Family Search for PF16332 (DUF4962)

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PF16332 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

BT4652 heparan sulfate cleaving enzyme from Bacteroides thetaiotaomicron VPI-5482
Aligns to 31:503 / 872 (54.2%), covers 100.0% of PF16332, 772.6 bits

• mutant phenotype: # Specifically important in carbon source Heparin sodium salt from porcine intestinal mucosa. 66% identical to the heparan sulfate cleaving enzyme ALJ58962.1 (PMID:30850540)

A9CEJ9 guluronate-specific alginate lyase (EC 4.2.2.11); mannuronate-specific alginate lyase (EC 4.2.2.3) from Agrobacterium tumefaciens (see paper)
Aligns to 44:464 / 776 (54.3%), covers 83.4% of PF16332, 139.5 bits

oal / Q9KWT4 oligoalginate lyase (EC 4.2.2.26) from Sphingomonas sp. (see 2 papers)
Aligns to 33:456 / 761 (55.7%), covers 84.7% of PF16332, 119.7 bits

Q5DWP2 mannuronate-specific alginate lyase (EC 4.2.2.3) from Sphingomonas sp. (see paper)
Aligns to 37:404 / 812 (45.3%), covers 72.7% of PF16332, 85.0 bits

E5X103 heparin lyase (EC 4.2.2.7) from Bacteroides eggerthii (see paper)
Aligns to 22:276 / 773 (33.0%), covers 34.9% of PF16332, 32.8 bits

C0JBW5 heparin lyase (EC 4.2.2.7) from Bacteroides stercoris (see paper)
Aligns to 41:275 / 773 (30.4%), covers 34.9% of PF16332, 32.1 bits

hepB / C6XZB6 heparinase II (EC 4.2.2.8; EC 4.2.2.7) from Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) (see 3 papers)
HEPB_PEDHD / C6XZB6 Heparin and heparin-sulfate lyase; Heparin lyase; Heparin-sulfate lyase; Heparinase II; HepII; EC 4.2.2.7; EC 4.2.2.8 from Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) (see 3 papers)
Aligns to 40:314 / 772 (35.6%), covers 32.4% of PF16332, 30.3 bits

• function: Cleaves both heparin and heparan sulfate glycosaminoglycans through a beta-elimination mechanism. Cleaves heparin at alpha-D- GlcNp2S6S(1->4) alpha-L-IdoAp2S and heparan sulfate at alpha-D- GlcNp2Ac(or 2S)6OH(1->4)beta-D-GlcAp.
  catalytic activity: Elimination of sulfate, appears to act on linkages between N- acetyl-D-glucosamine and uronate. Product is an unsaturated sugar.
  catalytic activity: Eliminative cleavage of polysaccharides containing (1->4)- linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends.
  subunit: Homodimer.

DSE_BOVIN / P0C2H4 Dermatan-sulfate epimerase; DS epimerase; Chondroitin-glucuronate 5-epimerase; EC 5.1.3.19 from Bos taurus (Bovine) (see paper)
Aligns to 109:354 / 958 (25.7%), covers 33.8% of PF16332, 29.3 bits

• function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
  catalytic activity: chondroitin 4'-sulfate = dermatan 4'-sulfate (RHEA:21084)
  cofactor: Mn(2+) (Also has weak activity in the presence of Mg(2+) or Ca(2+) ions.)

DSE / Q9UL01 dermatan-sulfate epimerase (EC 5.1.3.19) from Homo sapiens (see 4 papers)
DSE_HUMAN / Q9UL01 Dermatan-sulfate epimerase; DS epimerase; Chondroitin-glucuronate 5-epimerase; Squamous cell carcinoma antigen recognized by T-cells 2; SART-2; EC 5.1.3.19 from Homo sapiens (Human) (see 5 papers)
Aligns to 119:353 / 958 (24.5%), covers 33.6% of PF16332, 28.7 bits

• function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
  catalytic activity: chondroitin 4'-sulfate = dermatan 4'-sulfate (RHEA:21084)
  cofactor: Mn(2+) (Also has weak activity in the presence of Mg(2+) or Ca(2+) ions.)

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