Family Search for PF12478 (UBAP2-Lig)
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Running HMMer for PF12478
PF12478 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
LIG_AEDAE / Q16VD3 Protein lingerer from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see paper)
Aligns to 538:572 / 1250 (2.8%), covers 100.0% of PF12478, 71.3 bits
- function: Acts in the nervous system to mediate the control of copulatory organs during courtship.
LIG_DROME / Q86S05 Protein lingerer from Drosophila melanogaster (Fruit fly) (see 3 papers)
Aligns to 575:610 / 1375 (2.6%), covers 100.0% of PF12478, 71.3 bits
- function: Acts in the nervous system to mediate the control of copulatory organs during courtship.
disruption phenotype: Male flies exhibit abnormal copulation. They fail to successfully withdraw their genitalia upon termination of copulation so end up 'stuck' to the female, tugging to separate. There is also a 'non-copulating' behavioral phenotype. There are no morphological defects in the male genitalia. Females can mate successfully but have reduced fertility. Complete loss of lig function results in lethality during early pupal stages.
UBAP2_HUMAN / Q5T6F2 Ubiquitin-associated protein 2; UBAP-2; RNA polymerase II degradation factor UBAP2 from Homo sapiens (Human) (see 2 papers)
Aligns to 512:544 / 1119 (2.9%), covers 100.0% of PF12478, 64.0 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote the degradation of ANXA2 (PubMed:27121050).
subunit: May interact with ANXA2.
UBP2L_MOUSE / Q80X50 Ubiquitin-associated protein 2-like; RNA polymerase II degradation factor Ubap2l from Mus musculus (Mouse) (see paper)
Aligns to 515:546 / 1107 (2.9%), covers 97.0% of PF12478, 58.8 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (By similarity). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (PubMed:25185265). Required for efficient formation of stress granules (By similarity).
subunit: Interacts with BMI1. Part of a complex consisting of UBAP2L, BMI1 and RNF2. Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation.
UBP2L_HUMAN / Q14157 Ubiquitin-associated protein 2-like; Protein NICE-4; RNA polymerase II degradation factor UBAP2L from Homo sapiens (Human) (see 5 papers)
Aligns to 495:526 / 1087 (2.9%), covers 97.0% of PF12478, 58.7 bits
- function: Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT- HSCs) (By similarity). Required for efficient formation of stress granules (PubMed:29395067).
subunit: Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2(PubMed:25185265). Interacts with G3BP1 (via NTF2 domain); promoting stress granule formation (PubMed:32302570).
Or search for genetic data about PF12478 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory