Family Search for PF13274 (SocA_Panacea)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF13274 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

SOCA_CAUVN / A0A0H3CCP8 Antitoxin SocA; Adapter protein SocA from Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus) (see paper)
Aligns to 36:140 / 188 (55.9%), covers 99.1% of PF13274, 59.7 bits

• function: Antitoxin component of an atypical type II toxin-antitoxin (TA) system. Unlike most type II TA systems, neutralizes the toxic activity of cognate toxin SocB by acting as an adapter to promote its degradation by ClpXP; degradation is dependent on the N-terminus of ClpX.
  subunit: Interacts with cognate toxin SocB and with ClpX.
  disruption phenotype: Essential, it cannot be deleted unless the downstream gene for cognate toxin socB is also deleted. In depletion experiments the half-life of SocB is 19 minutes in the absence of SocA and about 2 minutes in its presence.

Or search for genetic data about PF13274 in the Fitness Browser