and Natterin-2 contain six evolutionarily conserved motifs in the interval (241320 aa) GV, AGIP, QSY, VPVPP, MVA, and PFTATLIR....”
NATT1_THANI / Q66S25 Natterin-1; EC 3.4.-.- from Thalassophryne nattereri (Copper Joe toadfish) (see paper)
Aligns to 51:161 / 355 (31.3%), covers 87.8% of PF11901, 44.7 bits
- function: Shows nociceptive, edema-inducing and kininogenase activity with release of kallidin from low molecular weight kininogen. The cleavage occurs at Met-Lys bonds.
- In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides from Thalassophryne nattereri Natterin Toxins
De, Pharmaceuticals (Basel, Switzerland) 2022 - “...is illustrated in Figure 6 . 3.2. Prediction of BAPs BAPs from natterin 1 (UniProt Q66S25), natterin 2 (UniProt Q66S21), natterin 3 (UniProt Q66S17), natterin 4 (UniProt Q66S13), and natterin P (UniProt Q66S08) were predicted using bioinformatics tools. AMPs were predicted using AMPA ( http://tcoffee.crg.cat/apps/ampa/do ,...”
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function
Lima, Toxins 2021 - “...(XP_032371798.1), Paramormyrops kingsleyae (XP_023657493.1), Epinephelus lanceolatus (XP_033476485.1), and Acanthochromis polyacanthus (XP_022070844.1) to compare with Natterin-1 (Q66S25), Natterin-2 (Q66S21), Natterin-3 (Q66S17), and Natterin-4 (Q66S13) of T. nattereri ( Figure 4 ). Natterin-1 and Natterin-2 contain six evolutionarily conserved motifs in the interval (241320 aa) GV, AGIP, QSY,...”
- The Toxins of Nemertean Worms.
Göransson, Toxins 2019 - “...repeats-in-toxin Notospermus geniculatus Ushimado Mar Inst Okayama Univ, Jpn Destroys actin cytoskeleton [ 15 ] Q66S25 Natterin-1 Notospermus geniculatus Ushimado Mar Inst Okayama Univ, Jpn Edema and nociception [ 15 ] Q66S13 Natterin-4 Lineus lacteus a Banyuls, Frjus, Fra [ 131 ] Edema and nociception [...”
NATT2_THANI / Q66S21 Natterin-2; EC 3.4.-.- from Thalassophryne nattereri (Copper Joe toadfish) (see paper)
Aligns to 53:162 / 376 (29.3%), covers 83.5% of PF11901, 41.7 bits
- function: Shows nociceptive, edema-inducing and kininogenase activity with release of kallidin from low molecular weight kininogen. The cleavage occurs at Met-Lys bonds.
- In Silico Prediction of Anti-Infective and Cell-Penetrating Peptides from Thalassophryne nattereri Natterin Toxins
De, Pharmaceuticals (Basel, Switzerland) 2022 - “...6 . 3.2. Prediction of BAPs BAPs from natterin 1 (UniProt Q66S25), natterin 2 (UniProt Q66S21), natterin 3 (UniProt Q66S17), natterin 4 (UniProt Q66S13), and natterin P (UniProt Q66S08) were predicted using bioinformatics tools. AMPs were predicted using AMPA ( http://tcoffee.crg.cat/apps/ampa/do , accessed on 5 January...”
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function
Lima, Toxins 2021 - “...kingsleyae (XP_023657493.1), Epinephelus lanceolatus (XP_033476485.1), and Acanthochromis polyacanthus (XP_022070844.1) to compare with Natterin-1 (Q66S25), Natterin-2 (Q66S21), Natterin-3 (Q66S17), and Natterin-4 (Q66S13) of T. nattereri ( Figure 4 ). Natterin-1 and Natterin-2 contain six evolutionarily conserved motifs in the interval (241320 aa) GV, AGIP, QSY, VPVPP, MVA,...”
Or search for genetic data about PF11901 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory