Family Search for PF12141 (BMT)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

Running HMMer for PF12141

PF12141 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

BMT2_CANAL / Q59MA6 Beta-mannosyltransferase 2; Repressed during hyphae development protein 1; WRY family protein 7; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 4 papers)
Aligns to 147:626 / 654 (73.4%), covers 100.0% of PF12141, 650.1 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.

EAK91609.1 α-mannoside β-1,2-mannosyltransferase (Wry7;Rhd1;Bmt2;CaBMT2;CaO19.54;CaO19.7715) (EC 2.4.1.-) (see protein)
RHD1 putative beta-mannosyltransferase from Candida albicans (see paper)
Aligns to 147:626 / 654 (73.4%), covers 100.0% of PF12141, 648.1 bits

• CharProtDB CGD description: Putative beta-mannosyltransferase, required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; transcriptionally regulated on yeast-hyphal and white-opaque switches

BMT8_CANAL / Q5AHD6 Beta-mannosyltransferase 8; WRY family protein 3; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
BMT8 putative beta-mannosyltransferase from Candida albicans (see paper)
Aligns to 117:642 / 694 (75.8%), covers 100.0% of PF12141, 625.4 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan (By similarity). Plays a role in the ability to produce hyphae in the presence of three bacterial species.
  disruption phenotype: Leads to a hypo-filamentous phenotype.
• CharProtDB CGD description: Putative beta-mannosyltransferase, member of a 9-gene family including characterized BMT genes with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; transposon insertion in promoter region causes decreased colony wrinkling

BMT1_CANAL / Q5ADQ9 Beta-mannosyltransferase 1; WRY family protein 4; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
EAL00889.1 α-mannoside β-1,2-mannosyltransferase (Wry4;Bmt1;CaBMT1;CaO19.6782;CaO19.14074) (EC 2.4.1.-) (see protein)
BMT1 hypothetical WRY family protein 4 from Candida albicans (see paper)
Aligns to 176:676 / 684 (73.2%), covers 100.0% of PF12141, 618.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response.
  disruption phenotype: Impairs the mannosylation of beta-mannose chains on the acid-stable fraction of cell wall phosphopeptidomannan.
• CharProtDB CGD description: Putative beta-mannosyltransferase, required for addition of the first beta-mannose residue to the acid-stable fraction of cell wall phosphopeptidomannan; member of a 9-gene family; predicted ORF in Assemblies 19, 20 and 21

BMT5_CANAL / Q5ALW2 Beta-mannosyltransferase 5; WRY family protein 6; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
EAL03620.1 α-mannoside β-1,2-mannosyltransferase (Wry6;Bmt5;CaBMT5;CaO19.1464;CaO19.9039) (EC 2.4.1.-) (see protein)
Aligns to 120:595 / 612 (77.8%), covers 98.6% of PF12141, 618.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan.

BMT4_CANAL / Q5ABT8 Beta-mannosyltransferase 4; WRY family protein 1; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Aligns to 139:630 / 781 (63.0%), covers 100.0% of PF12141, 594.1 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.

BMT6_CANAL / Q5ABU8 Beta-mannosyltransferase 6; WRY family protein 2; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
Aligns to 146:624 / 646 (74.1%), covers 100.0% of PF12141, 593.9 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan. Required for pro-inflammatory response in macrophages through phospholipomannan- induced TNF-alpha production.
  disruption phenotype: Leads to the production of phospholipomannan with short truncated oligomannosidic chain and impairs induction of TNF- alpha production in macrophages.

EAL00279.1 β-mannoside β-1,2-mannosyltransferase (Wry1;Bmt4;CaBMT4;CaO19.5612;Ca19.13055) (EC 2.4.1.-) (see protein)
BMT4 putative beta-mannosyltransferase from Candida albicans (see paper)
Aligns to 139:630 / 789 (62.4%), covers 100.0% of PF12141, 593.1 bits

• CharProtDB CGD description: Putative beta-mannosyltransferase, required for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; regulated by Tsa1p, Tsa1Bp

EAL00269.1 β-mannoside β-1,2-mannosyltransferase (Wry2;Bmt6;CaBMT6;CaO19.5602;CaO19.13045) (EC 2.4.1.-) (see protein)
Aligns to 146:624 / 646 (74.1%), covers 100.0% of PF12141, 578.8 bits

BMT9_CANAL / Q5AMH3 Beta-mannosyltransferase 9; WRY family protein 5; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
Aligns to 167:755 / 782 (75.3%), covers 100.0% of PF12141, 547.6 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.

BMT7_CANAL / Q5AEC6 Beta-mannosyltransferase 7; WRY family protein 8; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
2 alignments in 131:632 / 651 (77.1%), covering up to 51.0% of PF12141, 438.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.

BMT1_KOMPG / C4R7X9 Beta-mannosyltransferase 1; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
CAY71704.1 glycan β-1,2-mannosyltransferase 1 (Bmt1;PpBMT1;PAS_chr4_0451) (EC 2.4.1.-) (see protein)
2 alignments in 85:524 / 652 (67.5%), covering up to 51.0% of PF12141, 316.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Involved in the beta-mannosylation of outer chains of N-glycans.
  disruption phenotype: Impaired expression of beta-mannose epitopes and decreases alpha-mannosidase resistant glycans.

BMT3_KOMPG / C4QZ06 Beta-mannosyltransferase 3; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
CAY68480.1 glycan β-1,2-mannosyltransferase 3 (Bmt3;PpBMT3;PAS_chr1-4_0696) (EC 2.4.1.-) (see protein)
2 alignments in 75:506 / 594 (72.7%), covering up to 50.6% of PF12141, 283.6 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis.
  disruption phenotype: Decreases alpha-mannosidase resistant glycans.

BMT2_KOMPG / C4R7X8 Beta-mannosyltransferase 2; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
CAY71703.1 glycan β-1,2-mannosyltransferase 2 (Bmt2;PpBMT2;PAS_chr4_0450) (EC 2.4.1.-) (see protein)
2 alignments in 74:505 / 644 (67.1%), covering up to 50.0% of PF12141, 278.3 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Initiates the beta-mannosylation of core N-linked glycans.
  disruption phenotype: Strongly reduces de degree of mannosylation of the core glycans and eliminates glycans resistant to alpha-1,2- mannosidase treatment.

BMT3_CANAL / Q5A846 Beta-mannosyltransferase 3; WRY family protein 9; EC 2.4.1.- from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 3 papers)
EAK98957.1 β-mannoside β-1,2-mannosyltransferase (Wry9;Bmt3;CaBMT3;CaO19.3282;CaO19.10792) (EC 2.4.1.-) (see protein)
BMT3 putative beta-mannosyltransferase from Candida albicans (see paper)
2 alignments in 111:534 / 549 (77.0%), covering up to 49.4% of PF12141, 272.7 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta- mannose chains on the phosphopeptidomannan acid-labile fraction.
  disruption phenotype: Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan.
• CharProtDB CGD description: Putative beta-mannosyltransferase, required for addition of the 2nd beta-mannose to the acid-stable fraction of cell wall phosphopeptidomannan and for elongation of beta-mannose chains on the phosphopeptidomannan acid-labile fraction

KABA2_13S06644 uncharacterized protein from Kazachstania barnettii
2 alignments in 147:636 / 650 (74.2%), covering up to 49.6% of PF12141, 266.8 bits

• Whole-Genome Sequences of Two Kazachstania barnettii Strains Isolated from Anthropic Environments
  Devillers, Genome biology and evolution 2022
  • “...and hence probably resulted from incomplete assembly. The one gene which appeared to be specific (KABA2_13S06644, from the sourdough strain CLIB 1767) was predicted to encode a hypothetical protein of 650 aa length having a putative Beta-mannosyltransferase domain (InterProScan prediction; family IPR021988; Blum et al. 2021...”

BMT4_KOMPG / C4R7Z8 Beta-mannosyltransferase 4; EC 2.4.1.- from Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris) (see 2 papers)
2 alignments in 90:495 / 503 (79.7%), covering up to 50.8% of PF12141, 258.4 bits

• function: Beta-mannosyltransferase involved in cell wall biosynthesis. Responsible for addition of a hexose to the beta-mannose chain. Beta- mannosylation catalyzed by BMT4 masks beta-mannose epitopes recognized by monoclonal antibody (mAb) 5B2 reacting with beta-1,2-linked mannobiose as a minimal epitope.
  disruption phenotype: Leads to a size reduction of glycans resistant to alpha-mannosidase treatment.

CRD2 metallothionein from Candida albicans (see paper)
Aligns to 1:187 / 214 (87.4%), covers 27.6% of PF12141, 143.7 bits

• CharProtDB CGD description: Metallothionein; role in adaptation to growth with high concentration of copper ions; basal transcription is cadmium-repressed; regulated by Ssn6p; complements copper sensitivity of an S. cerevisiae cup1 null mutant

Or search for genetic data about PF12141 in the Fitness Browser