Family Search for PF13349 (DUF4097)

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PF13349 hits 49 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

LIAG_BACSU / O32200 Protein LiaG from Bacillus subtilis (strain 168) (see 6 papers)
Aligns to 48:290 / 290 (83.8%), covers 100.0% of PF13349, 229.8 bits

• disruption phenotype: Up-regulates expression of liaI which in turn induces the liaRS two-component regulatory system.

LIAX_ENTFA / Q834B6 Putative adhesin domain-containing protein LiaX; Daptomycin-sensing surface protein LiaX from Enterococcus faecalis (strain ATCC 700802 / V583) (see paper)
Aligns to 277:529 / 533 (47.5%), covers 97.6% of PF13349, 66.5 bits

• function: Involved in cell membrane remodeling, perhaps acting by negative modulation of the liaFSR and liaXYZ gene clusters, thereby regulating content and localization of anionic phospholipids (PubMed:31818937). Binds to the antibiotic daptomycin (DAP) and to cationic antimicrobial peptides, such as human LL-37, perhaps functioning as a sensor that activates the cell envelope stress response (PubMed:31818937).
  disruption phenotype: Deletion in the OG1RF strain causes anionic phospholipids to be redistributed away from the division septum; during exponential growth, there are increases in phosphatidylglycerol (PG), decreases in cardiolipin, with no change in lysyl-PG (PubMed:31818937). Confers resistance to the antibiotic daptomycin (DAP) in the OG1RF strain (PubMed:31818937). Resistant to killing of the OG1RF strain by human cathelicidin LL-37 (PubMed:31818937). Deletion in the OG1RF strain increases virulence in nematode C.elegans infection model (PubMed:31818937).

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