Family Search for PF12432 (DUF3677)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF12432 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

D3ZIT7 Integrator complex subunit 1-like from Rattus norvegicus
Aligns to 377:457 / 1998 (4.1%), covers 100.0% of PF12432, 118.5 bits

• Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat
  Tang, Stem cell research & therapy 2021
  • “...B2RZ82 Pcgf2 1.21 Up 0.043 R9PXW5 Nme6 1.20 Up 0.035 A0A0G2JTF6 Thtpa 1.20 Up 0.040 D3ZIT7 LOC103689975 1.20 Up 0.026 P47967 Lgals5 1.20 Up 0.048 Q1WIM1 Cadm4 0.83 Down 0.002 D3ZZR3 Ctss 0.79 Down 0.016 D3ZH40 Otud7b 0.79 Down 0.020 Q9JK15 Adap2 0.79 Down 0.033 G3V6E7...”

INT1_HUMAN / Q8N201 Integrator complex subunit 1; Int1 from Homo sapiens (Human) (see 5 papers)
NP_001073922 integrator complex subunit 1 from Homo sapiens
Aligns to 350:430 / 2190 (3.7%), covers 100.0% of PF12432, 118.4 bits

• function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
  subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).
• Clostridiumnovyi's Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
  Schweitzer, International journal of molecular sciences 2022
  • “...TcnA NPY4R P0DQD5 4.3 10 4 2.33 SMU1 Q2TAY7-2 1.5 10 2 1.53 TcnA INTS1 Q8N201 6.8 10 4 2.22 C1QTNF6 Q9BXI9-1 2.8 10 2 1.50 TcnA MTCL1 Q9Y4B5-2 2.7 10 3 2.11 MIF P14174 3.5 10 3 1.37 TcnA TAOK1 Q7L7X3 5.0 10 4 2.05...”
• Proteomic Profiling of Retinoblastoma-Derived Exosomes Reveals Potential Biomarkers of Vitreous Seeding.
  Galardi, Cancers 2020
  • “...cell division Q86T03-2 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase TMEM55B Plasma Membrane, Endosome, Lysosome catalytic activity Q8N201 Integrator complex subunit 1 INTS1 Nucleus snRNA processing Q8N5K1 CDGSH iron-sulfur domain-containing protein 2 CISD2 Mitochondrion, Endoplasmic Reticulum 2 iron, 2 sulfur cluster binding Q92752 Tenascin-R TNR Extracellular Region or...”
• The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study
  Yan, Scientific reports 2017
  • “...Epididymal secretory protein E1 NPC2 2.005*|- 2.005 Q562E7 WD repeat-containing protein 81 WDR81 0.311*|- 0.311 Q8N201 Integrator complex subunit 1 INTS1 0.292*|- 0.292 * P <0.05. Subcellular and functional characterization of the differentially expressed proteins We next catalogued the subcellular annotation of all the differentially expressed...”
• Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
  Gao, Cancer biology & medicine 2015
  • “...region HIL OS=Homo sapiens PE=1 SV=1 - [HV310_HUMAN] 9.09 1 1 1 121 13.6 9.36 Q8N201 Integrator complex subunit 1 OS=Homo sapiens GN=INTS1 PE=1 SV=2 - [INT1_HUMAN] 0.41 3 1 1 2,190 244.1 6.13 Q8NFU5 Inositol polyphosphate multikinase OS=Homo sapiens GN=IPMK PE=1 SV=1 - [IPMK_HUMAN] 5.29...”
• Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.
  Keshishian, Molecular & cellular proteomics : MCP 2015
• Biallelic INTS1 Mutations Cause a Rare Neurodevelopmental Disorder in Two Chinese Siblings.
  Zhang, Journal of molecular neuroscience : MN 2020 (PubMed)
  • GeneRIF: Biallelic INTS1 Mutations Cause a Rare Neurodevelopmental Disorder in Two Chinese Siblings.
• A family of fuchs endothelial corneal dystrophy and anterior polar cataract with an analysis of whole exome sequencing.
  Jiang, Ophthalmic genetics 2020 (PubMed)
  • GeneRIF: A family of fuchs endothelial corneal dystrophy and anterior polar cataract with an analysis of whole exome sequencing.
• Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies.
  Krall, European journal of human genetics : EJHG 2019
  • GeneRIF: The distinctive phenotype associated with biallelic variants in INTS1 points to dysfunction of the integrator complex as a mechanism for intellectual disability, eye defects and craniofacial anomalies
• Human mutations in integrator complex subunits link transcriptome integrity to brain development.
  Oegema, PLoS genetics 2017
  • GeneRIF: Mutations in INTS1 cause a severe neurodevelopmental syndrome.

K3W4P2 Integrator complex subunit 1 from Mus musculus
Aligns to 350:430 / 2193 (3.7%), covers 100.0% of PF12432, 118.4 bits

• Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis in vitro
  Adhikari, Heliyon 2021
  • “...type III domain-containing 1 13 7 67.9 1.66E-09 1.06E-08 16.4 Control Direct Microlia Effect INTS1 K3W4P2 Integrator complex subunit 1 43 8 228 9.03E-09 4.55E-08 41.3 Direct Microlia Effect Control LGMN A2RTI3 Legumain 8 2 51.3 3.27E-07 1.01E-06 443 Direct Microlia Effect Control MT1 P02802 Metallothionein-1...”
  • “...- - - - - - E9Q043 Fndc1 - - - - - - - K3W4P2 Ints1 - - - - - - - - A2RTI3 Lgmn - - - - - - - - P02802 Mt1 - - - - - - - - Q61481...”
• Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration.
  van, Neuron 2017
  • “...UniProt: Q61550 732 1.66 17 Mau2 UniProt: Q9D2X5 406 0.86 9 Integrator Complex Ints1 UniProt: K3W4P2 2,910 2.28 63 Ints6 UniProt: Q6PCM2 1,834 3.99 36 Ints3 UniProt: Q7TPD0 1,714 2.44 32 Ints7 UniProt: Q7TQK1 1,522 2.28 27 Asun UniProt: Q8QZV7 1,451 5.81 29 Ints5 UniProt: Q8CHT3...”

INT1_MOUSE / Q6P4S8 Integrator complex subunit 1; Int1 from Mus musculus (Mouse) (see paper)
Aligns to 352:432 / 2195 (3.7%), covers 100.0% of PF12432, 118.4 bits

• function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
  subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (PubMed:26206133).
• CRISPR-Cas9/phosphoproteomics identifies multiple noncanonical targets of myosin light chain kinase.
  Isobe, American journal of physiology. Renal physiology 2020
• Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism
  Jones, Molecular pharmacology 2019 (secret)
• Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.
  Piazzi, Oncotarget 2015
  • “...activity Q9CW46 Raver1 Ribonucleoprotein PTB-binding 1 LL pS PIASNR 1.33 0.49 0.65 Unannotated RNA binding Q6P4S8 Ints1 Integrator complex subunit 1 LS pS TP PLSALGR 2.45 0.66 1.62 snRNA processing; Blastocyst growth; Inner cell mass cell proliferation; Apoptosis Unannotated Q8CGU3 Pnn Pinin RGF pS D SGGGPPAK...”
  • “...ELPSAATAAATAR S117 Y N Q9CW46 Raver1 Ribonucleoprotein PTB-binding 1 LL pS PIASNR S576 Y N Q6P4S8 Ints1 Integrator complex subunit 1 LS pS TPPLSALGR S82 Y N Q8CGU3 Pnn Pinin RGF pS DSGGGPPAK S66 Y N The first three columns report the Accession Number (UniProtKB-SwissProt), the...”

INT1_DROME / Q9W1C5 Integrator complex subunit 1 from Drosophila melanogaster (Fruit fly) (see 3 papers)
Aligns to 327:407 / 2053 (3.9%), covers 100.0% of PF12432, 105.7 bits

• function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS12 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
  subunit: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS12 and IntS9 (PubMed:23288851). Interaction with IntS12 is likely to be important for promoting 3'-end processing of snRNAs (PubMed:23288851). Interacts with Mediator complex members Cdk8 and CycC (PubMed:23097424).

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