Family Search for PF16473 (Rv2179c-like)

April 2024: See Interactive Tools for Functional Annotation of Bacterial Genomes for advice on using these tools.

PF16473 hits 50 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

EXOD_BPT4 / P04536 Exodeoxyribonuclease; 3'-5' exonuclease; EC 3.1.11.1 from Enterobacteria phage T4 (Bacteriophage T4) (see 2 papers)
Aligns to 3:203 / 227 (88.5%), covers 79.1% of PF16473, 79.9 bits

• function: 3'-5' exonuclease that preferentially uses ssDNA as substrate. Plays a role in group I intron homing. May play a role in the final step of host DNA degradation, by scavenging DNA into mononucleotides.
  catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.

EXRBN_MYCTU / P9WJ73 3'-5' exoribonuclease Rv2179c; EC 3.1.13.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 1:157 / 168 (93.5%), covers 97.7% of PF16473, 47.8 bits

• function: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA. Has no activity with 5' overhangs. Has negligible endonuclease activity. Can bind ATP, dATP and AMP (in vitro); the nucleotide occupies the predicted substrate binding site.
  cofactor: Mg(2+) (Binds 1 Mg(2+) ion per subunit.)
  subunit: Homodimer.

B2HGU6 poly(A)-specific ribonuclease (EC 3.1.13.4) from Mycobacterium marinum (see paper)
Aligns to 1:157 / 159 (98.7%), covers 96.0% of PF16473, 45.2 bits

Or search for genetic data about PF16473 in the Fitness Browser