Family Search for PF12480 (GARIL_Rab2_bd)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF12480 hits 18 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
GAR3_HUMAN / Q8TC56 Golgi-associated RAB2 interactor protein 3 from Homo sapiens (Human) (see 2 papers)
Aligns to 116:186 / 605 (11.7%), covers 98.6% of PF12480, 103.8 bits
- function: May be involved in RNA biogenesis.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (By similarity). Interacts with FRG1 (PubMed:17103222). - Differential Proteomic Analysis of Human Sperm: A Systematic Review to Identify Candidate Targets to Monitor Sperm Quality.
Corda, The world journal of men's health 2024 - “...Sperm/oocyte interaction Q8IYQ7 THNSL1 Threonine synthase-like 1 3 [ 26 55 ] - - - Q8TC56 GARIN3 Golgi-associated RAB2 interactor protein 3 3 [ 26 31 48 ] Testis (enriched) - - Q8TDY3 ACTRT2 Actin-related protein T2 3 [ 26 33 48 ] Testis (enriched) -...”
- “...and 2, obesity [ 37 ]; Severe OAT [ 38 ] Testis (enhanced) - - Q8TC56 GARIN3 Golgi-associated RAB2 interactor protein 3 7 GZS [ 53 ]; RPL [ 57 ]; Hyperthermia [ 52 ]; AZS [ 26 31 48 ] Severe OAT [ 38 ]...”
- Effect of transient scrotal hyperthermia on human sperm: an iTRAQ-based proteomic analysis.
Wu, Reproductive biology and endocrinology : RB&E 2020 - “...0.62445 5 GAPDHS O14556 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0.65205 6 TEKT5 Q96M29 Tektin-5 0.61830 7 FAM71B Q8TC56 Protein FAM71B 0.55335 8 LRRC37B Q96QE4 Leucine-rich repeat-containing protein 37B 0.62535 9 TPI1 P60174 Triosephosphate isomerase 0.59305 10 ODF1 Q14990 Outer dense fiber protein 1 0.60095 11 GLUL P15104 Glutamine...”
- Quantitative proteomic analysis of sperm in unexplained recurrent pregnancy loss
Xue, Reproductive biology and endocrinology : RB&E 2019 - “...2 FSIP2 1.18 2.85668E-06 O75976 Carboxypeptidase D CPD 0.78 0.004574668 Q8TEX9 Importin-4 IPO4 1.20 0.002037515 Q8TC56 Protein FAM71B FAM71B 0.92 0.00900713 Q9BXF9 Tektin-3 TEKT3 0.70 0.016060278 A0A0C4DGB6 Serum albumin ALB 1.28 0.006274223 A0A0G2JML4 C6orf10 C6orf10 1.01 0.041954588 Q6ZU69 Protein FAM205A FAM205A 1.26 0.010902458 Q9UII2 ATPase inhibitor,...”
- Proteomic analysis reveals dysregulated cell signaling in ejaculated spermatozoa from infertile men.
Samanta, Asian journal of andrology 2019 - “...32.7 53.3 60.0 76.7 Actin-related protein T2 Q8TDY3 42 33.0 59.0 64.7 87.0 Protein FAM71B Q8TC56 65 41.3 60.0 81.0 103.3 Sodium/potassium-transporting ATPase subunit alpha-4 isoform 1 Q13733 114 46.0 93.0 105.3 131.3 Beta-galactosidase-1-like protein precursor Q6UWU2 74 48.3 63.7 71.3 105.3 Carnitine O--acetyltransferase precursor P43155...”
- Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach.
Singh, Oncotarget 2015 - “...domains & ankyrin repeats 162,505 3 2 3 3 9 1.26% 2.56% 3.55E-03 2.131 8 Q8TC56 FAM71B Protein FAM71B 64,756 2 2 5 4 7 6.61% 5.87% 1.20E-02 2.129 9 P50479 PDLIM4 PDZ and LIM domain protein 4 35,398 2 4 7 3 9 10.54% 5.98%...”
F1RQD7 Golgi associated RAB2B interactor family member 3 from Sus scrofa
Aligns to 120:190 / 593 (12.0%), covers 98.6% of PF12480, 102.5 bits
- Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa
Xu, Frontiers in cell and developmental biology 2021 - “...Family with sequence similarity 71, member A Thr115, Ser399/Ser405, Ser182, Ser405 Down RNA biogenesis 85 F1RQD7 FAM71B Family with sequence similarity 71, member B Ser184, Ser518, Ser494, Ser181/Ser183/Ser184, Ser494/Ser495, Ser183/Ser184, Ser24 Down RNA biogenesis 86 A0A286ZY95 FN1 Fibronectin Ser2378 Down Sperm maturation 87 F1RYK8 FSIP2 Fibrous...”
GAR3_MOUSE / Q5STT6 Golgi-associated RAB2B interactor protein 3; Protein FAM71B from Mus musculus (Mouse) (see 2 papers)
Aligns to 123:192 / 665 (10.5%), covers 91.5% of PF12480, 100.5 bits
- function: May be involved in RNA biogenesis.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (PubMed:18256213). Interacts with FRG1.
Q5VWN6 Protein TASOR 2 from Homo sapiens
Aligns to 94:167 / 2430 (3.0%), covers 98.6% of PF12480, 98.4 bits
- Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.
Ma, Cancer science 2021 - “...ligand 1 Q9NZQ7 12.11 6 1.7 Polyadenylatebinding protein 4 Q13310 (+1) 8.57 3 Protein FAM208B Q5VWN6 7.70 7 6.0 Fragile X mental retardation syndromerelated protein 1 P51114 6.07 5 2.0 Spermspecific antigen 2 P28290 5.83 4 1.7 FilaminB O75369 5.2 4 2.9 DNA topoisomerase 2alpha P11388...”
Q96KD3 Golgi-associated RAB2 interactor protein 1B from Homo sapiens
Aligns to 140:208 / 344 (20.1%), covers 98.6% of PF12480, 92.9 bits
GAR1A_MOUSE / B2RXB0 Golgi-associated RAB2 interactor protein 1A from Mus musculus (Mouse) (see 2 papers)
Aligns to 107:175 / 297 (23.2%), covers 98.6% of PF12480, 92.3 bits
- function: RAB2B effector protein required for accurate acrosome formation and normal male fertility.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
disruption phenotype: Mutant male fertility is significantly impaired compared with that of the controls (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal acrosome morphology (PubMed:34714330).
Q6NXP2 Golgi-associated RAB2 interactor protein 1A from Homo sapiens
Aligns to 117:185 / 309 (22.3%), covers 98.6% of PF12480, 89.7 bits
GAR1B_MOUSE / Q3UZD7 Golgi-associated RAB2 interactor protein 1B; Golgi-associated RAB2 interactor-like 1; GARI-L1 from Mus musculus (Mouse) (see paper)
Aligns to 140:208 / 341 (20.2%), covers 98.6% of PF12480, 89.4 bits
- function: RAB2B effector protein required for accurate acrosome formation and normal male fertility (PubMed:34714330). In complex with RAB2A/RAB2B, seems to suppress excessive vesicle trafficking during acrosome formation (PubMed:34714330).
disruption phenotype: Mutant males are sterile (PubMed:34714330). Spermatozoa from mutant mice showed abnormal head shapes with an abnormal swollen acrosome morphology and impaired acrosome reaction (PubMed:34714330).
XP_030111331 Golgi-associated RAB2 interactor protein 1B isoform X7 from Mus musculus
Aligns to 108:176 / 310 (22.3%), covers 98.6% of PF12480, 88.7 bits
GAR4_HUMAN / Q8IYT1 Golgi-associated RAB2 interactor protein 4; Golgi-associated Rab2B interactor-like 4; GARI-L4; GARI-like 4 from Homo sapiens (Human) (see paper)
NP_705834 Golgi-associated RAB2 interactor protein 4 from Homo sapiens
Aligns to 115:184 / 594 (11.8%), covers 97.2% of PF12480, 88.3 bits
GAR2_MOUSE / D3YV92 Golgi-associated RAB2 interactor protein 2 from Mus musculus (Mouse) (see paper)
Aligns to 114:184 / 440 (16.1%), covers 98.6% of PF12480, 84.4 bits
- function: Seems to play a role in sperm motility.
subunit: Interacts with CALM1. - Identification of tissue-enriched novel transcripts and novel exons in mice.
Hong, BMC genomics 2014 - “...Different 5UTR tNE-3 Skp2 chr15:9082539-9082780 242 - Q9Z0Z3 Different 5UTR tNE-4 Fam71d chr12:79824797-79824939 143 + D3YV92 26 shorter AA, different C term tNE-5 Fam71d chr12:79796826-79797030 205 + D3YV92 Different 5UTR tNE-6 Rfx1 chr8:86608465-86608794 330 + tNE-7 Fam71d chr12:79823117-79823280 164 + D3YV92 tNE-8 Pfkm chr15:97925522-97925641 120 +...”
GAR2_HUMAN / Q8N9W8 Golgi-associated RAB2 interactor protein 2 from Homo sapiens (Human) (see paper)
XP_011534805 Golgi-associated RAB2 interactor protein 2 isoform X1 from Homo sapiens
Aligns to 115:185 / 422 (16.8%), covers 97.2% of PF12480, 83.9 bits
NP_001138874 Golgi-associated RAB2 interactor protein 5B from Homo sapiens
Q8N5Q1 Golgi-associated RAB2 interactor protein 5B from Homo sapiens
Aligns to 97:167 / 922 (7.7%), covers 95.8% of PF12480, 83.3 bits
NP_001269718 Golgi-associated RAB2 interactor protein 1B isoform 3 from Homo sapiens
Aligns to 57:109 / 243 (21.8%), covers 63.4% of PF12480, 60.3 bits
GAR5A_MOUSE / A1L3C1 Golgi-associated RAB2 interactor protein 5A; Golgi-associated RAB2B interactor-like 5; GARIL5 from Mus musculus (Mouse) (see 2 papers)
Aligns to 93:160 / 212 (32.1%), covers 88.7% of PF12480, 60.2 bits
- function: RAB2B effector protein which promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis.
subunit: Interacts (via N-terminus) with RAB2B (in GTP-bound form).
XP_030098915 Golgi-associated RAB2 interactor protein 5A isoform X10 from Mus musculus
Aligns to 1:63 / 175 (36.0%), covers 84.5% of PF12480, 59.9 bits
NP_612420 Golgi-associated RAB2 interactor protein 5A isoform 2 from Homo sapiens
Aligns to 159:225 / 231 (29.0%), covers 78.9% of PF12480, 52.8 bits
Q6IPT2 Golgi-associated RAB2 interactor protein 5A from Homo sapiens
Aligns to 175:241 / 247 (27.1%), covers 78.9% of PF12480, 52.7 bits
- Predicting Functions of Uncharacterized Human Proteins: From Canonical to Proteoforms.
Poverennaya, Genes 2020 - “...was assigned for the largest number of proteins (24 proteins). For 10 proteins (A2RUT3, A6PVS8, Q6IPT2, Q6IPT2-2, Q7Z5L2, Q8N3J3, Q8N3J3-3, Q8TD91, Q8TD91-2, Q9HA90), a combination of biological processes including proteolysis (GO:0006508), cognition (GO:0050890), and regulation of cell migration (GO:0030334) was predicted. For 19 proteins (rightmost column),...”
- “...for 93 uPE1 proteins. * denotes the following set of proteins: A2RUT3, A6PVS8, Q2NL68, Q4KMZ1, Q6IPT2, Q6IPT2-2, Q7Z5L2, Q8N3J3, Q8N3J3-3, Q8TD91, Q8TD91-2, Q9H741, Q9HA90, Q9NWQ9. ** denotes the following set of proteins: Q0P6D6, Q2M3V2, Q53LP3, Q68CR1, Q6P995, Q6ZRI6-2, Q86X40, Q8IV32, Q8IW50, Q8N6V9, Q8NCJ5, Q8NCT3, Q8NCU4, Q8NEF3,...”
Or search for genetic data about PF12480 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory