Family Search for PF12597 (Cox20)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
Running HMMer for PF12597
PF12597 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
COX20_YEAST / Q04935 Cytochrome c oxidase assembly protein COX20, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
NP_010517 Cox20p from Saccharomyces cerevisiae S288C
NP_010517, YDR231C Cox20p from Saccharomyces cerevisiae
Aligns to 62:164 / 205 (50.2%), covers 97.0% of PF12597, 126.6 bits
- function: Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded COX2, the precursor of subunit 2 of cytochrome oxidase.
subunit: Interacts with COX2. - Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation.
Kumar, PloS one 2015 - GeneRIF: Expression of Mitochondrial Cytochrome C Oxidase Chaperone Gene (COX20) Improves Tolerance to Weak Acid and Oxidative Stress during Yeast Fermentation
- Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase.
Elliott, Genetics 2012 - GeneRIF: The Cox20 chaperone has important roles in leader peptide processing, C-tail export, and stabilization of Cox2.
- Systematic analysis of nuclear gene function in respiratory growth and expression of the mitochondrial genome in S. cerevisiae
Stenger, Microbial cell (Graz, Austria) 2020 - “...ATP15 YPL271W COX18 YGR062C PET117 YER058W ATP17 YDR377W COX19 YLL018C-A QCR2 YPR191W ATP2 YJR121W COX20 YDR231C QCR7 YDR529C ATP3 YBR039W COX5A YNL052W QCR8 YJL166W ATP4 YPL078C COX6 YHR051W RIP1 YEL024W ATP5 YDR298C COX7 YMR256C SCO1 YBR037C ATP7 YKL016C COX9 YDL067C SDH1 YKL148C BCS1 YDR375C CYC3 YAL039C...”
- morFeus: a web-based program to detect remotely conserved orthologs using symmetrical best hits and orthology network scoring
Wagner, BMC bioinformatics 2014 - “...vertebrate/human Found with morFeus Intermediate species Precision COX14 NP_013577 HMM COX14 NP_116290 No 82% COX20 NP_010517 Profile FAM36A ( M. mulatta ) NP_001244714 Yes 99% COX23 NP_011984 Sequence CHCHD7 NP_077276 Yes 91% COX24 NP_013305 HMM AURKAIP1 NP_060370 No Only found with S. japonicus, finds S. cerevisiae...”
- Transcription analysis of recombinant industrial and laboratory Saccharomyces cerevisiae strains reveals the molecular basis for fermentation of glucose and xylose
Matsushika, Microbial cell factories 2014 - “...cytochrome c oxidase YGL191W COX13 2.15 2.89 4.21 5.33 Subunit VIa of cytochrome c oxidase YDR231C COX20 4.97 4.39 4.61 4.94 Mitochondrial inner membrane protein YJL166W QCR8 2.66 3.36 3.87 5.50 Subunit 8 of ubiquinol cytochrome c reductase complex YAL039C CYC3 2.31 2.11 5.63 6.08 Cytochrome...”
- Spatio-temporal dynamics of yeast mitochondrial biogenesis: transcriptional and post-transcriptional mRNA oscillatory modules
Lelandais, PLoS computational biology 2009 - “...A YDL107W MSS2 RCCasm4 22.5 Yes I A YDR079W PET100 RCCasm4 15.4 Yes I A YDR231C COX20 RCCasm4 17.8 Yes I C YDR316W OMS1 RCCasm4* 100.0 Yes I A YER058W PET117 RCCasm4 43.1 Yes I A YER154W OXA1 RCCasm4* 67.4 Yes I A YGR062C COX18 RCCasm4...”
- Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span
Lavoie, Eukaryotic cell 2008 - “...(GO:0005751), cytochrome c oxidase YGL191W YML129C YLL009C YDR231C YGL187C YNL052W YHR051W YMR256C YLR395C YDL067C YDR079W YJR034W COX13 COX14 COX17 COX20 COX4...”
- Identification of coherent patterns in gene expression data using an efficient biclustering algorithm and parallel coordinate visualization
Cheng, BMC bioinformatics 2008 - “...YHR073W, YNL084C, YNL227C, YNL243W, YOR089C, YOR109W, YOR327C, YPL145C 2 aerobic respiration 2.47E-04 4.34E-02 YBR026C, YDL174C, YDR231C, YHR001W, YMR030W, YMR081C, YPL132W, YPL159C 3 ribosome biogenesis and assembly 2.75E-13 4.73E-11 YBL024W, YBR142W, YDL153C, YDL167C, YDR060W, YDR120C, YDR312W, YDR365C, YEL026W, YER082C, YGL099W, YGR162W, YGR245C, YJL033W, YJR002W, YJR066W, YLL008W, YLR175W,...”
NP_001108406 uncharacterized protein LOC100141456 from Bombyx mori
Aligns to 16:106 / 121 (75.2%), covers 74.3% of PF12597, 53.1 bits
- BmREEPa Is a Novel Gene that Facilitates BmNPV Entry into Silkworm Cells
Dong, PloS one 2015 - “...BGIBMGA013777 NP_001040329 receptor expression enhancing protein BGIBMGA000664 NP_001040235 uncharacterized protein BGIBMGA005451 NP_001040395 BET1-like protein BGIBMGA010376 NP_001108406 uncharacterized protein Cloning of BmREEPa BGIBMGA013777 was cloned from P50 silkworm larvae. We obtained two splice variants for BmREEPa ; BmREEPa-L and BmREEPa-S (GenBank accession number: KR260842, KR260843). The coding...”
COX20_HUMAN / Q5RI15 Cytochrome c oxidase assembly protein COX20, mitochondrial from Homo sapiens (Human) (see 5 papers)
NP_001299800 cytochrome c oxidase assembly protein COX20, mitochondrial isoform 1 from Homo sapiens
Aligns to 10:103 / 118 (79.7%), covers 84.2% of PF12597, 48.6 bits
- function: Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:23125284). Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme (PubMed:24403053).
subunit: Found in a complex with TMEM177, COA6, MT-CO2/COX2, COX18, SCO1 and SCO2. Interacts with SCO1, SCO2 and COA6 in a MT-CO2/COX2- and COX18-dependent manner (PubMed:29154948, PubMed:24403053, PubMed:28330871). Interacts with COX18 in a MT-CO2/COX2-dependent manner (PubMed:28330871). Interacts with MT-CO2/COX2 (PubMed:29154948, PubMed:24403053, PubMed:23125284, PubMed:28330871). Interacts with TMEM177 (PubMed:29154948). - Comparative Proteomic Analysis of Proteins Involved in Bioenergetics Pathways Associated with Human Sperm Motility.
Moscatelli, International journal of molecular sciences 2019 - “...ribosomal protein S9 0.26 Q9BWH2 FUNDC2 FUN (Function Unkown Now) 14 domain-containing protein 2 0.28 Q5RI15 COX20 Cytochrome c oxidase assembly protein COX20 0.31 P53587 SUCLG1 Succinate-CoA ligase [ADP-forming] subunit beta, hydrogenosomal 0.31 Q8NBX0 SCCPDH Saccharopine dehydrogenase-like oxidoreductase 0.37 Q9P2R7 SUCLA2 Succinate-CoA ligase [ADP-forming] subunit beta...”
- “...normozoospermics. UniProt ID Gene Name Protein Name Low/High P82933 MRPS9 28S ribosomal protein S9 0.18 Q5RI15 COX20 Cytochrome c oxidase assembly protein 0.22 Q9ULC5 ACSL5 Long-chain acyl-CoA synthetase 5 0.32 P21397 MAOA Amine oxidase [flavin-containing] A 0.32 Q8IYQ7 THNSL1 Threonine synthase-like 1 0.45 P17174 GOT1 Aspartate...”
- Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk.
Nuebel, Biochimica et biophysica acta 2016 - “...c oxidase assembly protein COX16 homolog, mitochondrial COX16, C14orf112 COX16 12.3 Mitochondrial membrane [10] No Q5RI15 Cytochrome c oxidase protein 20 homolog COX20, FAM36A COX20 13.3 CX 13 CX 3 C No P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial DLST, DLTS KGD2 48.8 CX...”
- The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease.
Suárez-Arroyo, American journal of cancer research 2016 - Clinical and genetic characteristics of children with COX20-associated mitochondrial disorder: case report and literature review.
Chen, BMC medical genomics 2023 - GeneRIF: Clinical and genetic characteristics of children with COX20-associated mitochondrial disorder: case report and literature review.
- Bi-allelic loss of function variants in COX20 gene cause autosomal recessive sensory neuronopathy.
Dong, Brain : a journal of neurology 2021 (PubMed)- GeneRIF: Bi-allelic loss of function variants in COX20 gene cause autosomal recessive sensory neuronopathy.
- Novel pathogenic COX20 variants causing dysarthria, ataxia, and sensory neuropathy.
Otero, Annals of clinical and translational neurology 2019 - GeneRIF: Study reports on four subjects with features that include childhood hypotonia, areflexia, ataxia, dysarthria, dystonia, and sensory neuropathy. Exome sequencing in all four subjects identified the same novel COX20 variants. One variant affected the splice donor site of intron-one (c.41A>G), while the other variant (c.157+3G>C) affected the splice donor site of intron-two.
- Observation of novel COX20 mutations related to autosomal recessive axonal neuropathy and static encephalopathy.
Xu, Human genetics 2019 (PubMed)- GeneRIF: COX20 mutation are associated with autosomal recessive axonal neuropathy and static encephalopathy.
- The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
Lorenzi, Biochimica et biophysica acta. Molecular cell research 2018 - GeneRIF: data shows that by unbalancing the amount of TMEM177, newly synthesized COX2 accumulates in a COX20-associated state.
- Recessive dystonia-ataxia syndrome in a Turkish family caused by a COX20 (FAM36A) mutation.
Doss, Journal of neurology 2014 (PubMed)- GeneRIF: This study deministrated that phenotypic spectrum of mutation in COX20 to a recessively inherited, early-onset dystonia-ataxia syndrome that is characterized by reduced complex IV activity.
- Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
Bourens, Human molecular genetics 2014 - GeneRIF: COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.
- A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.
Szklarczyk, Human molecular genetics 2013 (PubMed)- GeneRIF: The function of the human gene FAM36A/COX20 in complex IV assembly and role of the gene in complex IV deficiency.
- More
Q9D7J4 Cytochrome c oxidase assembly protein COX20, mitochondrial from Mus musculus
Aligns to 9:104 / 117 (82.1%), covers 78.2% of PF12597, 44.5 bits
LOC102399263 cytochrome c oxidase assembly protein COX20, mitochondrial from Bubalus bubalis
Aligns to 14:104 / 121 (75.2%), covers 77.2% of PF12597, 42.8 bits
- Genome-Wide DNA Methylation and Its Effect on Gene Expression During Subclinical Mastitis in Water Buffalo
Nayan, Frontiers in genetics 2022 - “...UBE2G2, NCKAP1, CD302, EPC2, SUZ12, PPM1D, SAP30, HPGD, PLGRKT, PLEKHA5, AMN1, LOC102406990, PTGES3, SLC25A16, PCBD1, LOC102399263, CNIH4, TMEM262, TIPRL, HSD17B7, ZNF644, NEXN, SRSF11, SPATA6, ATPAF1, RRAGC, PI4K2B, ZNRF2, SRI, SLC25A46, FAM174A, RNF130, MPC1, QKI, CD24, SLIRP, FAM214A, PIGB, TPM1, AP3S1, RPS27A, VRK2, GEN1, GPR180, NDFIP2, PAN3,...”
Or search for genetic data about PF12597 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory