Family Search for PF16297 (DUF4939)
April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.
PF16297 hits 31 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.
Q9D6I0 Cxx1c protein from Mus musculus
Aligns to 2:112 / 112 (99.1%), covers 100.0% of PF16297, 209.6 bits
RTL8C_HUMAN / A6ZKI3 Retrotransposon Gag-like protein 8C; Mammalian retrotransposon derived protein 8C from Homo sapiens (Human) (see paper)
NP_001071639 retrotransposon Gag-like protein 8C from Homo sapiens
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 183.1 bits
- RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
Mohan, Cellular and molecular life sciences : CMLS 2022 - “...Human and mouse RTL8 sequences were obtained from UniProt (Accession IDs Q9BWD3 (hRTL8A), Q17RB0 (hRTL8B), A6ZKI3 (hRTL8C), Q9D1F0 (mRTL8A/B) and Q9D6I0 (mRTL8C)). Alignment was conducted with the ESPript 3.0 web tool ( http://espript.ibcp.fr ) [ 80 ]. Percentage identity matrix based on sequence identity was generated...”
- Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues
Qian, Frontiers in endocrinology 2019 - “...Delphilin GK*MGTVSK*SR 10 570;576 1; 1 A6NNT2 C16orf96 Uncharacterized protein C16orf96 SALAGK*ASR 9 819 1 A6ZKI3 FAM127A Protein FAM127A K*ESPLLNDYR 10 86 1 1.64E+07 A8K6M4 cDNA FLJ75725, highly similar to Homo sapiens vesicle transport through interaction with t-SNAREs homolog 1B (yeast) (VTI1B), mRNA ASSAASSEHFEK*LHEIFR 18 13...”
- New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Liu, Journal of neuroinflammation 2018 - “...Significantly changed proteins in PCN033-infected hBMECs Accession Description MW [kDa] Fold change P value a A6ZKI3 Protein FAM127A 13.2 0.756 0.028947* O00625 Pirin 32.1 1.228 0.037445* O43633 Charged multivesicular body protein 2a 25.1 0.758 0.002376** O43752 Syntaxin-6 29.2 0.79 0.025619* O60524 Nuclear export mediator factor NEMF...”
- Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?
Dunning, ACS chemical neuroscience 2016 - “...UniProt gene protein intensity no. of residues Q8IUC8 GALNT13 polypeptide N -acetylgalactosaminyl-transferase 13 3.40 556 A6ZKI3 FAM127A protein FAM127A 3.09 113 or or or O15255 CAAX box protein1 209 Validation The array study provides a first clue to a direct high affinity interaction between A42 and...”
- RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
Mohan, Cellular and molecular life sciences : CMLS 2022 - GeneRIF: RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.
- Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling.
Franz, ChemMedChem 2021 - GeneRIF: Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling.
- Evaluation of expression level and methylation profile of CXX1 gene in breast cancer tissue blocks.
Mohammadi, Journal of cancer research and therapeutics (PubMed)- GeneRIF: Evaluation of expression level and methylation profile of CXX1 gene in breast cancer tissue blocks.
LDOC1_HUMAN / O95751 Protein LDOC1; Leucine zipper protein down-regulated in cancer cells from Homo sapiens (Human) (see 2 papers)
NP_036449 protein LDOC1 from Homo sapiens
Aligns to 24:138 / 146 (78.8%), covers 96.4% of PF16297, 182.9 bits
- function: May have an important role in the development and/or progression of some cancers
subunit: Interacts with NOD2. - Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar, PloS one 2019 - “...FN1 Fibronectin Q5JWF2 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas O95373 IPO7 Importin-7 O95751 LDOC1 Leucine zipper, down-regulated in cancer 1 Q9NTJ4 MAN2C1 -mannosidase 2C1 Q15084 PDIA6 Protein disulfide-isomerase Q15149 PLEC Plectin-1 P25789 PSMA4 Proteasome subunit alpha type-4 P62191 PSMC1 26S protease regulatory subunit...”
- LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma.
Zhao, Cell biology international 2020 (PubMed)- GeneRIF: LDOC1 is differentially expressed in thyroid cancer and display tumor-suppressive function in papillary thyroid carcinoma.
- LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients.
Wanka, International journal of molecular sciences 2020 - GeneRIF: LDOC1 as Negative Prognostic Marker for Vulvar Cancer Patients.
- Effects of LDOC1 on colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.
Jiang, Oncology reports 2019 - GeneRIF: LDOC1 is a tumor suppressor in Colorectal cancer (CRC) and it inhibits cell proliferation and promotes cell apoptosis. Additionally, it inhibits CRC cell metastasis by downregulating the Wnt/betacatenin signaling pathway.
- Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway.
Zhao, Stem cell research & therapy 2019 - GeneRIF: Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway.
- LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients.
Yong, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 (PubMed)- GeneRIF: data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas.
- NF-κB upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma.
Griesinger, Neuro-oncology 2017 - GeneRIF: that epigenetic silencing of LDOC1 in high-risk Group A ependymoma regulates tumor biology and drives inflammatory immune phenotype
- LDOC1 Gene Expression in Men With Klinefelter Syndrome.
Salemi, Journal of clinical laboratory analysis 2016 - GeneRIF: These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome.
- Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation.
Thoompumkal, Cell cycle (Georgetown, Tex.) 2016 - GeneRIF: GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis.
- More
RTL8A_HUMAN / Q9BWD3 Retrotransposon Gag-like protein 8A; Mammalian retrotransposon derived protein 8A from Homo sapiens (Human) (see paper)
Aligns to 2:113 / 113 (99.1%), covers 100.0% of PF16297, 181.7 bits
RTL8B_HUMAN / Q17RB0 Retrotransposon Gag-like protein 8B; Mammalian retrotransposon derived protein 8B from Homo sapiens (Human) (see paper)
NP_001071641 retrotransposon Gag-like protein 8B from Homo sapiens
Aligns to 2:113 / 113 (99.1%), covers 99.1% of PF16297, 181.7 bits
Q9D1F0 CAAX box 1 homolog A (Human) from Mus musculus
Aligns to 5:113 / 113 (96.5%), covers 86.6% of PF16297, 175.0 bits
NP_001127793 retrotransposon Gag-like protein 8A isoform 2 from Homo sapiens
Aligns to 2:77 / 83 (91.6%), covers 56.2% of PF16297, 88.3 bits
RTL6_HUMAN / Q6ICC9 Retrotransposon Gag-like protein 6; Leucine zipper protein down-regulated in cancer cells-like; Mammalian retrotransposon-derived protein 6; Protein LDOC1L from Homo sapiens (Human) (see paper)
Aligns to 84:179 / 239 (40.2%), covers 73.2% of PF16297, 73.6 bits
RTL6_MOUSE / Q505G4 Retrotransposon Gag-like protein 6; Mammalian retrotransposon-derived protein 6; Protein LDOC1L; Protein Sushi-15E3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 83:179 / 243 (39.9%), covers 73.2% of PF16297, 72.2 bits
NP_001277722 retrotransposon-derived protein PEG10 from Ovis aries
Aligns to 138:243 / 405 (26.2%), covers 74.1% of PF16297, 58.9 bits
NP_001103285 retrotransposon-derived protein PEG10 isoform 4 from Bos taurus
Aligns to 138:243 / 405 (26.2%), covers 74.1% of PF16297, 58.9 bits
PEG10_HUMAN / Q86TG7 Retrotransposon-derived protein PEG10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Homo sapiens (Human) (see 17 papers)
Aligns to 58:165 / 708 (15.3%), covers 74.1% of PF16297, 58.4 bits
- function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity). Involved at the immediate early stage of adipocyte differentiation (By similarity). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
subunit: Homooligomer; homooligomerizes into virion-like capsids (By similarity). Interacts with ACVRL1 (PubMed:15611116). Interacts with SIAH1 and SIAH2 (PubMed:12810624). - Functional Study of the Retrotransposon-Derived Human PEG10 Protease.
Golda, International journal of molecular sciences 2020 - “...using the Jpred4 server [ 43 ] based on the sequence of PR PEG10 (UniProtKB: Q86TG7). Disorder prediction was performed using the IUPred web server [ 46 ]. Modeller9v13 [ 47 ] was used to prepare a homology model for the 346477 region of RF1/RF2 PEG10...”
- Molecular spectrum of secretome regulates the relative hepatogenic potential of mesenchymal stem cells from bone marrow and dental tissue.
Kumar, Scientific reports 2017 - “...Adenomatous polyposis coli protein Plays a role in hepatocyte growth factor (HGF)-induced cell migration 2 Q86TG7 PEG10 Retrotransposon-derived protein PEG10 Prevents apoptosis in hepatocellular carcinoma. May also have a role in cell growth promotion and hepatoma formation 3 P21439 ABCB4 Phosphatidylcholine translocator ABCB4 Mediates the translocation...”
- High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.
Chiu, PloS one 2014 - “...Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. PEG10 Q86TG7 Retrotransposon-derived protein PEG10 0.37 4 3.2510 11 Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. CDK4 P11802 Cyclin-dependent kinase 4 0.37 2 2.1010...”
- Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
Nomura, Journal of clinical bioinformatics 2011 - “...1 13 84 1433S P31947 14-3-3 protein sigma 4.19 4.08E-02 -2.21 0 7 85 PEG10 Q86TG7 Retrotransposon-derived protein PEG10 4.19 4.08E-02 -2.21 0 7 86 CAYP1 Q13938 Calcyphosin 4.19 4.08E-02 -2.21 0 7 87 GBB1 P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 4.19 4.08E-02 -2.21 0...”
NP_001165908 retrotransposon-derived protein PEG10 isoform 3 from Homo sapiens
Aligns to 134:241 / 784 (13.8%), covers 74.1% of PF16297, 58.2 bits
F7G2J3 Retrotransposon Gag like 1 from Macaca mulatta
Aligns to 182:285 / 1359 (7.7%), covers 75.9% of PF16297, 55.7 bits
NP_001120696 retrotransposon-derived protein PEG10 isoform 3 from Sus scrofa
Aligns to 142:243 / 786 (13.0%), covers 70.5% of PF16297, 55.2 bits
XP_023484169 retrotransposon-like protein 1 from Equus caballus
Aligns to 168:270 / 1349 (7.6%), covers 75.0% of PF16297, 54.3 bits
XP_014957540 retrotransposon-like protein 1 from Ovis aries
Aligns to 168:271 / 1333 (7.8%), covers 75.9% of PF16297, 53.8 bits
NP_001035701 retrotransposon-derived protein PEG10 isoform 2 from Mus musculus
Aligns to 129:220 / 376 (24.5%), covers 68.8% of PF16297, 53.7 bits
- PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma.
Liu, Blood 2022 - GeneRIF: PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma.
- Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.
Segel, Science (New York, N.Y.) 2021 - GeneRIF: Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.
- PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta.
Shiura, Development (Cambridge, England) 2021 - GeneRIF: PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta.
- The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.
Abed, PloS one 2019 - GeneRIF: Expression of Hbegf was reduced in PEG10-deficient trophoblast stem cells (TSCs) suggesting that PEG10 might bind to and stabilize RNAs that are critical for normal placental development
- LncRNA PEG10 aggravates cardiac hypertrophy through regulating HOXA9.
Wen, European review for medical and pharmacological sciences 2019 (PubMed)- GeneRIF: LncRNA PEG10 aggravates cardiac hypertrophy through regulating HOXA9.
- Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development.
Koppes, PloS one 2015 - GeneRIF: Loss of DNA methylation at the Peg10 imprinted gDMD associated with decreased embryonic viability and decreased labyrinthine volume.
- peg10, an imprinted gene, plays a crucial role in adipocyte differentiation.
Hishida, FEBS letters 2007 (PubMed)- GeneRIF: These findings strongly indicate that peg10 plays a crucial role at the immediate early stage of adipocyte differentiation.
- Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues.
Clark, The Journal of biological chemistry 2007 (PubMed)- GeneRIF: the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals
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NP_001128360 retrotransposon-like protein 1 from Homo sapiens
Aligns to 181:283 / 1358 (7.6%), covers 75.9% of PF16297, 52.7 bits
- The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
Kitazawa, Genes to cells : devoted to molecular & cellular mechanisms 2021 - GeneRIF: The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
- Expression profiling of RTL1 in human breast cancer tissues and cell lines.
Mahmoudi, Experimental and molecular pathology 2021 (PubMed)- GeneRIF: Expression profiling of RTL1 in human breast cancer tissues and cell lines.
- Role of DNA methylation at the placental RTL1 gene locus in type 1 diabetes.
Belot, Pediatric diabetes 2017 (PubMed)- GeneRIF: Data suggest that DNA is differentially methylated (hypomethylated) at a gene locus associated with regulation of expression of RTL1 and miR136 in type 1 diabetes; these studies were conducted using tissue bank placentas and whole blood cell DNA from children with type 1 diabetes. (RTL1 = retrotransposon-like protein 1; miR136 = microRNA 136)
- The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humans.
Prats-Puig, American journal of obstetrics and gynecology 2017 (PubMed)- GeneRIF: We find that placental expression of DIO3 and RTL1) correlates with prenatal growth. Combined, these findings suggest that epigenetic programming and gene expression within the DLK1-DIO3 imprinted domain influence both prenatal and postnatal growth.
- Increased l1 retrotransposition in the neuronal genome in schizophrenia.
Bundo, Neuron 2014 (PubMed)- GeneRIF: The results of this study suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.
- Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.
Riordan, PLoS genetics 2013 - GeneRIF: In addition to identifying Rtl1 as a novel driver of HCC, our study represents one of the first direct in vivo demonstrations of a role for such a co-opted genetic element in promoting carcinogenesis.
- Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes.
Kagami, Nature genetics 2008 (PubMed)- GeneRIF: RTL1, a paternally expressed gene in a cluster of imprinted genes on chromosome 14q32.2, is associated with upd(14)pat-like and upd(14)mat-like phenotypes.
B9EK54 RTL1 protein from Homo sapiens
Aligns to 181:283 / 1358 (7.6%), covers 75.9% of PF16297, 52.6 bits
PEG10_MOUSE / Q7TN75 Retrotransposon-derived protein PEG10; MmPEG10; Embryonal carcinoma differentiation regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3; MyEF-3; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein from Mus musculus (Mouse) (see 10 papers)
Aligns to 130:220 / 958 (9.5%), covers 68.8% of PF16297, 51.7 bits
- function: Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:30951545, PubMed:34413232). Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232). Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232). Involved in placenta formation: required for trophoblast stem cells differentiation (PubMed:16341224, PubMed:30951545). Involved at the immediate early stage of adipocyte differentiation (PubMed:17707377). Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (By similarity). Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (PubMed:9473521).
subunit: Homooligomer; homooligomerizes into virion-like capsids (PubMed:34413232). Interacts with ACVRL1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity).
disruption phenotype: Embryonic lethality resulting from placental defects.
E9Q3F7 Paternally expressed 10 from Mus musculus
Aligns to 130:220 / 1005 (9.1%), covers 68.8% of PF16297, 51.6 bits
RTL3_HUMAN / Q8N8U3 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Homo sapiens (Human) (see paper)
Aligns to 219:325 / 475 (22.5%), covers 74.1% of PF16297, 50.1 bits
- function: May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
- Standardization of a protocol for shotgun proteomic analysis of saliva
Ventura, Journal of applied oral science : revista FOB 2018 - “...repeat-containing protein mio 208.07 1.94 Q9BUG6 Zinc finger and SCAN domain-containing protein 5A 97.41 13.71 Q8N8U3 Zinc finger CCHC domain-containing protein 5 189.02 7.79 Q9H0M4 Zinc finger CW-type PWWP domain protein 1 242.57 7.10 Q9NWS9 Zinc finger protein 446 77.75 7.56 P25311 Zinc-alpha-2-glycoprotein 1420.80 28.19 Q96DA0...”
NP_001127830 retrotransposon-like protein 1 from Sus scrofa
Aligns to 168:275 / 1357 (8.0%), covers 83.0% of PF16297, 48.1 bits
RTL5_HUMAN / Q5HYW3 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Homo sapiens (Human) (see paper)
Aligns to 138:231 / 569 (16.5%), covers 67.9% of PF16297, 47.1 bits
RTL5_MOUSE / Q5DTT4 Retrotransposon Gag-like protein 5; Retrotransposon gag domain-containing protein 4 from Mus musculus (Mouse) (see paper)
XP_006528164 retrotransposon Gag-like protein 5 isoform X1 from Mus musculus
Aligns to 141:237 / 599 (16.2%), covers 67.0% of PF16297, 45.3 bits
RTL1_MOUSE / Q7M732 Retrotransposon-like protein 1; Mammalian retrotransposon derived protein 1; Paternally expressed gene 11 protein; Retrotransposon-derived protein PEG11 from Mus musculus (Mouse) (see 3 papers)
NP_908998 retrotransposon-like protein 1 from Mus musculus
Aligns to 434:538 / 1744 (6.0%), covers 72.3% of PF16297, 44.8 bits
- function: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
disruption phenotype: Mice suffer from late fetal or neonatal lethality. Mice overexpressing Rtl1 show notable overgrowth and morphological abnormalities of the placenta. - The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
Kitazawa, Genes to cells : devoted to molecular & cellular mechanisms 2021 - GeneRIF: The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes.
- Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes.
Kitazawa, Development (Cambridge, England) 2020 - GeneRIF: Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes.
- Severe damage to the placental fetal capillary network causes mid- to late fetal lethality and reduction in placental size in Peg11/Rtl1 KO mice.
Kitazawa, Genes to cells : devoted to molecular & cellular mechanisms 2017 (PubMed)- GeneRIF: Paternally expressed 11/Retrotransposon-like 1 (Peg11/Rtl1) knockout (KO) mice show mid- to late fetal lethality or late fetal growth retardation associated with frequent neonatal lethality
- A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development.
Ito, Development (Cambridge, England) 2015 - GeneRIF: miR-127 is an essential regulator of Rtl1, mediated by a trans-homologue interaction between reciprocally imprinted genes on the maternally and paternally inherited chromosomes
- Aberrant epigenetic reprogramming of imprinted microRNA-127 and Rtl1 in cloned mouse embryos.
Cui, Biochemical and biophysical research communications 2009 (PubMed)- GeneRIF: These data support a role for mir-127 and mir-136 in the epigenetic reprogramming of the Rtl1 imprinting process.
- Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta.
Sekita, Nature genetics 2008 (PubMed)- GeneRIF: Rtl1, an imprinted gene with preferential expression from the paternal allele, is essential for maintenance of the fetal capillaries.
- Adipogenesis in mouse 3T3L1 cells: the effects of Rtl1 over-expression.
Leeton, Functional & integrative genomics 2007 (PubMed)- GeneRIF: Despite the coordinate down-regulation of Dlk1 and Rtl1 mRNA levels, Rtl1 over-expression did not affect the time course of adipogenesis or Dlk1 expression
BOP_HUMAN / Q7L3V2 Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10 from Homo sapiens (Human) (see paper)
NP_078903 protein Bop from Homo sapiens
Aligns to 85:183 / 364 (27.2%), covers 71.4% of PF16297, 40.5 bits
- function: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
subunit: Interacts (via BH3 domain) with VDAC1. Interacts with pro- survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2. Interacts with BAX and BAK1. - Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective
Sora, Frontiers in molecular biosciences 2022 - “...TGVNLTTVDDSI 25408501 Indirectly anti-apoptotic (HERC1 ubiquitinates BAK causing its subsequent degradation) [25408501] Protein BOP (BOP) Q7L3V2 RTL10 114 125 LDRFLAQLGDYM 23055042 Directly pro-apoptotic (BOP binds BAK) [23055042] The role of the (BH3-mediated) BOP/BCL2, BOP/BCLXL, BOP/MCL1, BOP/BCL2L2, and BOP/BFL1 interactions in apoptosis remains to be investigated [23055042]...”
- BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment.
Busche, Cell death & disease 2021 - GeneRIF: BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment.
- BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.
Greaves, Cell death and differentiation 2019 - GeneRIF: The BH3-only proteins were required for apoptosis induced as a result of BCL-XL inhibition, this requirement was overcome when both BCL-XL and MCL-1 were inhibited, implicating distinct mechanisms by which different anti-apoptotic BCL-2 family members may regulate apoptosis in cancer.
- BH3-only proteins: possible proapoptotic triggers for melanoma therapy.
Plötz, Experimental dermatology 2014 (PubMed)- GeneRIF: Members of the subfamily of BH3-only proteins function as proapoptotic triggers, and mimetics of these proteins are already in clinical trials in other cancers.
- [Effect and significance of BH3-only protein in targeted therapy of
non-small cell lung cancer].
Gao, Zhongguo fei ai za zhi = Chinese journal of lung cancer 2014 - GeneRIF: Studies indicate that BH3-only protein (C22orf29 protein) plays an important role in activation and communication in apoptosis pathways.
- Human Bop is a novel BH3-only member of the Bcl-2 protein family.
Zhang, Protein & cell 2012 - GeneRIF: Bop may be a novel BH3-only factor that can engage with the regulatory network of Bcl-2 family members to process intrinsic apoptotic signaling
An08g11200 uncharacterized protein from Aspergillus niger
Aligns to 172:266 / 496 (19.2%), covers 69.6% of PF16297, 31.8 bits
Z518_11416 uncharacterized protein from Rhinocladiella mackenziei CBS 650.93
Aligns to 37:146 / 372 (29.6%), covers 73.2% of PF16297, 31.7 bits
- Genomic Understanding of an Infectious Brain Disease from the Desert
Moreno, G3 (Bethesda, Md.) 2018 - “...in the reference genome. This scaffold was 4775 bp long and contained two protein-coding genes (Z518_11416 and Z518_11417) annotated as hypothetical proteins, holding PFAM functional domains associated with LTR retrotransposons (PF03732)/zinc finger domains (PF00098) and manipulation of chromatin (PF00385). In order to further investigate the genomic...”
RTL3_MOUSE / Q6P1Y1 Retrotransposon Gag-like protein 3; Zinc finger CCHC domain-containing protein 5 from Mus musculus (Mouse) (see 2 papers)
Aligns to 289:397 / 553 (19.7%), covers 80.4% of PF16297, 30.3 bits
- function: May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).
Or search for genetic data about PF16297 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory